JP2016014070A5 - - Google Patents
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- Publication number
- JP2016014070A5 JP2016014070A5 JP2015207655A JP2015207655A JP2016014070A5 JP 2016014070 A5 JP2016014070 A5 JP 2016014070A5 JP 2015207655 A JP2015207655 A JP 2015207655A JP 2015207655 A JP2015207655 A JP 2015207655A JP 2016014070 A5 JP2016014070 A5 JP 2016014070A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oligonucleotide decoy
- pain
- cell
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 10
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 210000002569 neuron Anatomy 0.000 claims 2
- 230000008055 nociceptive signaling Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 102100026865 Cyclin-dependent kinase 5 activator 1 Human genes 0.000 claims 1
- 102100027346 GTP cyclohydrolase 1 Human genes 0.000 claims 1
- 102000017679 HTR3A Human genes 0.000 claims 1
- 101000761343 Homo sapiens 5-hydroxytryptamine receptor 3A Proteins 0.000 claims 1
- 101000862581 Homo sapiens GTP cyclohydrolase 1 Proteins 0.000 claims 1
- 101001032845 Homo sapiens Metabotropic glutamate receptor 5 Proteins 0.000 claims 1
- 101001123678 Homo sapiens Phenylethanolamine N-methyltransferase Proteins 0.000 claims 1
- 101000654386 Homo sapiens Sodium channel protein type 9 subunit alpha Proteins 0.000 claims 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 claims 1
- 108010008858 Nitric Oxide Synthase Type I Proteins 0.000 claims 1
- 102000006538 Nitric Oxide Synthase Type I Human genes 0.000 claims 1
- 102100024611 Phosphatidylethanolamine N-methyltransferase Human genes 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 102100031367 Sodium channel protein type 9 subunit alpha Human genes 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 108010064131 neuronal Cdk5 activator (p25-p35) Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91758307P | 2007-05-11 | 2007-05-11 | |
| US60/917,583 | 2007-05-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014149516A Division JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016064037A Division JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016014070A JP2016014070A (ja) | 2016-01-28 |
| JP2016014070A5 true JP2016014070A5 (OSRAM) | 2016-05-19 |
| JP6082796B2 JP6082796B2 (ja) | 2017-02-15 |
Family
ID=40002879
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507728A Expired - Fee Related JP5646320B2 (ja) | 2007-05-11 | 2008-05-12 | 遺伝子発現と疼痛 |
| JP2014149516A Expired - Fee Related JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
| JP2015207655A Expired - Fee Related JP6082796B2 (ja) | 2007-05-11 | 2015-10-22 | 遺伝子発現と疼痛 |
| JP2016064037A Expired - Fee Related JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
| JP2017106521A Pending JP2017148074A (ja) | 2007-05-11 | 2017-05-30 | 遺伝子発現と疼痛 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507728A Expired - Fee Related JP5646320B2 (ja) | 2007-05-11 | 2008-05-12 | 遺伝子発現と疼痛 |
| JP2014149516A Expired - Fee Related JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016064037A Expired - Fee Related JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
| JP2017106521A Pending JP2017148074A (ja) | 2007-05-11 | 2017-05-30 | 遺伝子発現と疼痛 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US7943591B2 (OSRAM) |
| EP (3) | EP2158316B1 (OSRAM) |
| JP (5) | JP5646320B2 (OSRAM) |
| AU (1) | AU2008251320B2 (OSRAM) |
| CA (1) | CA2723672C (OSRAM) |
| DK (1) | DK2158316T3 (OSRAM) |
| ES (2) | ES2619314T3 (OSRAM) |
| HR (1) | HRP20150759T1 (OSRAM) |
| HU (1) | HUE025701T2 (OSRAM) |
| PL (1) | PL2158316T3 (OSRAM) |
| PT (1) | PT2158316E (OSRAM) |
| SI (1) | SI2158316T1 (OSRAM) |
| WO (1) | WO2008141308A2 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2158316T3 (en) * | 2007-05-11 | 2015-07-20 | Adynxx Inc | Gene expression and pain |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| IN2012DN00720A (OSRAM) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
| US8609617B2 (en) | 2009-09-04 | 2013-12-17 | University Of Miami | KLF family members regulate intrinsic axon regeneration ability |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
| US20130071444A1 (en) | 2011-09-16 | 2013-03-21 | The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System | Amphiphilic Cationic Polymers and Methods of Use Thereof |
| US9139829B2 (en) * | 2012-02-28 | 2015-09-22 | Medical Diagnostic Laboratories, Llc | SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment |
| RU2668136C2 (ru) | 2012-05-10 | 2018-09-26 | Эйдинкс, Инк. | Композиции для доставки активных ингредиентов |
| AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| EP2872485B1 (en) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| EP2872147B1 (en) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Method for making chiral oligonucleotides |
| GB201310853D0 (en) * | 2013-06-18 | 2013-07-31 | Ucb Pharma Sa | Method |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| CN106068325B (zh) | 2014-01-16 | 2021-07-09 | 波涛生命科学有限公司 | 手性设计 |
| JP6705807B2 (ja) | 2014-08-15 | 2020-06-03 | エーダイニクス インコーポレイテッド | 疼痛を治療するためのオリゴヌクレオチドデコイ |
| EP3348637B1 (en) * | 2015-09-09 | 2022-03-09 | AnGes, Inc. | Chimeric decoy |
| US20200017853A1 (en) * | 2016-02-29 | 2020-01-16 | Adynxx, Inc. | Compositions and methods for pain amelioration via modification of gene expression |
| WO2024044770A1 (en) * | 2022-08-26 | 2024-02-29 | Core Biotherapeutics, Inc. | Oligonucleotides for the treatment of breast cancer |
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| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5272056A (en) | 1991-01-03 | 1993-12-21 | The Research Foundation Of State University Of New York | Modification of DNA and oligonucleotides using metal complexes of polyaza ligands |
| US5683985A (en) | 1991-04-18 | 1997-11-04 | The Salk Institute For Biological Studies | Oligonucleotide decoys and methods relating thereto |
| FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| CA2168245A1 (en) | 1993-07-29 | 1995-02-09 | C. Anthony Hunt | Polynucleotide decoys that inhibit mhc-ii expression and uses thereof |
| DE69435100D1 (de) | 1993-10-29 | 2008-06-26 | Brigham & Womens Hospital | Therapeutische verwendung von cis-element-fallen in vivo |
| ATE295367T1 (de) | 1994-11-17 | 2005-05-15 | Taiho Pharmaceutical Co Ltd | Doppelsträngiges oligonukleotid und karzinostatisches mittel das dieses als aktiven inhaltsstoff enthält |
| AU5369396A (en) | 1995-03-23 | 1996-10-08 | Research Foundation Of The State University Of New York, The | Rest protein and dna |
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| RU2668136C2 (ru) | 2012-05-10 | 2018-09-26 | Эйдинкс, Инк. | Композиции для доставки активных ингредиентов |
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| JP6705807B2 (ja) | 2014-08-15 | 2020-06-03 | エーダイニクス インコーポレイテッド | 疼痛を治療するためのオリゴヌクレオチドデコイ |
| US20200017853A1 (en) | 2016-02-29 | 2020-01-16 | Adynxx, Inc. | Compositions and methods for pain amelioration via modification of gene expression |
-
2008
- 2008-05-12 DK DK08755344.2T patent/DK2158316T3/en active
- 2008-05-12 HR HRP20150759TT patent/HRP20150759T1/hr unknown
- 2008-05-12 EP EP08755344.2A patent/EP2158316B1/en not_active Not-in-force
- 2008-05-12 CA CA2723672A patent/CA2723672C/en active Active
- 2008-05-12 US US12/119,435 patent/US7943591B2/en not_active Expired - Fee Related
- 2008-05-12 PL PL08755344T patent/PL2158316T3/pl unknown
- 2008-05-12 JP JP2010507728A patent/JP5646320B2/ja not_active Expired - Fee Related
- 2008-05-12 EP EP14179247.3A patent/EP2818550B1/en not_active Not-in-force
- 2008-05-12 SI SI200831461T patent/SI2158316T1/sl unknown
- 2008-05-12 PT PT87553442T patent/PT2158316E/pt unknown
- 2008-05-12 HU HUE08755344A patent/HUE025701T2/en unknown
- 2008-05-12 ES ES14179247.3T patent/ES2619314T3/es active Active
- 2008-05-12 EP EP16199871.1A patent/EP3199635B1/en not_active Not-in-force
- 2008-05-12 AU AU2008251320A patent/AU2008251320B2/en not_active Ceased
- 2008-05-12 WO PCT/US2008/063471 patent/WO2008141308A2/en not_active Ceased
- 2008-05-12 ES ES08755344.2T patent/ES2542511T3/es active Active
-
2011
- 2011-03-15 US US13/048,793 patent/US8093225B2/en not_active Expired - Fee Related
- 2011-12-09 US US13/316,321 patent/US8741864B2/en active Active - Reinstated
-
2014
- 2014-04-22 US US14/258,927 patent/US9290762B2/en not_active Expired - Fee Related
- 2014-07-23 JP JP2014149516A patent/JP5890869B2/ja not_active Expired - Fee Related
-
2015
- 2015-10-22 JP JP2015207655A patent/JP6082796B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-09 US US15/019,791 patent/US10041069B2/en active Active
- 2016-03-28 JP JP2016064037A patent/JP6306075B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-30 JP JP2017106521A patent/JP2017148074A/ja active Pending
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