JP2016506418A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016506418A5 JP2016506418A5 JP2015552757A JP2015552757A JP2016506418A5 JP 2016506418 A5 JP2016506418 A5 JP 2016506418A5 JP 2015552757 A JP2015552757 A JP 2015552757A JP 2015552757 A JP2015552757 A JP 2015552757A JP 2016506418 A5 JP2016506418 A5 JP 2016506418A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- unsubstituted
- substituted
- pdgfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 108091008606 PDGF receptors Proteins 0.000 claims 8
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 claims 8
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 7
- 101710148465 Platelet-derived growth factor receptor alpha Proteins 0.000 claims 7
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 7
- QSZCGGBDNYTQHH-UHFFFAOYSA-N 2,3-dimethoxyphenol Chemical compound COC1=CC=CC(O)=C1OC QSZCGGBDNYTQHH-UHFFFAOYSA-N 0.000 claims 6
- 208000019693 Lung disease Diseases 0.000 claims 6
- 229910052794 bromium Inorganic materials 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 230000005764 inhibitory process Effects 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 108040008097 MAP kinase activity proteins Proteins 0.000 claims 5
- 102000019149 MAP kinase activity proteins Human genes 0.000 claims 5
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 5
- 230000002159 abnormal effect Effects 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims 4
- -1 guanidinyl groups Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 208000002815 pulmonary hypertension Diseases 0.000 claims 4
- 101000876610 Dictyostelium discoideum Extracellular signal-regulated kinase 2 Proteins 0.000 claims 3
- 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 claims 3
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- JHJNPOSPVGRIAN-SFHVURJKSA-N n-[3-[(1s)-1-[[6-(3,4-dimethoxyphenyl)pyrazin-2-yl]amino]ethyl]phenyl]-5-methylpyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C1=CN=CC(N[C@@H](C)C=2C=C(NC(=O)C=3C=C(C)C=NC=3)C=CC=2)=N1 JHJNPOSPVGRIAN-SFHVURJKSA-N 0.000 claims 3
- 102000020233 phosphotransferase Human genes 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 210000001147 pulmonary artery Anatomy 0.000 claims 3
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 3
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 3
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- ABDKAPXRBAPSQN-UHFFFAOYSA-N veratrole Chemical compound COC1=CC=CC=C1OC ABDKAPXRBAPSQN-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 208000026151 Chronic thromboembolic pulmonary hypertension Diseases 0.000 claims 2
- 102000012085 Endoglin Human genes 0.000 claims 2
- 108010036395 Endoglin Proteins 0.000 claims 2
- 208000031953 Hereditary hemorrhagic telangiectasia Diseases 0.000 claims 2
- 206010020880 Hypertrophy Diseases 0.000 claims 2
- 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 claims 2
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 2
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 125000001891 dimethoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 210000000651 myofibroblast Anatomy 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- 102100025422 Bone morphogenetic protein receptor type-2 Human genes 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
- 201000006306 Cor pulmonale Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000015872 Gaucher disease Diseases 0.000 claims 1
- 101000934635 Homo sapiens Bone morphogenetic protein receptor type-2 Proteins 0.000 claims 1
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021133 Hypoventilation Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000020875 Idiopathic pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000024934 IgG4-related mediastinitis Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 206010049459 Lymphangioleiomyomatosis Diseases 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 208000009905 Neurofibromatoses Diseases 0.000 claims 1
- 206010061876 Obstruction Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 108091008611 Protein Kinase B Proteins 0.000 claims 1
- 208000021068 Pulmonary arterial hypertension associated with portal hypertension Diseases 0.000 claims 1
- 208000021085 Pulmonary hypertension with unclear multifactorial mechanism Diseases 0.000 claims 1
- 208000011191 Pulmonary vascular disease Diseases 0.000 claims 1
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 1
- 102100021993 Sterol O-acyltransferase 1 Human genes 0.000 claims 1
- 101000697584 Streptomyces lavendulae Streptothricin acetyltransferase Proteins 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010071436 Systolic dysfunction Diseases 0.000 claims 1
- 208000024799 Thyroid disease Diseases 0.000 claims 1
- 208000024248 Vascular System injury Diseases 0.000 claims 1
- 208000012339 Vascular injury Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000017304 adult pulmonary Langerhans cell histiocytosis Diseases 0.000 claims 1
- 230000004872 arterial blood pressure Effects 0.000 claims 1
- 230000037147 athletic performance Effects 0.000 claims 1
- 230000001746 atrial effect Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 208000028831 congenital heart disease Diseases 0.000 claims 1
- 230000009547 development abnormality Effects 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000007345 glycogen storage disease Diseases 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000007475 hemolytic anemia Diseases 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229940001447 lactate Drugs 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 201000004931 neurofibromatosis Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 210000003492 pulmonary vein Anatomy 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000004409 schistosomiasis Diseases 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 238000010911 splenectomy Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000035488 systolic blood pressure Effects 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751217P | 2013-01-10 | 2013-01-10 | |
| US61/751,217 | 2013-01-10 | ||
| US201361889887P | 2013-10-11 | 2013-10-11 | |
| US61/889,887 | 2013-10-11 | ||
| PCT/US2014/010778 WO2014110200A1 (en) | 2013-01-10 | 2014-01-09 | Non-selective kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018106185A Division JP6547042B2 (ja) | 2013-01-10 | 2018-06-01 | 非選択的キナーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506418A JP2016506418A (ja) | 2016-03-03 |
| JP2016506418A5 true JP2016506418A5 (enExample) | 2016-04-14 |
| JP6387488B2 JP6387488B2 (ja) | 2018-09-12 |
Family
ID=51167358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552757A Active JP6387488B2 (ja) | 2013-01-10 | 2014-01-09 | 非選択的キナーゼ阻害剤 |
| JP2018106185A Active JP6547042B2 (ja) | 2013-01-10 | 2018-06-01 | 非選択的キナーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018106185A Active JP6547042B2 (ja) | 2013-01-10 | 2018-06-01 | 非選択的キナーゼ阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9815815B2 (enExample) |
| EP (1) | EP3007689B1 (enExample) |
| JP (2) | JP6387488B2 (enExample) |
| CN (2) | CN105142624A (enExample) |
| AU (5) | AU2014205483B2 (enExample) |
| CA (1) | CA2897651C (enExample) |
| DK (1) | DK3007689T3 (enExample) |
| ES (1) | ES2675720T3 (enExample) |
| WO (1) | WO2014110200A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2675720T3 (es) | 2013-01-10 | 2018-07-12 | Pulmokine, Inc. | Inhibidores de quinasa no selectivos |
| EP2988738A4 (en) * | 2013-01-10 | 2016-11-09 | Pulmokine Inc | THERAPEUTIC INDICATIONS OF KINASE INHIBITORS |
| JP6387360B2 (ja) | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン |
| EP3782604A1 (en) * | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| US9925184B2 (en) | 2013-10-11 | 2018-03-27 | Pulmokine, Inc. | Spray-dry formulations |
| CA3041679A1 (en) * | 2016-10-27 | 2018-05-03 | Lawrence S. ZISMAN | Combination therapy for treating pulmonary hypertension |
| WO2018170485A1 (en) * | 2017-03-16 | 2018-09-20 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic and therapeutic methods for kras positive cancers |
| US20210038510A1 (en) * | 2018-02-08 | 2021-02-11 | Pulmokine, Inc. | Formulations of kinase inhibitors and prostanoids |
| CN109574296B (zh) * | 2018-11-27 | 2021-05-07 | 合肥工业大学 | 一种从含蟹肉蛋白废水中回收蛋白的方法 |
| US20200360477A1 (en) | 2019-05-16 | 2020-11-19 | Aerovate Therapeutics, Inc. | Inhalable formulations for kinase inhibition |
| US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
| EP4334300A1 (en) * | 2021-05-07 | 2024-03-13 | GB005, Inc. | Crystalline forms of n-{3-[(1s)-1-{[6-(3,4-dimethoxyphenyl)pyrazin-2-yl]amino}ethyl]phenyl}-5-methylpyridine-3-carboxamide and related products and methods |
| AU2022379973A1 (en) | 2021-11-08 | 2024-06-27 | Progentos Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
| JP2025526021A (ja) | 2022-08-10 | 2025-08-07 | ジービー００２，インコーポレイティド | 肺動脈性高血圧症（ｐａｈ）を治療するためのチロシンキナーゼ阻害剤とアクチビン２型受容体アンタゴニストの併用療法 |
| CN119930631B (zh) * | 2025-04-07 | 2025-06-24 | 山东大学 | 一种靶向ddr1受体的化合物及其衍生的放射性示踪剂 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118401A (en) | 1977-10-19 | 1978-10-03 | American Hoechst Corporation | Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor |
| JPS5488231A (en) | 1977-12-22 | 1979-07-13 | Sumitomo Chem Co Ltd | 3-phenyloxymethylaniline derivative, its preparation, and herbicides consisting of it |
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| US5648369A (en) * | 1991-11-20 | 1997-07-15 | University Of Kentucky Research Foundation | Aminoalkylpyridine compounds which are useful as anitconvulsant drugs, excitatory amino acid inhibitors and NMDA sigma receptor antagonists |
| EP0848700B1 (de) | 1995-08-30 | 2003-07-02 | Bayer CropScience AG | Acylaminosalicylsäureamide und ihre verwendung als schädlingsbekämpfungsmittel |
| JPH09268169A (ja) | 1996-04-01 | 1997-10-14 | Otsuka Chem Co Ltd | サリチル酸アニリド誘導体、それを有効成分として含む植物病害防除剤 |
| ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| EP1210067A2 (en) | 1999-08-25 | 2002-06-05 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| US6479552B2 (en) | 1999-09-23 | 2002-11-12 | G.D. Searle & Co. | Use of substituted N, N-disubstituted diamino compounds for inhibiting cholesteryl ester transfer protein activity |
| CA2387351C (en) | 1999-10-19 | 2009-09-08 | Merck & Co., Inc. | Indole derivatives as tyrosine kinase inhibitors |
| AU778042B2 (en) | 1999-10-19 | 2004-11-11 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| EP1259236A4 (en) | 2000-02-25 | 2004-11-03 | Merck & Co Inc | Tyrosine kinase inhibitors |
| US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20040102455A1 (en) | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| WO2003099811A1 (en) | 2002-05-23 | 2003-12-04 | Cytopia Pty Ltd | Kinase inhibitors |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| CA2486183C (en) | 2002-05-23 | 2012-01-10 | Cytopia Pty Ltd. | Protein kinase inhibitors |
| WO2003099706A1 (en) | 2002-05-23 | 2003-12-04 | Cohen, Ben, Z. | Medically accurate pump system |
| JPWO2004002531A1 (ja) | 2002-06-26 | 2005-10-27 | 小野薬品工業株式会社 | 血管の収縮または拡張による疾患治療剤 |
| WO2004004720A1 (en) | 2002-07-03 | 2004-01-15 | Astex Technology Limited | 3-`(hetero) arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
| CN1681487A (zh) | 2002-07-15 | 2005-10-12 | 美瑞德生物工程公司 | 化合物、组合物及其使用方法 |
| US20060154936A1 (en) | 2002-10-25 | 2006-07-13 | Lasky Joseph A | Use of n-'5-'4-(4-methylpiperaziomethyl)-benzoylamido!-2-methylphenyl!-4-(3-pyridyl)2-pyridine-amine for the treatment of pulmonary hypertension |
| AU2002953255A0 (en) | 2002-12-11 | 2003-01-02 | Cytopia Research Pty Ltd | Protein kinase inhibitors |
| WO2005002673A1 (en) | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| US20050026879A1 (en) | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| WO2005013982A1 (en) | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| US20050209247A1 (en) | 2003-11-07 | 2005-09-22 | Chiron Corporation | Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties |
| NZ545694A (en) * | 2003-12-03 | 2010-04-30 | Ym Bioscience Australia Pty Lt | Azole-based kinase inhibitors |
| CA2545422C (en) | 2003-12-03 | 2015-06-02 | Cytopia Research Pty Ltd | Tubulin inhibitors |
| DK1704145T3 (da) | 2004-01-12 | 2012-09-24 | Ym Biosciences Australia Pty | Selektive kinaseinhibitorer |
| WO2005114219A2 (en) | 2004-05-20 | 2005-12-01 | Wyeth | Assays to identify irreversibly binding inhibitors of receptor tyrosine kinases |
| JP2006111553A (ja) | 2004-10-13 | 2006-04-27 | Dainippon Sumitomo Pharma Co Ltd | スルホニルオキシインドール誘導体及びそれを含有する医薬組成物 |
| ATE493986T1 (de) | 2005-11-10 | 2011-01-15 | Bayer Schering Pharma Ag | Diarylharnstoffe zur behandlung von pulmonaler hypertonie |
| WO2007087575A2 (en) | 2006-01-24 | 2007-08-02 | University Of Chicago | Compositions and methods for treating pulmonary hypertension |
| BRPI0708347A2 (pt) * | 2006-02-28 | 2011-05-24 | Cytopia Res Pty Ltd | inibição jak2 como um tratamento da hipertensão arterial pulmonar |
| WO2007124382A2 (en) | 2006-04-19 | 2007-11-01 | Novartis Vaccines And Diagnostics, Inc. | Inhaled imipenem |
| US8461161B2 (en) * | 2006-11-15 | 2013-06-11 | Ym Biosciences Australia Pty Ltd | Substituted pyrazines as inhibitors of kinase activity |
| KR101122481B1 (ko) | 2007-05-04 | 2012-02-29 | 아이알엠 엘엘씨 | Ｃ-ｋｉｔ 및 ｐｄｇｆｒ 키나제 억제제로서의 피리미딘 유도체 및 조성물 |
| EA019524B1 (ru) | 2007-05-04 | 2014-04-30 | Айрм Ллк | СОЕДИНЕНИЯ И КОМПОЗИЦИИ КАК ИНГИБИТОРЫ КИНАЗЫ с-kit И PDGFR |
| US8293757B2 (en) | 2007-08-22 | 2012-10-23 | Irm Llc | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
| MX2010002005A (es) | 2007-08-22 | 2010-03-11 | Irm Llc | Derivados de 2-heteroaril-amino-pirimidina como inhibidores de cinasa. |
| CN101903356B (zh) | 2007-12-20 | 2013-05-22 | 拜耳知识产权有限责任公司 | 4-(4-氰基-2-硫代芳基)二氢嘧啶酮和它们的使用 |
| KR20110053354A (ko) | 2008-08-13 | 2011-05-20 | 노파르티스 아게 | 폐동맥 고혈압의 치료 |
| DE102009004197A1 (de) | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| US8685458B2 (en) | 2009-03-05 | 2014-04-01 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
| WO2010132827A1 (en) | 2009-05-15 | 2010-11-18 | Bend Research, Inc. | Low-molecular dextran for powder inhalations |
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2611529B1 (en) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Spray-drying method |
| WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| JOP20120023B1 (ar) | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
| JP6012716B2 (ja) | 2011-05-19 | 2016-10-25 | サヴァラ，インク． | 乾燥粉末バンコマイシン組成物および関連する方法 |
| EP2751104B1 (en) | 2011-09-01 | 2019-09-25 | Novartis AG | Compounds and compositions as c-kit kinase inhibitors |
| US9199981B2 (en) | 2011-09-01 | 2015-12-01 | Novartis Ag | Compounds and compositions as C-kit kinase inhibitors |
| ES2675720T3 (es) | 2013-01-10 | 2018-07-12 | Pulmokine, Inc. | Inhibidores de quinasa no selectivos |
| EP2988738A4 (en) | 2013-01-10 | 2016-11-09 | Pulmokine Inc | THERAPEUTIC INDICATIONS OF KINASE INHIBITORS |
| EP3782604A1 (en) | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| US9925184B2 (en) | 2013-10-11 | 2018-03-27 | Pulmokine, Inc. | Spray-dry formulations |
| WO2015179369A1 (en) | 2014-05-20 | 2015-11-26 | Infinity Pharmaceuticals, Inc. | Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors |
-
2014
- 2014-01-09 ES ES14737648.7T patent/ES2675720T3/es active Active
- 2014-01-09 CN CN201480010529.XA patent/CN105142624A/zh active Pending
- 2014-01-09 EP EP14737648.7A patent/EP3007689B1/en active Active
- 2014-01-09 DK DK14737648.7T patent/DK3007689T3/en active
- 2014-01-09 WO PCT/US2014/010778 patent/WO2014110200A1/en not_active Ceased
- 2014-01-09 US US14/760,139 patent/US9815815B2/en active Active
- 2014-01-09 CA CA2897651A patent/CA2897651C/en active Active
- 2014-01-09 AU AU2014205483A patent/AU2014205483B2/en active Active
- 2014-01-09 CN CN201811323814.3A patent/CN109568319A/zh active Pending
- 2014-01-09 JP JP2015552757A patent/JP6387488B2/ja active Active
-
2017
- 2017-07-26 US US15/660,551 patent/US10246438B2/en active Active
-
2018
- 2018-02-27 AU AU2018201406A patent/AU2018201406A1/en not_active Abandoned
- 2018-06-01 JP JP2018106185A patent/JP6547042B2/ja active Active
-
2019
- 2019-02-12 US US16/273,878 patent/US10532994B2/en active Active
-
2020
- 2020-12-17 AU AU2020289802A patent/AU2020289802A1/en not_active Abandoned
-
2023
- 2023-03-15 AU AU2023201605A patent/AU2023201605B2/en active Active
-
2024
- 2024-11-04 AU AU2024259702A patent/AU2024259702A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016506418A5 (enExample) | ||
| JP7258832B2 (ja) | 多発性硬化症を処置するためのｓ１ｐ受容体モジュレーター | |
| JP6823095B2 (ja) | 噴霧乾燥製剤 | |
| JP2019507781A5 (enExample) | ||
| Forrest | Anaesthesia and right ventricular failure | |
| JP2016506417A5 (enExample) | ||
| JP2014077003A5 (enExample) | ||
| JP2010520306A5 (enExample) | ||
| JP2018168165A5 (enExample) | ||
| JP5149177B2 (ja) | 増殖性疾患の治療のための、チューブリンポリマー化の１，２，３−トリアゾール系抑制剤 | |
| JP2012528180A5 (enExample) | ||
| JP2014528418A5 (enExample) | ||
| JP2015532289A5 (enExample) | ||
| JP2024175025A (ja) | 組織の灌流の増加における使用のためのイノシトールリン酸化合物 | |
| JP2014500280A5 (enExample) | ||
| JP2025500826A5 (enExample) | ||
| David et al. | High-frequency oscillatory ventilation and an interventional lung assist device to treat hypoxaemia and hypercapnia | |
| JP2008540456A (ja) | 血管疾患の治療 | |
| CN110845408A (zh) | 同位素富集的乐伐替尼 | |
| WO2006082490A1 (en) | Injectable formulations of benzimidazole compounds | |
| JP2015533128A5 (enExample) | ||
| CN113164427A (zh) | 用于制备亚硝基化丙二醇的方法、包含其的组合物及其医学用途 | |
| HODSMAN et al. | Effect of ketanserin on sodium nitroprusside requirements, arterial pressure control and heart rate following coronary artery bypass surgery | |
| CA2674542A1 (en) | Neuroprotection by blood flow stabilization | |
| Naik et al. | Acute cor pulmonale and right heat failure complicating ethanol ablative therapy: anesthetic and radiologic considerations and management |