JP2015518377A - 水性無菌ビタミン調合物 - Google Patents
水性無菌ビタミン調合物 Download PDFInfo
- Publication number
- JP2015518377A JP2015518377A JP2015509434A JP2015509434A JP2015518377A JP 2015518377 A JP2015518377 A JP 2015518377A JP 2015509434 A JP2015509434 A JP 2015509434A JP 2015509434 A JP2015509434 A JP 2015509434A JP 2015518377 A JP2015518377 A JP 2015518377A
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- JP
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- Prior art keywords
- vitamin
- water
- formulation
- aqueous formulation
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940088594 vitamin Drugs 0.000 title claims abstract description 39
- 229930003231 vitamin Natural products 0.000 title claims abstract description 39
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 39
- 239000011782 vitamin Substances 0.000 title claims abstract description 39
- 238000009472 formulation Methods 0.000 title claims abstract description 33
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 26
- 239000013011 aqueous formulation Substances 0.000 claims abstract description 45
- 235000013305 food Nutrition 0.000 claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 claims abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 47
- 229930003270 Vitamin B Natural products 0.000 claims description 33
- 235000019156 vitamin B Nutrition 0.000 claims description 33
- 239000011720 vitamin B Substances 0.000 claims description 33
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 23
- 229930003268 Vitamin C Natural products 0.000 claims description 23
- 239000011718 vitamin C Substances 0.000 claims description 23
- 235000019154 vitamin C Nutrition 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 13
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 claims description 11
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims description 10
- 238000009928 pasteurization Methods 0.000 claims description 10
- 239000011148 porous material Substances 0.000 claims description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 6
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- 239000000047 product Substances 0.000 description 27
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 8
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- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
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- 230000036512 infertility Effects 0.000 description 2
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
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- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
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- 206010013496 Disturbance in attention Diseases 0.000 description 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 description 1
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- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229920012266 Poly(ether sulfone) PES Polymers 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- 235000008191 folinic acid Nutrition 0.000 description 1
- 239000011672 folinic acid Substances 0.000 description 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
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- 230000007407 health benefit Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 description 1
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- 235000007672 methylcobalamin Nutrition 0.000 description 1
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- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 description 1
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- 239000011664 nicotinic acid Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3589—Apparatus for preserving using liquids
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
(i)少なくとも20g/LのビタミンC、および
(ii)少なくとも10g/Lの少なくとも1つのさらなる水溶性ビタミン、および
(iii)水
を含んでなり、方法は、孔径≧0.22μmのフィルターを使用して水性調合物が濾過されることを特徴とする。
(i)20g/L〜50g/LのビタミンC、および
(ii)少なくとも30g/L〜60g/Lの少なくとも1つのさらなる水溶性ビタミン、および
(iii)水
を含んでなり、方法は、孔径≧0.22μmのフィルターを使用して水性調合物が濾過されることを特徴とする。
(i)少なくとも20g/LのビタミンC、および
(ii)ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB7、ビタミンB9、およびビタミンB12からなる群から選択される、少なくとも10g/Lの少なくとも1つの水溶性ビタミン、および
(iii)水
を含んでなり、方法は、孔径≧0.22mmのフィルターを使用して水性調合物が濾過されることを特徴とする。
(i)20g/L〜50g/LのビタミンC、および
(ii)少なくとも30g/L〜60g/Lの少なくとも1つのさらなる水溶性ビタミン、および
(iii)水
を含んでなり、孔径≧0.22μmのフィルターを使用して濾過される。
(i)少なくとも20g/LのビタミンC、および
(ii)少なくとも10g/Lの少なくとも1つのさらなる水溶性ビタミン、および
(iii)水
を含んでなり、粒度が0.22μm未満の粒子のみを含んでなる。
(i)ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB7、ビタミンB9、およびビタミンB12からなる群から選択される、少なくとも10g/Lの少なくとも1つの水溶性ビタミン、および
(ii)少なくとも20g/LのビタミンC
を含んでなる調合物(I)および/または(II)である、無菌水性調合物(III)にも関する。
[実施例1]
水性調合物は、1Lの脱ミネラル水に、1430mgのビタミンB1、1705mgのビタミンB2、1480mgのビタミンB3、5760mgのビタミンB5、2070mgのビタミンB6、125mgのビタミンB7、850mgのビタミンB12、および22520mgのビタミンCを添加して製造した。
1368mgのビタミンB1、1533mgのビタミンB2、1201mgのビタミンB3、5170mgのビタミンB5、2034mgのビタミンB6、116mgのビタミンB7、444mgのビタミンB12、および19930mgのビタミンC。
水性調合物は、最初に以下の水溶性ビタミン(乾燥形態)を混合することで製造した。
1Lの水に対して、24gのビタミンB1、36.3gのビタミンB2、21.6gのビタミンB3、66.6gのビタミンB5、34.1gのビタミンB6、168.6gのビタミンB7、12gのビタミンB12、および533gのビタミンC。さらに168.66gのショ糖を添加した。
実施例2と同一手順を使用して、以下の水溶性ビタミン含量を有する低温殺菌オレンジジュースを製造した。
2.51mg/LのビタミンB1、1.75mg/LのビタミンB2、2.80mg/LのビタミンB3、8.9mg/LのビタミンB5、3.37mg/LのビタミンB6、240μg/LのビタミンB7、1.90μg/LのビタミンB12、および295mg/LのビタミンC。
2.40mg/LのビタミンB1、1.80mg/LのビタミンB2、2.75mg/LのビタミンB3、10.9mg/LのビタミンB5、3.21mg/LのビタミンB6、200μg/LのビタミンB7、1.890μg/LのビタミンB12、および283mg/LのビタミンC。
Claims (11)
- (i)少なくとも20g/LのビタミンC、および
(ii)少なくとも10g/Lの少なくとも1つのさらなる水溶性ビタミン、および
(iii)水
を含んでなる無菌水性調合物を製造する方法において、孔径≧0.22μmのフィルターを使用して水性調合物が濾過されることを特徴とする、方法。 - 前記水性調合物が、20g/L〜50g/LのビタミンCを含んでなる、請求項1に記載の方法。
- 前記水性調合物が、少なくとも30g/L〜60g/Lの少なくとも1つのさらなる水溶性ビタミンを含んでなる、請求項1または2に記載の方法。
- 前記水性調合物が、少なくとも20g/LのビタミンCと、ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB7、ビタミンB9、およびビタミンB12からなる群から選択される、少なくとも10g/Lの少なくとも1つの水溶性ビタミンとを含んでなる、請求項1〜3のいずれか一項に記載の方法。
- 前記水性調合物が、さらなる成分を含んでなる、請求項1〜4のいずれか一項に記載の方法。
- (i)少なくとも20g/LのビタミンC、および
(ii)少なくとも10g/Lの少なくとも1つのさらなる水溶性ビタミン、および
(iii)水
を含んでなり、粒度が0.22μm未満の粒子のみを含んでなる、無菌水性調合物。 - 前記調合物が、20g/L〜50g/LのビタミンCを含んでなる、請求項6に記載の調合物。
- ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB7、ビタミンB9、およびビタミンB12からなる群から選択される、少なくとも10g/Lの少なくとも1つの水溶性ビタミンと、少なくとも20g/LのビタミンCとを含んでなる、請求項6または7に記載の調合物。
- 少なくとも1つの助剤を含んでなる、請求項6〜8のいずれか一項に記載の調合物。
- 調合物が、低温殺菌後に製品に添加される、低温殺菌食品、飼料および/またはパーソナルケア製品を製造する方法における、請求項6〜9のいずれか一項に記載の調合物の使用。
- 請求項6〜9のいずれか一項に記載の調合物を含んでなる、低温殺菌食品、飼料またはパーソナル製品。
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EP12166411.4 | 2012-05-02 | ||
EP12166411 | 2012-05-02 | ||
PCT/EP2013/059087 WO2013164382A1 (en) | 2012-05-02 | 2013-05-02 | Aqueous, sterile vitamin formulation |
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JP2015518377A true JP2015518377A (ja) | 2015-07-02 |
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US (1) | US20150086676A1 (ja) |
EP (1) | EP2844084A1 (ja) |
JP (1) | JP2015518377A (ja) |
KR (1) | KR20150005946A (ja) |
CN (1) | CN104302194A (ja) |
AU (1) | AU2013255887B2 (ja) |
BR (1) | BR112014027388A2 (ja) |
EA (1) | EA029207B1 (ja) |
WO (1) | WO2013164382A1 (ja) |
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JP2019062784A (ja) * | 2017-09-29 | 2019-04-25 | 株式会社 伊藤園 | 容器詰飲料、その製造方法、及びその異臭発生抑制方法 |
JP2020523001A (ja) * | 2017-06-15 | 2020-08-06 | アルガマ | 微細藻類および/またはシアノバクテリアの抽出物を含む果汁から製造される安定化された食品飲料を得る方法 |
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CN111511220A (zh) * | 2017-12-25 | 2020-08-07 | 好侍健康食品株式会社 | 维生素b族化合物的稳定性优异的含有维生素b族化合物的酸性组合物 |
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2013
- 2013-05-02 CN CN201380023109.0A patent/CN104302194A/zh active Pending
- 2013-05-02 WO PCT/EP2013/059087 patent/WO2013164382A1/en active Application Filing
- 2013-05-02 BR BR112014027388A patent/BR112014027388A2/pt not_active IP Right Cessation
- 2013-05-02 KR KR1020147030604A patent/KR20150005946A/ko not_active Application Discontinuation
- 2013-05-02 US US14/396,649 patent/US20150086676A1/en not_active Abandoned
- 2013-05-02 EP EP13724180.8A patent/EP2844084A1/en not_active Withdrawn
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AU2013255887A1 (en) | 2014-11-13 |
CN104302194A (zh) | 2015-01-21 |
EA201401198A1 (ru) | 2015-04-30 |
AU2013255887B2 (en) | 2017-03-23 |
US20150086676A1 (en) | 2015-03-26 |
WO2013164382A1 (en) | 2013-11-07 |
BR112014027388A2 (pt) | 2017-06-27 |
EA029207B1 (ru) | 2018-02-28 |
KR20150005946A (ko) | 2015-01-15 |
EP2844084A1 (en) | 2015-03-11 |
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