JP2015537210A5 - - Google Patents
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- JP2015537210A5 JP2015537210A5 JP2015541154A JP2015541154A JP2015537210A5 JP 2015537210 A5 JP2015537210 A5 JP 2015537210A5 JP 2015541154 A JP2015541154 A JP 2015541154A JP 2015541154 A JP2015541154 A JP 2015541154A JP 2015537210 A5 JP2015537210 A5 JP 2015537210A5
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- tumor
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- 238000000034 method Methods 0.000 claims 21
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 11
- 108010072257 fibroblast activation protein alpha Proteins 0.000 claims 11
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 7
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000013610 patient sample Substances 0.000 claims 4
- -1 CK18 Proteins 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 claims 2
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- 108091012583 BCL2 Proteins 0.000 claims 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 1
- 102100031102 C-C motif chemokine 4 Human genes 0.000 claims 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102000000905 Cadherin Human genes 0.000 claims 1
- 108050007957 Cadherin Proteins 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 102100031983 Ephrin type-B receptor 4 Human genes 0.000 claims 1
- 102100030708 GTPase KRas Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
- 101000803403 Homo sapiens Vimentin Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 101000777470 Mus musculus C-C motif chemokine 4 Proteins 0.000 claims 1
- 108050000637 N-cadherin Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 108010079855 Peptide Aptamers Proteins 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 102100040120 Prominin-1 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 1
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 1
- 108010002687 Survivin Proteins 0.000 claims 1
- 102000006280 Twist-Related Protein 1 Human genes 0.000 claims 1
- 108010083162 Twist-Related Protein 1 Proteins 0.000 claims 1
- 102100035071 Vimentin Human genes 0.000 claims 1
- UUOZISWTWURDGU-SSDOTTSWSA-N [(2S)-1-(2-acetamidoacetyl)pyrrolidin-2-yl]boronic acid Chemical compound CC(=O)NCC(=O)N1CCC[C@@H]1B(O)O UUOZISWTWURDGU-SSDOTTSWSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000007515 enzymatic degradation Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000036963 noncompetitive effect Effects 0.000 claims 1
- 108091008104 nucleic acid aptamers Proteins 0.000 claims 1
- CDXVUROVRIFQMV-UHFFFAOYSA-N oxo(diphenoxy)phosphanium Chemical compound C=1C=CC=CC=1O[P+](=O)OC1=CC=CC=C1 CDXVUROVRIFQMV-UHFFFAOYSA-N 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261724753P | 2012-11-09 | 2012-11-09 | |
| US61/724,753 | 2012-11-09 | ||
| PCT/EP2013/073381 WO2014072465A1 (en) | 2012-11-09 | 2013-11-08 | In vitro capture and analysis of circulating tumor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015537210A JP2015537210A (ja) | 2015-12-24 |
| JP2015537210A5 true JP2015537210A5 (https=) | 2016-12-15 |
| JP6404824B2 JP6404824B2 (ja) | 2018-10-17 |
Family
ID=49582733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015541154A Active JP6404824B2 (ja) | 2012-11-09 | 2013-11-08 | 循環腫瘍細胞のインビトロでの捕捉および解析 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9250242B2 (https=) |
| EP (1) | EP2919910B1 (https=) |
| JP (1) | JP6404824B2 (https=) |
| CN (1) | CN104781007B (https=) |
| CA (1) | CA2891028C (https=) |
| ES (1) | ES2660438T3 (https=) |
| WO (1) | WO2014072465A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10155988B2 (en) * | 2010-04-07 | 2018-12-18 | Board Of Regents, The University Of Texas System | Methods of detecting tumor cells |
| TWI539158B (zh) * | 2010-06-08 | 2016-06-21 | 維里德克斯有限責任公司 | 使用血液中之循環黑色素瘤細胞預測黑色素瘤病患之臨床結果的方法。 |
| WO2012170560A2 (en) | 2011-06-06 | 2012-12-13 | Cornell University | Microfluidic device for extracting, isolating, and analyzing dna from cells |
| US10130946B2 (en) | 2011-09-30 | 2018-11-20 | The Regents Of The University Of Michigan | System for detecting rare cells |
| WO2013049636A1 (en) | 2011-09-30 | 2013-04-04 | The Regents Of The University Of Michigan | System for detecting rare cells |
| US10073024B2 (en) | 2012-10-29 | 2018-09-11 | The Regents Of The University Of Michigan | Microfluidic device and method for detecting rare cells |
| WO2014072465A1 (en) | 2012-11-09 | 2014-05-15 | Roche Diagnostics Gmbh | In vitro capture and analysis of circulating tumor cells |
| EP2799872B1 (en) * | 2013-05-01 | 2017-10-18 | F. Hoffmann-La Roche AG | Selective release of sub-group of biological units |
| US20150160246A1 (en) | 2013-12-11 | 2015-06-11 | Analiza, Inc. | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells |
| US9709556B2 (en) | 2013-12-11 | 2017-07-18 | Analiza, Inc. | Devices and methods for determining and/or isolating circulating cancer cells |
| CA2959072C (en) * | 2014-08-25 | 2025-12-09 | Creatv Microtech, Inc. | Use of circulating cell biomarkers in the blood for detection and diagnosis of diseases and methods of isolating them |
| US10829804B2 (en) | 2015-03-23 | 2020-11-10 | The University Of North Carolina At Chapel Hill | Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or DNA methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions |
| ES2856691T3 (es) | 2015-03-23 | 2021-09-28 | Univ North Carolina Chapel Hill | Procesador molecular universal para la medicina de precisión |
| US10317406B2 (en) | 2015-04-06 | 2019-06-11 | The Regents Of The University Of Michigan | System for detecting rare cells |
| CN105259096B (zh) * | 2015-10-19 | 2018-01-12 | 武汉顺可达生物科技有限公司 | 磷酸锌纳米基底及其制备方法和在循环肿瘤细胞捕获与释放中的应用 |
| CN106868098A (zh) * | 2015-12-10 | 2017-06-20 | 益善生物技术股份有限公司 | 循环肿瘤细胞分型鉴定试剂盒 |
| CN108884445A (zh) | 2016-03-09 | 2018-11-23 | 北京智康博药肿瘤医学研究有限公司 | 肿瘤细胞悬浮培养物和相关方法 |
| JPWO2017188346A1 (ja) * | 2016-04-27 | 2019-02-28 | 国立大学法人 東京大学 | マイクロファイバーを用いた血中循環細胞の捕捉及び回収用材料及び当該材料を用いる方法 |
| US20190113510A1 (en) * | 2016-05-18 | 2019-04-18 | Sony Corporation | Biological material analysis device, biological material analysis system, biological material selection method, biological material analysis program, and cell culture vessel |
| US11602747B2 (en) | 2016-05-22 | 2023-03-14 | Cornell University | Multifunctional microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions |
| CN107475354A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 前列腺癌组织溯源ctc分型鉴定试剂盒 |
| CN107475355A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 肺癌早期筛查试剂盒 |
| CN106366197B (zh) * | 2016-08-31 | 2021-03-30 | 上海美吉生物医药科技有限公司 | 一种HER2、EGFR、EpCAM、MUC1多重抗体免疫磁珠及其制备方法 |
| CN106434904A (zh) * | 2016-09-07 | 2017-02-22 | 上海交通大学医学院附属仁济医院 | 一种实时监控肝癌复发或转移的CD133、EpCAM和CK19联合检测试剂盒 |
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| US20200088731A1 (en) * | 2016-12-22 | 2020-03-19 | Hitachi Chemical Company, Ltd. | Method for Detecting HER2-Positive Cancer Cells |
| CN106866820B (zh) * | 2017-02-17 | 2020-04-03 | 艾比玛特医药科技（上海）有限公司 | 一种用于捕获肿瘤细胞的抗人角蛋白18的单克隆抗体及其应用 |
| CN110573629B (zh) * | 2017-03-30 | 2024-08-13 | 伊利诺伊大学理事会 | 用于诊断早期胰腺癌的方法和试剂盒 |
| EP3735281B1 (en) | 2018-01-05 | 2024-11-27 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| CN108344615B (zh) * | 2018-01-24 | 2020-10-23 | 杭州安弼晟生物科技有限公司 | 一种循环肿瘤细胞捕获系统及控制方法 |
| CA3103714A1 (en) * | 2018-06-13 | 2019-12-19 | 23Ikigai Pte Ltd | Method for analysing pluripotent stem cell biomarkers, and implementations thereof |
| EP3870969A4 (en) * | 2018-10-24 | 2022-07-27 | Path Ex, Inc. | PROCESS FOR RECOVERING AND ISOLATION OF DISEASE MATERIAL FROM FLOWING MATERIAL |
| US12303899B2 (en) | 2018-11-28 | 2025-05-20 | Cornell University | Systems and methods for on-chip analysis of nucleic acids and for multiplexed analysis of cells |
| US12338487B2 (en) | 2018-11-28 | 2025-06-24 | Cornell University | Multiomic analysis of cell analytes using microfluidic systems |
| WO2020139211A1 (en) | 2018-12-28 | 2020-07-02 | Mikro Biyosistemler Elektronik Sanayi Ve Ticaret A.S. | A microfluidic device for selective capture of biological entities |
| CN110082529B (zh) * | 2019-03-11 | 2022-04-19 | 南方医科大学深圳医院 | 一种肿瘤细胞表面标志物及其应用 |
| CN112143732B (zh) * | 2019-06-28 | 2022-03-22 | 中国科学院苏州纳米技术与纳米仿生研究所 | 特异性识别N-cadherin的ssDNA适配体、其筛选方法及应用 |
| US12053569B2 (en) | 2019-09-04 | 2024-08-06 | The Regents Of The University Of Michigan | Indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells |
| WO2021241283A1 (ja) * | 2020-05-25 | 2021-12-02 | 東京応化工業株式会社 | ターゲット粒子の分離方法およびシステム |
| US20230242983A1 (en) * | 2020-07-06 | 2023-08-03 | Sony Group Corporation | Bioparticle analysis method and bioparticle analysis system |
| CN112569362B (zh) * | 2020-12-23 | 2022-05-17 | 北京航空航天大学 | 一种通过打散ctc细胞团抑制肿瘤转移的方法 |
| CN112924363A (zh) * | 2021-01-22 | 2021-06-08 | 中国科学院苏州纳米技术与纳米仿生研究所 | 中间型循环肿瘤细胞作为肿瘤诊断和预后标志物及其应用 |
| EP4284911A4 (en) * | 2021-01-27 | 2025-01-08 | BioFluidica, Inc. | High efficiency capture of fetal cells from maternal samples |
| CN112730840B (zh) * | 2021-01-29 | 2023-10-17 | 章毅 | 鉴别cd44和cd24分子表型的方法 |
| US12576194B2 (en) | 2021-06-29 | 2026-03-17 | Regents Of The University Of Michigan | Microfluidic flow control using direct-current peristaltic pump |
| CN114874989B (zh) * | 2022-04-11 | 2024-06-25 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种循环肿瘤细胞捕获方法 |
| EP4564006A1 (en) * | 2022-07-29 | 2025-06-04 | Fan-Gang Tseng | Cell identification method |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999041613A1 (en) * | 1998-02-12 | 1999-08-19 | Immunivest | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
| CA2422162C (en) | 2000-09-09 | 2012-10-23 | The Research Foundation Of State University Of New York | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
| AU2004286307A1 (en) * | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
| US20100233694A1 (en) * | 2007-04-16 | 2010-09-16 | On-O-ity, Inc | Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells |
| EP2201134B1 (en) | 2007-09-19 | 2018-11-21 | The Research Foundation of State University of New York | Gene expression signatures in enriched tumor cell samples |
| MX2010004671A (es) | 2007-12-10 | 2010-05-27 | Hoffmann La Roche | Seprasa como marcador para cancer. |
| EP2291509B1 (en) | 2008-05-16 | 2023-11-15 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids |
| GR1006582B (el) | 2008-07-14 | 2009-11-03 | Ελενη Στυλιανου Μωυσιαδου | Προϊοντα καθαρισμου και απολυμανσης με φυσικα αβλαβη υλικα που εχουν βαση την ζαχαρη |
| US20100210989A1 (en) * | 2008-12-23 | 2010-08-19 | Janet Lesley Macpherson | Processing blood |
| US9140697B2 (en) * | 2009-03-18 | 2015-09-22 | The Regents Of The University Of California | Device for capturing circulating cells |
| AU2010229924B2 (en) | 2009-03-24 | 2016-07-21 | Plus Therapeutics Inc. | Devices and methods of cell capture and analysis |
| US20120077246A1 (en) | 2009-04-24 | 2012-03-29 | The Board Of Trustees Of The University Of Illinoi | Methods and Devices for Capturing Circulating Tumor Cells |
| ES2687144T3 (es) | 2011-02-03 | 2018-10-23 | Northeastern University | Métodos y composiciones para la captura y liberación altamente específicas de materiales biológicos |
| CN202279815U (zh) * | 2011-07-19 | 2012-06-20 | 西门子公司 | 循环肿瘤细胞捕获装置 |
| WO2014072465A1 (en) | 2012-11-09 | 2014-05-15 | Roche Diagnostics Gmbh | In vitro capture and analysis of circulating tumor cells |
-
2013
- 2013-11-08 WO PCT/EP2013/073381 patent/WO2014072465A1/en not_active Ceased
- 2013-11-08 ES ES13789770.8T patent/ES2660438T3/es active Active
- 2013-11-08 CA CA2891028A patent/CA2891028C/en active Active
- 2013-11-08 CN CN201380058487.2A patent/CN104781007B/zh active Active
- 2013-11-08 US US14/075,143 patent/US9250242B2/en active Active
- 2013-11-08 EP EP13789770.8A patent/EP2919910B1/en active Active
- 2013-11-08 JP JP2015541154A patent/JP6404824B2/ja active Active
-
2015
- 2015-12-18 US US14/975,230 patent/US9952212B2/en active Active
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