JP2016171800A5 - - Google Patents
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- JP2016171800A5 JP2016171800A5 JP2016078592A JP2016078592A JP2016171800A5 JP 2016171800 A5 JP2016171800 A5 JP 2016171800A5 JP 2016078592 A JP2016078592 A JP 2016078592A JP 2016078592 A JP2016078592 A JP 2016078592A JP 2016171800 A5 JP2016171800 A5 JP 2016171800A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- modified
- wing
- nucleoside
- gap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 22
- 108091034117 Oligonucleotide Proteins 0.000 claims 16
- 239000002777 nucleoside Substances 0.000 claims 15
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 6
- 125000003835 nucleoside group Chemical group 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000000074 antisense oligonucleotide Substances 0.000 claims 5
- 238000012230 antisense oligonucleotides Methods 0.000 claims 5
- -1 bicyclic nucleoside Chemical class 0.000 claims 3
- 235000021092 sugar substitutes Nutrition 0.000 claims 3
- 239000003765 sweetening agent Substances 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30246910P | 2010-02-08 | 2010-02-08 | |
| US61/302,469 | 2010-02-08 | ||
| US37163510P | 2010-08-06 | 2010-08-06 | |
| US61/371,635 | 2010-08-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552932A Division JP6006120B2 (ja) | 2010-02-08 | 2011-02-08 | 対立遺伝子多様体の選択的低減 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018055560A Division JP6652984B2 (ja) | 2010-02-08 | 2018-03-23 | 対立遺伝子多様体の選択的低減 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016171800A JP2016171800A (ja) | 2016-09-29 |
| JP2016171800A5 true JP2016171800A5 (https=) | 2017-03-23 |
| JP6316334B2 JP6316334B2 (ja) | 2018-04-25 |
Family
ID=44355846
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552932A Active JP6006120B2 (ja) | 2010-02-08 | 2011-02-08 | 対立遺伝子多様体の選択的低減 |
| JP2016078592A Active JP6316334B2 (ja) | 2010-02-08 | 2016-04-11 | 対立遺伝子多様体の選択的低減 |
| JP2018055560A Active JP6652984B2 (ja) | 2010-02-08 | 2018-03-23 | 対立遺伝子多様体の選択的低減 |
| JP2020009595A Pending JP2020089382A (ja) | 2010-02-08 | 2020-01-24 | 対立遺伝子多様体の選択的低減 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552932A Active JP6006120B2 (ja) | 2010-02-08 | 2011-02-08 | 対立遺伝子多様体の選択的低減 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018055560A Active JP6652984B2 (ja) | 2010-02-08 | 2018-03-23 | 対立遺伝子多様体の選択的低減 |
| JP2020009595A Pending JP2020089382A (ja) | 2010-02-08 | 2020-01-24 | 対立遺伝子多様体の選択的低減 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8957040B2 (https=) |
| EP (3) | EP2534248B1 (https=) |
| JP (4) | JP6006120B2 (https=) |
| AU (3) | AU2011213562B2 (https=) |
| CA (1) | CA2789005A1 (https=) |
| DK (1) | DK2534248T3 (https=) |
| ES (1) | ES2733708T3 (https=) |
| IL (2) | IL221272A (https=) |
| WO (1) | WO2011097643A1 (https=) |
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| US9778708B1 (en) | 2016-07-18 | 2017-10-03 | Lenovo Enterprise Solutions (Singapore) Pte. Ltd. | Dual sided latching retainer for computer modules |
| WO2019157531A1 (en) | 2018-02-12 | 2019-08-15 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
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2011
- 2011-02-08 US US13/577,616 patent/US8957040B2/en active Active
- 2011-02-08 EP EP11740542.3A patent/EP2534248B1/en active Active
- 2011-02-08 CA CA2789005A patent/CA2789005A1/en not_active Abandoned
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- 2011-02-08 ES ES17206749T patent/ES2733708T3/es active Active
- 2011-02-08 JP JP2012552932A patent/JP6006120B2/ja active Active
- 2011-02-08 AU AU2011213562A patent/AU2011213562B2/en active Active
- 2011-02-08 EP EP17206749.8A patent/EP3321361B1/en not_active Revoked
- 2011-02-08 WO PCT/US2011/024103 patent/WO2011097643A1/en not_active Ceased
- 2011-02-08 EP EP19164928.4A patent/EP3561060A1/en active Pending
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2012
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2014
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2016
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2017
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2018
- 2018-03-23 JP JP2018055560A patent/JP6652984B2/ja active Active
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