PL2875022T3 - Związki difluorolaktamowe jako agoniści selektywni względem receptora EP4 do zastosowania w leczeniu chorób i stanów, w których pośredniczy EP4 - Google Patents

Związki difluorolaktamowe jako agoniści selektywni względem receptora EP4 do zastosowania w leczeniu chorób i stanów, w których pośredniczy EP4

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Publication number
PL2875022T3
PL2875022T3 PL13745744T PL13745744T PL2875022T3 PL 2875022 T3 PL2875022 T3 PL 2875022T3 PL 13745744 T PL13745744 T PL 13745744T PL 13745744 T PL13745744 T PL 13745744T PL 2875022 T3 PL2875022 T3 PL 2875022T3
Authority
PL
Poland
Prior art keywords
receptor
treatment
conditions
mediated disease
selective agonists
Prior art date
Application number
PL13745744T
Other languages
English (en)
Polish (pl)
Inventor
Stephen Douglas Barrett
Fred Lawrence Ciske
Joseph Michael Colombo
Gregory William Endres
Bradlee David Germain
Andriy Kornilov
James Bernard Kramer
Adam Uzieblo
Kirk M. Maxey
Original Assignee
Cayman Chemical Company, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cayman Chemical Company, Incorporated filed Critical Cayman Chemical Company, Incorporated
Publication of PL2875022T3 publication Critical patent/PL2875022T3/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
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  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL13745744T 2012-07-19 2013-07-19 Związki difluorolaktamowe jako agoniści selektywni względem receptora EP4 do zastosowania w leczeniu chorób i stanów, w których pośredniczy EP4 PL2875022T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261673514P 2012-07-19 2012-07-19
US201361793929P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
PL2875022T3 true PL2875022T3 (pl) 2017-06-30

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PL13745744T PL2875022T3 (pl) 2012-07-19 2013-07-19 Związki difluorolaktamowe jako agoniści selektywni względem receptora EP4 do zastosowania w leczeniu chorób i stanów, w których pośredniczy EP4

Country Status (20)

Country Link
US (8) US9180116B2 (https=)
EP (4) EP3176162B1 (https=)
JP (3) JP6141430B2 (https=)
KR (2) KR102151578B1 (https=)
CN (4) CN107802623B (https=)
AU (3) AU2013292357C1 (https=)
CA (2) CA2879507A1 (https=)
CY (1) CY1118929T1 (https=)
DK (2) DK2875022T3 (https=)
ES (3) ES2728159T3 (https=)
HR (1) HRP20170045T1 (https=)
HU (2) HUE031885T2 (https=)
IL (3) IL236636A (https=)
LT (1) LT2875022T (https=)
NZ (2) NZ704171A (https=)
PH (1) PH12015500111A1 (https=)
PL (1) PL2875022T3 (https=)
PT (2) PT3175852T (https=)
SI (1) SI2875022T1 (https=)
WO (2) WO2014015246A1 (https=)

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CN107802623B (zh) * 2012-07-19 2020-10-30 开曼化学股份有限公司 用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物
JP6368351B2 (ja) 2013-03-15 2018-08-01 ケイマン ケミカル カンパニー， インコーポレーテッド ジフルオロラクタムアナログを合成する方法
EP3235817B1 (en) 2013-03-15 2018-12-12 Cayman Chemical Company, Incorporated Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
WO2014144610A1 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
JP2016527006A (ja) 2013-07-19 2016-09-08 ケイマン ケミカル カンパニー， インコーポレーテッド 骨成長を促進するための方法、システム、及び組成物
HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására
CN106699604B (zh) * 2017-01-09 2019-01-01 四川同晟生物医药有限公司 一种沙库比曲及其中间体的制备方法
EP3446661B1 (en) 2017-08-21 2021-12-29 Cook Medical Technologies LLC Braided stent crown geometry and flare

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