JP2015522623A5 - - Google Patents

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Publication number
JP2015522623A5
JP2015522623A5 JP2015523282A JP2015523282A JP2015522623A5 JP 2015522623 A5 JP2015522623 A5 JP 2015522623A5 JP 2015523282 A JP2015523282 A JP 2015523282A JP 2015523282 A JP2015523282 A JP 2015523282A JP 2015522623 A5 JP2015522623 A5 JP 2015522623A5
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JP
Japan
Prior art keywords
difluoro
methyl
hydroxy
oxopyrrolidin
alkyl
Prior art date
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JP2015523282A
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English (en)
Japanese (ja)
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JP2015522623A (ja
JP6141430B2 (ja
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Priority claimed from PCT/US2013/051261 external-priority patent/WO2014015246A1/en
Publication of JP2015522623A publication Critical patent/JP2015522623A/ja
Publication of JP2015522623A5 publication Critical patent/JP2015522623A5/ja
Application granted granted Critical
Publication of JP6141430B2 publication Critical patent/JP6141430B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015523282A 2012-07-19 2013-07-19 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物 Expired - Fee Related JP6141430B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673514P 2012-07-19 2012-07-19
US61/673,514 2012-07-19
US201361793929P 2013-03-15 2013-03-15
US61/793,929 2013-03-15
PCT/US2013/051261 WO2014015246A1 (en) 2012-07-19 2013-07-19 Difluorolactam compositions for ep4-mediated osteo related diseases and conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017091147A Division JP6766008B2 (ja) 2012-07-19 2017-05-01 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物

Publications (3)

Publication Number Publication Date
JP2015522623A JP2015522623A (ja) 2015-08-06
JP2015522623A5 true JP2015522623A5 (https=) 2016-09-23
JP6141430B2 JP6141430B2 (ja) 2017-06-07

Family

ID=48916211

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015523282A Expired - Fee Related JP6141430B2 (ja) 2012-07-19 2013-07-19 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2017091147A Active JP6766008B2 (ja) 2012-07-19 2017-05-01 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2019096736A Pending JP2019163300A (ja) 2012-07-19 2019-05-23 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017091147A Active JP6766008B2 (ja) 2012-07-19 2017-05-01 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2019096736A Pending JP2019163300A (ja) 2012-07-19 2019-05-23 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物

Country Status (20)

Country Link
US (8) US9180116B2 (https=)
EP (4) EP3176162B1 (https=)
JP (3) JP6141430B2 (https=)
KR (2) KR102131378B1 (https=)
CN (4) CN104583201B (https=)
AU (3) AU2013292356B2 (https=)
CA (2) CA2879507A1 (https=)
CY (1) CY1118929T1 (https=)
DK (2) DK2875022T3 (https=)
ES (3) ES2612921T3 (https=)
HR (1) HRP20170045T1 (https=)
HU (2) HUE031885T2 (https=)
IL (3) IL236637A (https=)
LT (1) LT2875022T (https=)
NZ (2) NZ704171A (https=)
PH (1) PH12015500111A1 (https=)
PL (1) PL2875022T3 (https=)
PT (2) PT3175852T (https=)
SI (1) SI2875022T1 (https=)
WO (2) WO2014015247A1 (https=)

Families Citing this family (8)

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PT2989098T (pt) 2013-03-15 2017-08-16 Cayman Chemical Co Inc Compostos de lactama como agonistas selectivos do receptor ep4 para uso no tratamento de doenças e condições mediadas por ep4
CA2903314C (en) 2013-03-15 2023-02-14 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
KR20160048054A (ko) 2013-07-19 2016-05-03 카이맨 케미칼 컴파니 인코포레이티드 골 성장의 촉진을 위한 방법, 시스템 및 조성물
HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására
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