JP2015533181A5 - - Google Patents
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- JP2015533181A5 JP2015533181A5 JP2015537230A JP2015537230A JP2015533181A5 JP 2015533181 A5 JP2015533181 A5 JP 2015533181A5 JP 2015537230 A JP2015537230 A JP 2015537230A JP 2015537230 A JP2015537230 A JP 2015537230A JP 2015533181 A5 JP2015533181 A5 JP 2015533181A5
- Authority
- JP
- Japan
- Prior art keywords
- container
- typically
- powder
- chiral
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000843 powder Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- XLAKJQPTOJHYDR-QTQXQZBYSA-M aclidinium bromide Chemical compound [Br-].C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 XLAKJQPTOJHYDR-QTQXQZBYSA-M 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical compound CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000656145 Thyrsites atun Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382399.9 | 2012-10-16 | ||
| EP12382399 | 2012-10-16 | ||
| US201261718782P | 2012-10-26 | 2012-10-26 | |
| US61/718,782 | 2012-10-26 | ||
| PCT/EP2013/071551 WO2014060432A1 (en) | 2012-10-16 | 2013-10-15 | Pyrrolotriazinone derivatives as pi3k inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015533181A JP2015533181A (ja) | 2015-11-19 |
| JP2015533181A5 true JP2015533181A5 (https=) | 2016-11-10 |
Family
ID=47049114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537230A Withdrawn JP2015533181A (ja) | 2012-10-16 | 2013-10-15 | Ｐｉ３ｋ阻害剤としてのピロロトリアジノン誘導体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9388189B2 (https=) |
| EP (1) | EP2909207A1 (https=) |
| JP (1) | JP2015533181A (https=) |
| KR (1) | KR20150068953A (https=) |
| CN (1) | CN104854108A (https=) |
| AP (1) | AP2015008328A0 (https=) |
| AR (1) | AR093036A1 (https=) |
| AU (1) | AU2013333938A1 (https=) |
| BR (1) | BR112015007231A2 (https=) |
| CA (1) | CA2883426A1 (https=) |
| CL (1) | CL2015000956A1 (https=) |
| CR (1) | CR20150175A (https=) |
| DO (1) | DOP2015000077A (https=) |
| EA (1) | EA027277B1 (https=) |
| GE (1) | GEP201706623B (https=) |
| GT (1) | GT201500094A (https=) |
| HK (1) | HK1211027A1 (https=) |
| IL (1) | IL237475A0 (https=) |
| MD (1) | MD20150048A2 (https=) |
| MX (1) | MX2015004327A (https=) |
| NI (1) | NI201500054A (https=) |
| PE (1) | PE20150637A1 (https=) |
| PH (1) | PH12015500813A1 (https=) |
| SG (1) | SG11201502032VA (https=) |
| TN (1) | TN2015000112A1 (https=) |
| TW (1) | TW201429975A (https=) |
| UY (1) | UY35086A (https=) |
| WO (1) | WO2014060432A1 (https=) |
| ZA (1) | ZA201501220B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014015523A1 (en) * | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
| EP2997030B1 (en) * | 2013-05-14 | 2017-08-09 | Nerviano Medical Sciences S.R.L. | Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors |
| US9657007B2 (en) | 2013-09-22 | 2017-05-23 | Calitor Sciences, Llc | Substituted aminopyrimidine compounds and methods of use |
| MX2017000208A (es) | 2014-07-04 | 2017-05-01 | Lupin Ltd | Derivados de quinolizinona como inhibidores de pi3k. |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2016202800A1 (en) | 2015-06-16 | 2016-12-22 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
| CN106467545B (zh) * | 2015-08-20 | 2018-10-16 | 北大方正集团有限公司 | 一种噻吩并嘧啶化合物 |
| WO2017076990A1 (en) | 2015-11-05 | 2017-05-11 | Almirall, S.A. | Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide |
| US20190038713A1 (en) | 2015-11-07 | 2019-02-07 | Multivir Inc. | Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| PL3377495T3 (pl) | 2015-11-16 | 2022-05-16 | Topadur Pharma Ag | Pochodne 2-fenylo-3,4-dihydropirolo[2,1-f] [1,2,4]triazynonu jako inhibitory fosfodiesterazy i ich zastosowania |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3472165B1 (en) * | 2016-06-21 | 2023-09-06 | Nerviano Medical Sciences S.r.l. | N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors |
| TW201811795A (zh) | 2016-08-24 | 2018-04-01 | 美商亞闊股份有限公司 | 胺基－吡咯并嘧啶酮化合物及其用途 |
| WO2018111902A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| AU2019209960B2 (en) | 2018-01-20 | 2023-11-23 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
| EP3768698B1 (en) | 2018-03-19 | 2025-02-12 | MultiVir Inc. | Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| WO2022000443A1 (en) * | 2020-07-03 | 2022-01-06 | Nanjing Immunophage Biotech Co., Ltd. | Methods and compositions for targeting tregs using ccr8 inhibitors |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| ES2788383T3 (es) | 2000-04-25 | 2020-10-21 | Icos Corp | Inhibidores de delta fosfatidilo-inositol 3-quinasa humana |
| TW200407143A (en) | 2002-05-21 | 2004-05-16 | Bristol Myers Squibb Co | Pyrrolotriazinone compounds and their use to treat diseases |
| US6752411B2 (en) | 2002-06-24 | 2004-06-22 | Norco Industries, Inc. | Multi-stage torsion axle |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| MXPA05011296A (es) | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de la cinasa. |
| WO2005016348A1 (en) | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| SI2612862T1 (sl) * | 2004-05-13 | 2017-04-26 | Icos Corporation | Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta |
| DK200400182U4 (da) | 2004-06-23 | 2005-10-14 | Alfa Laval Tank Equipment As | Drivenhed især til brug i forbindelse med tankrenseudstyr |
| GB0417709D0 (en) | 2004-08-09 | 2004-09-08 | Glaxo Group Ltd | Compounds |
| AU2006283846B2 (en) * | 2005-08-26 | 2012-04-05 | Merck Serono Sa | Pyrazine derivatives and use as PI3K inhibitors |
| US7759350B2 (en) | 2005-09-15 | 2010-07-20 | Orchid Research Laboratories Ltd. | Pyrimidine carboxamides |
| US7525866B2 (en) | 2006-04-19 | 2009-04-28 | Freescale Semiconductor, Inc. | Memory circuit |
| FI20065449A0 (fi) | 2006-06-29 | 2006-06-29 | Nokia Corp | Tehonkulutuksen valvontamenetelmä, tehonkulutuksen valvontalaite, tietokoneohjelmatuote, tietokoneohjelman jakeluväline ja kommunikaatioväline |
| TW200840581A (en) | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| UY31137A1 (es) | 2007-06-14 | 2009-01-05 | Smithkline Beecham Corp | Derivados de quinazolina como inhibidores de la pi3 quinasa |
| ITRN20070034A1 (it) | 2007-06-27 | 2008-12-28 | Sica Spa | Macchina e metodo di taglio di un tubo estruso in continuo in spezzoni di minore e predeterminata lunghezza. |
| TWI441601B (zh) | 2007-06-28 | 2014-06-21 | Philip Morris Products Sa | 具有高白堊含量之圖案化包裝紙 |
| US20100286145A1 (en) | 2007-07-26 | 2010-11-11 | Comentis, Inc. | Isophthalamide derivatives inhibiting beta-secretase activity |
| US8658635B2 (en) | 2008-06-05 | 2014-02-25 | Glaxosmithkline Intellectual Property Development Limited | Benzpyrazol derivatives as inhibitors of PI3 kinases |
| EP2303890A4 (en) | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | INHIBITORS OF PHOSPHATIDYLINOSITE-3-KINASE |
| CA2756347A1 (en) | 2009-03-24 | 2010-09-30 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| BRPI1014253A2 (pt) | 2009-07-02 | 2016-04-12 | Merz Pharma Gmbh & Co Kgaa | polinucleotídeo codificado um polipeptídeo de neurotoxina, vetor, célula hospedeira, anticorpo, uso de um polinucleotídeo, método para a fabricação de um polipeptídeo de neurotoxina e método para a fabricação de um medicamento |
| WO2011058109A1 (en) * | 2009-11-12 | 2011-05-19 | Ucb Pharma S.A. | Fused bicyclic pyrrole and imidazole derivatives as kinase inhibitors |
| WO2011119704A1 (en) | 2010-03-23 | 2011-09-29 | Glaxosmithkline Llc | Trpv4 antagonists |
| CA2799579A1 (en) * | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| EP2394998A1 (en) | 2010-05-31 | 2011-12-14 | Almirall, S.A. | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors |
| WO2012000202A1 (zh) | 2010-07-02 | 2012-01-05 | Tsai Wen-Kai | 人员派遣事务机及其应用的人员派遣方法 |
| CN103209960A (zh) | 2010-07-26 | 2013-07-17 | 百时美施贵宝公司 | 用作cyp17抑制剂的磺酰胺化合物 |
| EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| EP2699257A4 (en) | 2011-04-21 | 2014-10-15 | Univ Louisiana State | PEPTIDE AND CONJUGATE VACCINES FOR FUNGI INFECTIONS |
| EP2518070A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| CN102229416B (zh) | 2011-06-29 | 2013-06-05 | 三一汽车起重机械有限公司 | 一种起重机闭式回转液压系统及起重机 |
| MX346095B (es) | 2011-09-12 | 2017-03-07 | Merck Patent Gmbh | Nuevas imidazol-aminas como moduladores de la actividad de cinasas. |
| WO2014015523A1 (en) | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
-
2013
- 2013-10-15 AU AU2013333938A patent/AU2013333938A1/en not_active Abandoned
- 2013-10-15 AP AP2015008328A patent/AP2015008328A0/xx unknown
- 2013-10-15 EP EP13779788.2A patent/EP2909207A1/en not_active Withdrawn
- 2013-10-15 CA CA2883426A patent/CA2883426A1/en not_active Abandoned
- 2013-10-15 MD MDA20150048A patent/MD20150048A2/ro not_active Application Discontinuation
- 2013-10-15 GE GEAP201313828A patent/GEP201706623B/en unknown
- 2013-10-15 JP JP2015537230A patent/JP2015533181A/ja not_active Withdrawn
- 2013-10-15 EA EA201500426A patent/EA027277B1/ru not_active IP Right Cessation
- 2013-10-15 KR KR1020157009063A patent/KR20150068953A/ko not_active Withdrawn
- 2013-10-15 WO PCT/EP2013/071551 patent/WO2014060432A1/en not_active Ceased
- 2013-10-15 SG SG11201502032VA patent/SG11201502032VA/en unknown
- 2013-10-15 MX MX2015004327A patent/MX2015004327A/es unknown
- 2013-10-15 US US14/435,851 patent/US9388189B2/en not_active Expired - Fee Related
- 2013-10-15 CN CN201380065926.2A patent/CN104854108A/zh active Pending
- 2013-10-15 PE PE2015000410A patent/PE20150637A1/es not_active Application Discontinuation
- 2013-10-15 HK HK15111815.3A patent/HK1211027A1/xx unknown
- 2013-10-15 BR BR112015007231A patent/BR112015007231A2/pt not_active IP Right Cessation
- 2013-10-16 UY UY0001035086A patent/UY35086A/es not_active Application Discontinuation
- 2013-10-16 AR ARP130103757A patent/AR093036A1/es unknown
- 2013-10-16 TW TW102137293A patent/TW201429975A/zh unknown
-
2015
- 2015-02-23 ZA ZA2015/01220A patent/ZA201501220B/en unknown
- 2015-02-26 IL IL237475A patent/IL237475A0/en unknown
- 2015-03-24 TN TNP2015000112A patent/TN2015000112A1/fr unknown
- 2015-03-30 DO DO2015000077A patent/DOP2015000077A/es unknown
- 2015-03-30 CR CR20150175A patent/CR20150175A/es unknown
- 2015-04-13 PH PH12015500813A patent/PH12015500813A1/en unknown
- 2015-04-15 CL CL2015000956A patent/CL2015000956A1/es unknown
- 2015-04-16 GT GT201500094A patent/GT201500094A/es unknown
- 2015-04-16 NI NI201500054AA patent/NI201500054A/es unknown
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