JP6523958B2 - ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 - Google Patents

ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 Download PDF

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JP6523958B2
JP6523958B2 JP2015534772A JP2015534772A JP6523958B2 JP 6523958 B2 JP6523958 B2 JP 6523958B2 JP 2015534772 A JP2015534772 A JP 2015534772A JP 2015534772 A JP2015534772 A JP 2015534772A JP 6523958 B2 JP6523958 B2 JP 6523958B2
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JP2015532289A (ja
JP2015532289A5 (enExample
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フィリップ ジー. ハイドン,
フィリップ ジー. ハイドン,
ジンボ リー,
ジンボ リー,
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タフツ・ユニバーシティ
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JP2015534772A 2012-09-28 2013-09-27 ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 Expired - Fee Related JP6523958B2 (ja)

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CN103906745B (zh) * 2011-09-30 2017-08-25 塔夫斯大学 用于治疗神经变性疾病的尿苷二磷酸衍生物、组合物和方法
JP6523958B2 (ja) 2012-09-28 2019-06-05 タフツ・ユニバーシティ ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用
HUE039871T2 (hu) 2013-03-13 2019-02-28 Univ Tufts Uridin nukleozid származékok, kompozíciók és alkalmazási eljárások
US10138265B2 (en) 2013-03-13 2018-11-27 Tufts University Uridine nucleoside derivatives, compositions and methods of use
EP3623364A1 (en) * 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
EP3286172B1 (en) 2015-04-23 2019-06-12 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
WO2018058148A1 (en) 2016-09-26 2018-03-29 Tufts University Uridine nucleoside derivatives, compositions and methods of use
HUE063848T2 (hu) 2016-10-26 2024-02-28 Constellation Pharmaceuticals Inc LSD1 gátlók és gyógyászati alkalmazásaik
WO2018236221A2 (en) * 2017-06-03 2018-12-27 Can Holding B.V. Neurodegenerative peptide deposit dissolution
KR102010558B1 (ko) * 2017-12-08 2019-08-13 윤주석 금속 미네랄 디아미네이트 및 이의 제조방법
WO2019112383A1 (ko) * 2017-12-08 2019-06-13 윤주석 금속 미네랄 디아미네이트 및 이의 제조방법
US20210169911A1 (en) * 2018-08-17 2021-06-10 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors
CN117700468B (zh) * 2024-02-05 2024-05-03 深圳赛陆医疗科技有限公司 一种核苷酸类似物的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0621073B2 (ja) 1986-03-06 1994-03-23 日水製薬株式会社 中枢抑制剤
JP3032053B2 (ja) 1991-09-06 2000-04-10 日水製薬株式会社 ウリジン誘導体及びこれを含有する医薬
ATE185070T1 (de) * 1992-05-22 1999-10-15 Senju Pharma Co Arzneimittel gegen glaukom
US5962459A (en) 1996-05-28 1999-10-05 Polifarma S.P.A. Therapeutic active agent for treatment of neuron degenerative diseases
WO1999009998A1 (en) 1997-08-29 1999-03-04 The University Of North Carolina At Chapel Hill Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases
US8314064B2 (en) 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
ATE446097T1 (de) 1998-07-31 2009-11-15 Massachusetts Inst Technology Verwendung von uridin in kombination mit cholin zur behandlung von gedächtnisstörungen
US20070004670A1 (en) 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
US20050203053A1 (en) 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US8518882B2 (en) 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US20060069061A1 (en) 1998-07-31 2006-03-30 Dick Wurtman Compositions containing uridine and choline, and methods utilizing same
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
CA2444161A1 (en) 2003-10-01 2005-04-01 Japan Health Sciences Foundation A screening method of drug for treatment of neuropathic pain
EP1765075A4 (en) 2004-06-10 2010-11-10 Mclean Hospital Corp PYRIMIDINES, AS FORM. uridine; IN THE TREATMENT OF PATIENTS WITH MANIC-DEPRESSIVE PSYCHOSIS
US7851456B2 (en) 2005-06-29 2010-12-14 Inspire Pharmaceuticals, Inc. P2Y6 receptor agonists for treating lung diseases
US8618074B2 (en) * 2007-03-15 2013-12-31 Board Of Regents Of The University Of Texas System GPCR enhanced neuroprotection to treat brain injury
WO2008115499A1 (en) 2007-03-19 2008-09-25 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The University Of Oregon Mannich base n-oxide drugs
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8962580B2 (en) * 2008-09-23 2015-02-24 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
IT1398378B1 (it) * 2010-02-22 2013-02-22 Omikron Italia S R L Citicolina per il trattamento del glaucoma e dell'ipertensione oculare.
CN103339136A (zh) 2010-12-01 2013-10-02 巴伊兰大学 尿苷二-或三-磷酸衍生物以及其用途
CN103906745B (zh) * 2011-09-30 2017-08-25 塔夫斯大学 用于治疗神经变性疾病的尿苷二磷酸衍生物、组合物和方法
JP6523958B2 (ja) 2012-09-28 2019-06-05 タフツ・ユニバーシティ ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用
US10138265B2 (en) 2013-03-13 2018-11-27 Tufts University Uridine nucleoside derivatives, compositions and methods of use
HUE039871T2 (hu) 2013-03-13 2019-02-28 Univ Tufts Uridin nukleozid származékok, kompozíciók és alkalmazási eljárások

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