AR093036A1 - Derivados de pirrolotriazinona como inhibidores de pi3k - Google Patents
Derivados de pirrolotriazinona como inhibidores de pi3kInfo
- Publication number
- AR093036A1 AR093036A1 ARP130103757A ARP130103757A AR093036A1 AR 093036 A1 AR093036 A1 AR 093036A1 AR P130103757 A ARP130103757 A AR P130103757A AR P130103757 A ARP130103757 A AR P130103757A AR 093036 A1 AR093036 A1 AR 093036A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- linear
- phenyl
- heteroatom selected
- branched
- Prior art date
Links
- 239000012828 PI3K inhibitor Substances 0.000 title 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 14
- 125000005842 heteroatom Chemical group 0.000 abstract 14
- 229910052757 nitrogen Inorganic materials 0.000 abstract 14
- 229910052760 oxygen Inorganic materials 0.000 abstract 14
- 229910052717 sulfur Inorganic materials 0.000 abstract 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 13
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 10
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 10
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000002950 monocyclic group Chemical group 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000002619 bicyclic group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 108091007960 PI3Ks Proteins 0.000 abstract 2
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 2
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 abstract 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- BEBRHYJBTAMGRW-UHFFFAOYSA-N pyrrolo[3,2-d]triazin-4-one Chemical class O=C1N=NN=C2C=CN=C12 BEBRHYJBTAMGRW-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382399 | 2012-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093036A1 true AR093036A1 (es) | 2015-05-13 |
Family
ID=47049114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103757A AR093036A1 (es) | 2012-10-16 | 2013-10-16 | Derivados de pirrolotriazinona como inhibidores de pi3k |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9388189B2 (https=) |
| EP (1) | EP2909207A1 (https=) |
| JP (1) | JP2015533181A (https=) |
| KR (1) | KR20150068953A (https=) |
| CN (1) | CN104854108A (https=) |
| AP (1) | AP2015008328A0 (https=) |
| AR (1) | AR093036A1 (https=) |
| AU (1) | AU2013333938A1 (https=) |
| BR (1) | BR112015007231A2 (https=) |
| CA (1) | CA2883426A1 (https=) |
| CL (1) | CL2015000956A1 (https=) |
| CR (1) | CR20150175A (https=) |
| DO (1) | DOP2015000077A (https=) |
| EA (1) | EA027277B1 (https=) |
| GE (1) | GEP201706623B (https=) |
| GT (1) | GT201500094A (https=) |
| HK (1) | HK1211027A1 (https=) |
| IL (1) | IL237475A0 (https=) |
| MD (1) | MD20150048A2 (https=) |
| MX (1) | MX2015004327A (https=) |
| NI (1) | NI201500054A (https=) |
| PE (1) | PE20150637A1 (https=) |
| PH (1) | PH12015500813A1 (https=) |
| SG (1) | SG11201502032VA (https=) |
| TN (1) | TN2015000112A1 (https=) |
| TW (1) | TW201429975A (https=) |
| UY (1) | UY35086A (https=) |
| WO (1) | WO2014060432A1 (https=) |
| ZA (1) | ZA201501220B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014015523A1 (en) * | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
| EP2997030B1 (en) * | 2013-05-14 | 2017-08-09 | Nerviano Medical Sciences S.R.L. | Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors |
| US9657007B2 (en) | 2013-09-22 | 2017-05-23 | Calitor Sciences, Llc | Substituted aminopyrimidine compounds and methods of use |
| MX2017000208A (es) | 2014-07-04 | 2017-05-01 | Lupin Ltd | Derivados de quinolizinona como inhibidores de pi3k. |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2016202800A1 (en) | 2015-06-16 | 2016-12-22 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
| CN106467545B (zh) * | 2015-08-20 | 2018-10-16 | 北大方正集团有限公司 | 一种噻吩并嘧啶化合物 |
| WO2017076990A1 (en) | 2015-11-05 | 2017-05-11 | Almirall, S.A. | Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide |
| US20190038713A1 (en) | 2015-11-07 | 2019-02-07 | Multivir Inc. | Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| PL3377495T3 (pl) | 2015-11-16 | 2022-05-16 | Topadur Pharma Ag | Pochodne 2-fenylo-3,4-dihydropirolo[2,1-f] [1,2,4]triazynonu jako inhibitory fosfodiesterazy i ich zastosowania |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3472165B1 (en) * | 2016-06-21 | 2023-09-06 | Nerviano Medical Sciences S.r.l. | N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors |
| TW201811795A (zh) | 2016-08-24 | 2018-04-01 | 美商亞闊股份有限公司 | 胺基－吡咯并嘧啶酮化合物及其用途 |
| WO2018111902A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| AU2019209960B2 (en) | 2018-01-20 | 2023-11-23 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
| EP3768698B1 (en) | 2018-03-19 | 2025-02-12 | MultiVir Inc. | Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| WO2022000443A1 (en) * | 2020-07-03 | 2022-01-06 | Nanjing Immunophage Biotech Co., Ltd. | Methods and compositions for targeting tregs using ccr8 inhibitors |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| ES2788383T3 (es) | 2000-04-25 | 2020-10-21 | Icos Corp | Inhibidores de delta fosfatidilo-inositol 3-quinasa humana |
| TW200407143A (en) | 2002-05-21 | 2004-05-16 | Bristol Myers Squibb Co | Pyrrolotriazinone compounds and their use to treat diseases |
| US6752411B2 (en) | 2002-06-24 | 2004-06-22 | Norco Industries, Inc. | Multi-stage torsion axle |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| MXPA05011296A (es) | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de la cinasa. |
| WO2005016348A1 (en) | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| SI2612862T1 (sl) * | 2004-05-13 | 2017-04-26 | Icos Corporation | Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta |
| DK200400182U4 (da) | 2004-06-23 | 2005-10-14 | Alfa Laval Tank Equipment As | Drivenhed især til brug i forbindelse med tankrenseudstyr |
| GB0417709D0 (en) | 2004-08-09 | 2004-09-08 | Glaxo Group Ltd | Compounds |
| AU2006283846B2 (en) * | 2005-08-26 | 2012-04-05 | Merck Serono Sa | Pyrazine derivatives and use as PI3K inhibitors |
| US7759350B2 (en) | 2005-09-15 | 2010-07-20 | Orchid Research Laboratories Ltd. | Pyrimidine carboxamides |
| US7525866B2 (en) | 2006-04-19 | 2009-04-28 | Freescale Semiconductor, Inc. | Memory circuit |
| FI20065449A0 (fi) | 2006-06-29 | 2006-06-29 | Nokia Corp | Tehonkulutuksen valvontamenetelmä, tehonkulutuksen valvontalaite, tietokoneohjelmatuote, tietokoneohjelman jakeluväline ja kommunikaatioväline |
| TW200840581A (en) | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| UY31137A1 (es) | 2007-06-14 | 2009-01-05 | Smithkline Beecham Corp | Derivados de quinazolina como inhibidores de la pi3 quinasa |
| ITRN20070034A1 (it) | 2007-06-27 | 2008-12-28 | Sica Spa | Macchina e metodo di taglio di un tubo estruso in continuo in spezzoni di minore e predeterminata lunghezza. |
| TWI441601B (zh) | 2007-06-28 | 2014-06-21 | Philip Morris Products Sa | 具有高白堊含量之圖案化包裝紙 |
| US20100286145A1 (en) | 2007-07-26 | 2010-11-11 | Comentis, Inc. | Isophthalamide derivatives inhibiting beta-secretase activity |
| US8658635B2 (en) | 2008-06-05 | 2014-02-25 | Glaxosmithkline Intellectual Property Development Limited | Benzpyrazol derivatives as inhibitors of PI3 kinases |
| EP2303890A4 (en) | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | INHIBITORS OF PHOSPHATIDYLINOSITE-3-KINASE |
| CA2756347A1 (en) | 2009-03-24 | 2010-09-30 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| BRPI1014253A2 (pt) | 2009-07-02 | 2016-04-12 | Merz Pharma Gmbh & Co Kgaa | polinucleotídeo codificado um polipeptídeo de neurotoxina, vetor, célula hospedeira, anticorpo, uso de um polinucleotídeo, método para a fabricação de um polipeptídeo de neurotoxina e método para a fabricação de um medicamento |
| WO2011058109A1 (en) * | 2009-11-12 | 2011-05-19 | Ucb Pharma S.A. | Fused bicyclic pyrrole and imidazole derivatives as kinase inhibitors |
| WO2011119704A1 (en) | 2010-03-23 | 2011-09-29 | Glaxosmithkline Llc | Trpv4 antagonists |
| CA2799579A1 (en) * | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| EP2394998A1 (en) | 2010-05-31 | 2011-12-14 | Almirall, S.A. | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors |
| WO2012000202A1 (zh) | 2010-07-02 | 2012-01-05 | Tsai Wen-Kai | 人员派遣事务机及其应用的人员派遣方法 |
| CN103209960A (zh) | 2010-07-26 | 2013-07-17 | 百时美施贵宝公司 | 用作cyp17抑制剂的磺酰胺化合物 |
| EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| EP2699257A4 (en) | 2011-04-21 | 2014-10-15 | Univ Louisiana State | PEPTIDE AND CONJUGATE VACCINES FOR FUNGI INFECTIONS |
| EP2518070A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| CN102229416B (zh) | 2011-06-29 | 2013-06-05 | 三一汽车起重机械有限公司 | 一种起重机闭式回转液压系统及起重机 |
| MX346095B (es) | 2011-09-12 | 2017-03-07 | Merck Patent Gmbh | Nuevas imidazol-aminas como moduladores de la actividad de cinasas. |
| WO2014015523A1 (en) | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
-
2013
- 2013-10-15 AU AU2013333938A patent/AU2013333938A1/en not_active Abandoned
- 2013-10-15 AP AP2015008328A patent/AP2015008328A0/xx unknown
- 2013-10-15 EP EP13779788.2A patent/EP2909207A1/en not_active Withdrawn
- 2013-10-15 CA CA2883426A patent/CA2883426A1/en not_active Abandoned
- 2013-10-15 MD MDA20150048A patent/MD20150048A2/ro not_active Application Discontinuation
- 2013-10-15 GE GEAP201313828A patent/GEP201706623B/en unknown
- 2013-10-15 JP JP2015537230A patent/JP2015533181A/ja not_active Withdrawn
- 2013-10-15 EA EA201500426A patent/EA027277B1/ru not_active IP Right Cessation
- 2013-10-15 KR KR1020157009063A patent/KR20150068953A/ko not_active Withdrawn
- 2013-10-15 WO PCT/EP2013/071551 patent/WO2014060432A1/en not_active Ceased
- 2013-10-15 SG SG11201502032VA patent/SG11201502032VA/en unknown
- 2013-10-15 MX MX2015004327A patent/MX2015004327A/es unknown
- 2013-10-15 US US14/435,851 patent/US9388189B2/en not_active Expired - Fee Related
- 2013-10-15 CN CN201380065926.2A patent/CN104854108A/zh active Pending
- 2013-10-15 PE PE2015000410A patent/PE20150637A1/es not_active Application Discontinuation
- 2013-10-15 HK HK15111815.3A patent/HK1211027A1/xx unknown
- 2013-10-15 BR BR112015007231A patent/BR112015007231A2/pt not_active IP Right Cessation
- 2013-10-16 UY UY0001035086A patent/UY35086A/es not_active Application Discontinuation
- 2013-10-16 AR ARP130103757A patent/AR093036A1/es unknown
- 2013-10-16 TW TW102137293A patent/TW201429975A/zh unknown
-
2015
- 2015-02-23 ZA ZA2015/01220A patent/ZA201501220B/en unknown
- 2015-02-26 IL IL237475A patent/IL237475A0/en unknown
- 2015-03-24 TN TNP2015000112A patent/TN2015000112A1/fr unknown
- 2015-03-30 DO DO2015000077A patent/DOP2015000077A/es unknown
- 2015-03-30 CR CR20150175A patent/CR20150175A/es unknown
- 2015-04-13 PH PH12015500813A patent/PH12015500813A1/en unknown
- 2015-04-15 CL CL2015000956A patent/CL2015000956A1/es unknown
- 2015-04-16 GT GT201500094A patent/GT201500094A/es unknown
- 2015-04-16 NI NI201500054AA patent/NI201500054A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013333938A1 (en) | 2015-04-09 |
| NI201500054A (es) | 2016-02-01 |
| CL2015000956A1 (es) | 2015-06-19 |
| IL237475A0 (en) | 2015-04-30 |
| GEP201706623B (en) | 2017-02-10 |
| GT201500094A (es) | 2017-08-01 |
| TW201429975A (zh) | 2014-08-01 |
| EA027277B1 (ru) | 2017-07-31 |
| PH12015500813B1 (en) | 2015-06-08 |
| SG11201502032VA (en) | 2015-05-28 |
| BR112015007231A2 (pt) | 2017-07-04 |
| KR20150068953A (ko) | 2015-06-22 |
| HK1211027A1 (en) | 2016-05-13 |
| UY35086A (es) | 2014-05-30 |
| CA2883426A1 (en) | 2014-04-24 |
| MX2015004327A (es) | 2015-06-10 |
| US9388189B2 (en) | 2016-07-12 |
| DOP2015000077A (es) | 2015-04-30 |
| WO2014060432A1 (en) | 2014-04-24 |
| PE20150637A1 (es) | 2015-05-08 |
| PH12015500813A1 (en) | 2015-06-08 |
| ZA201501220B (en) | 2017-04-26 |
| EP2909207A1 (en) | 2015-08-26 |
| JP2015533181A (ja) | 2015-11-19 |
| AP2015008328A0 (en) | 2015-03-31 |
| US20150291595A1 (en) | 2015-10-15 |
| TN2015000112A1 (en) | 2016-06-29 |
| EA201500426A1 (ru) | 2015-10-30 |
| CR20150175A (es) | 2015-05-11 |
| CN104854108A (zh) | 2015-08-19 |
| MD20150048A2 (ro) | 2015-10-31 |
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