JP2013507336A5 - - Google Patents
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- Publication number
- JP2013507336A5 JP2013507336A5 JP2012532583A JP2012532583A JP2013507336A5 JP 2013507336 A5 JP2013507336 A5 JP 2013507336A5 JP 2012532583 A JP2012532583 A JP 2012532583A JP 2012532583 A JP2012532583 A JP 2012532583A JP 2013507336 A5 JP2013507336 A5 JP 2013507336A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- alkyl
- hydroxyphenyl
- hydroxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0917576.1 | 2009-10-07 | ||
| GB0917576A GB0917576D0 (en) | 2009-10-07 | 2009-10-07 | Novel estrogenreceptor ligands |
| GB1011859.4 | 2010-07-14 | ||
| GBGB1011859.4A GB201011859D0 (en) | 2010-07-14 | 2010-07-14 | Novel estrogen receptor ligands |
| PCT/EP2010/064941 WO2011042475A1 (en) | 2009-10-07 | 2010-10-06 | Substituted pyrazoles as estrogen receptor ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507336A JP2013507336A (ja) | 2013-03-04 |
| JP2013507336A5 true JP2013507336A5 (https=) | 2013-11-14 |
| JP5735518B2 JP5735518B2 (ja) | 2015-06-17 |
Family
ID=43856389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532583A Expired - Fee Related JP5735518B2 (ja) | 2009-10-07 | 2010-10-06 | エストロゲン受容体リガンドとしての置換ピラゾール |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8653112B2 (https=) |
| EP (1) | EP2486018B1 (https=) |
| JP (1) | JP5735518B2 (https=) |
| CN (1) | CN102648183B (https=) |
| AR (2) | AR078536A1 (https=) |
| DK (1) | DK2486018T3 (https=) |
| ES (1) | ES2737429T3 (https=) |
| IN (1) | IN2012DN02556A (https=) |
| TW (2) | TW201124406A (https=) |
| WO (2) | WO2011042475A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| EP2800745B1 (en) | 2011-12-02 | 2020-02-12 | Phenex Pharmaceuticals AG | Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
| CN102558058B (zh) * | 2012-01-19 | 2014-10-29 | 陕西理工学院 | 1-芳基-3-取代-5-取代氨基-4-吡唑甲酰胺类化合物及其应用 |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| US9944597B2 (en) | 2013-09-16 | 2018-04-17 | The Board Of Regents Of The University Of Texas System | Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof |
| WO2015070366A1 (en) | 2013-11-12 | 2015-05-21 | Merck Sharp & Dohme Corp. | Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug |
| US9974776B2 (en) | 2013-12-05 | 2018-05-22 | Karo Pharma Ab | Estrogen receptor beta agonists for use in treating mesothelioma |
| CN104974091B (zh) * | 2014-04-10 | 2018-01-02 | 沈阳药科大学 | 3‑甲基‑1,5‑二芳基吡唑类化合物及其制备方法和用途 |
| EP3782616B1 (en) | 2014-09-02 | 2023-11-01 | The Regents of The University of California | Estrogen receptor ligand treatment for neurodegenerative diseases |
| WO2016097036A1 (en) * | 2014-12-17 | 2016-06-23 | Karo Bio Ab | Estrogen receptor ligand for use in treating melanoma |
| CN106397377B (zh) * | 2016-09-05 | 2019-04-05 | 中南大学 | 一种富电子五元杂环酸及其衍生物脱羧上氟的方法 |
| CA3062972C (en) | 2017-05-09 | 2021-09-14 | Kind Pharmaceutical | Indolizine derivatives and their application in medicine |
| CN108610246A (zh) * | 2018-06-01 | 2018-10-02 | 山东潍坊润丰化工股份有限公司 | 一种环丙唑醇中间体1-（4-氯苯基）-2-环丙基-1-丙酮的制备方法 |
| WO2021057998A1 (zh) * | 2019-09-29 | 2021-04-01 | 上海森辉医药有限公司 | 一种吡咯并氨基哒嗪酮化合物的制备方法 |
| WO2025087207A1 (zh) | 2023-10-24 | 2025-05-01 | 杭州安道药业有限公司 | 含有缺氧诱导因子-脯酰胺羟基化酶抑制剂的长效口服药物及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5726653A (en) * | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| JPS58208275A (ja) * | 1982-05-20 | 1983-12-03 | Lion Corp | ５−アミノ−ピラゾ−ル誘導体及び該化合物を含有する抗腫瘍剤 |
| US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
| CA2219269A1 (en) * | 1996-10-29 | 1998-04-29 | Novartis Ag | Novel herbicides |
| WO2000007996A2 (en) | 1998-08-07 | 2000-02-17 | Chiron Corporation | Pyrazoles as estrogen receptor modulators |
| AU1199600A (en) * | 1998-10-02 | 2000-04-26 | Board Of Trustees Of The University Of Illinois, The | Estrogen receptor ligands |
| EP1284260A4 (en) * | 2000-05-22 | 2004-03-31 | Takeda Chemical Industries Ltd | TYROSIN PHOSPHATASE INHIBITORS |
| ATE374753T1 (de) | 2001-12-21 | 2007-10-15 | Vernalis Cambridge Ltd | 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| ES2277273T3 (es) * | 2003-05-16 | 2007-07-01 | Wyeth | Derivados de oxima de aril-carbaldehido, y su utilizacion como agentes estrogenicos. |
| US7250440B2 (en) * | 2003-08-12 | 2007-07-31 | Wyeth | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents |
| US20070191336A1 (en) | 2003-12-24 | 2007-08-16 | Flynn Daniel L | Anti-inflammatory medicaments |
| JP2008514608A (ja) | 2004-09-24 | 2008-05-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | スルホンアミド化合物 |
| JP2006316054A (ja) * | 2005-04-15 | 2006-11-24 | Tanabe Seiyaku Co Ltd | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
| JP2006306755A (ja) | 2005-04-27 | 2006-11-09 | Nippon Kayaku Co Ltd | 新規なピラゾール誘導体とそれを有効成分とするｈｓｐ９０阻害剤 |
| EP1889617A1 (en) | 2006-07-11 | 2008-02-20 | Freie Universität Berlin | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents |
| EP2074102A1 (en) | 2006-10-13 | 2009-07-01 | Karo Bio Ab | 2-phenyl indene derivatives useful as estrogen receptor ligands |
| JP2010533668A (ja) | 2007-07-20 | 2010-10-28 | カロ バイオ アクチェブラーグ | 新規エストロゲン受容体リガンド |
| WO2009019278A1 (en) | 2007-08-08 | 2009-02-12 | Neurosearch A/S | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| GB0806656D0 (en) | 2008-04-11 | 2008-05-14 | Karobio Ab | Novel estrogen receptor ligands |
| HUE025471T2 (hu) | 2008-04-16 | 2016-03-29 | Karobio Ab | Új ösztrogén receptor ligandumok |
| GB0817221D0 (en) | 2008-09-19 | 2008-10-29 | Karobio Ab | Novel estrogen receptor ligands |
-
2010
- 2010-10-06 TW TW099133976A patent/TW201124406A/zh unknown
- 2010-10-06 WO PCT/EP2010/064941 patent/WO2011042475A1/en not_active Ceased
- 2010-10-06 CN CN201080055575.3A patent/CN102648183B/zh not_active Expired - Fee Related
- 2010-10-06 WO PCT/EP2010/064944 patent/WO2011042477A1/en not_active Ceased
- 2010-10-06 US US13/500,341 patent/US8653112B2/en not_active Expired - Fee Related
- 2010-10-06 ES ES10760729T patent/ES2737429T3/es active Active
- 2010-10-06 EP EP10760729.3A patent/EP2486018B1/en not_active Not-in-force
- 2010-10-06 AR ARP100103629A patent/AR078536A1/es unknown
- 2010-10-06 IN IN2556DEN2012 patent/IN2012DN02556A/en unknown
- 2010-10-06 TW TW099133977A patent/TW201124409A/zh unknown
- 2010-10-06 JP JP2012532583A patent/JP5735518B2/ja not_active Expired - Fee Related
- 2010-10-06 DK DK10760729.3T patent/DK2486018T3/da active
- 2010-10-06 AR ARP100103631A patent/AR078538A1/es unknown
-
2014
- 2014-01-10 US US14/152,584 patent/US8921402B2/en not_active Expired - Fee Related
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