JP2015532289A5 - - Google Patents
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- JP2015532289A5 JP2015532289A5 JP2015534772A JP2015534772A JP2015532289A5 JP 2015532289 A5 JP2015532289 A5 JP 2015532289A5 JP 2015534772 A JP2015534772 A JP 2015534772A JP 2015534772 A JP2015534772 A JP 2015534772A JP 2015532289 A5 JP2015532289 A5 JP 2015532289A5
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- 239000000651 prodrug Substances 0.000 claims description 129
- 229940002612 prodrug Drugs 0.000 claims description 129
- -1 1,2- methylenedioxy Chemical group 0.000 claims description 127
- 229910052736 halogen Inorganic materials 0.000 claims description 123
- 150000002367 halogens Chemical class 0.000 claims description 120
- 125000003118 aryl group Chemical group 0.000 claims description 103
- 125000001931 aliphatic group Chemical group 0.000 claims description 100
- 125000005842 heteroatom Chemical group 0.000 claims description 84
- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 83
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- 229910052717 sulfur Inorganic materials 0.000 claims description 83
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 66
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims description 66
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- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 claims description 33
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- 125000000753 cycloalkyl group Chemical group 0.000 description 28
- 125000000623 heterocyclic group Chemical group 0.000 description 28
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 18
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 18
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 12
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- 230000013629 beta-amyloid clearance Effects 0.000 description 10
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019004203A JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261707568P | 2012-09-28 | 2012-09-28 | |
| US61/707,568 | 2012-09-28 | ||
| US201361780171P | 2013-03-13 | 2013-03-13 | |
| US61/780,171 | 2013-03-13 | ||
| PCT/US2013/062413 WO2014052896A1 (en) | 2012-09-28 | 2013-09-27 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019004203A Division JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532289A JP2015532289A (ja) | 2015-11-09 |
| JP2015532289A5 true JP2015532289A5 (enExample) | 2016-10-20 |
| JP6523958B2 JP6523958B2 (ja) | 2019-06-05 |
Family
ID=50389029
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534772A Expired - Fee Related JP6523958B2 (ja) | 2012-09-28 | 2013-09-27 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
| JP2019004203A Expired - Fee Related JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019004203A Expired - Fee Related JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US9163055B2 (enExample) |
| EP (1) | EP2900680A4 (enExample) |
| JP (2) | JP6523958B2 (enExample) |
| AU (2) | AU2013323188B2 (enExample) |
| CA (1) | CA2885369A1 (enExample) |
| WO (1) | WO2014052896A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103906745B (zh) * | 2011-09-30 | 2017-08-25 | 塔夫斯大学 | 用于治疗神经变性疾病的尿苷二磷酸衍生物、组合物和方法 |
| JP6523958B2 (ja) | 2012-09-28 | 2019-06-05 | タフツ・ユニバーシティ | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
| HUE039871T2 (hu) | 2013-03-13 | 2019-02-28 | Univ Tufts | Uridin nukleozid származékok, kompozíciók és alkalmazási eljárások |
| US10138265B2 (en) | 2013-03-13 | 2018-11-27 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
| EP3623364A1 (en) * | 2014-02-13 | 2020-03-18 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| EP3286172B1 (en) | 2015-04-23 | 2019-06-12 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitors and uses thereof |
| WO2018058148A1 (en) | 2016-09-26 | 2018-03-29 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
| HUE063848T2 (hu) | 2016-10-26 | 2024-02-28 | Constellation Pharmaceuticals Inc | LSD1 gátlók és gyógyászati alkalmazásaik |
| WO2018236221A2 (en) * | 2017-06-03 | 2018-12-27 | Can Holding B.V. | Neurodegenerative peptide deposit dissolution |
| KR102010558B1 (ko) * | 2017-12-08 | 2019-08-13 | 윤주석 | 금속 미네랄 디아미네이트 및 이의 제조방법 |
| WO2019112383A1 (ko) * | 2017-12-08 | 2019-06-13 | 윤주석 | 금속 미네랄 디아미네이트 및 이의 제조방법 |
| US20210169911A1 (en) * | 2018-08-17 | 2021-06-10 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors |
| CN117700468B (zh) * | 2024-02-05 | 2024-05-03 | 深圳赛陆医疗科技有限公司 | 一种核苷酸类似物的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0621073B2 (ja) | 1986-03-06 | 1994-03-23 | 日水製薬株式会社 | 中枢抑制剤 |
| JP3032053B2 (ja) | 1991-09-06 | 2000-04-10 | 日水製薬株式会社 | ウリジン誘導体及びこれを含有する医薬 |
| ATE185070T1 (de) * | 1992-05-22 | 1999-10-15 | Senju Pharma Co | Arzneimittel gegen glaukom |
| US5962459A (en) | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
| WO1999009998A1 (en) | 1997-08-29 | 1999-03-04 | The University Of North Carolina At Chapel Hill | Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases |
| US8314064B2 (en) | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| ATE446097T1 (de) | 1998-07-31 | 2009-11-15 | Massachusetts Inst Technology | Verwendung von uridin in kombination mit cholin zur behandlung von gedächtnisstörungen |
| US20070004670A1 (en) | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
| US20050203053A1 (en) | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
| US8518882B2 (en) | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| US8143234B2 (en) | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
| US20060069061A1 (en) | 1998-07-31 | 2006-03-30 | Dick Wurtman | Compositions containing uridine and choline, and methods utilizing same |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| CA2444161A1 (en) | 2003-10-01 | 2005-04-01 | Japan Health Sciences Foundation | A screening method of drug for treatment of neuropathic pain |
| EP1765075A4 (en) | 2004-06-10 | 2010-11-10 | Mclean Hospital Corp | PYRIMIDINES, AS FORM. uridine; IN THE TREATMENT OF PATIENTS WITH MANIC-DEPRESSIVE PSYCHOSIS |
| US7851456B2 (en) | 2005-06-29 | 2010-12-14 | Inspire Pharmaceuticals, Inc. | P2Y6 receptor agonists for treating lung diseases |
| US8618074B2 (en) * | 2007-03-15 | 2013-12-31 | Board Of Regents Of The University Of Texas System | GPCR enhanced neuroprotection to treat brain injury |
| WO2008115499A1 (en) | 2007-03-19 | 2008-09-25 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The University Of Oregon | Mannich base n-oxide drugs |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US8962580B2 (en) * | 2008-09-23 | 2015-02-24 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| IT1398378B1 (it) * | 2010-02-22 | 2013-02-22 | Omikron Italia S R L | Citicolina per il trattamento del glaucoma e dell'ipertensione oculare. |
| CN103339136A (zh) | 2010-12-01 | 2013-10-02 | 巴伊兰大学 | 尿苷二-或三-磷酸衍生物以及其用途 |
| CN103906745B (zh) * | 2011-09-30 | 2017-08-25 | 塔夫斯大学 | 用于治疗神经变性疾病的尿苷二磷酸衍生物、组合物和方法 |
| JP6523958B2 (ja) | 2012-09-28 | 2019-06-05 | タフツ・ユニバーシティ | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
| US10138265B2 (en) | 2013-03-13 | 2018-11-27 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
| HUE039871T2 (hu) | 2013-03-13 | 2019-02-28 | Univ Tufts | Uridin nukleozid származékok, kompozíciók és alkalmazási eljárások |
-
2013
- 2013-09-27 JP JP2015534772A patent/JP6523958B2/ja not_active Expired - Fee Related
- 2013-09-27 EP EP13842176.3A patent/EP2900680A4/en not_active Withdrawn
- 2013-09-27 AU AU2013323188A patent/AU2013323188B2/en not_active Ceased
- 2013-09-27 US US14/039,748 patent/US9163055B2/en not_active Expired - Fee Related
- 2013-09-27 WO PCT/US2013/062413 patent/WO2014052896A1/en not_active Ceased
- 2013-09-27 CA CA2885369A patent/CA2885369A1/en not_active Abandoned
- 2013-09-27 US US14/432,104 patent/US9913855B2/en active Active
-
2015
- 2015-10-16 US US14/885,773 patent/US9750760B2/en not_active Expired - Fee Related
-
2018
- 2018-02-20 US US15/900,570 patent/US10632138B2/en not_active Expired - Fee Related
- 2018-04-05 AU AU2018202405A patent/AU2018202405A1/en not_active Abandoned
-
2019
- 2019-01-15 JP JP2019004203A patent/JP6913698B2/ja not_active Expired - Fee Related
-
2020
- 2020-04-15 US US16/849,946 patent/US11241450B2/en active Active
-
2022
- 2022-01-31 US US17/589,864 patent/US20230012655A1/en not_active Abandoned