JP2015521209A5 - - Google Patents
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- Publication number
- JP2015521209A5 JP2015521209A5 JP2015505699A JP2015505699A JP2015521209A5 JP 2015521209 A5 JP2015521209 A5 JP 2015521209A5 JP 2015505699 A JP2015505699 A JP 2015505699A JP 2015505699 A JP2015505699 A JP 2015505699A JP 2015521209 A5 JP2015521209 A5 JP 2015521209A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- cellulose ether
- methyl
- esterified cellulose
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920003086 cellulose ether Polymers 0.000 claims 12
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000007962 solid dispersion Substances 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- -1 aliphatic monocarboxylic acid Chemical class 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000007894 caplet Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622754P | 2012-04-11 | 2012-04-11 | |
| US61/622,754 | 2012-04-11 | ||
| PCT/US2012/061586 WO2013154607A1 (en) | 2012-04-11 | 2012-10-24 | Esterified cellulose ethers having a specific substituent distribution |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521209A JP2015521209A (ja) | 2015-07-27 |
| JP2015521209A5 true JP2015521209A5 (https=) | 2015-09-03 |
| JP6133969B2 JP6133969B2 (ja) | 2017-05-24 |
Family
ID=47146713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505699A Expired - Fee Related JP6133969B2 (ja) | 2012-04-11 | 2012-10-24 | 特定の置換基分布を有するエステル化セルロースエーテル |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9320799B2 (https=) |
| EP (1) | EP2836205B1 (https=) |
| JP (1) | JP6133969B2 (https=) |
| KR (1) | KR20140146181A (https=) |
| CN (1) | CN104427979B (https=) |
| WO (1) | WO2013154607A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015021179B1 (pt) | 2013-03-01 | 2021-11-30 | Hercules Incorporated | Polímero para melhor desempenho de fármaco e melhor processabilidade, composição compreendendo um fármaco e um polímero e método para a produção de acetato succinato de hidroxipropilmetilcelulose |
| JP6267239B2 (ja) * | 2013-03-07 | 2018-01-24 | ダウ グローバル テクノロジーズ エルエルシー | 極めて低粘度の新規エステル化セルロースエーテル |
| EP2964203B1 (en) * | 2013-03-07 | 2019-04-03 | Dow Global Technologies LLC | Novel esterified cellulose ethers of very high molecular weight |
| WO2014186185A1 (en) * | 2013-05-14 | 2014-11-20 | Dow Global Technologies Llc | Cellulose ethers esterified with dicarboxylic acids |
| KR102286952B1 (ko) | 2013-12-31 | 2021-08-09 | 롯데정밀화학 주식회사 | 입도분포가 조절된 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(hpmcas) 입자의 제조방법 및 hpmcas 분말 |
| JP2017505847A (ja) * | 2014-02-20 | 2017-02-23 | ダウ グローバル テクノロジーズ エルエルシー | 新規の高分子量及び高均一性のエステル化セルロースエーテル |
| WO2015179072A1 (en) * | 2014-05-20 | 2015-11-26 | Dow Global Technologies Llc | Dispersion comprising a partially neutralized esterified cellulose ether |
| JP7044550B2 (ja) * | 2014-08-27 | 2022-03-30 | ニュートリション アンド バイオサイエンシズ ユーエスエー １，リミティド ライアビリティ カンパニー | アセトン不溶性含有量の低いエステル化セルロースエーテル |
| JP6203702B2 (ja) | 2014-11-18 | 2017-09-27 | 信越化学工業株式会社 | ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法 |
| MX2017011096A (es) * | 2015-03-16 | 2017-11-10 | Dow Global Technologies Llc | Solucion acuosa de un eter de celulosa esterificado. |
| US10377835B2 (en) * | 2015-03-16 | 2019-08-13 | Dow Global Technologies Llc | Water-soluble esterified cellulose ethers |
| KR20170128349A (ko) * | 2015-03-16 | 2017-11-22 | 다우 글로벌 테크놀로지스 엘엘씨 | 지방족 카복실산의 존재하에서의 에스테르화된 셀룰로오스 에테르의 제조 방법 |
| EP3270970B1 (en) | 2015-03-16 | 2019-01-09 | Dow Global Technologies LLC | Gelling esterified cellulose ethers |
| US10214594B2 (en) | 2015-03-16 | 2019-02-26 | Dow Global Technologies Llc | Water-soluble esterified cellulose ethers having a low degree of neutralization |
| KR20180008524A (ko) * | 2015-05-15 | 2018-01-24 | 다우 글로벌 테크놀로지스 엘엘씨 | 초고분자량 및 저점도의 에스테르화된 셀룰로오스 에테르의 제조 방법 |
| US10577432B2 (en) | 2015-06-05 | 2020-03-03 | Dow Global Technologies Llc | Cellulose ether powders |
| CN107667121A (zh) * | 2015-06-05 | 2018-02-06 | 陶氏环球技术有限责任公司 | 纤维素醚粉末 |
| WO2017053337A1 (en) * | 2015-09-24 | 2017-03-30 | Dow Global Technologies Llc | Process for preparing an ester of a cellulose ether in the presence of acetic acid and a reaction catalyst |
| CN108026184B (zh) * | 2015-10-02 | 2020-09-15 | 陶氏环球技术有限责任公司 | 包含分散的酯化纤维素醚的水性组合物 |
| US9884922B2 (en) * | 2016-03-11 | 2018-02-06 | Shin-Etsu Chemical Co., Ltd. | Hypromellose acetate succinate, method for producing the same and composition containing the same |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| US20210115161A1 (en) * | 2017-03-17 | 2021-04-22 | Dow Global Technologies Llc | Process for Recovering an Esterified Cellulose Ether from a Reaction Product Mixture |
| WO2019036123A1 (en) * | 2017-08-16 | 2019-02-21 | Dow Global Technologies Llc | PROCESS FOR THE CONTROLLED PREPARATION OF LOW MOLECULAR WEIGHT CELLULOSE ETHER |
| US20220088037A1 (en) * | 2018-12-18 | 2022-03-24 | DDP Specialty Electronic Materials US, Inc. | A sustained release composition comprising a hydroxyalkyl methylcellulose |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| JP7128782B2 (ja) | 2019-08-09 | 2022-08-31 | 信越化学工業株式会社 | エアゾール食品用組成物、ヒドロキシプロピルメチルセルロース及びヒドロキシプロピルメチルセルロースの製造方法 |
| CN112704671B (zh) * | 2020-12-28 | 2022-04-19 | 普洛药业股份有限公司 | 一种阿莫西林克拉维酸钾胶囊及其制备方法 |
| EP4387732A4 (en) | 2021-08-19 | 2025-09-03 | Phenom Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARS-CoV-2 |
| KR102735401B1 (ko) * | 2021-08-26 | 2024-11-29 | 뉴트리션 ＆ 바이오사이언시즈 유에스에이 1, 엘엘씨 | 신규 하이드록시알킬 메틸셀룰로스 및 이의 용도 |
| CN114805787B (zh) * | 2022-02-24 | 2023-09-12 | 南京林业大学 | 一种纤维素基聚醚多元醇脂肪酸酯增塑剂及其制备方法和应用 |
| CN117659214A (zh) * | 2023-10-16 | 2024-03-08 | 武汉理工大学 | 一种羟丙甲基纤维素的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3435027A (en) | 1965-12-13 | 1969-03-25 | Hercules Inc | Cellulose ether-esters and process |
| US4226981A (en) | 1977-09-28 | 1980-10-07 | Shin-Etsu Chemical Co., Ltd. | Ether-ester derivatives of cellulose and their applications |
| DE2917104A1 (de) | 1979-04-27 | 1980-11-06 | Hoechst Ag | Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung |
| US4365060A (en) | 1979-04-28 | 1982-12-21 | Shin-Etsu Chemical Co. Ltd. | Enterosoluble capsules |
| JPS6225101A (ja) | 1985-07-24 | 1987-02-03 | Shin Etsu Chem Co Ltd | 低重合度セルロ−スエ−テルの製造方法 |
| JPS6281402A (ja) | 1985-10-07 | 1987-04-14 | Shin Etsu Chem Co Ltd | セルロ−スエ−テル酸性ジカルボン酸エステルの製造方法 |
| JP2916238B2 (ja) * | 1990-10-16 | 1999-07-05 | 旭化成工業株式会社 | アルキルセルロースの製造方法 |
| US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| JP3002916B2 (ja) * | 1991-10-29 | 2000-01-24 | ダイセル化学工業株式会社 | セルロース混合エーテルの製造法 |
| JP2872951B2 (ja) * | 1995-11-07 | 1999-03-24 | 第一工業製薬株式会社 | カルボキシメチルセルロースナトリウム塩 |
| JP3996653B2 (ja) * | 1996-01-26 | 2007-10-24 | 信越化学工業株式会社 | 置換度分布が制御されたヒドロキシプロピルセルロース |
| US6261218B1 (en) | 1998-12-01 | 2001-07-17 | The Dow Chemical Company | Process and apparatus for making low molecular weight cellulose ethers |
| DE10141680B4 (de) | 2001-08-25 | 2004-02-26 | Clariant Gmbh | Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern |
| WO2005115330A2 (en) | 2004-05-28 | 2005-12-08 | Pfizer Products Inc. | Pharmaceutical compositions with enhanced performance |
| JP2011074113A (ja) * | 2009-09-29 | 2011-04-14 | Toray Ind Inc | セルロース混合エステルおよびその製造方法 |
| JP5792807B2 (ja) | 2010-06-14 | 2015-10-14 | ダウ グローバル テクノロジーズ エルエルシー | アセテートおよびサクシネートの置換が向上されたヒドロキシプロピルメチルセルロースアセテートサクシネート |
| WO2015047762A1 (en) | 2013-09-25 | 2015-04-02 | Dow Global Technologies Llc | Composition for application to a mucosa comprising a cellulose ether |
-
2012
- 2012-10-24 EP EP12783771.4A patent/EP2836205B1/en not_active Revoked
- 2012-10-24 JP JP2015505699A patent/JP6133969B2/ja not_active Expired - Fee Related
- 2012-10-24 WO PCT/US2012/061586 patent/WO2013154607A1/en not_active Ceased
- 2012-10-24 US US14/390,041 patent/US9320799B2/en not_active Expired - Fee Related
- 2012-10-24 KR KR1020147031594A patent/KR20140146181A/ko not_active Ceased
- 2012-10-24 CN CN201280072177.1A patent/CN104427979B/zh not_active Expired - Fee Related
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