JP2015527355A5 - - Google Patents

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JP2015527355A5
JP2015527355A5 JP2015527965A JP2015527965A JP2015527355A5 JP 2015527355 A5 JP2015527355 A5 JP 2015527355A5 JP 2015527965 A JP2015527965 A JP 2015527965A JP 2015527965 A JP2015527965 A JP 2015527965A JP 2015527355 A5 JP2015527355 A5 JP 2015527355A5
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pharmaceutical composition
disease
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JP2015527965A
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JP2015527355A (ja
JP6392754B2 (ja
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Priority claimed from PCT/GB2013/052192 external-priority patent/WO2014029983A1/en
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JP2015527965A 2012-08-21 2013-08-20 体液貯留又は塩過負荷に関係する疾患及び消化管疾患の治療におけるnhe仲介の逆輸送を阻害するための化合物並びに方法 Active JP6392754B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261691635P 2012-08-21 2012-08-21
US61/691,635 2012-08-21
PCT/GB2013/052192 WO2014029983A1 (en) 2012-08-21 2013-08-20 Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders

Publications (3)

Publication Number Publication Date
JP2015527355A JP2015527355A (ja) 2015-09-17
JP2015527355A5 true JP2015527355A5 (enExample) 2016-10-20
JP6392754B2 JP6392754B2 (ja) 2018-09-19

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ID=49083709

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JP2015527965A Active JP6392754B2 (ja) 2012-08-21 2013-08-20 体液貯留又は塩過負荷に関係する疾患及び消化管疾患の治療におけるnhe仲介の逆輸送を阻害するための化合物並びに方法

Country Status (12)

Country Link
US (1) US20150336892A1 (enExample)
EP (1) EP2887964B1 (enExample)
JP (1) JP6392754B2 (enExample)
KR (1) KR102138390B1 (enExample)
CN (1) CN104902930A (enExample)
AU (3) AU2013304812B2 (enExample)
BR (1) BR112015003527A2 (enExample)
CA (1) CA2880338A1 (enExample)
HK (1) HK1211469A1 (enExample)
MX (1) MX366293B (enExample)
RU (1) RU2015107019A (enExample)
WO (1) WO2014029983A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2590965B1 (en) 2010-07-07 2016-04-20 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5827328B2 (ja) 2010-07-07 2015-12-02 アーデリクス,インコーポレーテッド リン酸輸送を阻害する化合物及び方法
EP2590656B1 (en) 2010-07-07 2017-11-15 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5827326B2 (ja) 2010-07-07 2015-12-02 アーデリクス,インコーポレーテッド リン酸輸送を阻害する化合物及び方法
CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
EP3137115B1 (en) * 2014-05-01 2020-10-14 Ionis Pharmaceuticals, Inc. Method for synthesis of reactive conjugate clusters
WO2016013657A1 (ja) 2014-07-25 2016-01-28 大正製薬株式会社 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
KR20240090875A (ko) * 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
CN111386279A (zh) 2017-08-04 2020-07-07 阿德利克斯股份有限公司 用于治疗高钾血症的甘草次酸衍生物
JP7365332B2 (ja) 2017-08-07 2023-10-19 ジョイント・ストック・カンパニー “バイオキャド” Cdk8/19阻害薬としての新規ヘテロ環式化合物
JP7735185B2 (ja) 2019-02-07 2025-09-08 アルデリックス, インコーポレイテッド 高カリウム血症の治療で使用するためのグリチルレチン酸誘導体
WO2026013682A1 (en) * 2024-07-07 2026-01-15 Badipati Dr Raju A kit and composition for treating edema in patients and method of use

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