JP2015516001A5 - - Google Patents
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- Publication number
- JP2015516001A5 JP2015516001A5 JP2015510758A JP2015510758A JP2015516001A5 JP 2015516001 A5 JP2015516001 A5 JP 2015516001A5 JP 2015510758 A JP2015510758 A JP 2015510758A JP 2015510758 A JP2015510758 A JP 2015510758A JP 2015516001 A5 JP2015516001 A5 JP 2015516001A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- cycloalkyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(nc1)cc2c1OC(C1)(CC11CCN(*)CC1)C2 Chemical compound *c(nc1)cc2c1OC(C1)(CC11CCN(*)CC1)C2 0.000 description 17
- BKUQVCVAPOWJLW-UHFFFAOYSA-N CCC1(CC1)C(F)(F)F Chemical compound CCC1(CC1)C(F)(F)F BKUQVCVAPOWJLW-UHFFFAOYSA-N 0.000 description 2
- FZAXBPZVVJOFKX-UHFFFAOYSA-N Cc1n[o]cn1 Chemical compound Cc1n[o]cn1 FZAXBPZVVJOFKX-UHFFFAOYSA-N 0.000 description 2
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ncccc1 Chemical compound Cc1ncccc1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 2
- LNJMHEJAYSYZKK-UHFFFAOYSA-N Cc1ncccn1 Chemical compound Cc1ncccn1 LNJMHEJAYSYZKK-UHFFFAOYSA-N 0.000 description 2
- RGTBLCLLSZPOKR-UHFFFAOYSA-N Cc1ncn[o]1 Chemical compound Cc1ncn[o]1 RGTBLCLLSZPOKR-UHFFFAOYSA-N 0.000 description 2
- RQSCFNPNNLWQBJ-UHFFFAOYSA-N Cc1nnc[s]1 Chemical compound Cc1nnc[s]1 RQSCFNPNNLWQBJ-UHFFFAOYSA-N 0.000 description 2
- WZCPELGQNQALKK-UHFFFAOYSA-N CC(C)c1n[o]c(C)n1 Chemical compound CC(C)c1n[o]c(C)n1 WZCPELGQNQALKK-UHFFFAOYSA-N 0.000 description 1
- IWPJLTLNQASVKH-UHFFFAOYSA-N CCCc1cnc(C)nc1 Chemical compound CCCc1cnc(C)nc1 IWPJLTLNQASVKH-UHFFFAOYSA-N 0.000 description 1
- BHEWJAIXUMSOCL-UHFFFAOYSA-N CCCc1n[o]c(C)n1 Chemical compound CCCc1n[o]c(C)n1 BHEWJAIXUMSOCL-UHFFFAOYSA-N 0.000 description 1
- VPNWSCPWRVXGFZ-UHFFFAOYSA-N CCCc1nc(C)n[o]1 Chemical compound CCCc1nc(C)n[o]1 VPNWSCPWRVXGFZ-UHFFFAOYSA-N 0.000 description 1
- MTLVCZCTTNTNHX-UHFFFAOYSA-N CCc1cnc(C)nc1 Chemical compound CCc1cnc(C)nc1 MTLVCZCTTNTNHX-UHFFFAOYSA-N 0.000 description 1
- YYDNBUBMBZRNQQ-UHFFFAOYSA-N Cc(cc1)ccc1S(C)(=O)=O Chemical compound Cc(cc1)ccc1S(C)(=O)=O YYDNBUBMBZRNQQ-UHFFFAOYSA-N 0.000 description 1
- UISREOKYJBBYSC-UHFFFAOYSA-N Cc(nc1)ncc1Cl Chemical compound Cc(nc1)ncc1Cl UISREOKYJBBYSC-UHFFFAOYSA-N 0.000 description 1
- SITMKUXMSQMJGR-UHFFFAOYSA-N Cc1ccc(CS(C)(=O)=O)cc1 Chemical compound Cc1ccc(CS(C)(=O)=O)cc1 SITMKUXMSQMJGR-UHFFFAOYSA-N 0.000 description 1
- RHOOLJLEYYXKTK-UHFFFAOYSA-N Cc1cnc(C)nc1 Chemical compound Cc1cnc(C)nc1 RHOOLJLEYYXKTK-UHFFFAOYSA-N 0.000 description 1
- RNUJYGMOBQWWGH-UHFFFAOYSA-N Cc1ncc(C(F)(F)[F]C)cc1 Chemical compound Cc1ncc(C(F)(F)[F]C)cc1 RNUJYGMOBQWWGH-UHFFFAOYSA-N 0.000 description 1
- YVQBEUZBBNGLIE-UHFFFAOYSA-N Cc1ncc(C2CC2)cn1 Chemical compound Cc1ncc(C2CC2)cn1 YVQBEUZBBNGLIE-UHFFFAOYSA-N 0.000 description 1
- AMOWZMFGYUOXOU-UHFFFAOYSA-N Cc1nnc(C(F)(F)F)[s]1 Chemical compound Cc1nnc(C(F)(F)F)[s]1 AMOWZMFGYUOXOU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12166992.3 | 2012-05-07 | ||
| EP12166992 | 2012-05-07 | ||
| PCT/EP2013/059346 WO2013167514A1 (en) | 2012-05-07 | 2013-05-06 | New 2,3-dihydro-furo[2,3-c]pyridines, their use as modulators of the g-protein-coupled receptor gpr119 and pharmaceutical compositions comprising them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516001A JP2015516001A (ja) | 2015-06-04 |
| JP2015516001A5 true JP2015516001A5 (enExample) | 2016-06-23 |
| JP6136032B2 JP6136032B2 (ja) | 2017-05-31 |
Family
ID=48325708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510758A Active JP6136032B2 (ja) | 2012-05-07 | 2013-05-06 | 新規な２，３−ジヒドロ−フロ［２，３−ｃ］ピリジン、Ｇタンパク質共役受容体ＧＰＲ１１９のモジュレーターとしてのそれらの使用、及びそれらを含む医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8809361B2 (enExample) |
| EP (1) | EP2847196B1 (enExample) |
| JP (1) | JP6136032B2 (enExample) |
| WO (1) | WO2013167514A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| WO2021236654A1 (en) * | 2020-05-18 | 2021-11-25 | The Johns Hopkins University | Anti-cancer spirocyclic-guanidine compounds and uses thereof |
| EP4153589A4 (en) | 2020-05-19 | 2024-06-12 | Kallyope, Inc. | AMPK ACTIVATORS |
| WO2021263039A1 (en) | 2020-06-26 | 2021-12-30 | Kallyope, Inc. | Ampk activators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140161A1 (en) * | 2010-05-06 | 2011-11-10 | Bristol-Myers Squibb Company | Benzofuranyl analogues as gpr119 modulators |
| WO2012077655A1 (ja) * | 2010-12-07 | 2012-06-14 | 塩野義製薬株式会社 | Ｇｐｒ１１９アゴニスト活性を有するスピロ誘導体 |
| UY33805A (es) * | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
| EA201300846A1 (ru) * | 2011-01-21 | 2013-12-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Конденсированные дигидрофураны в качестве модуляторов gpr119, предназначенные для лечения диабета, ожирения и родственных нарушений |
-
2013
- 2013-05-06 US US13/887,887 patent/US8809361B2/en active Active
- 2013-05-06 EP EP13720937.5A patent/EP2847196B1/en active Active
- 2013-05-06 WO PCT/EP2013/059346 patent/WO2013167514A1/en not_active Ceased
- 2013-05-06 JP JP2015510758A patent/JP6136032B2/ja active Active
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