JP2015521466A5 - - Google Patents
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- JP2015521466A5 JP2015521466A5 JP2015516728A JP2015516728A JP2015521466A5 JP 2015521466 A5 JP2015521466 A5 JP 2015521466A5 JP 2015516728 A JP2015516728 A JP 2015516728A JP 2015516728 A JP2015516728 A JP 2015516728A JP 2015521466 A5 JP2015521466 A5 JP 2015521466A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- region
- fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660232P | 2012-06-15 | 2012-06-15 | |
| US61/660,232 | 2012-06-15 | ||
| PCT/IB2013/054810 WO2013186719A1 (en) | 2012-06-15 | 2013-06-12 | Improved antagonist antibodies against gdf-8 and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209932A Division JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521466A JP2015521466A (ja) | 2015-07-30 |
| JP2015521466A5 true JP2015521466A5 (enExample) | 2016-07-28 |
| JP6433889B2 JP6433889B2 (ja) | 2018-12-05 |
Family
ID=48914383
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516728A Expired - Fee Related JP6433889B2 (ja) | 2012-06-15 | 2013-06-12 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2018209932A Pending JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2020124373A Withdrawn JP2021001170A (ja) | 2012-06-15 | 2020-07-21 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209932A Pending JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2020124373A Withdrawn JP2021001170A (ja) | 2012-06-15 | 2020-07-21 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8992913B2 (enExample) |
| EP (1) | EP2861617A1 (enExample) |
| JP (3) | JP6433889B2 (enExample) |
| KR (1) | KR101704893B1 (enExample) |
| CN (1) | CN104487453B (enExample) |
| AR (1) | AR093217A1 (enExample) |
| AU (1) | AU2013276131B2 (enExample) |
| CA (1) | CA2876397C (enExample) |
| CO (1) | CO7151524A2 (enExample) |
| IL (1) | IL236289A0 (enExample) |
| MX (1) | MX364738B (enExample) |
| MY (1) | MY177331A (enExample) |
| NZ (1) | NZ702269A (enExample) |
| PE (1) | PE20150223A1 (enExample) |
| PH (1) | PH12014502698B1 (enExample) |
| RU (1) | RU2630634C2 (enExample) |
| SA (1) | SA113340642B1 (enExample) |
| SG (1) | SG11201408042YA (enExample) |
| TW (1) | TWI495643B (enExample) |
| WO (1) | WO2013186719A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| WO2013074557A1 (en) | 2011-11-14 | 2013-05-23 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
| KR101704893B1 (ko) * | 2012-06-15 | 2017-02-08 | 화이자 인코포레이티드 | Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도 |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| WO2014030728A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | FcγRIIb特異的Fc領域改変体 |
| PL3564258T3 (pl) | 2012-09-13 | 2021-10-25 | Bristol-Myers Squibb Company | Oparte na fibronektynie białka z domeną rusztowania, które wiążą się z miostatyną |
| ES2715710T3 (es) | 2013-01-25 | 2019-06-05 | Shire Human Genetic Therapies | Folistatina en el tratamiento de la distrofía muscular de Duchenne |
| CN113621057A (zh) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc区变体 |
| PL2981822T3 (pl) | 2013-05-06 | 2021-07-12 | Scholar Rock, Inc. | Kompozycje i sposoby modulacji czynnika wzrostu |
| TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| US9994641B2 (en) * | 2013-12-25 | 2018-06-12 | Jcr Pharmaceuticals Co., Ltd. | Anti-human transferrin receptor antibody that passes through blood-brain barrier |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| IL278014B2 (en) | 2014-12-19 | 2023-10-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use |
| CN104829728B (zh) * | 2015-01-21 | 2019-03-12 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体her2xcd3的构建及应用 |
| SG10201907215QA (en) | 2015-02-05 | 2019-09-27 | Chugai Pharmaceutical Co Ltd | Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof |
| DK3277321T3 (da) | 2015-04-01 | 2024-09-02 | Anaptysbio Inc | Antistoffer, der er rettet mod T-celle-immunglobulin og mucin-protein 3 (TIM-3) |
| EP3283519A1 (en) | 2015-04-15 | 2018-02-21 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| PL3350220T3 (pl) | 2015-09-15 | 2022-01-03 | Scholar Rock, Inc. | Przeciwciała przeciwko pro/latentnej miostatynie i ich zastosowania |
| CA3002422C (en) | 2015-12-18 | 2024-04-16 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE |
| AU2017206069A1 (en) | 2016-01-08 | 2018-07-19 | Scholar Rock, Inc. | Anti-pro/latent myostatin antibodies and methods of use thereof |
| CN109069638B (zh) | 2016-03-24 | 2022-03-29 | 璟尚生物制药公司 | 用于癌症治疗的三特异性抑制剂 |
| PT3368069T (pt) * | 2016-06-13 | 2020-11-11 | Scholar Rock Inc | Uso de inibidores da miostatina e terapias de combinação |
| KR102376582B1 (ko) | 2016-06-17 | 2022-03-18 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체 및 사용 방법 |
| CA2971303A1 (en) | 2016-06-21 | 2017-12-21 | Bamboo Therapeutics, Inc. | Optimized mini-dystrophin genes and expression cassettes and their use |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| MA46113A (fr) | 2016-11-01 | 2019-07-10 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de lymphocyte t et la protéine 3 de mucine (tim-3) |
| EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| SI3565592T1 (sl) | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| TWI841209B (zh) | 2017-01-09 | 2024-05-01 | 美商提薩羅有限公司 | 用抗tim-3抗體治療癌症之方法 |
| US12083148B2 (en) | 2017-02-22 | 2024-09-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | IL13Ra2-binding chimeric antigen receptors |
| IL321873A (en) | 2018-03-01 | 2025-08-01 | Regeneron Pharma | Methods for altering body composition |
| CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制剂的开发和应用 |
| US11001635B2 (en) | 2018-06-29 | 2021-05-11 | Gensun Biopharma Inc. | Antitumor antagonists |
| CA3144864A1 (en) | 2019-06-27 | 2020-12-30 | Pfizer Inc. | Methods of treating duchenne muscular dystrophy using aav mini-dystrophin gene therapy |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| GB2595299B (en) | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| MX2023004598A (es) * | 2020-10-23 | 2023-06-29 | Asher Biotherapeutics Inc | Fusiones con moléculas de unión al antígeno cd8 para modular la función de las células inmunitarias. |
| WO2022106976A1 (en) | 2020-11-18 | 2022-05-27 | Pfizer Inc. | Stable pharmaceutical formulations of soluble fgfr3 decoys |
| KR20240024829A (ko) | 2021-05-19 | 2024-02-26 | 애셔 바이오테라퓨틱스, 인크. | Il-21 폴리펩타이드 및 표적화된 작제물 |
| WO2022271867A1 (en) | 2021-06-23 | 2022-12-29 | Scholar Rock, Inc. | A myostatin pathway inhibitor in combination with a glp-1 pathway activator for use in treating metabolic disorders |
| WO2023196957A2 (en) * | 2022-04-08 | 2023-10-12 | The Wistar Institute Of Anatomy And Biology | Bispecific t cell engagers targeting tumor antigens |
| WO2024064842A1 (en) * | 2022-09-21 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Methods of treating obesity, diabetes, and liver dysfunction |
| KR20250122524A (ko) | 2022-12-22 | 2025-08-13 | 스칼러 락, 인크. | 미오스타틴 활성화의 선택적이고 강력한 억제 항체 |
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| KR101704893B1 (ko) * | 2012-06-15 | 2017-02-08 | 화이자 인코포레이티드 | Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도 |
-
2013
- 2013-06-12 KR KR1020147034989A patent/KR101704893B1/ko not_active Expired - Fee Related
- 2013-06-12 RU RU2014150433A patent/RU2630634C2/ru active
- 2013-06-12 AU AU2013276131A patent/AU2013276131B2/en not_active Ceased
- 2013-06-12 MX MX2014014995A patent/MX364738B/es active IP Right Grant
- 2013-06-12 SA SA113340642A patent/SA113340642B1/ar unknown
- 2013-06-12 CA CA2876397A patent/CA2876397C/en not_active Expired - Fee Related
- 2013-06-12 MY MYPI2014703762A patent/MY177331A/en unknown
- 2013-06-12 PE PE2014002435A patent/PE20150223A1/es active IP Right Grant
- 2013-06-12 SG SG11201408042YA patent/SG11201408042YA/en unknown
- 2013-06-12 WO PCT/IB2013/054810 patent/WO2013186719A1/en not_active Ceased
- 2013-06-12 NZ NZ702269A patent/NZ702269A/en not_active IP Right Cessation
- 2013-06-12 US US13/916,379 patent/US8992913B2/en not_active Expired - Fee Related
- 2013-06-12 EP EP13744828.8A patent/EP2861617A1/en not_active Withdrawn
- 2013-06-12 JP JP2015516728A patent/JP6433889B2/ja not_active Expired - Fee Related
- 2013-06-12 CN CN201380030753.0A patent/CN104487453B/zh not_active Expired - Fee Related
- 2013-06-14 AR ARP130102122A patent/AR093217A1/es unknown
- 2013-06-14 TW TW102121200A patent/TWI495643B/zh not_active IP Right Cessation
-
2014
- 2014-11-27 CO CO14261553A patent/CO7151524A2/es unknown
- 2014-12-03 PH PH12014502698A patent/PH12014502698B1/en unknown
- 2014-12-15 IL IL236289A patent/IL236289A0/en active IP Right Grant
-
2015
- 2015-02-19 US US14/626,321 patent/US9751937B2/en not_active Expired - Fee Related
-
2017
- 2017-08-01 US US15/666,317 patent/US20180057579A1/en not_active Abandoned
-
2018
- 2018-11-07 JP JP2018209932A patent/JP2019059738A/ja active Pending
-
2019
- 2019-11-13 US US16/682,437 patent/US20200277365A1/en not_active Abandoned
-
2020
- 2020-07-21 JP JP2020124373A patent/JP2021001170A/ja not_active Withdrawn
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