HRP20191923T1 - Postupci i sastavi za isporuku arilsulfataze a u cns - Google Patents
Postupci i sastavi za isporuku arilsulfataze a u cns Download PDFInfo
- Publication number
- HRP20191923T1 HRP20191923T1 HRP20191923TT HRP20191923T HRP20191923T1 HR P20191923 T1 HRP20191923 T1 HR P20191923T1 HR P20191923T T HRP20191923T T HR P20191923TT HR P20191923 T HRP20191923 T HR P20191923T HR P20191923 T1 HRP20191923 T1 HR P20191923T1
- Authority
- HR
- Croatia
- Prior art keywords
- stable aqueous
- optionally
- concentration
- polysorbate
- formula
- Prior art date
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- 102100022146 Arylsulfatase A Human genes 0.000 title claims 8
- 108010036867 Cerebroside-Sulfatase Proteins 0.000 title claims 8
- 239000000203 mixture Substances 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 2
- 238000007913 intrathecal administration Methods 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000013011 aqueous formulation Substances 0.000 claims 4
- 229920000136 polysorbate Polymers 0.000 claims 4
- 229950008882 polysorbate Drugs 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims 3
- 239000006172 buffering agent Substances 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 3
- 229940068977 polysorbate 20 Drugs 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 239000005388 borosilicate glass Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 229940071643 prefilled syringe Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims 1
- 229920001219 Polysorbate 40 Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229940101027 polysorbate 40 Drugs 0.000 claims 1
- 229940113124 polysorbate 60 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 239000004447 silicone coating Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (16)
1. Stabilna vodena formula za intratekalnu primjenu koja sadrži protein arilsulfatazu A (ASA) u koncentraciji većoj od 10 mg/ml, sol, polisorbatni surfaktant i puferski agens, pri čemu je sol NaCl.
2. Stabilna vodena formula prema patentnom zahtjevu 1, gdje je ASA protein prisutan u koncentraciji u rasponu od 15-100 mg/ml, opcionalno gdje je ASA protein prisutan u koncentraciji izabranoj između 30 mg/ml, 50 mg/ml ili 100 mg/ml.
3. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, gdje ASA protein sadrži aminokiselinsku sekvencu SEQ ID NO: 1.
4. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu:
(i) ASA protein se proizvodi iz ljudske stanične linije, ili
(ii) ASA protein se proizvodi iz CHO stanica.
5. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, gde je NaCl prisutan u koncentraciji koja je u rasponu od 30-300 mM, opcionalno u koncentraciji u rasponu od 137-154 mM, opcionalno u koncentraciji od približno 154 mM.
6. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, gde je polisorbatni surfaktant izabran iz skupine koja se sastoji od polisorbata 20, polisorbata 40, polisorbata 60, polisorbata 80 i njihove kombinacije, opcionalno gdje polisorbatni surfaktant je polisorbat 20, opcionalno gdje je polisorbatni surfaktant prisutan u koncentraciji u rasponu od 0,001 do 0,5% i opcionalno gdje je polisorbat 20 prisutan u koncentraciji od približno 0,005%.
7. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, gdje je puferski agens izabran iz skupine koja se sastoji od fosfata, acetata, histidina, sukcinata, citrata, Trisa i njihovih kombinacija, a opcionalno gdje je puferski agens fosfat i prisutan je u koncentraciji ne većoj od 50 mM i opcionalno u koncentraciji ne većoj od 20 mM.
8. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu formula ima pH od približno 3-8,0, približno 6,0-6,5 ili približno 6,0.
9. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu je formula rekonstituirana iz liofilizirane formule s razblaživačem.
10. Stabilna vodena formula prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu formula dalјe sadrži stabilizator.
11. Stabilna vodena formula prema patentnom zahtjevu 10, gdje je stabilizator izabran iz skupine koja se sastoji od saharoze, glukoze, manitola, sorbitola, PEG 4000, histidina, arginina, lizina, fosfolipida i njihove kombinacije.
12. Posuda za skladištenje koja sadrži jedinični dozni oblik stabilne vodene formule prema bilo kojem od prethodnih patentnih zahtjeva.
13. Posuda za skladištenje prema patentnom zahtjevu 12, pri čemu je posuda za skladištenje izabrana između ampule, bočice, patrone, rezervoara, lyo-injektora ili prethodno napunjene šprice, opcionalno gdje je posuda za skladištenje prethodno napunjena šprica i opcionalno je izabrana između borosilikatnih staklenih šprica s premazom od pečenog silikona, borosilikatnih staklenih šprica s raspršenim silikonom ili plastičnih šprica od smola bez silikona.
14. Posuda za skladištenje prema patentnom zahtjevu 12, pri čemu je stabilna vodena formula prisutna u obujmu manjem od oko 50,0 mL, opcionalno gdje je stabilna vodena formula prisutna u obujmu manjem od oko 5,0 mL.
15. Stabilna vodena formula prema bilo kojem od patentnih zahtjeva 1-11, za upotrebu u postupku liječenja bolesti metakromatske leukodistrofije (MLD) koji obuhvaća korak intratekalne primjene formule subjektu.
16. Stabilna vodena formula za upotrebu prema patentnom zahtjevu 15, pri čemu:
(i) intratekalna primjena se upotrebljava zajedno sa intravenskom primjenom, opcionalno gdje intravenska primjena nije češća od jednom mjesečno ili nije češća od jednom u svaka dva mjeseca, ili
(ii) intratekalna primjena se upotrebljava u odsutstvu intravenske primjene, i/ili
(iii) intratekalna primjena se vrši jednom u svaka dva tjedna, jednom mjesečno ili jednom u svaka dva mjeseca, i/ili
(iv) intratekalna primjena se upotrebljava u odsutstvu istovremene imunosupresivne terapije.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35885710P | 2010-06-25 | 2010-06-25 | |
| US36078610P | 2010-07-01 | 2010-07-01 | |
| US38786210P | 2010-09-29 | 2010-09-29 | |
| US201161435710P | 2011-01-24 | 2011-01-24 | |
| US201161442115P | 2011-02-11 | 2011-02-11 | |
| US201161476210P | 2011-04-15 | 2011-04-15 | |
| US201161495268P | 2011-06-09 | 2011-06-09 | |
| PCT/US2011/041926 WO2011163650A2 (en) | 2010-06-25 | 2011-06-25 | Methods and compositions for cns delivery of arylsulfatase a |
| EP11799037.4A EP2585104B1 (en) | 2010-06-25 | 2011-06-25 | Methods and compositions for cns delivery of arylsulfatase a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191923T1 true HRP20191923T1 (hr) | 2020-01-10 |
Family
ID=46888844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191923TT HRP20191923T1 (hr) | 2010-06-25 | 2019-10-22 | Postupci i sastavi za isporuku arilsulfataze a u cns |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9770410B2 (hr) |
| EP (3) | EP3626257B1 (hr) |
| JP (1) | JP6045493B2 (hr) |
| KR (4) | KR102094094B1 (hr) |
| CN (1) | CN103282046B (hr) |
| AU (4) | AU2011270670B2 (hr) |
| BR (1) | BR112012033216B1 (hr) |
| CA (1) | CA2803003C (hr) |
| CY (2) | CY1122282T1 (hr) |
| DK (1) | DK2585104T3 (hr) |
| ES (1) | ES2754776T3 (hr) |
| HR (1) | HRP20191923T1 (hr) |
| IL (3) | IL291556B2 (hr) |
| LT (1) | LT2585104T (hr) |
| ME (1) | ME03647B (hr) |
| MX (1) | MX344795B (hr) |
| NZ (2) | NZ605873A (hr) |
| PL (2) | PL3626257T3 (hr) |
| RS (1) | RS59468B1 (hr) |
| RU (1) | RU2671503C2 (hr) |
| SI (1) | SI2585104T1 (hr) |
| TW (1) | TWI667037B (hr) |
| UA (1) | UA115650C2 (hr) |
| WO (1) | WO2011163650A2 (hr) |
| ZA (1) | ZA201300675B (hr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20180130A1 (es) | 2010-06-25 | 2018-01-18 | Shire Human Genetic Therapies | Composiciones y metodos para suministro al sistema nervioso central de arilsulfatasa a |
| US8545837B2 (en) | 2010-06-25 | 2013-10-01 | Shire Human Genetic Therapies, Inc. | Methods and compositions for CNS delivery of iduronate-2-sulfatase |
| UA115650C2 (uk) | 2010-06-25 | 2017-12-11 | Шае Хюмен Дженетік Терапіс, Інк. | Способи та композиції для доставки до цнс арилсульфатази а |
| PE20230169A1 (es) | 2010-06-25 | 2023-02-01 | Shire Human Genetic Therapies | Suministro al sistema nervioso central de agentes terapeuticos |
| RU2012154576A (ru) | 2010-06-25 | 2014-07-27 | Шир Хьюман Дженетик Терапис, Инк. | Способы и композиции для доставки к цнс гепаран-n-сульфатазы |
| WO2013096899A2 (en) | 2011-12-23 | 2013-06-27 | Shire Human Genetic Therapies, Inc. | Stable formulations for cns delivery of arylsulfatase a |
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