AU2014249150B2 - Transgenic mice expressing chimeric major histocompatibility complex (MHC) class I molecules - Google Patents

Transgenic mice expressing chimeric major histocompatibility complex (MHC) class I molecules Download PDF

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Publication number
AU2014249150B2
AU2014249150B2 AU2014249150A AU2014249150A AU2014249150B2 AU 2014249150 B2 AU2014249150 B2 AU 2014249150B2 AU 2014249150 A AU2014249150 A AU 2014249150A AU 2014249150 A AU2014249150 A AU 2014249150A AU 2014249150 B2 AU2014249150 B2 AU 2014249150B2
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AU
Australia
Prior art keywords
human
mouse
polypeptide
mhc
hla
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AU2014249150A
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English (en)
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AU2014249150A1 (en
Inventor
Cagan Gurer
Faith HARRIS
Lynn Macdonald
John Mcwhirter
Andrew J. Murphy
Sean Stevens
Vera VORONINA
Yingzi Xue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/793,812 external-priority patent/US9591835B2/en
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of AU2014249150A1 publication Critical patent/AU2014249150A1/en
Application granted granted Critical
Publication of AU2014249150B2 publication Critical patent/AU2014249150B2/en
Priority to AU2020204410A priority Critical patent/AU2020204410C1/en
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Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2014249150A 2013-03-11 2014-03-11 Transgenic mice expressing chimeric major histocompatibility complex (MHC) class I molecules Active AU2014249150B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020204410A AU2020204410C1 (en) 2013-03-11 2020-07-01 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/793,812 2013-03-11
US13/793,812 US9591835B2 (en) 2011-10-28 2013-03-11 Genetically modified major histocompatibility complex animals
PCT/US2014/023076 WO2014164640A1 (en) 2013-03-11 2014-03-11 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020204410A Division AU2020204410C1 (en) 2013-03-11 2020-07-01 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules

Publications (2)

Publication Number Publication Date
AU2014249150A1 AU2014249150A1 (en) 2015-09-24
AU2014249150B2 true AU2014249150B2 (en) 2020-04-02

Family

ID=50513441

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014249150A Active AU2014249150B2 (en) 2013-03-11 2014-03-11 Transgenic mice expressing chimeric major histocompatibility complex (MHC) class I molecules
AU2020204410A Active AU2020204410C1 (en) 2013-03-11 2020-07-01 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020204410A Active AU2020204410C1 (en) 2013-03-11 2020-07-01 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules

Country Status (8)

Country Link
EP (1) EP2967014B1 (enExample)
JP (1) JP6456351B2 (enExample)
KR (1) KR102313053B1 (enExample)
CN (1) CN105188358B (enExample)
AU (2) AU2014249150B2 (enExample)
CA (1) CA2902543A1 (enExample)
ES (1) ES2764829T3 (enExample)
WO (1) WO2014164640A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
CA2900832A1 (en) 2013-02-20 2014-08-28 Regeneron Pharmaceuticals, Inc. Mice expressing humanized t-cell co-receptors
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
JP6444321B2 (ja) 2013-02-22 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化主要組織適合性遺伝子複合体を発現するマウス
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
EP3209769B1 (en) 2014-10-24 2020-08-05 The Board of Trustees of the Leland Stanford Junior University Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
AU2016246698B2 (en) * 2015-04-06 2022-06-02 Regeneron Pharmaceuticals, Inc. Humanized T cell mediated immune responses in non-human animals
CN109456942A (zh) * 2017-09-06 2019-03-12 亘喜生物科技（上海）有限公司 通用型嵌合抗原受体t细胞制备技术
JP7699749B2 (ja) * 2019-05-27 2025-06-30 株式会社トランスジェニックグループ エクソンヒト化マウス
US10841728B1 (en) 2019-10-10 2020-11-17 Boomcloud 360, Inc. Multi-channel crosstalk processing
CN113105555B (zh) * 2020-01-10 2023-05-30 百奥赛图(北京)医药科技股份有限公司 Mhc分子人源化的非人动物的构建方法及应用
IL307238A (en) 2021-03-31 2023-11-01 Regeneron Pharma Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire
EP4215042A1 (en) 2022-01-21 2023-07-26 Max-Delbrück-Centrum für Molekulare Medizin A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof
WO2025212991A1 (en) 2024-04-05 2025-10-09 Regeneron Pharmaceuticals, Inc. Rodent models of disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005004592A2 (en) * 2003-07-30 2005-01-20 Institut Pasteur Transgenic mice having a human major histocompatibility complex (mhc) phenotype, experimental uses and applications
WO2013063346A1 (en) * 2011-10-28 2013-05-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489742A (en) * 1990-10-23 1996-02-06 Board Of Regents, The University Of Texas System Transgenic rats and animal models of inflammatory disease
US20020151690A1 (en) * 1997-08-12 2002-10-17 Luxemburg Alain T Purification of antigen-specific t cells
WO2000065058A1 (en) * 1999-04-23 2000-11-02 Pharmexa A/S Method for down-regulating il5 activity
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JPWO2002047474A1 (ja) 2000-12-13 2004-04-15 住友製薬株式会社 Ｈｌａ−ａ２４発現トランスジェニック動物及びその利用
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US20040052773A1 (en) * 2002-01-18 2004-03-18 Inovio As Production of multi-chain protein from muscle
SE0301109D0 (sv) * 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
EP1802193B1 (en) 2004-10-19 2014-04-30 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005004592A2 (en) * 2003-07-30 2005-01-20 Institut Pasteur Transgenic mice having a human major histocompatibility complex (mhc) phenotype, experimental uses and applications
WO2013063346A1 (en) * 2011-10-28 2013-05-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice

Also Published As

Publication number Publication date
CA2902543A1 (en) 2014-10-09
AU2020204410C1 (en) 2023-02-02
CN105188358B (zh) 2018-01-26
KR102313053B1 (ko) 2021-10-18
EP2967014A1 (en) 2016-01-20
AU2020204410B2 (en) 2022-11-24
CN105188358A (zh) 2015-12-23
AU2020204410A1 (en) 2020-07-23
AU2014249150A1 (en) 2015-09-24
KR20150131150A (ko) 2015-11-24
ES2764829T3 (es) 2020-06-04
EP2967014B1 (en) 2019-10-16
HK1212859A1 (en) 2016-06-24
JP2016510998A (ja) 2016-04-14
WO2014164640A1 (en) 2014-10-09
JP6456351B2 (ja) 2019-01-23

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