JP2015529809A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015529809A5 JP2015529809A5 JP2015524473A JP2015524473A JP2015529809A5 JP 2015529809 A5 JP2015529809 A5 JP 2015529809A5 JP 2015524473 A JP2015524473 A JP 2015524473A JP 2015524473 A JP2015524473 A JP 2015524473A JP 2015529809 A5 JP2015529809 A5 JP 2015529809A5
- Authority
- JP
- Japan
- Prior art keywords
- eam
- erm
- electrode
- target analyte
- test sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012491 analyte Substances 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 15
- 239000002094 self assembled monolayer Substances 0.000 claims 15
- 239000013545 self-assembled monolayer Substances 0.000 claims 15
- 102000004190 Enzymes Human genes 0.000 claims 14
- 108090000790 Enzymes Proteins 0.000 claims 14
- 229910052723 transition metal Inorganic materials 0.000 claims 13
- 150000003624 transition metals Chemical class 0.000 claims 13
- 239000007787 solid Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 7
- 238000003556 assay Methods 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 102000035195 Peptidases Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 3
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 2
- 102000004157 Hydrolases Human genes 0.000 claims 2
- 108090000604 Hydrolases Proteins 0.000 claims 2
- 102000004195 Isomerases Human genes 0.000 claims 2
- 108090000769 Isomerases Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 102000004317 Lyases Human genes 0.000 claims 2
- 108090000856 Lyases Proteins 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 2
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 230000008520 organization Effects 0.000 claims 2
- 229910052762 osmium Inorganic materials 0.000 claims 2
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- 229920000193 polymethacrylate Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229920002717 polyvinylpyridine Polymers 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- 235000019419 proteases Nutrition 0.000 claims 2
- 229910052707 ruthenium Inorganic materials 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000006911 enzymatic reaction Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261676641P | 2012-07-27 | 2012-07-27 | |
| US61/676,641 | 2012-07-27 | ||
| US201261677593P | 2012-07-31 | 2012-07-31 | |
| US61/677,593 | 2012-07-31 | ||
| US201261708301P | 2012-10-01 | 2012-10-01 | |
| US61/708,301 | 2012-10-01 | ||
| PCT/US2013/052340 WO2014018899A1 (en) | 2012-07-27 | 2013-07-26 | Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015529809A JP2015529809A (ja) | 2015-10-08 |
| JP2015529809A5 true JP2015529809A5 (https=) | 2016-09-08 |
Family
ID=48918486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524473A Pending JP2015529809A (ja) | 2012-07-27 | 2013-07-26 | 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9416390B2 (https=) |
| EP (1) | EP2877851A1 (https=) |
| JP (1) | JP2015529809A (https=) |
| CA (1) | CA2880104A1 (https=) |
| WO (1) | WO2014018899A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2770071C (en) | 2009-08-07 | 2014-07-15 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
| WO2012012537A1 (en) | 2010-07-20 | 2012-01-26 | Ohmx Corporation | Novel chemistry used in biosensors |
| WO2012100078A1 (en) | 2011-01-19 | 2012-07-26 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay |
| WO2013059293A1 (en) | 2011-10-17 | 2013-04-25 | Ohmx Corporation | Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
| JP2014532720A (ja) | 2011-11-04 | 2014-12-08 | オームクス コーポレイション | バイオセンサーにおいて使用される新規化学 |
| US9250203B2 (en) | 2012-01-09 | 2016-02-02 | Ohmx Corporation | Enzyme cascade methods for E-TRACE assay signal amplification |
| EP3121288A1 (en) | 2012-07-27 | 2017-01-25 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
| EP3137904A1 (en) * | 2014-04-29 | 2017-03-08 | Ohmx Corporation | Bioelectronic binding assay using peak profiling |
| US20160041118A1 (en) | 2014-08-11 | 2016-02-11 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities |
| US10024817B2 (en) | 2014-10-17 | 2018-07-17 | Pelogenix, Llc | Method for detecting proteases and active infection in biological fluids and tissues |
| US20160178562A1 (en) | 2014-12-19 | 2016-06-23 | Ohmx Corporation | Competitive enzymatic assay |
| WO2017063074A1 (en) * | 2015-10-14 | 2017-04-20 | University Health Network (Uhn) | Electrochemical assay for a protein analyte |
| US10323331B2 (en) | 2016-12-29 | 2019-06-18 | Industrial Technology Research Institute | Valuable metal selectively adsorbing electrode and method for selectively recovering valuable metals |
| CN112881492A (zh) * | 2021-02-26 | 2021-06-01 | 长沙市信励致和科技有限责任公司 | 基于人绒毛膜促性腺激素肽适配体的丝网印刷电极体系及其制备方法 |
| KR102661260B1 (ko) * | 2021-08-27 | 2024-04-29 | 고려대학교 산학협력단 | 전자전달 능력이 향상된 효소기반 전극, 그 제조방법 및 그 응용 |
| CN114414642B (zh) * | 2022-01-07 | 2023-06-02 | 重庆医科大学 | 用于人乳头瘤病毒16型e6癌蛋白检测的电化学传感器 |
| CN115950933B (zh) * | 2022-11-29 | 2025-02-07 | 常州先趋医疗科技有限公司 | 自组装单分子膜修饰电极及其制备方法和用途 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247533A (en) | 1978-05-01 | 1981-01-27 | The Rockefeller University | Hemoglobin A1c radioimmunoassay |
| DE3061860D1 (en) | 1979-04-24 | 1983-03-17 | Marcel Jozefonvicz | Process for the determination of proteases and antiproteases |
| US4727036A (en) | 1985-08-08 | 1988-02-23 | Molecular Diagnostics, Inc. | Antibodies for use in determining hemoglobin A1c |
| US5206144A (en) | 1985-03-29 | 1993-04-27 | Novo Industri A/S | Determination of glycated (glycosylated) hemoglobin in blood |
| US4806468A (en) | 1987-02-05 | 1989-02-21 | Becton, Dickinson And Company | Measurement of glycosylated hemoglobin by immunoassay |
| DE68910828T2 (de) | 1988-08-02 | 1994-05-11 | London Biotechnology Ltd | Ein verstärkungs-testverfahren für hydrolase-enzyme. |
| US5173373A (en) | 1989-09-14 | 1992-12-22 | Yamaha Hatsudoki Kabushiki Kaisha | Gasket for fuel cell |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| EP0786469B1 (en) | 1990-06-11 | 2006-03-01 | Gilead Sciences, Inc. | Methods of use of nucleic acid ligands |
| DE69228817T2 (de) | 1991-07-26 | 1999-09-23 | Dade Chemistry Systems Inc., Deerfield | Signalerkennungspruefung in der anwesenheit von einem suspendierten festen träger |
| DE4430023A1 (de) | 1994-08-24 | 1996-02-29 | Boehringer Mannheim Gmbh | Elektrochemischer Sensor |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US6348319B1 (en) | 1996-02-08 | 2002-02-19 | Australian Membrane And Biotechnology Research Institute | Enzyme detection biosensors |
| US7393645B2 (en) | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US7160678B1 (en) | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US6162645A (en) | 1997-03-13 | 2000-12-19 | Abbott Laboratories | Determination of % glycated hemoglobin |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| DK0988534T3 (da) | 1997-06-12 | 2011-05-23 | Clinical Micro Sensors Inc | Elektroniske fremgangsmåder og apparat til detektering af analytter |
| US6134461A (en) | 1998-03-04 | 2000-10-17 | E. Heller & Company | Electrochemical analyte |
| ATE407220T1 (de) | 1998-05-06 | 2008-09-15 | Clinical Micro Sensors Inc | Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten |
| RU2161653C2 (ru) | 1998-08-24 | 2001-01-10 | ФАРМАКОВСКИЙ Дмитрий Александрович | Способ количественного электрохимического анализа биомолекул |
| US6281006B1 (en) | 1998-08-24 | 2001-08-28 | Therasense, Inc. | Electrochemical affinity assay |
| US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
| US6541617B1 (en) | 1998-10-27 | 2003-04-01 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
| US6432723B1 (en) | 1999-01-22 | 2002-08-13 | Clinical Micro Sensors, Inc. | Biosensors utilizing ligand induced conformation changes |
| US20050148101A1 (en) * | 1999-01-23 | 2005-07-07 | Bamdad Cynthia C. | Interaction of colloid-immobilized species with species on non-colloidal structures |
| US6495336B1 (en) | 1999-02-23 | 2002-12-17 | Pentapharm Ag | Oligopeptide derivatives for the electrochemical measurement of protease activity |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| US7312087B2 (en) | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
| US8268143B2 (en) * | 1999-11-15 | 2012-09-18 | Abbott Diabetes Care Inc. | Oxygen-effect free analyte sensor |
| US7234414B2 (en) | 1999-11-18 | 2007-06-26 | Sensortec Limited | Mastitis detection |
| GB0002201D0 (en) | 2000-01-31 | 2000-03-22 | Imperial College | Process |
| JP2003522963A (ja) | 2000-02-18 | 2003-07-29 | アクララ バイオサイエンシーズ， インコーポレイテッド | 複数部位反応デバイスおよび方法 |
| US6753143B2 (en) | 2000-05-01 | 2004-06-22 | Clinical Micro Sensors, Inc. | Target analyte detection using asymmetrical self-assembled monolayers |
| DE10024314A1 (de) | 2000-05-17 | 2001-11-22 | Basf Ag | Verfahren, umfassend die indirekte elektrochemische Regeneration von NAD(P)H |
| IL138229A (en) * | 2000-09-04 | 2005-03-20 | Yissum Res Dev Co | Method and system for detecting nucleic acids |
| WO2002029411A2 (en) * | 2000-10-03 | 2002-04-11 | Minerva Biotechnologies Corporation | Magnetic in situ dilution |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| JP4567333B2 (ja) | 2001-08-24 | 2010-10-20 | センサーテック・リミテッド | 高感度電位差測定センサを製造する方法 |
| US6562581B2 (en) | 2001-08-31 | 2003-05-13 | Portascience | Method for quantitative determination of glycated hemoglobin |
| KR100407822B1 (ko) | 2001-12-04 | 2003-12-01 | 한국전자통신연구원 | 전기화학식 면역 센서와 이를 이용한 생화학 시료검출장치 및 방법 |
| US20060134713A1 (en) * | 2002-03-21 | 2006-06-22 | Lifescan, Inc. | Biosensor apparatus and methods of use |
| US20040018611A1 (en) * | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
| JP2006507322A (ja) | 2002-11-14 | 2006-03-02 | シンタルガ・ビーブイ | 多重自己脱離放出スペーサーとして構築されたプロドラッグ |
| US7214528B1 (en) | 2002-12-31 | 2007-05-08 | Oregon Health & Sciences University | Device for direct electrical detection of molecules and molecule-molecule interactions |
| US8425745B2 (en) | 2006-10-06 | 2013-04-23 | Nanomix, Inc. | Electrochemical nanosensors for biomolecule detection |
| AU2003903504A0 (en) | 2003-07-08 | 2003-07-24 | Johnson, Daniel | Improvements in sensor chips |
| GB0316075D0 (en) | 2003-07-09 | 2003-08-13 | Molecular Sensing Plc | Protease detection assay |
| EP1718667B1 (en) | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| TWI245894B (en) | 2004-02-26 | 2005-12-21 | Univ Tamkang | Method and chemical sensor for determining concentrations of hydrogen peroxide and its precursor in a solution |
| WO2006093505A2 (en) * | 2004-05-10 | 2006-09-08 | Northwestern University | Compositions and methods for analyte detection |
| US7511142B2 (en) | 2004-07-28 | 2009-03-31 | Agency For Science, Technology And Research | Mediator-modified redox biomolecules for use in electrochemical determination of analyte |
| ES2334671T3 (es) | 2004-08-13 | 2010-03-15 | Egomedical Technologies Ag | Sistema de ensayo de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso. |
| FR2874385B1 (fr) * | 2004-08-18 | 2006-12-08 | Biopep Sa | Procede et dispositif de mesure d'une activite enzymatique dans un fluide biologique |
| GB2420180A (en) | 2004-11-11 | 2006-05-17 | Sensor Tech Ltd | Method of electrochemical analysis of an analyte |
| KR100773543B1 (ko) | 2005-12-05 | 2007-11-07 | 삼성전자주식회사 | 전기화학적 생분자 검출 센서, 그의 제조 방법 및 그를이용한 생분자 검출 방법 |
| US7892816B2 (en) * | 2006-09-28 | 2011-02-22 | Colorado State University Research Foundation | Electrochemical detection of substrates |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| WO2009032901A1 (en) * | 2007-09-04 | 2009-03-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biosensors and related methods |
| JP5248613B2 (ja) * | 2007-09-17 | 2013-07-31 | レッド・アイボリー・エルエルシー | 自己作動性信号発生検出装置及び方法 |
| JP2011502245A (ja) * | 2007-10-17 | 2011-01-20 | オームクス コーポレーション | 酵素検出のための電気化学的検定方法 |
| US20100291591A1 (en) * | 2007-11-05 | 2010-11-18 | Life Technologies Corporation | Novel plating media |
| EP2283149A1 (en) | 2008-05-13 | 2011-02-16 | General Atomics | Electrochemical biosensor for direct determination of percentage of glycated hemoglobin |
| WO2009148406A1 (en) | 2008-06-06 | 2009-12-10 | Agency For Science Technology And Research | Immunoassay |
| US20120073987A1 (en) | 2009-06-08 | 2012-03-29 | Heinz-Bernhard Kraatz | Electrochemical method and apparatus of identifying the presence of a target |
| CA2770071C (en) * | 2009-08-07 | 2014-07-15 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
| WO2011041586A1 (en) | 2009-09-30 | 2011-04-07 | Virogenomics, Inc. | Electromagnetic detection of analytes |
| CA2798812A1 (en) | 2010-05-21 | 2011-11-24 | Ohmx Corporation | Detection of cancer by assaying psa enzymatic activity |
| US20140134658A1 (en) | 2010-05-21 | 2014-05-15 | Notrhwestern University, An Illinois Not For Profit Corporation | Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness |
| EP2576806B1 (en) | 2010-05-26 | 2017-03-08 | The Board of Trustees of the University of Illionis | Personal glucose meters for detection and quantification of a broad range of analytes |
| WO2012012537A1 (en) | 2010-07-20 | 2012-01-26 | Ohmx Corporation | Novel chemistry used in biosensors |
| KR101702837B1 (ko) * | 2010-07-22 | 2017-02-07 | 삼성전자주식회사 | 필름형 전자회로를 구비하는 전자제품의 케이스 구조물 및 그 제조방법 |
| WO2012100078A1 (en) | 2011-01-19 | 2012-07-26 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay |
| WO2013059293A1 (en) | 2011-10-17 | 2013-04-25 | Ohmx Corporation | Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
| JP2014532720A (ja) | 2011-11-04 | 2014-12-08 | オームクス コーポレイション | バイオセンサーにおいて使用される新規化学 |
| US9250203B2 (en) | 2012-01-09 | 2016-02-02 | Ohmx Corporation | Enzyme cascade methods for E-TRACE assay signal amplification |
| EP3121288A1 (en) | 2012-07-27 | 2017-01-25 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
| US9659398B2 (en) | 2013-03-15 | 2017-05-23 | Dreamworks Animation Llc | Multiple visual representations of lighting effects in a computer animation scene |
| EP3137904A1 (en) | 2014-04-29 | 2017-03-08 | Ohmx Corporation | Bioelectronic binding assay using peak profiling |
-
2013
- 2013-07-26 JP JP2015524473A patent/JP2015529809A/ja active Pending
- 2013-07-26 US US13/952,345 patent/US9416390B2/en not_active Expired - Fee Related
- 2013-07-26 CA CA2880104A patent/CA2880104A1/en not_active Abandoned
- 2013-07-26 WO PCT/US2013/052340 patent/WO2014018899A1/en not_active Ceased
- 2013-07-26 EP EP13745769.3A patent/EP2877851A1/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015529809A5 (https=) | ||
| Liss et al. | An aptamer-based quartz crystal protein biosensor | |
| Su et al. | Determination of endotoxin through an aptamer-based impedance biosensor | |
| Diba et al. | Amperometric bioaffinity sensing platform for avian influenza virus proteins with aptamer modified gold nanoparticles on carbon chips | |
| JP2011137830A5 (https=) | ||
| WO2007024676A3 (en) | Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof | |
| WO2001079562A1 (en) | Aptamer based two-site binding assay | |
| Yang et al. | DNA aptamer-based surface plasmon resonance sensing of human C-reactive protein | |
| GB201101621D0 (en) | Method and product | |
| WO2016019929A3 (en) | Method of detection of analyte active forms and determination of the ability of substances to bind into analyte active sites | |
| WO2013040435A2 (en) | Molecular diagnostic assay device and method of use | |
| JP2015508500A5 (https=) | ||
| Bai et al. | Reversible detection of vancomycin using peptide-functionalized cantilever array sensor | |
| CA2696083A1 (en) | An enzyme detection device | |
| Kim et al. | Electrochemical biosensor using direct electron transfer and an antibody–aptamer hybrid sandwich for target detection in complex biological samples | |
| JP2012509062A5 (https=) | ||
| RU2017107871A (ru) | Способ детектирования молекулы-мишени и набор для использования в этом способе | |
| Geldert et al. | Enhancing the sensing specificity of a MoS 2 nanosheet-based FRET aptasensor using a surface blocking strategy | |
| Thipmanee et al. | Label-free capacitive DNA sensor using immobilized pyrrolidinyl PNA probe: Effect of the length and terminating head group of the blocking thiols | |
| DK1786927T3 (da) | Indretning og fremgangsmåde til påvisning af ladede makromolekyler | |
| JP2012509063A5 (https=) | ||
| US20110046015A1 (en) | Peptide immobilization solution and use thereof | |
| JP2010510526A5 (https=) | ||
| WO2018210927A3 (en) | KITS, METHODS AND USES THEREOF FOR DETECTING CELL-CELL INTERACTIONS IN A SAMPLE KIT | |
| US20200003767A1 (en) | Method and system for substance detection with a magnetic sensor |