JP2012528180A5 - - Google Patents

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Publication number
JP2012528180A5
JP2012528180A5 JP2012513215A JP2012513215A JP2012528180A5 JP 2012528180 A5 JP2012528180 A5 JP 2012528180A5 JP 2012513215 A JP2012513215 A JP 2012513215A JP 2012513215 A JP2012513215 A JP 2012513215A JP 2012528180 A5 JP2012528180 A5 JP 2012528180A5
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JP
Japan
Prior art keywords
disease
pharmaceutically acceptable
isotope
acceptable salt
propan
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JP2012513215A
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English (en)
Japanese (ja)
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JP2012528180A (ja
JP5625050B2 (ja
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Priority claimed from PCT/US2010/036211 external-priority patent/WO2010138598A2/en
Publication of JP2012528180A publication Critical patent/JP2012528180A/ja
Publication of JP2012528180A5 publication Critical patent/JP2012528180A5/ja
Application granted granted Critical
Publication of JP5625050B2 publication Critical patent/JP5625050B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012513215A 2009-05-28 2010-05-26 Ｌｘｒの調節因子 Expired - Fee Related JP5625050B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18173609P 2009-05-28 2009-05-28
US61/181,736 2009-05-28
PCT/US2010/036211 WO2010138598A2 (en) 2009-05-28 2010-05-26 Lxr modulators

Publications (3)

Publication Number Publication Date
JP2012528180A JP2012528180A (ja) 2012-11-12
JP2012528180A5 true JP2012528180A5 (enExample) 2013-05-30
JP5625050B2 JP5625050B2 (ja) 2014-11-12

Family

ID=43223342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012513215A Expired - Fee Related JP5625050B2 (ja) 2009-05-28 2010-05-26 Ｌｘｒの調節因子

Country Status (31)

Country Link
US (4) US8618154B2 (enExample)
EP (1) EP2435410B1 (enExample)
JP (1) JP5625050B2 (enExample)
KR (1) KR101676704B1 (enExample)
CN (1) CN102648184B (enExample)
AR (1) AR078049A1 (enExample)
AU (1) AU2010254082B2 (enExample)
BR (1) BRPI1013259B8 (enExample)
CA (1) CA2761934C (enExample)
CL (1) CL2011002972A1 (enExample)
CO (1) CO6470826A2 (enExample)
CY (1) CY1119407T1 (enExample)
DK (1) DK2435410T3 (enExample)
EA (1) EA019960B1 (enExample)
ES (1) ES2620451T3 (enExample)
HR (1) HRP20170194T1 (enExample)
IL (1) IL216176A (enExample)
LT (1) LT2435410T (enExample)
MX (1) MX2011012559A (enExample)
MY (1) MY153958A (enExample)
NZ (1) NZ596330A (enExample)
PE (1) PE20120797A1 (enExample)
PL (1) PL2435410T3 (enExample)
PT (1) PT2435410T (enExample)
SG (1) SG176247A1 (enExample)
SI (1) SI2435410T1 (enExample)
SM (1) SMT201700253T1 (enExample)
TN (1) TN2011000585A1 (enExample)
TW (1) TWI488844B (enExample)
WO (1) WO2010138598A2 (enExample)
ZA (1) ZA201108181B (enExample)

Families Citing this family (16)

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DK2435410T3 (da) * 2009-05-28 2017-04-10 Exelixis Patent Co Llc LXR-modulatorer
AR088728A1 (es) 2011-03-25 2014-07-02 Bristol Myers Squibb Co Moduladores de lxr como prodroga de imidazol
HUE040231T2 (hu) 2012-03-02 2019-02-28 Ralexar Therapeutics Inc Máj X receptor (LXR) modulátorok bõrbetegségek, rendellenességek és állapotok kezelésére
EP3626309B1 (en) 2012-08-13 2023-03-08 The Rockefeller University Lxrbeta agonist for the treatment of cancer
ES2694001T3 (es) 2013-03-15 2018-12-17 Bristol-Myers Squibb Company Moduladores de LXR
WO2014144037A1 (en) * 2013-03-15 2014-09-18 Bristol-Myers Squibb Company Lxr modulators
US9981913B2 (en) 2013-09-04 2018-05-29 Ralexar Therapeutics, Inc. Liver X receptor (LXR) modulators
CN110003108A (zh) 2013-09-04 2019-07-12 瑞雷克萨治疗公司 肝脏x受体（lxr）调节剂
WO2015106164A1 (en) 2014-01-10 2015-07-16 Rgenix, Inc. Lxr agonists and uses thereof
KR101815734B1 (ko) 2015-05-29 2018-01-05 가톨릭대학교 산학협력단 ｍｉＲ－７, ｍｉＲ－１８ａ 또는 ｍｉＲ－１８ｂ를 유효성분으로 포함하는 대사성 질환의 예방 또는 치료용 약학적 조성물
CA3010883A1 (en) 2016-01-11 2017-07-20 The Rockefeller University Methods for the treatment of myeloid derived suppressor cells related disorders
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
EP3999055A1 (en) 2019-07-15 2022-05-25 Novartis AG Methods for treating meibomian gland dysfunction with liver x receptor agonists
CN110305141B (zh) * 2019-07-18 2022-01-11 深圳市三启药物开发有限公司 一种螺(3,3’-异丙基吡咯烷氧化吲哚)类肝x受体调节剂及其制备方法和应用
WO2021119397A1 (en) 2019-12-13 2021-06-17 Rgenix, Inc. Metal salts and uses thereof
CN115656401B (zh) * 2022-11-09 2025-03-28 武汉海特生物创新医药研究有限公司 一种咪唑-4-甲酸乙酯纯度的hplc检测方法

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DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
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AU5994199A (en) 1998-09-23 2000-04-10 Alexander Mata De Urquiza Analysis of ligand activated nuclear receptors (in vivo)
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MX2008000141A (es) * 2005-06-27 2008-04-07 Exelixis Inc Moduladores de lxr basados en imidazol.
EP2121621B1 (en) 2006-12-08 2014-05-07 Exelixis Patent Company LLC Lxr and fxr modulators
DK2435410T3 (da) * 2009-05-28 2017-04-10 Exelixis Patent Co Llc LXR-modulatorer

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