JP2019201643A5 - - Google Patents
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- Publication number
- JP2019201643A5 JP2019201643A5 JP2019111990A JP2019111990A JP2019201643A5 JP 2019201643 A5 JP2019201643 A5 JP 2019201643A5 JP 2019111990 A JP2019111990 A JP 2019111990A JP 2019111990 A JP2019111990 A JP 2019111990A JP 2019201643 A5 JP2019201643 A5 JP 2019201643A5
- Authority
- JP
- Japan
- Prior art keywords
- isolated antibody
- functional fragment
- antibody
- domain
- collection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012634 fragment Substances 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021169020A JP2022028659A (ja) | 2013-06-26 | 2021-10-14 | 新規抗体フレームワーク |
| JP2023199881A JP2024026176A (ja) | 2013-06-26 | 2023-11-27 | 新規抗体フレームワーク |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003264.2 | 2013-06-26 | ||
| EP13003264 | 2013-06-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522319A Division JP6708544B2 (ja) | 2013-06-26 | 2014-06-26 | 新規抗体フレームワーク |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169020A Division JP2022028659A (ja) | 2013-06-26 | 2021-10-14 | 新規抗体フレームワーク |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019201643A JP2019201643A (ja) | 2019-11-28 |
| JP2019201643A5 true JP2019201643A5 (enExample) | 2020-01-16 |
Family
ID=48699516
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522319A Active JP6708544B2 (ja) | 2013-06-26 | 2014-06-26 | 新規抗体フレームワーク |
| JP2019111990A Withdrawn JP2019201643A (ja) | 2013-06-26 | 2019-06-17 | 新規抗体フレームワーク |
| JP2021169020A Pending JP2022028659A (ja) | 2013-06-26 | 2021-10-14 | 新規抗体フレームワーク |
| JP2023199881A Pending JP2024026176A (ja) | 2013-06-26 | 2023-11-27 | 新規抗体フレームワーク |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522319A Active JP6708544B2 (ja) | 2013-06-26 | 2014-06-26 | 新規抗体フレームワーク |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169020A Pending JP2022028659A (ja) | 2013-06-26 | 2021-10-14 | 新規抗体フレームワーク |
| JP2023199881A Pending JP2024026176A (ja) | 2013-06-26 | 2023-11-27 | 新規抗体フレームワーク |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10174102B2 (enExample) |
| EP (1) | EP3013864A1 (enExample) |
| JP (4) | JP6708544B2 (enExample) |
| KR (4) | KR20240000622A (enExample) |
| CN (2) | CN113943366B (enExample) |
| AU (2) | AU2014301629B2 (enExample) |
| CA (1) | CA2914829A1 (enExample) |
| HK (1) | HK1218549A1 (enExample) |
| IL (3) | IL313351A (enExample) |
| NZ (1) | NZ714320A (enExample) |
| SG (2) | SG11201509899PA (enExample) |
| WO (1) | WO2014206561A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174102B2 (en) | 2013-06-26 | 2019-01-08 | Numab Innovation Ag | Antibody frameworks |
| WO2016202457A1 (en) | 2015-06-15 | 2016-12-22 | Numab Ag | Hetero-dimeric multi-specific antibody format |
| US11434294B2 (en) | 2016-02-25 | 2022-09-06 | Cell Medica, Inc. | Binding members to PD-L1 |
| DK3219726T3 (da) | 2016-03-17 | 2020-12-07 | Tillotts Pharma Ag | Anti-TNF-alfa-antistoffer og funktionelle fragmenter deraf |
| BR112018017276A2 (pt) | 2016-03-17 | 2019-02-05 | Numab Innovation Ag | anticorpos anti-tnf-alfa e fragmentos funcionais dos mesmos |
| RS61412B1 (sr) | 2016-03-17 | 2021-03-31 | Tillotts Pharma Ag | Anti-tnf alfa-antitela i njihovi funkcionalni fragmenti |
| CA3016870A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnf.alpha.-antibodies and functional fragments thereof |
| BR112018017165A2 (pt) | 2016-03-17 | 2019-01-02 | Numab Innovation Ag | anticorpos anti-tnf-alfa e fragmentos funcionais dos mesmos |
| GB201621591D0 (en) * | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Antibody molecules and method |
| WO2018224441A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
| KR102651965B1 (ko) | 2017-06-05 | 2024-03-28 | 누맙 세러퓨틱스 아게 | 신규 항 cd3 항체 |
| WO2018224443A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Hetero-dimeric multi-specific antibody format targeting at least cd3 and hsa |
| WO2018224439A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-hsa antibodies |
| AU2018280679B2 (en) * | 2017-06-05 | 2025-04-24 | Numab Therapeutics AG | Novel anti-HSA antibodies |
| US11787863B2 (en) * | 2017-06-25 | 2023-10-17 | Systimmune, Inc. | Multi-specific antibodies and methods of making and using thereof |
| JP7474193B2 (ja) * | 2017-06-25 | 2024-04-24 | システィミューン， インク． | 多重特異性抗体とその作製及び使用方法 |
| EP3459968A1 (en) | 2017-09-20 | 2019-03-27 | Numab Innovation AG | Novel stable antibody variable domain framework combinations |
| IL320091A (en) | 2019-01-31 | 2025-06-01 | Numab Therapeutics AG | Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof |
| EP3689907A1 (en) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Antibodies targeting il-17a and methods of use thereof |
| CA3203552A1 (en) * | 2020-12-30 | 2022-07-07 | Ascendo Biotechnology, Inc. | Monoclonal antibody against human mac-1 and uses thereof |
| KR20230146053A (ko) | 2021-02-12 | 2023-10-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 보체 c3 항원 결합 단백질 |
| US12467094B2 (en) | 2021-03-11 | 2025-11-11 | IgGenix, Inc. | Methods and systems for predicting allergic response |
| JP2024546183A (ja) | 2021-12-22 | 2024-12-17 | ツェーデーエァ－ライフ アクチェンゲゼルシャフト | 抗ｃ３抗体及びその抗原結合性断片並びに眼科疾患又は眼疾患を処置するためのそれらの使用 |
| EP4611774A2 (en) * | 2022-11-04 | 2025-09-10 | MiNK Therapeutics, Inc. | B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| US20050033031A1 (en) | 2003-08-07 | 2005-02-10 | Couto Fernando Jose Rebelo Do | Methods for humanizing rabbit monoclonal antibodies |
| WO2008004834A1 (en) | 2006-07-06 | 2008-01-10 | Isu Abxis Co., Ltd | Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor |
| FR2910896B1 (fr) * | 2006-12-29 | 2012-11-16 | Lab Francais Du Fractionnement | Anticorps monoclonal dirige contre le recepteur humain des ldl |
| NZ581418A (en) | 2007-05-21 | 2012-08-31 | Alderbio Holdings Llc | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| JP5611820B2 (ja) | 2007-06-25 | 2014-10-22 | エスバテック − ア ノバルティスカンパニー エルエルシー | 抗体の修飾方法並びに改善された機能特性を有する修飾された抗体 |
| EP3628686B1 (en) | 2008-06-25 | 2021-07-21 | Novartis AG | Humanization of rabbit antibodies using a universal antibody framework |
| MX347972B (es) | 2008-06-25 | 2017-05-22 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles que inhiben el vegf. |
| CA2727992C (en) | 2008-06-25 | 2017-10-17 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting tnf.alpha. |
| WO2010144780A1 (en) | 2009-06-12 | 2010-12-16 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
| KR20130098161A (ko) * | 2010-04-30 | 2013-09-04 | 알렉시온 파마슈티칼스, 인코포레이티드 | 인간에서 감소된 면역원성을 갖는 항체 |
| WO2012163519A1 (en) * | 2011-05-27 | 2012-12-06 | Dutalys | Antibodies with improved folding stability |
| US10174102B2 (en) | 2013-06-26 | 2019-01-08 | Numab Innovation Ag | Antibody frameworks |
| EP3459968A1 (en) | 2017-09-20 | 2019-03-27 | Numab Innovation AG | Novel stable antibody variable domain framework combinations |
-
2014
- 2014-06-26 US US14/900,550 patent/US10174102B2/en active Active
- 2014-06-26 KR KR1020237043185A patent/KR20240000622A/ko active Pending
- 2014-06-26 AU AU2014301629A patent/AU2014301629B2/en active Active
- 2014-06-26 KR KR1020167001339A patent/KR102286053B1/ko active Active
- 2014-06-26 KR KR1020227006072A patent/KR20220029763A/ko not_active Ceased
- 2014-06-26 IL IL313351A patent/IL313351A/en unknown
- 2014-06-26 CN CN202111136784.7A patent/CN113943366B/zh active Active
- 2014-06-26 SG SG11201509899PA patent/SG11201509899PA/en unknown
- 2014-06-26 IL IL243311A patent/IL243311B/en unknown
- 2014-06-26 IL IL293477A patent/IL293477B2/en unknown
- 2014-06-26 CA CA2914829A patent/CA2914829A1/en active Pending
- 2014-06-26 SG SG10201811017QA patent/SG10201811017QA/en unknown
- 2014-06-26 HK HK16106054.2A patent/HK1218549A1/zh unknown
- 2014-06-26 CN CN201480036689.1A patent/CN105579472B/zh active Active
- 2014-06-26 JP JP2016522319A patent/JP6708544B2/ja active Active
- 2014-06-26 NZ NZ714320A patent/NZ714320A/en unknown
- 2014-06-26 WO PCT/EP2014/001730 patent/WO2014206561A1/en not_active Ceased
- 2014-06-26 KR KR1020217024096A patent/KR20210097829A/ko not_active Ceased
- 2014-06-26 EP EP14737144.7A patent/EP3013864A1/en active Pending
-
2018
- 2018-10-10 US US16/156,036 patent/US11427628B2/en active Active
-
2019
- 2019-06-17 JP JP2019111990A patent/JP2019201643A/ja not_active Withdrawn
-
2020
- 2020-04-27 AU AU2020202770A patent/AU2020202770B2/en active Active
-
2021
- 2021-10-14 JP JP2021169020A patent/JP2022028659A/ja active Pending
-
2022
- 2022-08-29 US US17/822,959 patent/US20230212265A1/en active Pending
-
2023
- 2023-11-27 JP JP2023199881A patent/JP2024026176A/ja active Pending
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