JP2018126170A5 - - Google Patents
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- JP2018126170A5 JP2018126170A5 JP2018101501A JP2018101501A JP2018126170A5 JP 2018126170 A5 JP2018126170 A5 JP 2018126170A5 JP 2018101501 A JP2018101501 A JP 2018101501A JP 2018101501 A JP2018101501 A JP 2018101501A JP 2018126170 A5 JP2018126170 A5 JP 2018126170A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- polypeptide
- mhc
- human
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767811P | 2013-02-22 | 2013-02-22 | |
| US61/767,811 | 2013-02-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558950A Division JP6444321B2 (ja) | 2013-02-22 | 2014-02-20 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018126170A JP2018126170A (ja) | 2018-08-16 |
| JP2018126170A5 true JP2018126170A5 (enExample) | 2019-02-07 |
| JP6681939B2 JP6681939B2 (ja) | 2020-04-15 |
Family
ID=50236326
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558950A Active JP6444321B2 (ja) | 2013-02-22 | 2014-02-20 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| JP2018101501A Active JP6681939B2 (ja) | 2013-02-22 | 2018-05-28 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558950A Active JP6444321B2 (ja) | 2013-02-22 | 2014-02-20 | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10154658B2 (enExample) |
| EP (3) | EP3699190B9 (enExample) |
| JP (2) | JP6444321B2 (enExample) |
| KR (1) | KR102211267B1 (enExample) |
| CN (2) | CN110192541B (enExample) |
| AU (2) | AU2014218893C1 (enExample) |
| CA (1) | CA2900824A1 (enExample) |
| CY (1) | CY1121223T1 (enExample) |
| DK (1) | DK2958937T3 (enExample) |
| ES (3) | ES2949029T3 (enExample) |
| HR (1) | HRP20181866T1 (enExample) |
| HU (1) | HUE041878T2 (enExample) |
| LT (1) | LT2958937T (enExample) |
| PL (1) | PL2958937T3 (enExample) |
| PT (1) | PT2958937T (enExample) |
| RS (1) | RS57963B1 (enExample) |
| SI (1) | SI2958937T1 (enExample) |
| SM (1) | SMT201800614T1 (enExample) |
| WO (1) | WO2014130667A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| RS63220B1 (sr) | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
| SI2958937T1 (sl) | 2013-02-22 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| AU2014249148B2 (en) * | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| HRP20231121T1 (hr) | 2013-09-23 | 2023-12-22 | Regeneron Pharmaceuticals, Inc. | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale |
| JP6492095B2 (ja) | 2013-10-15 | 2019-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｉｌ−１５動物 |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
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| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| ES2841353T3 (es) * | 2014-12-09 | 2021-07-08 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado |
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| CN108366548B (zh) | 2015-11-20 | 2021-10-08 | 瑞泽恩制药公司 | 具有人源化淋巴细胞活化基因3的非人动物 |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| EP4534560A3 (en) | 2018-03-24 | 2025-06-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| IL277355B2 (en) | 2018-03-26 | 2025-01-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| CA3098040A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| JP7506686B2 (ja) | 2019-04-04 | 2024-06-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化凝固因子１２遺伝子座を含む非ヒト動物 |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
| EP4087392A4 (en) * | 2020-01-10 | 2024-02-21 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC MHC PROTEIN COMPLEX |
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| EP4654982A1 (en) | 2023-01-27 | 2025-12-03 | Regeneron Pharmaceuticals, Inc. | Modified rhabdovirus glycoproteins and uses thereof |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| KR20260074976A (ko) | 2023-09-19 | 2026-05-27 | 리제너론 파마슈티칼스 인코포레이티드 | 바이러스 펩티드 및 이의 용도 |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| CN122438694A (zh) | 2023-12-19 | 2026-07-21 | 瑞泽恩制药公司 | Foxp3肽及其用途 |
| WO2025178991A1 (en) | 2024-02-21 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | Splicing factor gene mutation-associated neoantigenic peptides and uses thereof |
| WO2026006734A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Off-target peptide-mhc complex conformation modeling systems and methods for antigen-recognition molecule development |
| WO2026006724A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Prame off-target peptides and uses thereof |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
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-
2014
- 2014-02-20 SI SI201430965T patent/SI2958937T1/sl unknown
- 2014-02-20 US US14/185,316 patent/US10154658B2/en active Active
- 2014-02-20 KR KR1020157026032A patent/KR102211267B1/ko active Active
- 2014-02-20 HU HUE14708429A patent/HUE041878T2/hu unknown
- 2014-02-20 PL PL14708429T patent/PL2958937T3/pl unknown
- 2014-02-20 ES ES20163735T patent/ES2949029T3/es active Active
- 2014-02-20 ES ES14708429T patent/ES2697248T3/es active Active
- 2014-02-20 DK DK14708429.7T patent/DK2958937T3/en active
- 2014-02-20 JP JP2015558950A patent/JP6444321B2/ja active Active
- 2014-02-20 CN CN201910379017.5A patent/CN110192541B/zh active Active
- 2014-02-20 SM SM20180614T patent/SMT201800614T1/it unknown
- 2014-02-20 EP EP20163735.2A patent/EP3699190B9/en active Active
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- 2014-02-20 CN CN201480022254.1A patent/CN105164154B/zh active Active
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2021
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