JP2014532411A5 - - Google Patents
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- Publication number
- JP2014532411A5 JP2014532411A5 JP2014539027A JP2014539027A JP2014532411A5 JP 2014532411 A5 JP2014532411 A5 JP 2014532411A5 JP 2014539027 A JP2014539027 A JP 2014539027A JP 2014539027 A JP2014539027 A JP 2014539027A JP 2014532411 A5 JP2014532411 A5 JP 2014532411A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mhc
- chimeric
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 175
- 229920001184 polypeptide Polymers 0.000 claims description 174
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 174
- 241000283984 Rodentia Species 0.000 claims description 64
- 239000002773 nucleotide Substances 0.000 claims description 34
- 125000003729 nucleotide group Chemical group 0.000 claims description 34
- 241001465754 Metazoa Species 0.000 claims description 33
- 230000001086 cytosolic effect Effects 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 19
- 230000001105 regulatory effect Effects 0.000 claims description 18
- 108010046732 HLA-DR4 Antigen Proteins 0.000 claims description 16
- 108010010378 HLA-DP Antigens Proteins 0.000 claims description 12
- 102000015789 HLA-DP Antigens Human genes 0.000 claims description 12
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims description 12
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 12
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 12
- 101100263837 Bovine ephemeral fever virus (strain BB7721) beta gene Proteins 0.000 claims description 3
- 101100316840 Enterobacteria phage P4 Beta gene Proteins 0.000 claims description 3
- 101150087698 alpha gene Proteins 0.000 claims description 3
- 101150062179 II gene Proteins 0.000 claims description 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 2
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 13
- 241001529936 Murinae Species 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 102000043131 MHC class II family Human genes 0.000 claims 2
- 108091054438 MHC class II family Proteins 0.000 claims 2
- 230000006269 (delayed) early viral mRNA transcription Effects 0.000 claims 1
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000006303 immediate early viral mRNA transcription Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552584P | 2011-10-28 | 2011-10-28 | |
| US61/552,584 | 2011-10-28 | ||
| PCT/US2012/062029 WO2013063340A1 (en) | 2011-10-28 | 2012-10-26 | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157497A Division JP6652529B2 (ja) | 2011-10-28 | 2017-08-17 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532411A JP2014532411A (ja) | 2014-12-08 |
| JP2014532411A5 true JP2014532411A5 (enExample) | 2015-12-17 |
| JP6285361B2 JP6285361B2 (ja) | 2018-02-28 |
Family
ID=47430036
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539027A Active JP6285361B2 (ja) | 2011-10-28 | 2012-10-26 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
| JP2017157497A Active JP6652529B2 (ja) | 2011-10-28 | 2017-08-17 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157497A Active JP6652529B2 (ja) | 2011-10-28 | 2017-08-17 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US8847005B2 (enExample) |
| EP (4) | EP2770822B9 (enExample) |
| JP (2) | JP6285361B2 (enExample) |
| KR (2) | KR101926442B1 (enExample) |
| CN (3) | CN108401986B (enExample) |
| AU (4) | AU2012327205B2 (enExample) |
| BR (1) | BR112014009941B1 (enExample) |
| CA (1) | CA2852962C (enExample) |
| CY (3) | CY1119283T1 (enExample) |
| DK (3) | DK2770822T3 (enExample) |
| ES (3) | ES2914374T3 (enExample) |
| HR (3) | HRP20171327T1 (enExample) |
| HU (2) | HUE034374T2 (enExample) |
| IL (3) | IL231895B (enExample) |
| IN (1) | IN2014CN03892A (enExample) |
| LT (3) | LT2770822T (enExample) |
| MX (2) | MX355726B (enExample) |
| PL (3) | PL3272214T3 (enExample) |
| PT (3) | PT2770822T (enExample) |
| RS (3) | RS63220B1 (enExample) |
| RU (1) | RU2660564C2 (enExample) |
| SG (3) | SG10201510056SA (enExample) |
| SI (3) | SI3590332T1 (enExample) |
| SM (3) | SMT202200205T1 (enExample) |
| WO (1) | WO2013063340A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008054865A2 (en) | 2006-04-26 | 2008-05-08 | L-3 Communications Security And Detection Systems, Inc. | Multi-source surveillance systems |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| RU2751240C2 (ru) | 2011-10-28 | 2021-07-12 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
| SG10201510056SA (en) | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| AU2014249148B2 (en) | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| SMT202500280T1 (it) | 2013-09-23 | 2025-09-12 | Regeneron Pharma | Animali non umani aventi un gene umanizzato della proteina regolatrice del segnale |
| TR201904342T4 (tr) * | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
| EP3071024B1 (en) | 2013-11-19 | 2018-09-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| SMT202000332T1 (it) | 2014-04-08 | 2020-07-08 | Regeneron Pharma | Animali non umani aventi recettori fc-gamma umanizzati |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| DK3157956T3 (da) | 2014-06-19 | 2020-04-27 | Regeneron Pharma | Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 |
| KR20170083534A (ko) | 2014-09-19 | 2017-07-18 | 리제너론 파마슈티칼스 인코포레이티드 | 키메라 항원 수용체 |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| ES2969389T3 (es) | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| EP4399969A3 (en) | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| US10582702B2 (en) * | 2016-02-04 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered ANGPTL8 gene |
| CA3014645C (en) | 2016-02-29 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| IL263160B2 (en) | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| SMT202500038T1 (it) | 2018-03-24 | 2025-03-12 | Regeneron Pharma | Topi o ratti geneticamente modificati per la generazione di anticorpi terapeutici contro complessi peptide-mhc, metodi di produzione e loro utilizzo |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| HUE067361T2 (hu) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Ditra betegség rágcsáló modelljei és alkalmazásaik |
| WO2021081156A1 (en) * | 2019-10-22 | 2021-04-29 | The Trustees Of Columbia University In The City Of New York | Transgenic swine, methods of making and uses thereof, and methods of making human immune system mice |
| WO2021113297A1 (en) | 2019-12-02 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| CA3258639A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharma | Multispecific molecules to modulate T lymphocyte activity, and their uses |
| WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
| EP4590120A1 (en) | 2022-09-22 | 2025-07-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| US20250339384A1 (en) | 2023-01-27 | 2025-11-06 | Regeneron Pharmaceuticals, Inc. | Modified rhabdovirus glycoproteins and uses thereof |
| WO2025064470A1 (en) | 2023-09-19 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Viral peptides and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2025136809A2 (en) | 2023-12-19 | 2025-06-26 | Regeneron Pharmaceuticals, Inc. | Foxp3 peptides and uses thereof |
| WO2025178991A1 (en) | 2024-02-21 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | Splicing factor gene mutation-associated neoantigenic peptides and uses thereof |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
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| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
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| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| AU2014249148B2 (en) | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
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2012
- 2012-10-26 SG SG10201510056SA patent/SG10201510056SA/en unknown
- 2012-10-26 WO PCT/US2012/062029 patent/WO2013063340A1/en not_active Ceased
- 2012-10-26 MX MX2014004896A patent/MX355726B/es active IP Right Grant
- 2012-10-26 RS RS20220473A patent/RS63220B1/sr unknown
- 2012-10-26 RS RS20200224A patent/RS59997B1/sr unknown
- 2012-10-26 PT PT128061991T patent/PT2770822T/pt unknown
- 2012-10-26 HR HRP20171327TT patent/HRP20171327T1/hr unknown
- 2012-10-26 JP JP2014539027A patent/JP6285361B2/ja active Active
- 2012-10-26 PL PL17171524T patent/PL3272214T3/pl unknown
- 2012-10-26 CN CN201810239986.6A patent/CN108401986B/zh active Active
- 2012-10-26 ES ES19189533T patent/ES2914374T3/es active Active
- 2012-10-26 SI SI201231999T patent/SI3590332T1/sl unknown
- 2012-10-26 IN IN3892CHN2014 patent/IN2014CN03892A/en unknown
- 2012-10-26 MX MX2017013492A patent/MX379060B/es unknown
- 2012-10-26 EP EP12806199.1A patent/EP2770822B9/en active Active
- 2012-10-26 HU HUE12806199A patent/HUE034374T2/en unknown
- 2012-10-26 ES ES17171524T patent/ES2774488T3/es active Active
- 2012-10-26 LT LTEP12806199.1T patent/LT2770822T/lt unknown
- 2012-10-26 SM SM20220205T patent/SMT202200205T1/it unknown
- 2012-10-26 PT PT191895333T patent/PT3590332T/pt unknown
- 2012-10-26 US US13/661,116 patent/US8847005B2/en active Active
- 2012-10-26 CN CN201810239690.4A patent/CN108707608A/zh active Pending
- 2012-10-26 HU HUE17171524A patent/HUE048511T2/hu unknown
- 2012-10-26 AU AU2012327205A patent/AU2012327205B2/en active Active
- 2012-10-26 KR KR1020147014315A patent/KR101926442B1/ko active Active
- 2012-10-26 RU RU2014116577A patent/RU2660564C2/ru active
- 2012-10-26 PL PL12806199T patent/PL2770822T3/pl unknown
- 2012-10-26 CA CA2852962A patent/CA2852962C/en active Active
- 2012-10-26 SM SM20170437T patent/SMT201700437T1/it unknown
- 2012-10-26 PT PT171715246T patent/PT3272214T/pt unknown
- 2012-10-26 RS RS20170897A patent/RS56330B1/sr unknown
- 2012-10-26 CN CN201280065075.7A patent/CN104039133B/zh active Active
- 2012-10-26 PL PL19189533T patent/PL3590332T3/pl unknown
- 2012-10-26 SG SG10201909638U patent/SG10201909638UA/en unknown
- 2012-10-26 DK DK12806199.1T patent/DK2770822T3/en active
- 2012-10-26 KR KR1020187034955A patent/KR102113108B1/ko active Active
- 2012-10-26 SI SI201231056T patent/SI2770822T1/sl unknown
- 2012-10-26 DK DK19189533.3T patent/DK3590332T3/da active
- 2012-10-26 LT LTEP17171524.6T patent/LT3272214T/lt unknown
- 2012-10-26 HR HRP20220616TT patent/HRP20220616T1/hr unknown
- 2012-10-26 ES ES12806199.1T patent/ES2640241T3/es active Active
- 2012-10-26 EP EP22152099.2A patent/EP4052572B1/en active Active
- 2012-10-26 SG SG11201400938UA patent/SG11201400938UA/en unknown
- 2012-10-26 DK DK17171524.6T patent/DK3272214T3/da active
- 2012-10-26 LT LTEP19189533.3T patent/LT3590332T/lt unknown
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