JP2014505734A5 - - Google Patents

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Publication number
JP2014505734A5
JP2014505734A5 JP2013554588A JP2013554588A JP2014505734A5 JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5 JP 2013554588 A JP2013554588 A JP 2013554588A JP 2013554588 A JP2013554588 A JP 2013554588A JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5
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JP
Japan
Prior art keywords
alkylene
alkyl
compound according
halo
benzyl
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JP2013554588A
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English (en)
Japanese (ja)
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JP5959066B2 (ja
JP2014505734A (ja
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Priority claimed from PCT/US2012/025369 external-priority patent/WO2012154249A1/en
Publication of JP2014505734A publication Critical patent/JP2014505734A/ja
Publication of JP2014505734A5 publication Critical patent/JP2014505734A5/ja
Application granted granted Critical
Publication of JP5959066B2 publication Critical patent/JP5959066B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013554588A 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体 Expired - Fee Related JP5959066B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443828P 2011-02-17 2011-02-17
US61/443,828 2011-02-17
PCT/US2012/025369 WO2012154249A1 (en) 2011-02-17 2012-02-16 Substituted aminobutyric derivatives as neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015246947A Division JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Publications (3)

Publication Number Publication Date
JP2014505734A JP2014505734A (ja) 2014-03-06
JP2014505734A5 true JP2014505734A5 (https=) 2015-04-02
JP5959066B2 JP5959066B2 (ja) 2016-08-02

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ID=45814662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013554588A Expired - Fee Related JP5959066B2 (ja) 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Family Applications After (1)

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JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Country Status (5)

Country Link
US (5) US8449890B2 (https=)
EP (1) EP2675792B1 (https=)
JP (2) JP5959066B2 (https=)
ES (1) ES2564275T3 (https=)
WO (1) WO2012154249A1 (https=)

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JP5466759B2 (ja) 2009-05-28 2014-04-09 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
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CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
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LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
JP7306828B2 (ja) 2016-03-08 2023-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 結晶性（２ｓ，４ｒ）－５－（５’－クロロ－２’－フルオロ－［１，１’－ビフェニル］－４－イル）－２－（エトキシメチル）－４－（３－ヒドロキシイソオキサゾール－５－カルボキサミド）－２－メチルペンタン酸およびその使用
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UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

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HUE028051T2 (hu) 2010-12-15 2016-11-28 Theravance Biopharma R&D Ip Llc Neprilizin inhibitorok
CA2819153A1 (en) 2010-12-15 2012-06-21 Theravance, Inc. Neprilysin inhibitors
JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP5959065B2 (ja) * 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
CN103748070B (zh) 2011-05-31 2015-06-24 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
CN103582630B (zh) 2011-05-31 2016-08-17 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
SMT201700306T1 (it) 2012-06-08 2017-07-18 Theravance Biopharma R&D Ip Llc Inibitori di neprilisina
WO2013184898A1 (en) 2012-06-08 2013-12-12 Theravance, Inc. Neprilysin inhibitors
MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
DK2964616T3 (en) 2013-03-05 2017-08-28 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors

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