JP2015520154A5 - - Google Patents

Download PDF

Info

Publication number
JP2015520154A5
JP2015520154A5 JP2015511951A JP2015511951A JP2015520154A5 JP 2015520154 A5 JP2015520154 A5 JP 2015520154A5 JP 2015511951 A JP2015511951 A JP 2015511951A JP 2015511951 A JP2015511951 A JP 2015511951A JP 2015520154 A5 JP2015520154 A5 JP 2015520154A5
Authority
JP
Japan
Prior art keywords
chung
kim
pain
pharmacologically active
monoeuropathy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015511951A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015520154A (ja
JP6116672B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2013/001464 external-priority patent/WO2013170965A1/en
Publication of JP2015520154A publication Critical patent/JP2015520154A/ja
Publication of JP2015520154A5 publication Critical patent/JP2015520154A5/ja
Application granted granted Critical
Publication of JP6116672B2 publication Critical patent/JP6116672B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015511951A 2012-05-18 2013-05-16 (1r,4r)−6’−フルオロ−N,N−ジメチル−4−フェニル−4’,9’−ジヒドロ−3’H−スピロ[シクロヘキサン−1,1’−ピラノ[3,4,b]インドール]−4−アミンおよび抗うつ薬を含む医薬組成物 Active JP6116672B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003937.5 2012-05-18
EP12003937 2012-05-18
PCT/EP2013/001464 WO2013170965A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants

Publications (3)

Publication Number Publication Date
JP2015520154A JP2015520154A (ja) 2015-07-16
JP2015520154A5 true JP2015520154A5 (https=) 2016-06-02
JP6116672B2 JP6116672B2 (ja) 2017-04-19

Family

ID=48446243

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015511951A Active JP6116672B2 (ja) 2012-05-18 2013-05-16 (1r,4r)−6’−フルオロ−N,N−ジメチル−4−フェニル−4’,9’−ジヒドロ−3’H−スピロ[シクロヘキサン−1,1’−ピラノ[3,4,b]インドール]−4−アミンおよび抗うつ薬を含む医薬組成物

Country Status (22)

Country Link
US (2) US20130310385A1 (https=)
EP (1) EP2849744B1 (https=)
JP (1) JP6116672B2 (https=)
CN (1) CN104271131A (https=)
AU (1) AU2013262071B2 (https=)
BR (1) BR112014028562A2 (https=)
CA (1) CA2873634A1 (https=)
CY (1) CY1119825T1 (https=)
DK (1) DK2849744T3 (https=)
EA (1) EA027268B1 (https=)
ES (1) ES2660461T3 (https=)
HR (1) HRP20171922T1 (https=)
HU (1) HUE037746T2 (https=)
IL (1) IL235657B (https=)
LT (1) LT2849744T (https=)
MX (1) MX354684B (https=)
NO (1) NO2849744T3 (https=)
PL (1) PL2849744T3 (https=)
PT (1) PT2849744T (https=)
RS (1) RS56856B1 (https=)
SI (1) SI2849744T1 (https=)
WO (1) WO2013170965A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246418C1 (ru) * 2003-06-19 2005-02-20 Общество с ограниченной ответственностью "ТехноМастер" Усилитель щитка передка кузова легкового автомобиля
CA2974578C (en) 2015-01-23 2020-11-17 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3273329D1 (en) 1981-06-26 1986-10-23 Upjohn Co Analgesic process and composition
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4404208A (en) 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and tiflamizole
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
DE3665538D1 (en) 1985-01-23 1989-10-19 Asta Pharma Ag Synergistic combination of flupirtin and non-steroidal anti-phlogistics
ES2098264T3 (es) 1989-05-22 1997-05-01 Biochemical Veterinary Res Sales metalicas divalentes de indometacina.
US5708035A (en) * 1991-02-04 1998-01-13 Sepracor Inc. Methods of use and compositions of R(-) fluoxetine
KR940701249A (ko) 1991-07-04 1994-05-28 우에하라 아키라 진통제
JPH05221857A (ja) 1992-02-14 1993-08-31 Arakusu:Kk 配合解熱鎮痛剤
US5472711A (en) 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
US5330761A (en) 1993-01-29 1994-07-19 Edward Mendell Co. Inc. Bioadhesive tablet for non-systemic use products
JPH08511522A (ja) 1993-06-07 1996-12-03 メルク エンド カンパニー インコーポレーテッド ニューロキニンアンタゴニストとしてのスピロ置換アザ環
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5399362A (en) 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
US20030056896A1 (en) 1995-05-12 2003-03-27 Frank Jao Effective therapy for epilepsies
US5914129A (en) 1996-07-23 1999-06-22 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
ATE232382T1 (de) 1998-09-10 2003-02-15 Nycomed Danmark As Pharmazeutische zusammensetzungen mit schneller freisetzung von wirkstoffen
ATE234090T1 (de) 1998-11-13 2003-03-15 Lilly Co Eli Kombination von duloxetin mit nichtsteroid- entzündungshemmern für die behandlung von schmerz
US6117900A (en) 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
AU2001288110A1 (en) 2000-09-27 2002-04-08 Takeda Chemical Industries Ltd. Spiro compounds
EP1219304B1 (de) 2000-12-28 2004-10-20 Fresenius Kabi Austria GmbH Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung
WO2003064425A1 (en) 2002-01-28 2003-08-07 Pfizer Japan Inc. N-substituted spiropiperidine compounds as ligands for orl-1 receptor
EP1374906B1 (en) 2002-06-17 2007-04-18 CHIESI FARMACEUTICI S.p.A. A process for the preparation of piroxicam: beta-cyclodextrin inclusion compounds
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
WO2004047844A1 (en) 2002-11-26 2004-06-10 Alexza Pharmaceuticals, Inc. Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
DE10257824B4 (de) 2002-12-10 2004-11-11 Kochem, Hans-Günter, Dr. Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen
US20100297252A1 (en) 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US7132452B2 (en) 2003-03-10 2006-11-07 Fang-Yu Lee Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
US20040222123A1 (en) 2003-05-06 2004-11-11 Barr Laboratories, Inc. Kit for pharmaceuticals
CN1245379C (zh) 2003-10-30 2006-03-15 曹桂东 加巴喷丁的制法
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
GB0412878D0 (en) * 2004-06-09 2004-07-14 Pfizer Ltd Use
BRPI0511941A (pt) 2004-06-09 2008-01-22 Pfizer uso de (s, s)-reboxetina ou reboxetina racêmica
EP1893610A2 (en) 2005-06-17 2008-03-05 Pfizer, Inc. Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists
US8093408B2 (en) * 2005-06-21 2012-01-10 The Company Wockhardt Antidepressant oral pharmaceutical compositions
CN105561311B (zh) 2006-04-28 2019-07-16 格吕伦塔尔有限公司 包含3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和nsaid的药物组合物
RU2442576C2 (ru) 2006-04-28 2012-02-20 Грюненталь Гмбх Фармацевтическая комбинация, содержащая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и парацетамол
US20080014271A1 (en) 2006-07-13 2008-01-17 Ucb, S.A. Novel pharmaceutical compositions comprising levetiracetam
CN101147735A (zh) 2006-09-19 2008-03-26 沈阳华泰药物研究有限公司 注射用药物组合物及其药盒
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
JP2008106028A (ja) 2006-10-26 2008-05-08 Boehringer Ingelheim Internatl Gmbh 慢性疼痛の治療におけるフリバンセリンの使用
DE102006056458A1 (de) 2006-11-28 2008-05-29 Grünenthal GmbH Arzneimittelzubereitung von Tramadol und Acetaminophen
US20080153874A1 (en) 2006-12-22 2008-06-26 Allergan Inc. Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain
WO2008108639A1 (en) 2007-03-08 2008-09-12 Avantium Holding B.V. Co-crystalline forms of carbamazepine
EP1977744A1 (en) 2007-04-03 2008-10-08 Chemo Ibérica, S.A. Polymorphic Form alpha of (S)-Pregabalin and process for its preparation
WO2009046801A1 (en) 2007-10-09 2009-04-16 Merck Patent Gmbh Pharmaceutical compositions containing benfotiamine and one or one more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin
MX2010006608A (es) * 2007-12-21 2010-10-05 Paz Arzneimittelentwicklung Composiciones farmaceuticas y produccion y uso de las mismas en el tratamiento de neuropatias asociadas con el dolor.
EP2123626A1 (en) * 2008-05-21 2009-11-25 Laboratorios del Dr. Esteve S.A. Co-crystals of duloxetine and co-crystal formers for the treatment of pain
EA201170356A1 (ru) 2008-05-28 2011-08-30 Плива Хрватска Д.О.О. Полиморфные и аморфные формы лакозамида и аморфные композиции
CN100560061C (zh) 2008-06-20 2009-11-18 海南锦瑞制药股份有限公司 一种氯诺昔康冻干粉针剂及其制备方法
SI2735338T1 (sl) 2008-09-05 2019-04-30 Grunenthal Gmbh Farmacevtska kombinacija 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol in pregabalina ali gabapentina
US20100063009A1 (en) 2008-09-05 2010-03-11 Gruenenthal Gmbh Pharmaceutical Combination Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1.3-diol and an NSAID
PE20110799A1 (es) 2008-09-05 2011-11-10 Gruenenthal Chemie Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y paracetamol
DE102009013613A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Trockenverarbeitung von Retigabin
CA2805371C (en) 2010-07-30 2017-10-31 Toray Industries, Inc. Therapeutic agent or prophylactic agent for neuropathic pain
RS54438B1 (sr) * 2010-08-04 2016-06-30 Grünenthal GmbH Farmaceutski dozni oblik koji sadrži 6`-fluoro-(n-metil-ili n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro[cikloheksan-1,1`-pirano[3,4,b]indol]-4-amina
DK2600846T3 (en) * 2010-08-04 2016-01-11 Gruenenthal Gmbh PHARMACEUTICAL DOSAGE FORM COMPRISING 6'-fluoro- (N-methyl or N, N-dimethyl -) - 4-phenyl-4 ', 9'-dihydro-3'H-spiro [cyclohexane-1,1'-pyrano [3 , 4, b] indole] -4-amine
PE20131096A1 (es) * 2010-08-04 2013-10-10 Gruenenthal Chemie Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative

Similar Documents

Publication Publication Date Title
IN2014DN09571A (https=)
AR084932A1 (es) Composicion oftalmica que comprende un androgeno y su uso para la fabricacion de un medicamento util para el tratamiento de una enfermedad ocular resultante de una deficiencia androgenica
PH12019501937A1 (en) Crystalline forms of a 4-pyrimidinesulfamide derivative aprocitentan
EA201190145A1 (ru) Фармацевтические композиции, содержащие основание прасугреля или его фармацевтически приемлемые соли присоединения кислоты, и способы их приготовления
CL2012003573A1 (es) Combinaciones que comprenden un derivado de antranilamida y otro principio activo con propiedades insecticidas y acaricidas; composiciones agroquimicas que contienen; uso de dicha combinacion; procedimiento para combatir parasitos animales; y procedimiento para la preparacion de dicha composicion agroquimica.
PH12015501247A1 (en) Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
PH12013502551A1 (en) Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
EA201390662A1 (ru) Фармацевтическая композиция, содержащая дутастерид
WO2015066302A3 (en) Compositions, methods of use, and methods of treatment
EA201792595A1 (ru) Контрацептивное средство на основе дроспиренона для пациентки, страдающей избыточной массой тела
PH12017501424B1 (en) Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
JP2015520154A5 (https=)
AR093802A1 (es) Relleno estable al horneado que contiene microparticulas
BR112014004737A2 (pt) composto de composição de cloridrato de ambroxol e método de preparação do composto
WO2014116015A3 (ko) 자죽염을 포함하는 알츠하이머병 예방용 조성물 및 자죽염의 제조방법
MY173893A (en) Non-aqueous oily injectable formulation exhibiting preservative efficacy
BR112014023092A8 (pt) Composição imunogênica, método para a prevenção de infecção ou doença por hpv em um indivíduo, e, kit
PH12015501643A1 (en) Methods of use of phenoxypropylamine compounds to treat depression
JP2016540799A5 (https=)
EA201500446A1 (ru) Фармацевтическая композиция для снижения уровня n-оксида триметиламина
RU2012100120A (ru) Акарицидная фармацевтическая композиция на основе соли четвертичного фосфония, замещенного динитробензофураксана и ксимедонгидрохлорида
JP2014159381A5 (https=)
GEP201706790B (en) Sterile s-adenosyl methionine with a high content of active isomer for injectable solutions, and procedure for obtaining it
WO2012154725A3 (en) Steroid-sparing effects of beta-adrenergic inverse agonists and use thereof
UA60688U (ru) Фармацевтическая композиция для лечения заболеваний органов дыхания и заболеваний аллергического типа