SI2849744T1 - A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano - (3,4, b) indol) -4-amine and duloxetine - Google Patents
A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano - (3,4, b) indol) -4-amine and duloxetine Download PDFInfo
- Publication number
- SI2849744T1 SI2849744T1 SI201330895T SI201330895T SI2849744T1 SI 2849744 T1 SI2849744 T1 SI 2849744T1 SI 201330895 T SI201330895 T SI 201330895T SI 201330895 T SI201330895 T SI 201330895T SI 2849744 T1 SI2849744 T1 SI 2849744T1
- Authority
- SI
- Slovenia
- Prior art keywords
- active ingredient
- pain
- pharmacologically active
- pharmaceutical composition
- composition according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 13
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title claims 3
- 229960002866 duloxetine Drugs 0.000 title claims 3
- 239000002831 pharmacologic agent Substances 0.000 claims abstract 12
- 150000003839 salts Chemical class 0.000 claims abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract 2
- 208000002193 Pain Diseases 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 230000003040 nociceptive effect Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001107 psychogenic effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003937 | 2012-05-18 | ||
| PCT/EP2013/001464 WO2013170965A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants |
| EP13723003.3A EP2849744B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and duloxetine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2849744T1 true SI2849744T1 (en) | 2018-01-31 |
Family
ID=48446243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201330895T SI2849744T1 (en) | 2012-05-18 | 2013-05-16 | A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano - (3,4, b) indol) -4-amine and duloxetine |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20130310385A1 (https=) |
| EP (1) | EP2849744B1 (https=) |
| JP (1) | JP6116672B2 (https=) |
| CN (1) | CN104271131A (https=) |
| AU (1) | AU2013262071B2 (https=) |
| BR (1) | BR112014028562A2 (https=) |
| CA (1) | CA2873634A1 (https=) |
| CY (1) | CY1119825T1 (https=) |
| DK (1) | DK2849744T3 (https=) |
| EA (1) | EA027268B1 (https=) |
| ES (1) | ES2660461T3 (https=) |
| HR (1) | HRP20171922T1 (https=) |
| HU (1) | HUE037746T2 (https=) |
| IL (1) | IL235657B (https=) |
| LT (1) | LT2849744T (https=) |
| MX (1) | MX354684B (https=) |
| NO (1) | NO2849744T3 (https=) |
| PL (1) | PL2849744T3 (https=) |
| PT (1) | PT2849744T (https=) |
| RS (1) | RS56856B1 (https=) |
| SI (1) | SI2849744T1 (https=) |
| WO (1) | WO2013170965A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2246418C1 (ru) * | 2003-06-19 | 2005-02-20 | Общество с ограниченной ответственностью "ТехноМастер" | Усилитель щитка передка кузова легкового автомобиля |
| CA2974578C (en) | 2015-01-23 | 2020-11-17 | Grunenthal Gmbh | Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3273329D1 (en) | 1981-06-26 | 1986-10-23 | Upjohn Co | Analgesic process and composition |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| ES2098264T3 (es) | 1989-05-22 | 1997-05-01 | Biochemical Veterinary Res | Sales metalicas divalentes de indometacina. |
| US5708035A (en) * | 1991-02-04 | 1998-01-13 | Sepracor Inc. | Methods of use and compositions of R(-) fluoxetine |
| KR940701249A (ko) | 1991-07-04 | 1994-05-28 | 우에하라 아키라 | 진통제 |
| JPH05221857A (ja) | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| JPH08511522A (ja) | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US20030056896A1 (en) | 1995-05-12 | 2003-03-27 | Frank Jao | Effective therapy for epilepsies |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| ATE232382T1 (de) | 1998-09-10 | 2003-02-15 | Nycomed Danmark As | Pharmazeutische zusammensetzungen mit schneller freisetzung von wirkstoffen |
| ATE234090T1 (de) | 1998-11-13 | 2003-03-15 | Lilly Co Eli | Kombination von duloxetin mit nichtsteroid- entzündungshemmern für die behandlung von schmerz |
| US6117900A (en) | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
| AU2001288110A1 (en) | 2000-09-27 | 2002-04-08 | Takeda Chemical Industries Ltd. | Spiro compounds |
| EP1219304B1 (de) | 2000-12-28 | 2004-10-20 | Fresenius Kabi Austria GmbH | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| WO2003064425A1 (en) | 2002-01-28 | 2003-08-07 | Pfizer Japan Inc. | N-substituted spiropiperidine compounds as ligands for orl-1 receptor |
| EP1374906B1 (en) | 2002-06-17 | 2007-04-18 | CHIESI FARMACEUTICI S.p.A. | A process for the preparation of piroxicam: beta-cyclodextrin inclusion compounds |
| US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| WO2004047844A1 (en) | 2002-11-26 | 2004-06-10 | Alexza Pharmaceuticals, Inc. | Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| US20040222123A1 (en) | 2003-05-06 | 2004-11-11 | Barr Laboratories, Inc. | Kit for pharmaceuticals |
| CN1245379C (zh) | 2003-10-30 | 2006-03-15 | 曹桂东 | 加巴喷丁的制法 |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| GB0412878D0 (en) * | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Use |
| BRPI0511941A (pt) | 2004-06-09 | 2008-01-22 | Pfizer | uso de (s, s)-reboxetina ou reboxetina racêmica |
| EP1893610A2 (en) | 2005-06-17 | 2008-03-05 | Pfizer, Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
| US8093408B2 (en) * | 2005-06-21 | 2012-01-10 | The Company Wockhardt | Antidepressant oral pharmaceutical compositions |
| CN105561311B (zh) | 2006-04-28 | 2019-07-16 | 格吕伦塔尔有限公司 | 包含3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和nsaid的药物组合物 |
| RU2442576C2 (ru) | 2006-04-28 | 2012-02-20 | Грюненталь Гмбх | Фармацевтическая комбинация, содержащая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и парацетамол |
| US20080014271A1 (en) | 2006-07-13 | 2008-01-17 | Ucb, S.A. | Novel pharmaceutical compositions comprising levetiracetam |
| CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| JP2008106028A (ja) | 2006-10-26 | 2008-05-08 | Boehringer Ingelheim Internatl Gmbh | 慢性疼痛の治療におけるフリバンセリンの使用 |
| DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| US20080153874A1 (en) | 2006-12-22 | 2008-06-26 | Allergan Inc. | Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain |
| WO2008108639A1 (en) | 2007-03-08 | 2008-09-12 | Avantium Holding B.V. | Co-crystalline forms of carbamazepine |
| EP1977744A1 (en) | 2007-04-03 | 2008-10-08 | Chemo Ibérica, S.A. | Polymorphic Form alpha of (S)-Pregabalin and process for its preparation |
| WO2009046801A1 (en) | 2007-10-09 | 2009-04-16 | Merck Patent Gmbh | Pharmaceutical compositions containing benfotiamine and one or one more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
| MX2010006608A (es) * | 2007-12-21 | 2010-10-05 | Paz Arzneimittelentwicklung | Composiciones farmaceuticas y produccion y uso de las mismas en el tratamiento de neuropatias asociadas con el dolor. |
| EP2123626A1 (en) * | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
| EA201170356A1 (ru) | 2008-05-28 | 2011-08-30 | Плива Хрватска Д.О.О. | Полиморфные и аморфные формы лакозамида и аморфные композиции |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| SI2735338T1 (sl) | 2008-09-05 | 2019-04-30 | Grunenthal Gmbh | Farmacevtska kombinacija 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol in pregabalina ali gabapentina |
| US20100063009A1 (en) | 2008-09-05 | 2010-03-11 | Gruenenthal Gmbh | Pharmaceutical Combination Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1.3-diol and an NSAID |
| PE20110799A1 (es) | 2008-09-05 | 2011-11-10 | Gruenenthal Chemie | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y paracetamol |
| DE102009013613A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Trockenverarbeitung von Retigabin |
| CA2805371C (en) | 2010-07-30 | 2017-10-31 | Toray Industries, Inc. | Therapeutic agent or prophylactic agent for neuropathic pain |
| RS54438B1 (sr) * | 2010-08-04 | 2016-06-30 | Grünenthal GmbH | Farmaceutski dozni oblik koji sadrži 6`-fluoro-(n-metil-ili n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro[cikloheksan-1,1`-pirano[3,4,b]indol]-4-amina |
| DK2600846T3 (en) * | 2010-08-04 | 2016-01-11 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM COMPRISING 6'-fluoro- (N-methyl or N, N-dimethyl -) - 4-phenyl-4 ', 9'-dihydro-3'H-spiro [cyclohexane-1,1'-pyrano [3 , 4, b] indole] -4-amine |
| PE20131096A1 (es) * | 2010-08-04 | 2013-10-10 | Gruenenthal Chemie | Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
-
2013
- 2013-05-13 US US13/892,803 patent/US20130310385A1/en not_active Abandoned
- 2013-05-16 JP JP2015511951A patent/JP6116672B2/ja active Active
- 2013-05-16 WO PCT/EP2013/001464 patent/WO2013170965A1/en not_active Ceased
- 2013-05-16 EA EA201401269A patent/EA027268B1/ru not_active IP Right Cessation
- 2013-05-16 EP EP13723003.3A patent/EP2849744B1/en not_active Not-in-force
- 2013-05-16 MX MX2014012859A patent/MX354684B/es active IP Right Grant
- 2013-05-16 PT PT137230033T patent/PT2849744T/pt unknown
- 2013-05-16 HR HRP20171922TT patent/HRP20171922T1/hr unknown
- 2013-05-16 BR BR112014028562A patent/BR112014028562A2/pt not_active IP Right Cessation
- 2013-05-16 LT LTEP13723003.3T patent/LT2849744T/lt unknown
- 2013-05-16 CA CA2873634A patent/CA2873634A1/en not_active Abandoned
- 2013-05-16 DK DK13723003.3T patent/DK2849744T3/en active
- 2013-05-16 ES ES13723003.3T patent/ES2660461T3/es active Active
- 2013-05-16 NO NO13723003A patent/NO2849744T3/no unknown
- 2013-05-16 RS RS20180143A patent/RS56856B1/sr unknown
- 2013-05-16 CN CN201380025639.9A patent/CN104271131A/zh active Pending
- 2013-05-16 AU AU2013262071A patent/AU2013262071B2/en not_active Ceased
- 2013-05-16 HU HUE13723003A patent/HUE037746T2/hu unknown
- 2013-05-16 SI SI201330895T patent/SI2849744T1/en unknown
- 2013-05-16 PL PL13723003T patent/PL2849744T3/pl unknown
-
2014
- 2014-11-12 IL IL235657A patent/IL235657B/en active IP Right Grant
-
2016
- 2016-09-22 US US15/272,979 patent/US10328055B2/en not_active Expired - Fee Related
-
2018
- 2018-01-24 CY CY20181100091T patent/CY1119825T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA027268B1 (ru) | 2017-07-31 |
| EP2849744A1 (en) | 2015-03-25 |
| MX2014012859A (es) | 2015-01-19 |
| NO2849744T3 (https=) | 2018-04-21 |
| CN104271131A (zh) | 2015-01-07 |
| US20130310385A1 (en) | 2013-11-21 |
| EA201401269A1 (ru) | 2016-05-31 |
| PL2849744T3 (pl) | 2018-06-29 |
| IL235657A0 (en) | 2015-01-29 |
| LT2849744T (lt) | 2018-02-26 |
| DK2849744T3 (en) | 2018-01-22 |
| JP2015520154A (ja) | 2015-07-16 |
| HK1204944A1 (en) | 2015-12-11 |
| PT2849744T (pt) | 2018-02-28 |
| CY1119825T1 (el) | 2018-06-27 |
| MX354684B (es) | 2018-03-15 |
| BR112014028562A2 (pt) | 2017-06-27 |
| WO2013170965A1 (en) | 2013-11-21 |
| ES2660461T3 (es) | 2018-03-22 |
| CA2873634A1 (en) | 2013-11-21 |
| JP6116672B2 (ja) | 2017-04-19 |
| AU2013262071B2 (en) | 2018-01-18 |
| HUE037746T2 (hu) | 2018-09-28 |
| IL235657B (en) | 2018-08-30 |
| RS56856B1 (sr) | 2018-04-30 |
| AU2013262071A1 (en) | 2015-01-22 |
| EP2849744B1 (en) | 2017-11-22 |
| US10328055B2 (en) | 2019-06-25 |
| HRP20171922T1 (hr) | 2018-02-09 |
| US20170065560A1 (en) | 2017-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ605888A (en) | Pharmaceutical dosage form comprising 6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain | |
| JP2013528600A5 (https=) | ||
| TN2013000293A1 (en) | Derivatives of azaindazole or diazaindazole type as medicament | |
| JP2012180381A5 (https=) | ||
| TN2012000421A1 (en) | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents | |
| BR112015029512A8 (pt) | derivados de pirazolopirrolidina, seus usos, e composição e combinação farmacêuticas | |
| NZ587202A (en) | Methods for measuring a patient response upon administration of a drug and compositions thereof | |
| HRP20240082T1 (hr) | Inhibitor pde9 s okosnicom imidazopirazinona za liječenje perifernih bolesti | |
| HRP20150375T1 (hr) | Derivati piridazinona | |
| RU2015155283A (ru) | Фармацевтическая комбинация, содержащая метроформин и дигидрокверценин, и ее применение для лечения рака | |
| TN2012000493A1 (en) | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations | |
| HRP20171693T1 (hr) | Farmaceutski pripravak koji sadrži (1r, 4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano-[3,4,b]indol]-4-amin i ibuprofen | |
| MX388825B (es) | Uso y dosificacion de agentes terapeuticos para endometriosis. | |
| HK1215672A1 (zh) | 用於治療炎症和癌症的吲哚類化合物 | |
| SI2849744T1 (en) | A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano - (3,4, b) indol) -4-amine and duloxetine | |
| BR112012020377A2 (pt) | utilização de um ou mais selecionado do grupo constituído por um composto da fórmula (i), uma mistura racêmica-diastereomérica e um isômero óptico do referido composto, e um sal farmaceuticamente aceitável e uma pródroga do mesmo, método, composição farmacêutica e kit para tratamento de caquexia e embalagem comercial | |
| SI2849748T1 (en) | A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano , 4, b) indol) -4-amine and gabapentinoid | |
| SI2849746T1 (en) | A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano- 3,4, b) indol) -4-amine and meloxicam | |
| RU2013148627A (ru) | Производные тиено [2, 3-d] пиримидина и их применение для лечения аритмии | |
| HRP20171725T1 (hr) | FARMACEUTSKI PRIPRAVAK KOJI SADRŽI (1R,4R)-6'-FLUORO-N,N-DIMETIL-4-FENIL-4',9'-DIHIDRO-3'H-SPIRO[CIKLOHEKSAN-1,1'-PIRANO [3,4,b]INDOL]-4-AMIN I NSAR | |
| HRP20171927T1 (hr) | Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluor-n,n-dimetil-4-fenil-4',9'-diidro-3'h-spiro[cikloheksan-1,1'-pirano-[3,4,b]indol]-4-amin i acetilsalicilnu kiselinu | |
| BR112012020415A2 (pt) | composição farmacêutica para a prevenção ou tratamento da osteoartrite | |
| SI2849740T1 (en) | A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano , 4, b) indol) -4-amine and paracetamol or propacetamol | |
| RU2013127794A (ru) | Фармацевтическая комбинация и композиция для лечения ожирения и ее применение | |
| HRP20241063T1 (hr) | Terapeutske formulacije koje sadrže cox-2 inhibitor i njihove uporabe |