ES2764829T3 - Ratones transgénicos que expresan moléculas quiméricas del complejo mayor de histocompatibilidad (mhc) de clase I - Google Patents
Ratones transgénicos que expresan moléculas quiméricas del complejo mayor de histocompatibilidad (mhc) de clase I Download PDFInfo
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- ES2764829T3 ES2764829T3 ES14718226T ES14718226T ES2764829T3 ES 2764829 T3 ES2764829 T3 ES 2764829T3 ES 14718226 T ES14718226 T ES 14718226T ES 14718226 T ES14718226 T ES 14718226T ES 2764829 T3 ES2764829 T3 ES 2764829T3
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| PCT/US2014/023076 WO2014164640A1 (en) | 2013-03-11 | 2014-03-11 | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
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| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
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| EP3209769B1 (en) | 2014-10-24 | 2020-08-05 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
| AU2016246698B2 (en) * | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| CN109456942A (zh) * | 2017-09-06 | 2019-03-12 | 亘喜生物科技（上海）有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
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| CN113105555B (zh) * | 2020-01-10 | 2023-05-30 | 百奥赛图(北京)医药科技股份有限公司 | Mhc分子人源化的非人动物的构建方法及应用 |
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| EP4215042A1 (en) | 2022-01-21 | 2023-07-26 | Max-Delbrück-Centrum für Molekulare Medizin | A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof |
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| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
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| EP2967014A1 (en) | 2016-01-20 |
| AU2020204410B2 (en) | 2022-11-24 |
| CN105188358A (zh) | 2015-12-23 |
| AU2020204410A1 (en) | 2020-07-23 |
| AU2014249150A1 (en) | 2015-09-24 |
| KR20150131150A (ko) | 2015-11-24 |
| EP2967014B1 (en) | 2019-10-16 |
| HK1212859A1 (en) | 2016-06-24 |
| JP2016510998A (ja) | 2016-04-14 |
| WO2014164640A1 (en) | 2014-10-09 |
| JP6456351B2 (ja) | 2019-01-23 |
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