JP2015525215A5 - - Google Patents
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- Publication number
- JP2015525215A5 JP2015525215A5 JP2015516217A JP2015516217A JP2015525215A5 JP 2015525215 A5 JP2015525215 A5 JP 2015525215A5 JP 2015516217 A JP2015516217 A JP 2015516217A JP 2015516217 A JP2015516217 A JP 2015516217A JP 2015525215 A5 JP2015525215 A5 JP 2015525215A5
- Authority
- JP
- Japan
- Prior art keywords
- chr
- alkyl
- och
- nhc
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(C)c1n[n](C)c(*)c1 Chemical compound CC(C)(C)c1n[n](C)c(*)c1 0.000 description 12
- WUAXWWJRNIODRY-UHFFFAOYSA-N CC(c1cc(C)n[nH]1)=O Chemical compound CC(c1cc(C)n[nH]1)=O WUAXWWJRNIODRY-UHFFFAOYSA-N 0.000 description 2
- OPTCHSMAUQAOEX-UHFFFAOYSA-N CCC(O1)=C(C)OC1=O Chemical compound CCC(O1)=C(C)OC1=O OPTCHSMAUQAOEX-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657229P | 2012-06-08 | 2012-06-08 | |
| US61/657,229 | 2012-06-08 | ||
| US201361773969P | 2013-03-07 | 2013-03-07 | |
| US61/773,969 | 2013-03-07 | ||
| PCT/US2013/044546 WO2013184934A1 (en) | 2012-06-08 | 2013-06-06 | Neprilysin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080465A Division JP2017125063A (ja) | 2012-06-08 | 2017-04-14 | ネプリライシン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525215A JP2015525215A (ja) | 2015-09-03 |
| JP2015525215A5 true JP2015525215A5 (https=) | 2016-06-23 |
| JP6162230B2 JP6162230B2 (ja) | 2017-07-12 |
Family
ID=48626696
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516217A Expired - Fee Related JP6162230B2 (ja) | 2012-06-08 | 2013-06-06 | ネプリライシン阻害剤 |
| JP2017080465A Withdrawn JP2017125063A (ja) | 2012-06-08 | 2017-04-14 | ネプリライシン阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080465A Withdrawn JP2017125063A (ja) | 2012-06-08 | 2017-04-14 | ネプリライシン阻害剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9108934B2 (https=) |
| EP (2) | EP3199517B1 (https=) |
| JP (2) | JP6162230B2 (https=) |
| KR (1) | KR102102197B1 (https=) |
| CN (1) | CN104350042B (https=) |
| AR (1) | AR091381A1 (https=) |
| AU (1) | AU2013271537B2 (https=) |
| BR (1) | BR112014030743B1 (https=) |
| CA (1) | CA2876024C (https=) |
| DK (1) | DK2864292T3 (https=) |
| ES (2) | ES2632600T3 (https=) |
| HR (1) | HRP20171037T1 (https=) |
| HU (1) | HUE032802T2 (https=) |
| IL (1) | IL235737B (https=) |
| LT (1) | LT2864292T (https=) |
| ME (1) | ME02698B (https=) |
| MX (1) | MX356260B (https=) |
| NZ (2) | NZ723772A (https=) |
| PH (1) | PH12014502733A1 (https=) |
| PL (1) | PL2864292T3 (https=) |
| PT (1) | PT2864292T (https=) |
| RS (1) | RS55967B1 (https=) |
| RU (1) | RU2663618C2 (https=) |
| SG (2) | SG11201408094YA (https=) |
| SI (1) | SI2864292T1 (https=) |
| SM (1) | SMT201700306T1 (https=) |
| TW (2) | TWI644901B (https=) |
| WO (1) | WO2013184934A1 (https=) |
| ZA (1) | ZA201408634B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8586536B2 (en) | 2010-12-15 | 2013-11-19 | Theravance, Inc. | Neprilysin inhibitors |
| ES2548887T3 (es) | 2010-12-15 | 2015-10-21 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| JP5959066B2 (ja) | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| KR101854874B1 (ko) | 2011-02-17 | 2018-05-04 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 억제제로서 치환된 아미노부티릭 유도체 |
| ES2653215T3 (es) | 2011-05-31 | 2018-02-06 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| MX356260B (es) | 2012-06-08 | 2018-05-21 | Theravance Biopharma R&D Ip Llc | Inhibidores de la neprilisina. |
| CN104470521B (zh) | 2012-06-08 | 2017-04-12 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| MX366149B (es) | 2012-08-08 | 2019-06-28 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina. |
| CA2902456A1 (en) | 2013-03-05 | 2014-09-12 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| US9585882B2 (en) | 2014-01-30 | 2017-03-07 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| WO2015116786A1 (en) | 2014-01-30 | 2015-08-06 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| CN105338467B (zh) * | 2014-08-07 | 2019-04-02 | 电信科学技术研究院 | 一种设备到设备通信中数据接收方法、发送方法及设备 |
| CN104592163B (zh) * | 2015-01-08 | 2016-08-24 | 爱斯特（成都）生物制药有限公司 | 一种手性2-苯基吡咯烷的合成方法 |
| KR102640906B1 (ko) | 2015-02-11 | 2024-02-27 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 저해제로서 (2s,4r)-5-(5''-클로로-2''-플루오로비페닐-4-일)-4-(에톡시옥살릴아미노)-2-히드록시메틸-2-메틸펜타노익산 |
| CN107250119B (zh) | 2015-02-19 | 2020-09-22 | 施万生物制药研发Ip有限责任公司 | (2r,4r)-5-(5′-氯-2′-氟联苯-4-基)-2-羟基-4-[(5-甲基恶唑-2-羰基)氨基]戊酸 |
| PL3390412T3 (pl) | 2015-12-14 | 2021-10-25 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Rozpuszczalne w wodzie pochodne związków 3,5-difenylodiazolowych |
| SMT202100434T1 (it) | 2016-03-08 | 2021-09-14 | Theravance Biopharma R&D Ip Llc | Acido (2s,4r)-5-(5’-cloro-2-fluoro-[1,1’-bifenil]-4-il)-2-(etossimetil)-4-(3-idrossiisossazol-5-carbossammido)-2-metilpentanoico cristallino e suoi usi |
| CN107071636B (zh) * | 2016-12-29 | 2019-12-31 | 北京小鸟听听科技有限公司 | 对带麦克风的设备的去混响控制方法和装置 |
| JP6580097B2 (ja) | 2017-09-05 | 2019-09-25 | 株式会社東芝 | 面発光量子カスケードレーザ |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| US20230089867A1 (en) | 2018-11-27 | 2023-03-23 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
| US11419917B2 (en) * | 2020-04-07 | 2022-08-23 | Drora Shevy | Treatment for SARS-CoV-2 and other coronaviruses |
| WO2023084449A1 (en) | 2021-11-12 | 2023-05-19 | Novartis Ag | Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder |
| KR102485499B1 (ko) * | 2022-07-15 | 2023-01-09 | 오가노이드사이언스 주식회사 | 신장 질환의 치료 또는 예방용 조성물 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189604A (en) | 1975-07-22 | 1980-02-19 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin |
| US4206232A (en) | 1976-05-10 | 1980-06-03 | E. R. Squibb & Sons, Inc. | Relieving hypertension with carboxyalkylacylamino acids |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
| US4906615A (en) | 1980-12-18 | 1990-03-06 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
| US4722810A (en) | 1984-08-16 | 1988-02-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| US4939261A (en) | 1984-06-08 | 1990-07-03 | Ciba-Geigy Corporation | N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase |
| EP0225292A3 (en) | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Certain n-substituted butyramide derivatives |
| US4929641B1 (en) | 1988-05-11 | 1994-08-30 | Schering Corp | Mercapto-acylamino acid antihypertensives |
| KR880007441A (ko) | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
| FR2623498B1 (fr) | 1987-11-24 | 1990-04-06 | Bioprojet Soc Civ | Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques |
| GB8820844D0 (en) | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| US5599951A (en) | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| US5294632A (en) | 1991-05-01 | 1994-03-15 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipetide derivatives |
| US5155100A (en) | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
| US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| DE19510566A1 (de) | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| AU5687396A (en) | 1995-04-21 | 1996-11-07 | Novarits Ag | N-aroylamino acid amides as endothelin inhibitors |
| US6660756B2 (en) | 2001-03-28 | 2003-12-09 | Pfizer Inc. | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| ATE455096T1 (de) * | 2002-11-19 | 2010-01-15 | Galderma Res & Dev | Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen |
| WO2006027680A1 (en) | 2004-09-10 | 2006-03-16 | Pfizer Limited | 3-(1-carbamoylcyclohexyl) propionic acid derivatives as inhibitors of neutral endopeptidase enzyme |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| WO2007106708A2 (en) | 2006-03-10 | 2007-09-20 | Novartis Ag | Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril |
| KR101580067B1 (ko) | 2007-01-12 | 2015-12-23 | 노파르티스 아게 | 5-바이페닐-4-아미노-2-메틸 펜탄산의 제조 방법 |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| PE20091364A1 (es) | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| US20120150643A1 (en) * | 2010-12-14 | 2012-06-14 | Moneyhoney Llc | System and method for processing remainder amounts of money from gift cards |
| EP2435402B1 (en) * | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
| CN103896796B (zh) * | 2009-05-28 | 2016-04-27 | 诺华股份有限公司 | 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物 |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| KR101463670B1 (ko) | 2010-01-22 | 2014-11-19 | 노파르티스 아게 | 중성 엔도펩티다제 억제제의 중간체 및 그의 제조 방법 |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| ES2548887T3 (es) | 2010-12-15 | 2015-10-21 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| US8586536B2 (en) * | 2010-12-15 | 2013-11-19 | Theravance, Inc. | Neprilysin inhibitors |
| KR101854874B1 (ko) * | 2011-02-17 | 2018-05-04 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 억제제로서 치환된 아미노부티릭 유도체 |
| JP5959066B2 (ja) | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| ES2653215T3 (es) | 2011-05-31 | 2018-02-06 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| WO2012166389A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
| JP5959075B2 (ja) | 2011-05-31 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤 |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| ES2609810T3 (es) | 2012-05-31 | 2017-04-24 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina donadores de óxido nítrico |
| MX356260B (es) | 2012-06-08 | 2018-05-21 | Theravance Biopharma R&D Ip Llc | Inhibidores de la neprilisina. |
| CN107250119B (zh) * | 2015-02-19 | 2020-09-22 | 施万生物制药研发Ip有限责任公司 | (2r,4r)-5-(5′-氯-2′-氟联苯-4-基)-2-羟基-4-[(5-甲基恶唑-2-羰基)氨基]戊酸 |
-
2013
- 2013-06-06 MX MX2014014918A patent/MX356260B/es active IP Right Grant
- 2013-06-06 PT PT137292322T patent/PT2864292T/pt unknown
- 2013-06-06 CN CN201380030259.4A patent/CN104350042B/zh active Active
- 2013-06-06 NZ NZ723772A patent/NZ723772A/en not_active IP Right Cessation
- 2013-06-06 AU AU2013271537A patent/AU2013271537B2/en not_active Ceased
- 2013-06-06 SG SG11201408094YA patent/SG11201408094YA/en unknown
- 2013-06-06 RU RU2014153578A patent/RU2663618C2/ru active
- 2013-06-06 SM SM20170306T patent/SMT201700306T1/it unknown
- 2013-06-06 CA CA2876024A patent/CA2876024C/en active Active
- 2013-06-06 HU HUE13729232A patent/HUE032802T2/hu unknown
- 2013-06-06 KR KR1020157000506A patent/KR102102197B1/ko active Active
- 2013-06-06 JP JP2015516217A patent/JP6162230B2/ja not_active Expired - Fee Related
- 2013-06-06 WO PCT/US2013/044546 patent/WO2013184934A1/en not_active Ceased
- 2013-06-06 EP EP17160870.6A patent/EP3199517B1/en active Active
- 2013-06-06 US US13/911,819 patent/US9108934B2/en active Active
- 2013-06-06 RS RS20170515A patent/RS55967B1/sr unknown
- 2013-06-06 ES ES13729232.2T patent/ES2632600T3/es active Active
- 2013-06-06 DK DK13729232.2T patent/DK2864292T3/en active
- 2013-06-06 SG SG10201703185VA patent/SG10201703185VA/en unknown
- 2013-06-06 LT LTEP13729232.2T patent/LT2864292T/lt unknown
- 2013-06-06 EP EP13729232.2A patent/EP2864292B1/en active Active
- 2013-06-06 ME MEP-2017-121A patent/ME02698B/me unknown
- 2013-06-06 PL PL13729232T patent/PL2864292T3/pl unknown
- 2013-06-06 HR HRP20171037TT patent/HRP20171037T1/hr unknown
- 2013-06-06 NZ NZ702749A patent/NZ702749A/en not_active IP Right Cessation
- 2013-06-06 ES ES17160870T patent/ES2700152T3/es active Active
- 2013-06-06 SI SI201330690A patent/SI2864292T1/sl unknown
- 2013-06-06 BR BR112014030743-1A patent/BR112014030743B1/pt not_active IP Right Cessation
- 2013-06-07 AR ARP130102017 patent/AR091381A1/es active IP Right Grant
- 2013-06-07 TW TW106111422A patent/TWI644901B/zh not_active IP Right Cessation
- 2013-06-07 TW TW102120448A patent/TWI583671B/zh not_active IP Right Cessation
-
2014
- 2014-11-17 IL IL235737A patent/IL235737B/en active IP Right Grant
- 2014-11-24 ZA ZA2014/08634A patent/ZA201408634B/en unknown
- 2014-12-05 PH PH12014502733A patent/PH12014502733A1/en unknown
-
2015
- 2015-07-07 US US14/792,810 patent/US9670140B2/en not_active Expired - Fee Related
-
2017
- 2017-04-14 JP JP2017080465A patent/JP2017125063A/ja not_active Withdrawn
- 2017-04-28 US US15/581,327 patent/US9884807B2/en not_active Expired - Fee Related
- 2017-12-15 US US15/843,427 patent/US10315984B2/en active Active
-
2019
- 2019-04-24 US US16/392,920 patent/US10829438B2/en active Active
-
2020
- 2020-10-05 US US16/948,872 patent/US11174219B2/en not_active Expired - Fee Related
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