JP2016187361A5 - - Google Patents
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- JP2016187361A5 JP2016187361A5 JP2016155127A JP2016155127A JP2016187361A5 JP 2016187361 A5 JP2016187361 A5 JP 2016187361A5 JP 2016155127 A JP2016155127 A JP 2016155127A JP 2016155127 A JP2016155127 A JP 2016155127A JP 2016187361 A5 JP2016187361 A5 JP 2016187361A5
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- JP
- Japan
- Prior art keywords
- polynucleotide
- nucleic acid
- acid molecule
- sequence
- isolated nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000023 polynucleotide Polymers 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 3
- 230000002103 transcriptional Effects 0.000 claims 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 102100003272 GDF11 Human genes 0.000 claims 1
- 101700065866 GDF11 Proteins 0.000 claims 1
- 102100019916 MSTN Human genes 0.000 claims 1
- 108010056852 Myostatin Proteins 0.000 claims 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 230000000295 complement Effects 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- 239000011778 trisodium citrate Substances 0.000 claims 1
Claims (7)
- 少なくとも1つの異種タンパク質をコードする第一のポリヌクレオチド、および下記（ａ）〜（ｃ）からなる群より選択される第二のポリヌクレオチドを含む、単離核酸分子：
（ａ）配列番号１に示すポリヌクレオチド配列に少なくとも９５％同一であるポリヌクレオチド配列を含むポリヌクレオチド；
（ｂ）配列番号２に示すアミノ酸配列に少なくとも９５％同一であるアミノ酸配列を含むポリペプチドをコードするポリヌクレオチドであって、シグナル配列を有し、または欠いており、かつミオスタチン、アクチビンＡ、またはＧＤＦ−１１に結合可能である、前記ポリヌクレオチド；ならびに
（ｃ）４２℃で５０％ホルムアミド、６Ｘ塩化ナトリウム／クエン酸ナトリウム（ＳＳＣ）の存在下、および６０℃、０．５Ｘ ＳＳＣ、０．１％ドデシル硫酸ナトリウム（ＳＤＳ）の洗浄条件下で、（ａ）もしくは（ｂ）、または（ａ）もしくは（ｂ）の完全相補体のいずれかにハイブリダイズする、ポリヌクレオチド。 - 異種タンパク質がＦｃポリペプチドである、請求項１記載の単離核酸分子。
- Ｆｃポリペプチドがリンカーペプチドによって付着している、請求項２記載の単離核酸分子。
- 第一のポリヌクレオチドが、転写または翻訳制御配列に機能可能であるように連結されている、請求項１記載の核酸分子。
- 転写または翻訳配列が転写プロモーターまたはエンハンサーを含む、請求項４記載の核酸分子。
- 請求項１記載の核酸分子の発現を指示する、単離された組換えベクター。
- 実質的に明細書本文に記載し、かつ図面に示した通りの単離核酸分子。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73227005P | 2005-11-01 | 2005-11-01 | |
| US60/732,270 | 2005-11-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014136375A Division JP6072731B2 (ja) | 2005-11-01 | 2014-07-02 | 新規アクチビン受容体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016187361A JP2016187361A (ja) | 2016-11-04 |
| JP2016187361A5 true JP2016187361A5 (ja) | 2017-06-08 |
Family
ID=37762538
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539077A Expired - Fee Related JP5349966B2 (ja) | 2005-11-01 | 2006-11-01 | 新規アクチビン受容体およびその使用 |
| JP2012171705A Pending JP2013027391A (ja) | 2005-11-01 | 2012-08-02 | 新規アクチビン受容体およびその使用 |
| JP2014136375A Expired - Fee Related JP6072731B2 (ja) | 2005-11-01 | 2014-07-02 | 新規アクチビン受容体およびその使用 |
| JP2016155127A Pending JP2016187361A (ja) | 2005-11-01 | 2016-08-08 | 新規アクチビン受容体およびその使用 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539077A Expired - Fee Related JP5349966B2 (ja) | 2005-11-01 | 2006-11-01 | 新規アクチビン受容体およびその使用 |
| JP2012171705A Pending JP2013027391A (ja) | 2005-11-01 | 2012-08-02 | 新規アクチビン受容体およびその使用 |
| JP2014136375A Expired - Fee Related JP6072731B2 (ja) | 2005-11-01 | 2014-07-02 | 新規アクチビン受容体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8067562B2 (ja) |
| EP (1) | EP1943273B1 (ja) |
| JP (4) | JP5349966B2 (ja) |
| AT (1) | ATE554101T1 (ja) |
| AU (1) | AU2006308614B2 (ja) |
| CA (1) | CA2627200C (ja) |
| ES (1) | ES2385581T3 (ja) |
| WO (1) | WO2007053775A1 (ja) |
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| TW201934141A (zh) | 2007-02-09 | 2019-09-01 | 美商艾瑟勒朗法瑪公司 | 包含ＡｃｔＲＩＩａ-Ｆｃ融合蛋白的醫藥組合物；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防與癌症相關的骨質流失之用途；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防多發性骨髓瘤之用途 |
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-
2006
- 2006-10-31 US US11/590,962 patent/US8067562B2/en active Active
- 2006-11-01 AU AU2006308614A patent/AU2006308614B2/en not_active Ceased
- 2006-11-01 EP EP06827481A patent/EP1943273B1/en active Active
- 2006-11-01 CA CA2627200A patent/CA2627200C/en not_active Expired - Fee Related
- 2006-11-01 AT AT06827481T patent/ATE554101T1/de active
- 2006-11-01 ES ES06827481T patent/ES2385581T3/es active Active
- 2006-11-01 WO PCT/US2006/043044 patent/WO2007053775A1/en active Application Filing
- 2006-11-01 JP JP2008539077A patent/JP5349966B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-25 US US13/190,255 patent/US8614292B2/en active Active
-
2012
- 2012-08-02 JP JP2012171705A patent/JP2013027391A/ja active Pending
-
2013
- 2013-11-20 US US14/085,056 patent/US9284364B2/en active Active
-
2014
- 2014-07-02 JP JP2014136375A patent/JP6072731B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-03 US US15/014,889 patent/US20160152683A1/en not_active Abandoned
- 2016-08-08 JP JP2016155127A patent/JP2016187361A/ja active Pending
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