JP2016153424A5 - - Google Patents

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JP2016153424A5
JP2016153424A5 JP2016097613A JP2016097613A JP2016153424A5 JP 2016153424 A5 JP2016153424 A5 JP 2016153424A5 JP 2016097613 A JP2016097613 A JP 2016097613A JP 2016097613 A JP2016097613 A JP 2016097613A JP 2016153424 A5 JP2016153424 A5 JP 2016153424A5
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dioxol
difluoro
benzo
formula
cyclopropanecarboxylic acid
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JP2016097613A
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JP2016153424A (ja
JP6158985B2 (ja
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JP2016097613A 2004-01-30 2016-05-16 Atp結合カセットトランスポーターのモジュレーター Expired - Lifetime JP6158985B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54056404P 2004-01-30 2004-01-30
US60/540,564 2004-01-30
US60350304P 2004-08-20 2004-08-20
US60/603,503 2004-08-20

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JP2015019897A Division JP2015091875A (ja) 2004-01-30 2015-02-04 Atp結合カセットトランスポーターのモジュレーター

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JP2016153424A JP2016153424A (ja) 2016-08-25
JP2016153424A5 true JP2016153424A5 (cg-RX-API-DMAC7.html) 2017-03-30
JP6158985B2 JP6158985B2 (ja) 2017-07-05

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JP2006551487A Expired - Lifetime JP4960708B2 (ja) 2004-01-30 2005-01-31 Atp結合カセットトランスポーターのモジュレーター
JP2012009781A Expired - Lifetime JP5669319B2 (ja) 2004-01-30 2012-01-20 Atp結合カセットトランスポーターのモジュレーター
JP2014021918A Expired - Lifetime JP5840239B2 (ja) 2004-01-30 2014-02-07 Atp結合カセットトランスポーターのモジュレーター
JP2015019897A Pending JP2015091875A (ja) 2004-01-30 2015-02-04 Atp結合カセットトランスポーターのモジュレーター
JP2016097613A Expired - Lifetime JP6158985B2 (ja) 2004-01-30 2016-05-16 Atp結合カセットトランスポーターのモジュレーター

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JP2006551487A Expired - Lifetime JP4960708B2 (ja) 2004-01-30 2005-01-31 Atp結合カセットトランスポーターのモジュレーター
JP2012009781A Expired - Lifetime JP5669319B2 (ja) 2004-01-30 2012-01-20 Atp結合カセットトランスポーターのモジュレーター
JP2014021918A Expired - Lifetime JP5840239B2 (ja) 2004-01-30 2014-02-07 Atp結合カセットトランスポーターのモジュレーター
JP2015019897A Pending JP2015091875A (ja) 2004-01-30 2015-02-04 Atp結合カセットトランスポーターのモジュレーター

Country Status (10)

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US (1) US8759335B2 (cg-RX-API-DMAC7.html)
EP (2) EP1716122B1 (cg-RX-API-DMAC7.html)
JP (5) JP4960708B2 (cg-RX-API-DMAC7.html)
CN (1) CN1938279B (cg-RX-API-DMAC7.html)
AU (1) AU2005210474B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0507278A (cg-RX-API-DMAC7.html)
CA (1) CA2554796A1 (cg-RX-API-DMAC7.html)
ES (2) ES2791303T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA06008606A (cg-RX-API-DMAC7.html)
WO (1) WO2005075435A1 (cg-RX-API-DMAC7.html)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06002567A (es) 2003-09-06 2006-09-04 Vertex Pharma Moduladores de transportadores con casete de union de atp.
CN1925854A (zh) * 2003-11-14 2007-03-07 沃泰克斯药物股份有限公司 可用作atp-结合弹夹转运蛋白调控剂的噻唑和噁唑
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
ME02799B (me) 2004-06-24 2018-01-20 Vertex Pharma Modulatori ATP-vezujućih kasetnih transportera
AU2005303223A1 (en) * 2004-11-15 2006-05-18 Taisho Pharmaceutical Co., Ltd. Imine compound
WO2007021982A2 (en) * 2005-08-11 2007-02-22 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
KR20080064971A (ko) 2005-10-06 2008-07-10 버텍스 파마슈티칼스 인코포레이티드 Atp-결합 카세트 전달체의 조절자
AU2012201325B2 (en) * 2005-11-08 2012-05-03 Vertex Pharmaceuticals Incorporated Heterocyclic Modulators of ATP-Binding Cassette Transporters
SI1945632T1 (sl) 2005-11-08 2014-03-31 Vertex Pharmaceuticals Incorporated Heterocikliäśni modulatorji za prenaĺ alce z atp-vezavno kaseto
CN101395147B (zh) 2005-12-28 2013-05-29 弗特克斯药品有限公司 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物
CA2635581C (en) 2005-12-28 2017-02-28 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
AU2007210159A1 (en) * 2006-01-26 2007-08-09 Foldrx Pharmaceuticals, Inc. Compounds and methods for modulating protein trafficking
AU2013205183B2 (en) * 2006-04-07 2016-07-28 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
IN2014KN02423A (cg-RX-API-DMAC7.html) 2006-04-07 2015-05-01 Vertex Pharma
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
JP5284268B2 (ja) 2006-11-03 2013-09-11 バーテックス ファーマシューティカルズ インコーポレイテッド Cftrモジュレーターとしてのアザインドール誘導体
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) * 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
PT2155721E (pt) 2007-05-07 2011-05-09 Novartis Ag Compostos org?nicos
US20110009351A1 (en) * 2007-05-09 2011-01-13 Traffick Therepeutics Inc. Screening assay to identify correctors of protein trafficking defects
EP2164840A2 (en) * 2007-05-09 2010-03-24 Vertex Pharmaceuticals Incorporated Modulators of cftr
US8193194B2 (en) * 2007-05-25 2012-06-05 Vertex Pharmaceuticals Incorporated Ion channel modulators and methods of use
EP2190850A4 (en) * 2007-07-03 2011-03-09 Univ British Columbia DELTAF508 CFTR DELTAF508 DELTAFLECTIVE TRANSPORTATION MOLECULES
US20100292236A1 (en) * 2007-07-19 2010-11-18 H. Lundbeck A/S 5-Membered Heterocyclic Amides And Related Compounds
CN101827593B (zh) 2007-08-24 2013-07-24 沃泰克斯药物股份有限公司 用于治疗(特别是)囊性纤维化的异噻唑并吡啶酮
AU2013231151B2 (en) * 2007-11-16 2015-06-25 Vertex Pharmaceuticals Incorporated Isoquinoline modulators of ATP-Binding Cassette transporters
WO2009064959A1 (en) * 2007-11-16 2009-05-22 Vertex Pharmaceuticals Incorporated Isoquinoline modulators of atp-binding cassette transporters
US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
PL2639223T3 (pl) 2007-12-07 2017-09-29 Vertex Pharmaceuticals Incorporated Sposób wytwarzania kwasów cykloalkilokarboksyamido-pirydyno-benzoesowych
EA201070699A1 (ru) * 2007-12-07 2011-02-28 Вертекс Фармасьютикалз Инкорпорейтед Композиции 3-(6-(1-2,2-дифторбензо[d][1,3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты
PT2225230T (pt) * 2007-12-07 2016-12-07 Vertex Pharma Formas sólidas de ácido 3-(6(1-(2,2-difluorobenzo[d][1,3] dioxol-5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico
NZ585789A (en) 2007-12-10 2012-03-30 Novartis Ag Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel
AU2015228930B2 (en) * 2008-02-28 2017-02-23 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as CFTR modulators
AU2013205162B2 (en) * 2008-02-28 2015-07-09 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as CFTR modulators
NZ620944A (en) * 2008-02-28 2015-02-27 Vertex Pharma Heteroaryl derivatives as cftr modulators
AU2013270464B2 (en) * 2008-03-31 2016-05-26 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as CFTR modulators
EP2271621B1 (en) 2008-03-31 2013-11-20 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators
AU2009256645A1 (en) 2008-06-10 2009-12-17 Novartis Ag Pyrazine derivatives as epithelial sodium channel blockers
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
AU2009296271A1 (en) * 2008-09-29 2010-04-01 Vertex Pharmaceuticals Incorporated Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
NZ592685A (en) 2008-10-23 2013-04-26 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
US8513242B2 (en) 2008-12-12 2013-08-20 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
WO2010098428A1 (ja) 2009-02-27 2010-09-02 帝人ファーマ株式会社 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法
SI2408750T1 (sl) 2009-03-20 2015-11-30 Vertex Pharmaceuticals Incorporated Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
MX2012004792A (es) 2009-10-22 2013-02-01 Vertex Pharma Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas.
JPWO2011093352A1 (ja) 2010-01-27 2013-06-06 武田薬品工業株式会社 チアゾール誘導体
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
HRP20211752T1 (hr) 2010-04-07 2022-02-18 Vertex Pharmaceuticals Incorporated Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
EP2555754B1 (en) 2010-04-07 2016-04-06 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
WO2011133956A1 (en) 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
AU2011242452A1 (en) 2010-04-22 2012-11-08 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
KR20130056244A (ko) 2010-04-22 2013-05-29 버텍스 파마슈티칼스 인코포레이티드 시클로알킬카르복스아미도-인돌 화합물의 제조 방법
WO2011133953A1 (en) 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
PT2610248T (pt) 2010-08-27 2016-08-23 Teijin Pharma Ltd Método para produção de derivado heterocíclico substituído por fenilo por meio de método de acoplamento usando um composto de paládio
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
EP2651930B1 (en) * 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Biarylamide inhibitors of leukotriene production
LT2776427T (lt) 2011-11-08 2017-04-10 Vertex Pharmaceuticals Incorporated Atp surišančios kasetės transporterių moduliatoriai
TWI640519B (zh) * 2011-11-29 2018-11-11 泰緯生命科技股份有限公司 Hec1活性調控因子及其調節方法
HK1203840A1 (en) 2012-02-27 2015-11-06 沃泰克斯药物股份有限公司 Pharmaceutical composition and administration thereof
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
CA2869847A1 (en) 2012-04-20 2013-10-24 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8674108B2 (en) 2012-04-20 2014-03-18 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EP2858645A1 (en) 2012-06-08 2015-04-15 Vertex Pharmaceuticals Incorporated Pharmaceuticl compositions for the treatment of cftr -mediated disorders
HK1209318A1 (en) 2012-07-16 2016-04-01 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
ITMI20122065A1 (it) 2012-12-03 2014-06-04 Univ Padova Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato
US9382254B2 (en) * 2013-05-07 2016-07-05 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
JP6522602B2 (ja) 2013-07-02 2019-05-29 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Rock阻害剤としての三環式ピリド−カルボキサミド誘導体
JP6434968B2 (ja) 2013-07-02 2018-12-05 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Rock阻害剤としての三環式ピリド−カルボキサミド誘導体
KR102280372B1 (ko) 2013-11-12 2021-07-22 버텍스 파마슈티칼스 인코포레이티드 Cftr 매개된 질환 치료용 약제학적 조성물의 제조 방법
EP2878339A1 (en) 2013-12-02 2015-06-03 Siena Biotech S.p.A. SIP3 antagonists
ES2885181T3 (es) 2014-04-15 2021-12-13 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
WO2016057572A1 (en) 2014-10-06 2016-04-14 Mark Thomas Miller Modulators of cystic fibrosis transmembrane conductance regulator
JP6746569B2 (ja) 2014-10-07 2020-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶
EP3212189B1 (en) 2014-10-31 2020-09-09 AbbVie Overseas S.à r.l. Substituted chromanes and method of use
DK3221692T3 (da) 2014-11-18 2021-08-23 Vertex Pharma Fremgangsmåde til udførsel af tests med høj kapacitet ved hjælp af højtryksvæskekromatografi
CN104693164B (zh) * 2015-03-31 2017-03-08 衢州康鹏化学有限公司 一种 2,2‑二氟胡椒酸甲酯的制备方法
US9840513B2 (en) * 2015-07-16 2017-12-12 Abbvie S.Á.R.L. Substituted tricyclics and method of use
KR102733897B1 (ko) 2015-12-24 2024-11-22 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Cftr 조절제 및 이의 사용방법
ES2901002T3 (es) 2015-12-24 2022-03-21 Univ California Derivados de N-[5-[(3,4-dimetoxifenil)metil]-1,3,4-tiadiazol-2-il]-2-metoxi-bencenoacetamida y compuestos relacionados como activadores de CFTR para tratar estreñimiento o colestasis
CR20180482A (es) * 2016-04-06 2019-04-09 Innovative Molecules Gmbh Derivados de aminotiazol útiles como agentes antivíricos
MA46357B1 (fr) 2016-09-30 2021-10-29 Vertex Pharma Modulateur de régulateur de conductance transmembranaire de fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur
US20180251431A1 (en) * 2016-12-09 2018-09-06 Vertex Pharmaceuticals Incorporated 1,3-substituted pyrazole compounds useful for reduction of very long chain fatty acid levels
CN110267948B (zh) 2016-12-09 2023-12-08 弗特克斯药品有限公司 囊性纤维化跨膜传导调控剂的调节剂、药物组合物、治疗方法和制备所述调节剂的方法
WO2018107040A1 (en) * 2016-12-09 2018-06-14 Vertex Pharmaceuticals Incorporated 1-(2-fluorophenyl)-n-[1-(2-fluoro-4-pyridyl)pyrazol-3-yl]cyclopropanecarboxamide, its solid forms and pharmaceutical uses thereof
US10968225B2 (en) 2017-03-14 2021-04-06 Fondazione Istituto Italiano Di Tecnologia Compounds and compositions for the treatment of cystic fibrosis
IT201700028184A1 (it) 2017-03-14 2018-09-14 Fondazione St Italiano Tecnologia Composti e composizioni per il trattamento della fibrosi cistica
IT201700028127A1 (it) * 2017-03-14 2018-09-14 Fondazione St Italiano Tecnologia Composti e composizioni per il trattamento della fibrosi cistica
MA54105A (fr) 2017-06-08 2021-09-15 Vertex Pharma Méthodes de traitement de la fibrose kystique
CA3069226A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
MA49752A (fr) 2017-08-02 2021-04-21 Vertex Pharma Procédés de préparation de composés de pyrrolidine
JP2020531511A (ja) 2017-08-24 2020-11-05 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 眼球用医薬組成物
MD3692039T2 (ro) 2017-10-05 2023-05-31 Innovative Molecules Gmbh Enantiomerii tiazolilor substituiți ca compuși antivirali
TWI719349B (zh) 2017-10-19 2021-02-21 美商維泰克斯製藥公司 Cftr調節劑之結晶形式及組合物
KR102716244B1 (ko) 2017-12-08 2024-10-14 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
SI3752510T1 (sl) 2018-02-15 2023-03-31 Vertex Pharmaceuticals Incorporated Makrocikli kot modulatorji regulatorja transmembranske prevodnosti pri cistični fibrozi, farmacevtski sestavki iz le-teh, njihova uporaba pri zdravljenju cistične fibroze in postopek za njihovo proizvodnjo
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
EP3846801B1 (en) 2018-09-09 2025-03-12 Qanatpharma AG Use of cftr modulators for treating cerebrovascular conditions
TWI848092B (zh) 2019-04-03 2024-07-11 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白調節劑
CN110117263B (zh) * 2019-06-11 2020-12-25 湖南中医药大学 2-氨基-5-酰基噻唑衍生物及其合成方法
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
HUE066896T2 (hu) 2019-08-14 2024-09-28 Vertex Pharma Eljárás CFTR modulátorok elõállítására
MX2022001828A (es) 2019-08-14 2022-06-08 Vertex Pharma Formas cristalinas de moduladores del regulador de conductancia transmembrana de la fibrosis quistica (cftr).
WO2021113809A1 (en) * 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
WO2021113806A1 (en) * 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
EP4161921A4 (en) * 2020-06-09 2024-06-19 Anima Biotech Inc. COLLAGEN-1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
CR20230120A (es) 2020-08-07 2023-09-01 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
CN116034103B (zh) * 2020-09-07 2025-05-13 日产化学株式会社 1,3,4-噁二唑-2-胺化合物的制造方法
US12324802B2 (en) 2020-11-18 2025-06-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
MX2023006770A (es) 2020-12-10 2023-08-14 Vertex Pharma Metodos de tratamiento para fibrosis quistica.
CN113527225B (zh) * 2021-07-15 2022-11-18 南昌大学 一种丙烯酰噻二唑衍生物及其制备方法和应用
WO2023111996A1 (en) 2021-12-17 2023-06-22 Reglagene Holding, Inc. Compositions and methods of making and using small molecules in the treatment of cancer
US12215102B2 (en) 2023-02-28 2025-02-04 Reglagene, Inc. Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions
TW202528310A (zh) * 2023-09-20 2025-07-16 美商深蘋果治療股份有限公司 經取代胺化合物,組合物及使用方法
WO2025163461A1 (ko) * 2024-02-02 2025-08-07 삼진제약주식회사 Mrgprx2 (mas-related g-protein coupled receptor member x2) 길항제로서 신규 화합물 및 이를 포함하는 약학적 조성물

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
PL340727A1 (en) 1997-11-10 2001-02-26 Bristol Myers Squibb Co Benzothiazolic inhibitors of proteinous thyrosinic kinase
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
CA2366932C (en) * 1999-04-15 2009-08-25 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
JP2003507329A (ja) * 1999-08-12 2003-02-25 フアルマシア・イタリア・エツセ・ピー・アー 3(5)−アミノ−ピラゾール誘導体、それらの製造方法および抗腫瘍薬としてのそれらの使用
CA2386318A1 (en) * 1999-11-18 2001-05-25 Pierre Ducray Pesticidal aminoheterocyclamide compounds
AU2010601A (en) * 1999-12-16 2001-07-03 Novartis Ag Organic compounds
KR100423899B1 (ko) * 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6414013B1 (en) * 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
JP4742333B2 (ja) * 2000-11-13 2011-08-10 日本農薬株式会社 N−チアジアゾリルシクロプロパンカルボン酸アミド類およびこれを有効成分とする殺虫、殺ダニ剤
MXPA03009847A (es) * 2001-04-27 2004-02-12 Vertex Pharma Inhibidores de cinasa derivados de pirazol.
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
EP1487824B1 (en) * 2002-03-01 2007-06-20 SmithKline Beecham Corporation Diamino-pyrimidines and their use as angiogenesis inhibitors
US6900219B2 (en) * 2002-04-04 2005-05-31 Cv Therapeutics, Inc. ABCA-1 elevating compounds
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
CA2504320A1 (en) * 2002-10-30 2004-05-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
WO2004041277A1 (en) * 2002-11-01 2004-05-21 Merck & Co., Inc. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
WO2004056744A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
WO2004063179A1 (en) * 2003-01-06 2004-07-29 Eli Lilly And Company Substituted arylcyclopropylacetamides as glucokinase activators
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
JP4895811B2 (ja) * 2003-09-11 2012-03-14 ケミア,インコーポレイテッド サイトカイン阻害剤
EP1674454A4 (en) * 2003-10-17 2006-12-27 Nippon Kayaku Kk SUBSTITUTED 2-AMINO-1,2,4-TRIAZOLO 1,5-A-PYRIMIDINE DERIVATIVE AND THE USE THEREOF
ATE473967T1 (de) * 2003-11-26 2010-07-15 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
US7977322B2 (en) * 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
WO2007021982A2 (en) * 2005-08-11 2007-02-22 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
SI1945632T1 (sl) * 2005-11-08 2014-03-31 Vertex Pharmaceuticals Incorporated Heterocikliäśni modulatorji za prenaĺ alce z atp-vezavno kaseto
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN101395147B (zh) * 2005-12-28 2013-05-29 弗特克斯药品有限公司 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物
IN2014KN02423A (cg-RX-API-DMAC7.html) * 2006-04-07 2015-05-01 Vertex Pharma
US7645789B2 (en) * 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US7754739B2 (en) * 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
WO2009064959A1 (en) * 2007-11-16 2009-05-22 Vertex Pharmaceuticals Incorporated Isoquinoline modulators of atp-binding cassette transporters
NZ620944A (en) * 2008-02-28 2015-02-27 Vertex Pharma Heteroaryl derivatives as cftr modulators
EP2271621B1 (en) * 2008-03-31 2013-11-20 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators

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