JP2016129515A5 - - Google Patents

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JP2016129515A5
JP2016129515A5 JP2016027812A JP2016027812A JP2016129515A5 JP 2016129515 A5 JP2016129515 A5 JP 2016129515A5 JP 2016027812 A JP2016027812 A JP 2016027812A JP 2016027812 A JP2016027812 A JP 2016027812A JP 2016129515 A5 JP2016129515 A5 JP 2016129515A5
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protein
cells
tat
tat protein
proliferation
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JP2016027812A
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JP2016027812A 2005-10-18 2016-02-17 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。 Pending JP2016129515A (ja)

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US72813105P 2005-10-18 2005-10-18
US60/728,131 2005-10-18
US76599306P 2006-02-06 2006-02-06
US60/765,993 2006-02-06

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JP2014108137A Division JP6302356B2 (ja) 2005-10-18 2014-05-26 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

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JP2017166334A Division JP6655050B2 (ja) 2005-10-18 2017-08-31 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

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JP2016129515A JP2016129515A (ja) 2016-07-21
JP2016129515A5 true JP2016129515A5 (https=) 2016-09-01

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JP2008536713A Pending JP2009511081A (ja) 2005-10-18 2006-10-18 条件的に不死化された長期幹細胞およびそのような細胞を作製および使用する方法
JP2012221023A Expired - Fee Related JP5726148B2 (ja) 2005-10-18 2012-10-03 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2014108137A Expired - Fee Related JP6302356B2 (ja) 2005-10-18 2014-05-26 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2016027812A Pending JP2016129515A (ja) 2005-10-18 2016-02-17 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2017166334A Expired - Fee Related JP6655050B2 (ja) 2005-10-18 2017-08-31 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2019006759A Expired - Fee Related JP6797221B2 (ja) 2005-10-18 2019-01-18 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2020119082A Expired - Fee Related JP7078673B2 (ja) 2005-10-18 2020-07-10 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2022025236A Pending JP2022065146A (ja) 2005-10-18 2022-02-22 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

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JP2008536713A Pending JP2009511081A (ja) 2005-10-18 2006-10-18 条件的に不死化された長期幹細胞およびそのような細胞を作製および使用する方法
JP2012221023A Expired - Fee Related JP5726148B2 (ja) 2005-10-18 2012-10-03 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2014108137A Expired - Fee Related JP6302356B2 (ja) 2005-10-18 2014-05-26 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

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JP2017166334A Expired - Fee Related JP6655050B2 (ja) 2005-10-18 2017-08-31 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2019006759A Expired - Fee Related JP6797221B2 (ja) 2005-10-18 2019-01-18 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2020119082A Expired - Fee Related JP7078673B2 (ja) 2005-10-18 2020-07-10 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2022025236A Pending JP2022065146A (ja) 2005-10-18 2022-02-22 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

Country Status (12)

Country Link
US (7) US8883507B2 (https=)
EP (1) EP1942739B1 (https=)
JP (8) JP2009511081A (https=)
KR (2) KR101441843B1 (https=)
CN (2) CN105483088B (https=)
AT (1) ATE491022T1 (https=)
AU (1) AU2006304392B2 (https=)
CA (2) CA2626525C (https=)
DE (1) DE602006018768D1 (https=)
IL (7) IL296832A (https=)
IN (1) IN2014DN06624A (https=)
WO (1) WO2007047583A2 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101441843B1 (ko) 2005-10-18 2014-09-17 내셔날 쥬이쉬 헬스 조건부 불멸화 장기 줄기 세포 및 상기 세포의 제조 및 사용 방법
SI2772535T1 (sl) 2006-05-31 2022-08-31 Children's Medical Center Corporation ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji
GB0619500D0 (en) * 2006-10-03 2006-11-08 Univ Keele Treatment of fibrosis
EP2134852A4 (en) 2007-03-13 2010-04-28 Nat Jewish Health PROCESS FOR THE PRODUCTION OF ANTIBODIES
EP2285832B1 (en) * 2008-05-16 2020-08-26 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
ES2525411T3 (es) * 2008-07-21 2014-12-22 Taiga Biotechnologies, Inc. Células anucleadas diferenciadas y método para preparar las mismas
EP2318435B1 (en) * 2008-08-28 2015-12-23 Taiga Biotechnologies, Inc. Modulators of myc, methods of using the same, and methods of identifying agents that modulate myc
EP3978928A1 (en) 2008-11-14 2022-04-06 The Brigham and Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
DK2448967T3 (en) * 2009-06-29 2015-07-20 Ilya B Leskov NON-HUMAN MAMMALS MODEL OF CANCER human hematopoietic
AU2014240253B2 (en) * 2009-09-15 2017-08-03 The University Of Tokyo Novel Method for Producing Differentiated Cells
CA2774193C (en) * 2009-09-15 2020-08-25 The University Of Tokyo Novel method for producing differentiated cells
DK2498796T3 (en) 2009-11-09 2018-03-05 Aal Scient Inc HEART DISEASE TREATMENT
AU2011249406B2 (en) * 2010-05-06 2015-05-14 Stem Cell Medicine Ltd. Stem cell bank for personalized medicine
WO2012043651A1 (ja) * 2010-09-30 2012-04-05 国立大学法人 熊本大学 ミエロイド系血液細胞の製造方法
US8889630B2 (en) 2011-12-23 2014-11-18 Carlos Lopez Method for hair regrowth using Granulocyte-Colony Stimulating Factor
US20130171115A1 (en) * 2011-12-30 2013-07-04 Gang Li Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene
JP6285930B2 (ja) 2012-07-20 2018-02-28 タイガ バイオテクノロジーズ,インク. 造血コンパートメントの再構築及び自家再構築の増進
WO2014130518A1 (en) 2013-02-19 2014-08-28 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
US10272115B2 (en) * 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9365825B2 (en) * 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
AU2014262590B2 (en) 2013-05-10 2018-05-10 Children's Medical Center Corporation Wound healing and tissue engineering
KR101638403B1 (ko) * 2013-07-17 2016-07-11 아주대학교산학협력단 RGMc를 유효성분으로 포함하는 줄기세포 유도용 배지 조성물 및 이를 이용한 줄기세포의 유도방법
WO2015020993A2 (en) * 2013-08-05 2015-02-12 The Trustees Of The University Of Pennsylvania RNAi COMPOSITIONS AND METHODS FOR TREATMENT OF FRIEDREICH'S ATAXIA
CN103509101B (zh) * 2013-08-12 2016-11-02 中国科学院广州生物医药与健康研究院 一种扩增脐带血造血干细胞的细胞因子及其培养基
WO2016149672A1 (en) 2015-03-18 2016-09-22 The Regents Of The University Of California Methods of preventing and reversing stem cell aging
CN106148266A (zh) * 2015-04-20 2016-11-23 烟台赛泽生物技术有限公司 一种免疫细胞用培养基及该培养基的添加剂
CN104928247B (zh) * 2015-07-02 2018-03-23 广州赛莱拉干细胞科技股份有限公司 一种神经干细胞培养基及神经干细胞贴壁培养方法
RU2018106515A (ru) 2015-07-21 2019-08-21 Зе Чилдрен'С Медикал Сентер Корпорейшн Pd-l1-экспрессирующие гемопоэтические стволовые клетки и применения
CN108243607A (zh) 2015-09-09 2018-07-03 西雅图儿童医院(Dba西雅图儿童研究所) 用于免疫疗法的巨噬细胞的遗传工程
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
CN105695511B (zh) * 2016-04-13 2025-01-21 中国人民解放军第三军医大学 一种永生化毛囊干细胞系及其制备方法
CN105713880A (zh) * 2016-04-20 2016-06-29 广东艾时代生物科技有限责任公司 一种造血干细胞体外扩增培养的无血清培养基及其应用
CN106279403B (zh) * 2016-08-16 2019-06-11 长春市海兰深生物医学技术有限公司 一种检测天然肺癌相关抗体的组合物、试剂盒和方法
KR20190092472A (ko) 2016-12-02 2019-08-07 타이가 바이오테크놀로지스, 인코포레이티드 나노입자 제제
CN106754728B (zh) * 2016-12-30 2020-05-15 中国人民解放军总医院 后肾间充质细胞系及其制备方法与应用
FR3068366B1 (fr) * 2017-06-30 2023-11-24 Francais Du Sang Ets Procede de production de progeniteurs erythroides
US20200155600A1 (en) * 2017-08-03 2020-05-21 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of cancer
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
US12023357B2 (en) 2017-10-13 2024-07-02 Hackensack University Medical Center Rejuvenated aged hematopoietic stem cells and methods of use
CN107937342B (zh) * 2017-11-06 2021-07-06 中国人民解放军第四军医大学 一种通过内皮细胞来源的外泌体扩增神经干细胞的方法
CN108070567A (zh) * 2018-01-19 2018-05-25 皓昇莱生物制药有限公司 一种永生化的尿液来源细胞株及其构建方法
MX2020011297A (es) 2018-04-25 2020-11-18 Childrens Medical Center Ligandos y substratos de abcb5.
SG11202103096PA (en) * 2018-10-12 2021-04-29 Reneuron Ltd Induced pluripotent cell comprising a controllable transgene for conditional immortalisation
GB201902068D0 (en) * 2019-02-14 2019-04-03 Cambridge Entpr Ltd Methods of reactivating proliferative capacity non-proliferative tissues
WO2020210231A1 (en) 2019-04-08 2020-10-15 Taiga Biotechnologies, Inc. Compositions and methods for the cry opreservation of immune cells
EP3969041A4 (en) 2019-05-14 2023-05-10 Taiga Biotechnologies, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF T-CELL DEPLETION
EP4006145A4 (en) * 2019-07-24 2023-08-23 Slbigen Inc. Method for preparation of immortalized stem cell line and use thereof
CN110622921B (zh) * 2019-09-29 2021-06-15 江苏大学 阿尔茨海默病病变区FoxG1过表达小鼠模型的构建方法及应用
GB202005494D0 (en) * 2020-04-15 2020-05-27 Reneuron Ltd Induced pluripotent cell comprising a contollable transgene for conditional immortalisation
KR20220057859A (ko) 2020-10-30 2022-05-09 전상수 펜터리
JP7805590B2 (ja) 2020-11-06 2026-01-26 株式会社Trans Chromosomics 可逆的不死化細胞の製造方法
CN113444730A (zh) * 2021-03-17 2021-09-28 昆明市延安医院 一种原发性肝细胞klotho基因转导干细胞筛选构建方法
JPWO2023277153A1 (https=) * 2021-06-30 2023-01-05
CN113583965A (zh) * 2021-08-05 2021-11-02 大连干细胞与精准医学创新研究院 一种条件永生化人神经干细胞来源细胞膜纳米囊泡制剂及其制备方法和应用
WO2023069882A1 (en) * 2021-10-20 2023-04-27 University Of Rochester Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se
JP7773257B2 (ja) 2022-03-28 2025-11-19 合同会社HiRoko Science miR-140を含む医薬組成物及びその製造方法

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
EP0207147A4 (en) * 1984-12-21 1988-07-14 Techniclone Res Partners METHOD OF ELECTRICAL IMMORTALIZATION OF LYMPHOID CELLS.
DE3531430A1 (de) 1985-09-03 1987-03-05 Biotest Pharma Gmbh Verfahren zur gewinnung von komponenten aus einer fluessigkeit mit in raeumlich getrennten bereichen vorliegenden komponenten
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4900322A (en) 1986-09-22 1990-02-13 Adams James D Blood component pooling valve and kit
US5476996A (en) * 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5670617A (en) 1989-12-21 1997-09-23 Biogen Inc Nucleic acid conjugates of tat-derived transport polypeptides
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
US5849288A (en) * 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US6004811A (en) 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US5843728A (en) 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5912170A (en) 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US6753162B1 (en) 1991-03-07 2004-06-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
NZ241855A (en) 1991-03-07 1994-04-27 Gen Hospital Corp Use of therapeutic cells to obtain cellular response to infection, tumours or autoimmune-generated cells, cells with chimaeric receptors (with binding component and destruction signal), dna encoding the receptor, vectors and antibodies to receptor
AU781922B2 (en) 1991-12-17 2005-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5289858A (en) 1991-12-18 1994-03-01 Abbott Laboratories System for accommodating withdrawal of liquid from a bulk supply
US8211422B2 (en) 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
CA2135642C (en) 1992-08-21 1999-12-14 James G. Barsoum Tat-derived transport polypeptides
US5580760A (en) 1993-02-22 1996-12-03 The United States Of America As Represented By The Department Of Health And Human Services FUSE binding protein and cDNA therefor
EP0710283A4 (en) * 1993-07-22 1997-07-02 Merck & Co Inc THE EXPRESSION OF HUMAN INTERLEUKIN-1-g (b) IN A TRANSGENIC ANIMAL
US5599705A (en) * 1993-11-16 1997-02-04 Cameron; Robert B. In vitro method for producing differentiated universally compatible mature human blood cells
WO1995023512A1 (en) 1994-03-03 1995-09-08 Alexion Pharmaceuticals, Inc. Terminal complement inhibitor fusion genes and proteins
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6713247B1 (en) * 1996-09-03 2004-03-30 Signal Pharmaceuticials, Inc. Human CNS cell lines and methods of use therefor
IL132941A0 (en) 1997-05-21 2001-03-19 Univ Leland Stanford Junior Composition and method for enhancing transport across biological membranes
EP0893493A3 (de) * 1997-07-21 2002-12-04 Aventis Pharma Deutschland GmbH Genetisch veränderte Zellen und deren Verwendung in der Prophylaxe oder Therapie von Erkrankungen
GB9720585D0 (en) 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
CA2314267A1 (en) 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof
DE69923550T2 (de) 1998-04-08 2006-02-16 Shionogi & Co., Ltd. Verfahren um Vorläuferzellen von Osteoklasten zu isolieren und ihre Differenzierung in Osteoklasten zu induzieren.
US6835567B1 (en) 1998-04-14 2004-12-28 Signal Pharmaceuticals, Inc. PNS cell lines and methods of use therefor
US6451558B1 (en) * 1998-08-03 2002-09-17 Novartis Ag Genes in the control of hematopoiesis
US6913925B1 (en) 1998-08-12 2005-07-05 Signal Pharmaceuticals Llc Human mesencephalon cell lines and methods of use therefor
EP1157275A4 (en) 1999-02-28 2003-01-15 Univ Washington NOVEL TRANSDUCTION MOLECULES AND METHODS OF USING THE SAME
WO2000059540A1 (en) * 1999-04-05 2000-10-12 Biocrystal Ltd. Assay kits and methods for immune complex-mediated activation involving shed antigens
US6451601B1 (en) * 1999-04-12 2002-09-17 Modex Therapeutiques, S.A. Transiently immortalized cells for use in gene therapy
US6358739B1 (en) 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
EP1175436B1 (en) * 1999-04-12 2006-10-11 Heart Biosystems GmbH Transiently immortalized cells for use in gene therapy
US7135287B1 (en) * 1999-10-02 2006-11-14 Biosite, Inc. Human antibodies
US7311920B1 (en) * 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
DK1228233T3 (da) 1999-11-10 2007-05-14 Rigel Pharmaceuticals Inc Fremgangsmåder og sammensætninger omfattende grönfluorescerende proteiner (GFP) fra Renilla
EP1103615A1 (en) * 1999-11-25 2001-05-30 Universite De Geneve Vectors capable of immortalizing non-dividing cells and cells immortalized with said vectors
US20010049393A1 (en) * 1999-12-07 2001-12-06 Whitehead Institute For Biomedical Research Methods for defining MYC target genes and uses thereof
WO2001087058A1 (en) * 2000-05-15 2001-11-22 Sonoko Habu Chimeric mouse having immunity constructed by using human cd34-positive cells and use thereof
US20020155127A1 (en) 2000-06-02 2002-10-24 Danher Wang Genetic vaccine against human immunodeficiency virus
US20030072794A1 (en) * 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
US20070248618A1 (en) * 2004-03-16 2007-10-25 Cohen David I Tat-Based vaccine Compositions and Methods of Making and Using Same
CA2423093C (en) 2000-09-25 2013-09-17 Valentis, Inc. Improved system for regulation of transgene expression
AU2002227112A1 (en) 2000-10-30 2002-05-15 Kalobios, Inc. Affinity maturation by competitive selection
JP2004528012A (ja) 2000-11-01 2004-09-16 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 改善された免疫応答を誘導し得る発現ベクターおよびこのベクターの使用方法
EP1338198B1 (en) * 2000-12-01 2007-11-28 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
WO2002057436A2 (en) 2001-01-19 2002-07-25 Gendel Limited Red blood cell from a transgenic animal as vehicle for polypeptide delivery
US7033744B2 (en) * 2001-03-16 2006-04-25 Naoya Kobayashi Method for proliferating a liver cell, a liver cell obtained thereby, and use thereof
WO2002097050A2 (en) * 2001-05-31 2002-12-05 Novartis Ag Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions
AU2002321581C1 (en) 2001-08-31 2008-09-18 Adaptimmune Limited Soluble T cell receptor
CN1408850A (zh) * 2001-09-18 2003-04-09 王虹 人血树突状细胞永生化技术
CN100506978C (zh) 2001-09-21 2009-07-01 中国人民解放军军事医学科学院野战输血研究所 一种新的造血干/祖细胞的富集方法及其体外定向诱导分化
GB0124391D0 (en) 2001-10-11 2001-11-28 Gene Expression Technologies L Control of gene expression
WO2003039462A2 (en) 2001-11-02 2003-05-15 Tanox, Inc. B-cell lymphoma specific antigen for use in diagnosis and treatment of b-cell malignancies
EP1321034A1 (en) * 2001-12-21 2003-06-25 Pfizer Products Inc. Disruption of the phosphodieterase 10 gene
WO2003057171A2 (en) 2002-01-03 2003-07-17 The Trustees Of The University Of Pennsylvania Activation and expansion of t-cells using an engineered multivalent signaling platform
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
WO2003068941A2 (en) 2002-02-13 2003-08-21 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
CN1240439C (zh) 2002-03-28 2006-02-08 南京凯基生物科技发展有限公司 肿瘤基因开关药物
US7211191B2 (en) 2004-09-30 2007-05-01 Thermogenesis Corp. Blood component separation method and apparatus
EP1499180A4 (en) 2002-04-16 2006-09-13 Dana Farber Cancer Inst Inc CANCER MODELS
GB2387599B (en) * 2002-04-17 2005-08-10 Jason Peter Brown Methods for producing antibodies
EP1504037B1 (en) * 2002-05-10 2009-12-30 New Century Pharmaceuticals, Inc. Ferritin fusion proteins for use in vaccines and other applications
CA2483640A1 (en) * 2002-05-16 2003-11-27 Bavarian Nordic A/S Fusion protein of hiv regulatory/accessory proteins
CA2485939C (en) * 2002-05-29 2013-10-29 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
DK1408114T3 (da) * 2002-10-11 2007-05-07 Imvision Gmbh Modulære antigen-transporter molekyler (MAT-molekyler) til modulation af immunreaktioner, tilhörende konstrukter, fremgangsmåder og anvendelser
WO2004035535A2 (en) 2002-10-15 2004-04-29 Yeda Research And Development Co. Ltd. Erythrocyte differentiation factor, gene encoding same, and methods of use thereof
DE60327795D1 (de) 2002-11-09 2009-07-09 Immunocore Ltd T zell rezeptor "display"
JP2006509010A (ja) 2002-12-05 2006-03-16 インペリアル・カレッジ・イノベイションズ・リミテッド アポトーシスの制御
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
WO2004084805A2 (en) 2003-03-19 2004-10-07 The J. David Gladstone Institutes Acetylated tat polypeptides and methods of use thereof
EP1623017B1 (en) 2003-05-08 2010-09-15 Life Technologies Corporation Generation and isolation of antigen-specific t cells
WO2005014785A2 (en) 2003-06-18 2005-02-17 The George Washington University Conditionally-immortalized hematopoietic progenitor cell lines
CA2529752A1 (en) 2003-06-20 2005-09-15 The Regents Of The University Of California Polypeptide transduction and fusogenic peptides
IL161903A0 (en) 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
US7705049B2 (en) * 2004-01-21 2010-04-27 New York University Methods for treating non-melanoma cancers with PABA
JP2005232148A (ja) 2004-02-03 2005-09-02 Technion Research & Development Foundation Ltd 神経保護剤としてプロパルギルアミンの使用
NZ550815A (en) 2004-05-19 2009-04-30 Immunocore Ltd Method of improving T cell receptors
DK1765860T3 (da) 2004-05-19 2009-03-09 Immunocore Ltd Ny-ESO-T.cellereceptor med höj affinitet
US8361794B2 (en) 2004-06-29 2013-01-29 Immunocore Limited Cells expressing a modified T cell receptor
WO2006137836A2 (en) 2004-08-17 2006-12-28 Research Development Foundation Bacterial vector systems
GB0420963D0 (en) * 2004-09-21 2004-10-20 Reneuron Ltd Hepatocyte
WO2006045064A2 (en) * 2004-10-20 2006-04-27 Whitehead Institute For Biomedical Research Cultured hematopoietic stem cells and method for expansion and analysis thereof
WO2007067183A1 (en) 2005-12-09 2007-06-14 The Regents Of The University Of California Derivation of unlimited quantities of neutrophils or monocyte/dendritic cells
US20060156422A1 (en) * 2005-01-10 2006-07-13 Medical Research Council Methods and compositions for the generation of antibodies
JP2008535823A (ja) 2005-03-25 2008-09-04 キュラジェン コーポレイション テネイシンの主要な抗原に対する抗体
EP1876894A1 (en) 2005-04-26 2008-01-16 The Board of Trustees of the University of Illinois Nucleoside compounds and methods of use thereof
WO2006125962A2 (en) 2005-05-25 2006-11-30 Medigene Limited T cell receptors which specifically bind to vygfvracl-hla-a24
CA2620202C (en) * 2005-08-26 2016-10-04 The Board Of Trustees Of The Leland Stanford Junior University Therapy procedure for drug delivery for trigeminal pain
US20070047583A1 (en) 2005-08-29 2007-03-01 Siemens Aktiengesellschaft Method for using a short address in a packet header
KR101441843B1 (ko) 2005-10-18 2014-09-17 내셔날 쥬이쉬 헬스 조건부 불멸화 장기 줄기 세포 및 상기 세포의 제조 및 사용 방법
EP1942948A4 (en) * 2005-11-04 2010-03-03 Alnylam Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR INHIBITING THE EXPRESSION OF THE NAV1.8 GENE
EP1792627A1 (en) 2005-12-05 2007-06-06 ImVisioN AG Modulation of the immune response by administration of intralymphatic transduction allergen (ITAG-)-molecules
WO2008039818A2 (en) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
EP2087000A2 (en) 2006-09-29 2009-08-12 Immunocore Ltd. T cell therapies
EP2134852A4 (en) * 2007-03-13 2010-04-28 Nat Jewish Health PROCESS FOR THE PRODUCTION OF ANTIBODIES
EP2214670A2 (en) 2007-11-02 2010-08-11 Taiga Biotechnologies, Inc. Compounds for treating abnormal cellular proliferation
SG188904A1 (en) 2008-03-17 2013-04-30 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
EP2285832B1 (en) * 2008-05-16 2020-08-26 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
WO2009149956A2 (en) 2008-06-13 2009-12-17 Life & Brain Gmbh Fusion protein and use thereof
ES2525411T3 (es) 2008-07-21 2014-12-22 Taiga Biotechnologies, Inc. Células anucleadas diferenciadas y método para preparar las mismas
EP2318435B1 (en) 2008-08-28 2015-12-23 Taiga Biotechnologies, Inc. Modulators of myc, methods of using the same, and methods of identifying agents that modulate myc
PT3031907T (pt) 2008-11-06 2021-01-28 Univ Indiana Res & Tech Corp Materiais e métodos para melhorar procedimentos de enxerto de células estaminais hematopoiéticas
CN102272153B (zh) 2008-11-24 2015-04-15 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 高亲和力t细胞受体及其应用
WO2011100477A2 (en) 2010-02-10 2011-08-18 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
US20120107317A1 (en) 2010-10-27 2012-05-03 The University Of Hong Kong Use of cytoplasmic c-myc for regulating immune responses
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
ES2834070T3 (es) 2011-09-15 2021-06-16 Us Health Receptores de células T que reconocen MAGE restringido por HLA-A1 o HLA-Cw7
SG10201609210SA (en) 2012-05-03 2016-12-29 Hutchinson Fred Cancer Res Enhanced affinity t cell receptors and methods for making the same
DE102012209673A1 (de) 2012-06-08 2013-12-24 Artcline Gmbh Verfahren zum Herstellen einer Leukozytenpräparation und Leukozytenpräparation
JP6285930B2 (ja) 2012-07-20 2018-02-28 タイガ バイオテクノロジーズ,インク. 造血コンパートメントの再構築及び自家再構築の増進
AU2013295652B2 (en) 2012-07-27 2018-02-08 The Board Of Trustees Of The University Of Illinois Engineering T-cell receptors
US20140109246A1 (en) 2012-09-24 2014-04-17 The Regents Of The University Of Colorado, A Body Corporate Methods of generating xenochimaeric mice with tumor and hematopoietic system from the same heterologous species
GB2508414A (en) 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
RU2671897C2 (ru) 2013-03-01 2018-11-07 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Способы получения из опухоли обогащенных популяций реактивных в отношении опухоли т-клеток
EP3628322A1 (en) 2013-03-01 2020-04-01 The United States of America, as represented by the Secretary, Department of Health and Human Services Cd8+ t cells that also express pd-1 and/or tim-3 for the treatment of cancer
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
EP3134515B1 (en) 2014-04-24 2019-03-27 Board of Regents, The University of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
SG11201705064XA (en) 2014-12-24 2017-07-28 Neximmune Inc Nanoparticle compositions and methods for immunotherapy
CA3011087A1 (en) 2016-01-15 2017-07-20 Berkeley Lights, Inc. Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma

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