JP2016094451A5 - - Google Patents

Download PDF

Info

Publication number
JP2016094451A5
JP2016094451A5 JP2015246589A JP2015246589A JP2016094451A5 JP 2016094451 A5 JP2016094451 A5 JP 2016094451A5 JP 2015246589 A JP2015246589 A JP 2015246589A JP 2015246589 A JP2015246589 A JP 2015246589A JP 2016094451 A5 JP2016094451 A5 JP 2016094451A5
Authority
JP
Japan
Prior art keywords
nmol
hour
composition
naglu
fold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015246589A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016094451A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2016094451A publication Critical patent/JP2016094451A/ja
Publication of JP2016094451A5 publication Critical patent/JP2016094451A5/ja
Pending legal-status Critical Current

Links

JP2015246589A 2010-06-25 2015-12-17 サンフィリポ症候群b型の処置 Pending JP2016094451A (ja)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US35885710P 2010-06-25 2010-06-25
US61/358,857 2010-06-25
US36078610P 2010-07-01 2010-07-01
US61/360,786 2010-07-01
US38786210P 2010-09-29 2010-09-29
US61/387,862 2010-09-29
US201161435710P 2011-01-24 2011-01-24
US61/435,710 2011-01-24
US201161442115P 2011-02-11 2011-02-11
US61/442,115 2011-02-11
US201161476210P 2011-04-15 2011-04-15
US61/476,210 2011-04-15
US201161495268P 2011-06-09 2011-06-09
US61/495,268 2011-06-09

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2013516847A Division JP6063380B2 (ja) 2010-06-25 2011-06-25 サンフィリポ症候群b型の処置

Publications (2)

Publication Number Publication Date
JP2016094451A JP2016094451A (ja) 2016-05-26
JP2016094451A5 true JP2016094451A5 (https=) 2016-09-08

Family

ID=45352777

Family Applications (22)

Application Number Title Priority Date Filing Date
JP2015236539A Active JP6250616B2 (ja) 2010-06-25 2015-12-03 治療薬のcns送達
JP2015246589A Pending JP2016094451A (ja) 2010-06-25 2015-12-17 サンフィリポ症候群b型の処置
JP2015246244A Active JP6285409B2 (ja) 2010-06-25 2015-12-17 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2015246258A Withdrawn JP2016040335A (ja) 2010-06-25 2015-12-17 ヘパランn−スルファターゼのcns送達のための方法および組成物
JP2015246952A Active JP6346162B2 (ja) 2010-06-25 2015-12-18 アリールスルファターゼaのcns送達の方法および組成物
JP2017177784A Active JP6466538B2 (ja) 2010-06-25 2017-09-15 治療薬のcns送達
JP2017194508A Active JP6522073B2 (ja) 2010-06-25 2017-10-04 アリールスルファターゼaのcns送達の方法および組成物
JP2017194348A Active JP6522072B2 (ja) 2010-06-25 2017-10-04 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2018192589A Active JP6797876B2 (ja) 2010-06-25 2018-10-11 治療薬のcns送達
JP2018226358A Active JP6898909B2 (ja) 2010-06-25 2018-12-03 アリールスルファターゼaのcns送達の方法および組成物
JP2018227369A Active JP6938456B2 (ja) 2010-06-25 2018-12-04 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2020000930A Withdrawn JP2020079244A (ja) 2010-06-25 2020-01-07 治療薬のcns送達
JP2020023620A Pending JP2020079297A (ja) 2010-06-25 2020-02-14 アリールスルファターゼaのcns送達の方法および組成物
JP2020024183A Pending JP2020079298A (ja) 2010-06-25 2020-02-17 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2021115560A Active JP7448507B2 (ja) 2010-06-25 2021-07-13 アリールスルファターゼaのcns送達の方法および組成物
JP2021115564A Active JP7087175B2 (ja) 2010-06-25 2021-07-13 治療薬のcns送達
JP2021133184A Active JP7591476B2 (ja) 2010-06-25 2021-08-18 イズロン酸-2-スルファターゼのcns送達のための方法および組成物
JP2021196898A Active JP7359827B2 (ja) 2010-06-25 2021-12-03 治療薬のcns送達
JP2023014814A Active JP7543459B2 (ja) 2010-06-25 2023-02-02 アリールスルファターゼaのcns送達の方法および組成物
JP2023024170A Pending JP2023062114A (ja) 2010-06-25 2023-02-20 イズロン酸-2-スルファターゼのcns送達のための方法および組成物
JP2023078673A Pending JP2023099216A (ja) 2010-06-25 2023-05-11 治療薬のcns送達
JP2024069806A Ceased JP2024097029A (ja) 2010-06-25 2024-04-23 アリールスルファターゼaのcns送達の方法および組成物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2015236539A Active JP6250616B2 (ja) 2010-06-25 2015-12-03 治療薬のcns送達

Family Applications After (20)

Application Number Title Priority Date Filing Date
JP2015246244A Active JP6285409B2 (ja) 2010-06-25 2015-12-17 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2015246258A Withdrawn JP2016040335A (ja) 2010-06-25 2015-12-17 ヘパランn−スルファターゼのcns送達のための方法および組成物
JP2015246952A Active JP6346162B2 (ja) 2010-06-25 2015-12-18 アリールスルファターゼaのcns送達の方法および組成物
JP2017177784A Active JP6466538B2 (ja) 2010-06-25 2017-09-15 治療薬のcns送達
JP2017194508A Active JP6522073B2 (ja) 2010-06-25 2017-10-04 アリールスルファターゼaのcns送達の方法および組成物
JP2017194348A Active JP6522072B2 (ja) 2010-06-25 2017-10-04 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2018192589A Active JP6797876B2 (ja) 2010-06-25 2018-10-11 治療薬のcns送達
JP2018226358A Active JP6898909B2 (ja) 2010-06-25 2018-12-03 アリールスルファターゼaのcns送達の方法および組成物
JP2018227369A Active JP6938456B2 (ja) 2010-06-25 2018-12-04 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2020000930A Withdrawn JP2020079244A (ja) 2010-06-25 2020-01-07 治療薬のcns送達
JP2020023620A Pending JP2020079297A (ja) 2010-06-25 2020-02-14 アリールスルファターゼaのcns送達の方法および組成物
JP2020024183A Pending JP2020079298A (ja) 2010-06-25 2020-02-17 イズロン酸−2−スルファターゼのcns送達のための方法および組成物
JP2021115560A Active JP7448507B2 (ja) 2010-06-25 2021-07-13 アリールスルファターゼaのcns送達の方法および組成物
JP2021115564A Active JP7087175B2 (ja) 2010-06-25 2021-07-13 治療薬のcns送達
JP2021133184A Active JP7591476B2 (ja) 2010-06-25 2021-08-18 イズロン酸-2-スルファターゼのcns送達のための方法および組成物
JP2021196898A Active JP7359827B2 (ja) 2010-06-25 2021-12-03 治療薬のcns送達
JP2023014814A Active JP7543459B2 (ja) 2010-06-25 2023-02-02 アリールスルファターゼaのcns送達の方法および組成物
JP2023024170A Pending JP2023062114A (ja) 2010-06-25 2023-02-20 イズロン酸-2-スルファターゼのcns送達のための方法および組成物
JP2023078673A Pending JP2023099216A (ja) 2010-06-25 2023-05-11 治療薬のcns送達
JP2024069806A Ceased JP2024097029A (ja) 2010-06-25 2024-04-23 アリールスルファターゼaのcns送達の方法および組成物

Country Status (24)

Country Link
US (17) US9814764B2 (https=)
JP (22) JP6250616B2 (https=)
CN (4) CN104857504A (https=)
AR (6) AR082025A1 (https=)
BR (1) BR112012033214B1 (https=)
CA (1) CA3171308A1 (https=)
CL (7) CL2012003656A1 (https=)
DK (3) DK3626258T3 (https=)
ES (3) ES2895655T3 (https=)
HK (1) HK1214149A1 (https=)
HR (3) HRP20211520T1 (https=)
HU (6) HUE056884T2 (https=)
LT (3) LT3626258T (https=)
MX (1) MX354776B (https=)
NZ (2) NZ702803A (https=)
PE (8) PE20130637A1 (https=)
PL (1) PL2588130T3 (https=)
PT (6) PT3103469T (https=)
RS (3) RS61683B1 (https=)
RU (1) RU2761342C2 (https=)
SI (3) SI3103469T1 (https=)
SM (1) SMT201600385B (https=)
TW (9) TWI698252B (https=)
UA (3) UA125743C2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759297B2 (en) 2006-08-18 2014-06-24 Armagen Technologies, Inc. Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
AU2008282496B2 (en) 2007-07-27 2013-04-04 Armagen Technologies, Inc. Methods and compositions for increasing alpha-iduronidase activity in the CNS
EP2485761B1 (en) 2009-10-09 2019-02-27 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
PT3103469T (pt) 2010-06-25 2021-03-04 Shire Human Genetic Therapies Administração de agentes terapêuticos no snc
LT2588130T (lt) 2010-06-25 2016-12-12 Shire Human Genetic Therapies, Inc. Terapinės priemonės pristatymas cns
JP6073783B2 (ja) 2010-06-25 2017-02-01 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ヘパランn−スルファターゼのcns送達のための方法および組成物
HRP20191923T1 (hr) 2010-06-25 2020-01-10 Shire Human Genetic Therapies, Inc. Postupci i sastavi za isporuku arilsulfataze a u cns
US20220133863A1 (en) * 2010-06-25 2022-05-05 Shire Human Genetic Therapies, Inc. Treatment of sanfilippo syndrome type b
AU2012346448B2 (en) 2011-12-02 2017-09-14 Armagen, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
US9682129B2 (en) * 2011-12-23 2017-06-20 Shire Human Genetic Therapies, Inc. Treatment of cognitive impairment of hunter syndrome by intrathecal delivery of iduronate-2-sulfatase
CN115120746A (zh) * 2013-05-15 2022-09-30 明尼苏达大学董事会 腺相关病毒介导的基因向中枢神经系统转移
US10538589B2 (en) * 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
CA2985235A1 (en) 2015-05-07 2016-11-10 Shire Human Genetic Therapies, Inc. Glucocerebrosidase gene therapy for parkinson's disease
PL3397270T3 (pl) * 2015-12-30 2024-08-19 Green Cross Corporation Kompozycje do zastosowania w leczeniu zespołu huntera
MX2018010196A (es) * 2016-02-24 2018-11-19 Biomarin Pharm Inc Proteinas de fusion de enzimas lisosomales terapeuticas dirigidas, formulaciones asociadas y usos de las mismas.
SG10201912761UA (en) 2016-04-15 2020-02-27 The Trustees Of The Univ Of Pennsyvania Gene therapy for treating mucopolysaccharidosis type ii
KR102883778B1 (ko) 2017-09-22 2025-11-12 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Ii형 점액다당류증의 치료를 위한 유전자 요법
EP3760220B1 (en) * 2018-02-28 2025-02-19 Seikagaku Corporation A package comprising lyophilized chondroitinase abc and method for manufacturing the same
JP7321142B2 (ja) 2018-02-28 2023-08-04 生化学工業株式会社 医薬組成物、包装体及びその製造方法
CN108534695A (zh) * 2018-05-04 2018-09-14 无锡恩特卫自动化检测设备有限公司 一种基于机器视觉系统的瓶塞漏酒检测方法及装置
KR102671857B1 (ko) * 2018-05-30 2024-06-04 주식회사 녹십자 대뇌 측뇌실 투여에 의해 헌터증후군을 치료하기 위한 방법 및 조성물
US11738068B2 (en) 2018-06-25 2023-08-29 Jcr Pharmaceuticals Co., Ltd. Protein-containing aqueous liquid formulation
JP7253770B2 (ja) * 2019-01-18 2023-04-07 株式会社大一商会 遊技機
JP7253771B2 (ja) * 2019-01-18 2023-04-07 株式会社大一商会 遊技機
EP4229192A1 (en) 2020-10-14 2023-08-23 Denali Therapeutics Inc. Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
CN113283465B (zh) * 2021-04-02 2022-04-29 电子科技大学 一种弥散张量成像数据分析方法及装置
WO2022271466A1 (en) 2021-06-21 2022-12-29 Juvena Therapeutics, Inc. Regenerative polypeptides and uses thereof
CN115116623A (zh) * 2022-06-28 2022-09-27 深圳市儿童医院 一种基于icd疾病编码的抗菌药物使用指标评价方法、终端
WO2025054521A1 (en) * 2023-09-07 2025-03-13 Juvena Therapeutics, Inc. Igf2 fusion protein formulations and therapeutic uses thereof
WO2025075929A1 (en) * 2023-10-02 2025-04-10 Neurona Therapeutics Inc. Methods of treating seizure activity

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133001A (en) * 1959-11-26 1964-05-12 Muset Pedro Puig Stabilization of enzymes
US4743265A (en) 1986-04-23 1988-05-10 Dij Catheter Corp Articulated catheter placement device
US5222982A (en) 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
JP3946246B2 (ja) * 1993-02-02 2007-07-18 ゾーマ・コーポレイション 殺菌性/浸透性増大タンパク質(Bactericidal/Permeability Increasing protein:BPI)及び界面活性剤を含有する医薬組成物
US5863782A (en) 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US6118045A (en) 1995-08-02 2000-09-12 Pharming B.V. Lysosomal proteins produced in the milk of transgenic animals
AUPN674895A0 (en) 1995-11-23 1995-12-14 Women's And Children's Hospital Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences encoding same
US6063378A (en) 1997-08-22 2000-05-16 Seikagaku Corporation Therapeutic agent for herniated intervertebral disc
ES2312222T3 (es) 1998-12-07 2009-02-16 Genzyme Corporation Tratamiento de la enfermedad de pompe.
US6217552B1 (en) 1999-03-01 2001-04-17 Coaxia, Inc. Medical device for selective intrathecal spinal cooling in aortic surgery and spinal trauma
US6368315B1 (en) 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
US20020052311A1 (en) 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
US6534300B1 (en) 1999-09-14 2003-03-18 Genzyme Glycobiology Research Institute, Inc. Methods for producing highly phosphorylated lysosomal hydrolases
US20020099025A1 (en) * 1999-12-30 2002-07-25 Heywood James A. Treatment of neurological disorders
US6866844B2 (en) * 2002-11-07 2005-03-15 Biomarin Pharmaceutical Inc. Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
US20040005309A1 (en) 2002-05-29 2004-01-08 Symbiontics, Inc. Targeted therapeutic proteins
US7629309B2 (en) 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
WO2002087510A2 (en) 2001-04-30 2002-11-07 Symbiontics, Inc. Subcellular targeting of therapeutic proteins
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US20030040479A1 (en) 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
US20030072761A1 (en) 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
AU2002347910A1 (en) 2001-10-16 2003-04-28 Symbiontics Inc. Methods and compositions for targeting proteins across the blood brain barrier
US20030181426A1 (en) 2002-02-11 2003-09-25 Eisenach James C. Compositions and methods for treating pain using cyclooxygenase-1 inhibitors
DK1503788T3 (da) 2002-04-25 2011-10-17 Shire Human Genetic Therapies Behandling af alpha-galactosidase A-deficiens
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
EP1514106A4 (en) 2002-05-29 2007-05-09 Zystor Therapeutics Inc TARGETED THERAPEUTIC PROTEINS
EP1426069A1 (en) 2002-12-02 2004-06-09 Diana Evelyn Miller Drug delivery system
ES2371913T3 (es) 2003-01-22 2012-01-11 Duke University Constructos mejorados para expresar polipéptidos lisosomales.
EP2857036B1 (en) 2003-01-31 2016-12-21 Mount Sinai School of Medicine of New York University Combination therapy for treating protein deficiency disorders
US8026209B2 (en) 2003-02-10 2011-09-27 Bbb Holding B.V. Methods and compositions for targeting agents into and across the blood-barrier and other endothelial cell microvascular barriers
CN1788017B (zh) * 2003-02-10 2013-04-24 to-BBB控股股份有限公司 炎症状态下在血脑屏障中差异表达的核酸
EP1638605B1 (en) 2003-06-20 2014-01-08 Raptor Pharmaceutical, Inc. Delivery of therapeutic compounds to the brain and other tissues
US20050026823A1 (en) 2003-06-20 2005-02-03 Biomarin Pharmaceutical Inc. Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
EP1713904B1 (en) 2004-01-30 2016-06-29 Shire Pharmaceuticals Ireland Limited Production and purification of recombinant arylsulfatase a
WO2005074888A2 (en) 2004-02-03 2005-08-18 Biodelivery Sciences International, Inc. Replacement enzyme cochleates
US20080014188A1 (en) 2004-02-06 2008-01-17 Zankel Todd C Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof
CA2553955C (en) 2004-02-10 2012-08-28 Zystor Therapeutics, Inc. Acid alpha-glucosidase and fragments thereof
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
UA11577U (en) 2004-04-21 2006-01-16 Academician A P Romodanov Inst Device for intrathecal drug administration into spinal canal
RU2006144851A (ru) 2004-06-15 2008-06-20 Бакстер Интернэшнл Инк. (Us) Применение терапевтических средств ex-vivo в виде твердых микрочастиц
US7736866B2 (en) * 2004-08-11 2010-06-15 Ciba Corporation Enzyme-based time temperature indicator
IL165334A0 (en) * 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
US20090297592A1 (en) * 2005-05-11 2009-12-03 Jcr Pharmaceuticals Co., Ltd. Lipid Vesicle Composition
AU2006254796B2 (en) 2005-06-08 2012-08-16 Amicus Therapeutics, Inc. Treatment of CNS disorders associated with mutations in genes encoding lysosomal enzymes
AR059089A1 (es) * 2006-01-20 2008-03-12 Genzyme Corp Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal
HUE040490T2 (hu) 2006-02-09 2019-03-28 Genzyme Corp Lassú intraventrikuláris szállítás
HUE042402T2 (hu) 2006-04-04 2019-06-28 Chiesi Farm Spa Eljárás polipeptid töményítésére
CN101410408A (zh) * 2006-04-04 2009-04-15 希尔制药爱尔兰有限责任公司 用于浓缩多肽的方法
GB0611463D0 (en) 2006-06-09 2006-07-19 Novartis Ag Organic compounds
US20080076120A1 (en) 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008070769A1 (en) * 2006-12-06 2008-06-12 Medtronic, Inc. Intrathecal catheter
CA2680189A1 (en) 2007-03-06 2008-09-12 Saint Louis University Modified enzyme and treatment method
US20110059508A1 (en) 2007-06-29 2011-03-10 National University Corporation Nagoya University Improving agent for dysfunction due to neuropathy and rho kinase activation inhibitor
WO2009017005A1 (ja) 2007-07-27 2009-02-05 Sharp Kabushiki Kaisha 移動局装置、基地局装置、通信システム及びプログラム
JP2010536341A (ja) 2007-08-15 2010-12-02 アムニクス, インコーポレイテッド 生物学的に活性なポリペプチドの特性を改変するための組成物および方法
WO2009062348A1 (en) * 2007-11-14 2009-05-22 Institute Of Microbiology, Chinese Academy Of Sciences Methods for inhibiting influenza virus infection and their drugs
US8420081B2 (en) 2007-11-30 2013-04-16 Abbvie, Inc. Antibody formulations and methods of making same
US7722865B2 (en) * 2008-01-18 2010-05-25 Biomarin Pharmaceutical Inc. Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
CA2711590C (en) 2008-01-18 2021-03-23 Biomarin Pharmaceutical Inc. Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
TW200936156A (en) * 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
WO2009131698A2 (en) 2008-04-23 2009-10-29 Iowa State University Research Foundation, Inc. PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF
JP5627571B2 (ja) 2008-05-07 2014-11-19 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム標的化ペプチドおよびその使用
US8436489B2 (en) 2009-06-29 2013-05-07 Lightsail Energy, Inc. Compressed air energy storage system utilizing two-phase flow to facilitate heat exchange
LT2588130T (lt) 2010-06-25 2016-12-12 Shire Human Genetic Therapies, Inc. Terapinės priemonės pristatymas cns
PT3103469T (pt) 2010-06-25 2021-03-04 Shire Human Genetic Therapies Administração de agentes terapêuticos no snc
US20110318324A1 (en) 2010-06-25 2011-12-29 Shire Human Genetic Therapies, Inc. Methods and compositions for cns delivery of b-galactocerebrosidase
AU2011270672B2 (en) 2010-06-25 2017-01-12 Shire Human Genetic Therapies, Inc. Treatment of Sanfilippo Syndrome type B
KR20230159646A (ko) 2010-06-25 2023-11-21 샤이어 휴먼 지네틱 테라피즈 인크. 이듀로네이트-2-설파타제의 cns 전달을 위한 방법들 및 조성물들
JP6073783B2 (ja) 2010-06-25 2017-02-01 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ヘパランn−スルファターゼのcns送達のための方法および組成物
HRP20191923T1 (hr) 2010-06-25 2020-01-10 Shire Human Genetic Therapies, Inc. Postupci i sastavi za isporuku arilsulfataze a u cns
JP2012062312A (ja) 2010-08-19 2012-03-29 Yoshikatsu Eto ハンター症候群の治療剤
US8580922B2 (en) * 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
MA40460A (fr) 2014-08-11 2016-02-18 Shire Human Genetic Therapies Ciblage lysosomial et utilisation correspondante
EP3185889B1 (en) 2014-08-11 2020-07-15 Shire Human Genetic Therapies, Inc. Mannose-6-phosphate bearing peptides fused to lysosomal enzymes
WO2016065319A1 (en) 2014-10-24 2016-04-28 Shire Human Genetic Therapies, Inc. Lysosomal targeting of enzymes, and uses thereof
US9673835B1 (en) 2015-12-04 2017-06-06 Taiwan Semiconductor Manufacturing Co., Ltd. Pipelined SAR with TDC converter

Similar Documents

Publication Publication Date Title
JP2016094451A5 (https=)
JP2013542913A5 (https=)
US20200270590A1 (en) P97-ids fusion proteins
JP2016040335A5 (https=)
US9192649B2 (en) Annexin and its use to treat inflammatory disorders
CN104039811B (zh) 具有改善的细胞渗透性的新的大分子转导结构域的研发及其使用方法
US20200048324A1 (en) Tissue-specific wnt signal enhancing molecules and uses thereof
JP2017529326A5 (https=)
JP6794409B2 (ja) シータデフェンシンによる炎症性プロテアーゼの遮断
JP2018522563A5 (https=)
JP2019519528A5 (https=)
CN114341195B (zh) 治疗性融合蛋白
WO2011036442A3 (en) Thrombin c- terminal polypeptides and uses thereof for treating inflammation coagulation disorders
JP2011504366A5 (https=)
EA201200515A1 (ru) Полипептиды и их применение
US20170029798A1 (en) Development of Improved Cell-Permeable (iCP) Parkin Recombinant Protein as a Protein-Based Anti-Neurodegenerative Agent for the Treatment of Parkinson's Disease-Associated Phenotypes by Utilizing BBB-Penetrating Protein Delivery System MITT, Enabled by Advanced Macromolecule Transduction Domain (aMTD)
JP2011528222A5 (https=)
US12428445B2 (en) Mini-nucleosome core proteins and use in nucleic acid delivery
RU2016152151A (ru) Препарат, содержащий фактор viii и пептиды фактора фон виллебранда
CN106279439A (zh) 一种含有穿膜肽的寡肽‑1融合蛋白及其制备方法
CA3205570A1 (en) Fusion molecule having non-inflammatory phagocytosis inducing activity
JP2020037538A (ja) アンジオテンシン変換酵素2活性を有する原核微生物由来ポリペプチドの医薬用途
JP2021534206A (ja) Gsx1を使用した脊髄損傷(sci)および脳損傷の処置
WO2013052814A8 (en) E1 enzyme mutants and uses thereof
CN115427428A (zh) 新的细胞穿透肽及其用途