JP2015514739A5 - - Google Patents

Download PDF

Info

Publication number
JP2015514739A5
JP2015514739A5 JP2015506258A JP2015506258A JP2015514739A5 JP 2015514739 A5 JP2015514739 A5 JP 2015514739A5 JP 2015506258 A JP2015506258 A JP 2015506258A JP 2015506258 A JP2015506258 A JP 2015506258A JP 2015514739 A5 JP2015514739 A5 JP 2015514739A5
Authority
JP
Japan
Prior art keywords
agent
composition
radiprodil
antagonist
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015506258A
Other languages
English (en)
Japanese (ja)
Other versions
JP6042968B2 (ja
JP2015514739A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2013/058212 external-priority patent/WO2013156614A1/en
Publication of JP2015514739A publication Critical patent/JP2015514739A/ja
Publication of JP2015514739A5 publication Critical patent/JP2015514739A5/ja
Application granted granted Critical
Publication of JP6042968B2 publication Critical patent/JP6042968B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015506258A 2012-04-20 2013-04-19 パーキンソン病の処置方法 Expired - Fee Related JP6042968B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636054P 2012-04-20 2012-04-20
US61/636,054 2012-04-20
PCT/EP2013/058212 WO2013156614A1 (en) 2012-04-20 2013-04-19 Methods for treating parkinson's disease

Publications (3)

Publication Number Publication Date
JP2015514739A JP2015514739A (ja) 2015-05-21
JP2015514739A5 true JP2015514739A5 (enExample) 2016-03-24
JP6042968B2 JP6042968B2 (ja) 2016-12-14

Family

ID=48182898

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015506258A Expired - Fee Related JP6042968B2 (ja) 2012-04-20 2013-04-19 パーキンソン病の処置方法

Country Status (9)

Country Link
US (2) US9387212B2 (enExample)
EP (1) EP2838530B1 (enExample)
JP (1) JP6042968B2 (enExample)
KR (1) KR20140146217A (enExample)
CN (1) CN104321057B (enExample)
AU (1) AU2013251079B2 (enExample)
CA (1) CA2869216A1 (enExample)
ES (1) ES2627541T3 (enExample)
WO (1) WO2013156614A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201701853YA (en) 2014-09-15 2017-04-27 Rugen Holdings Cayman Ltd Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
CA2970958A1 (en) * 2014-12-23 2016-06-30 Cerecor, Inc. Compounds, compositions and methods
KR102613179B1 (ko) 2015-06-01 2023-12-14 뤼겐 홀딩스 (케이맨) 리미티드 Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물
WO2017136375A1 (en) * 2016-02-05 2017-08-10 Concert Pharmaceuticals, Inc. Deuterated tozadenant
CN106214652A (zh) * 2016-08-31 2016-12-14 安徽省润生医药股份有限公司 一种含有伊曲茶碱的药物组合物
EP3544610A1 (en) 2016-11-22 2019-10-02 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
CA3126735A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
WO2025137652A2 (en) 2023-12-20 2025-06-26 Grin Therapeutics, Inc. Methods of using radiprodil in the treatment of disorders

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037226A2 (en) * 1995-05-26 1996-11-28 Pfizer Inc. Combinations for the treatment of parkinsonism containing selective nmda antagonists
ATE325610T1 (de) * 1997-09-05 2006-06-15 Kyowa Hakko Kogyo Kk Xanthinderivative zur behandlung von hirnischämie
EP1178835A4 (en) 1999-05-10 2002-08-21 Univ Princeton COMPOSITIONS AND METHODS FOR IMPROVING LEARNING AND REMEMBERABILITY
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
GB0015488D0 (en) 2000-06-23 2000-08-16 Merck Sharp & Dohme Therapeutic agents
WO2002000629A1 (en) 2000-06-26 2002-01-03 Merck & Co., Inc. Iminopyrimidine nmda nr2b receptor antagonists
WO2002009736A1 (en) 2000-07-27 2002-02-07 Washington University Methods and agents for treating persistent pain
AU2001280996A1 (en) 2000-08-04 2002-02-18 Cis Biotech, Inc. Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
HUP0303258A3 (en) 2001-02-23 2004-06-28 Merck & Co Inc N-substituted nonaryl-heterocyclic nmda/nr2b antagonists and pharmaceutical compositions containing them
AU2002338334B8 (en) 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
CA2449249A1 (en) 2001-06-12 2002-12-19 Merck & Co., Inc. Nr2b receptor antagonists for the treatment or prevention of migraines
SI1409477T1 (sl) 2001-07-24 2009-02-28 Richter Gedeon Nyrt Derivati piperidina kot antagonisti nmda-receptorjev
AU2003230758A1 (en) 2002-04-02 2003-10-20 Merck And Co., Inc. 5h-benzo(4,5)cyclohepta(1,2-b)pyridine nmda/nr2b antagonists
US6713490B2 (en) 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
JP2006509763A (ja) 2002-11-22 2006-03-23 メルク エンド カムパニー インコーポレーテッド Nr2b受容体アンタゴニストとしての2−[(4−ベンジル)−1−ピペリジニル)メチル]ベンゾイミダゾール−5−オール誘導体
AU2003303042A1 (en) 2002-12-17 2004-07-09 Pfizer Inc. 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as nr2b receptor antagonists
US20060128694A1 (en) 2002-12-19 2006-06-15 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
US20060106040A1 (en) 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
EP1615636A1 (en) 2003-04-10 2006-01-18 Pfizer Inc. Bicyclic compounds as nr2b receptor antagonists
BRPI0410837A (pt) 2003-06-04 2006-06-27 Merck & Co Inc composto, composição farmacêutica, e, método para tratar ou prevenir uma doença ou condição
WO2005019222A1 (en) 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
JP2007502772A (ja) 2003-08-15 2007-02-15 メルク エンド カムパニー インコーポレーテッド 4−シクロアルキルアミノピラゾロピリミジンnmda/nr2b拮抗薬
EP1666464A4 (en) 2003-09-25 2008-12-10 Shionogi & Co PIPERIDINE DERIVATIVE HAVING ANTAGONIST ACTIVITY OF THE NDMA RECEPTOR
MXPA06004038A (es) 2003-10-08 2006-06-28 Pfizer Compuestos de 1-'2-(4-hidroxifenil)-2-hidroxietil-piperidin-4-ol como antagonsitas del receptor n-metil-d-aspartato.
WO2005035523A1 (en) 2003-10-08 2005-04-21 Pfizer Japan Inc. Fused lactam compounds
BRPI0507636A (pt) 2004-02-11 2007-07-10 Pfizer compostos, derivados terapêuticos de amida, composição farmacêutica, uso dos mesmos e combinação
WO2005102390A2 (en) 2004-04-22 2005-11-03 Pfizer Japan, Inc. Combinations comprising alpha-2-delta ligands and nmda receptor antagonists
EP1753760B1 (en) * 2004-05-24 2008-01-02 F.Hoffmann-La Roche Ag 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
HU226977B1 (en) 2004-07-29 2010-04-28 Richter Gedeon Nyrt Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them
HUP0401522A2 (en) 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
US20070293515A1 (en) 2004-08-03 2007-12-20 Layton Mark E 1,3-Disubstituted Heteroaryl Nmda/Nr2b Antagonists
WO2006083949A2 (en) 2005-02-01 2006-08-10 University Of Medicine And Dentistry Of New Jersey Sepsis prevention through adenosine receptor modulation
JP2008536927A (ja) 2005-04-19 2008-09-11 メルク エンド カムパニー インコーポレーテッド N−アルキル−アザシクロアルキルnmda/nr2b拮抗物質
EP1885365A4 (en) 2005-05-13 2012-07-11 The Feinstein Inst Medical Res TREATMENT OF SEPSIS AND INFLAMMATION WITH ADRENEER ALPHA2A ANTAGONISTS
WO2006129626A1 (ja) 2005-05-30 2006-12-07 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法
JPWO2006137527A1 (ja) 2005-06-23 2009-01-22 協和発酵キリン株式会社 チアゾール誘導体
WO2006137465A1 (ja) 2005-06-24 2006-12-28 Shionogi & Co., Ltd. 含窒素複素環誘導体
WO2007006157A1 (en) 2005-07-14 2007-01-18 The University Of British Columbia Neuroprotective modulation of nmda receptor subtype activities
US7799947B2 (en) 2005-11-29 2010-09-21 Hammersmith Imanet Limited In vivo imaging compounds
WO2007063839A1 (ja) 2005-11-30 2007-06-07 Shionogi & Co., Ltd. シクロヘキサン誘導体
EP1988077A4 (en) 2006-02-23 2009-09-02 Shionogi & Co NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS
JP2010509189A (ja) * 2006-06-26 2010-03-25 シェーリング コーポレイション アデノシンA2aレセプターアンタゴニスト
BRPI0719056A2 (pt) 2006-11-09 2013-11-26 Ct De Rech Public De La Sante Uso de um antagonista de adenosina
EP2162742B1 (en) 2007-06-19 2015-09-30 Rajiv Gandhi Centre For Biotechnology Assay for detection of transient intracellular ca2+
EP2184272A4 (en) 2007-08-21 2011-11-09 Shionogi & Co PIPERAZINE DERIVATIVE
US20090181934A1 (en) 2007-10-17 2009-07-16 Novartis Ag Organic Compounds
CN101835759A (zh) 2007-10-24 2010-09-15 詹森药业有限公司 芳基茚并嘧啶及其作为腺苷A2a受体拮抗剂的用途
WO2009054544A1 (en) * 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
EP2215073A4 (en) 2007-10-31 2011-04-06 Merck Sharp & Dohme SLEEP MODULATION WITH NR2B RECEPTOR ANTAGONISTS
KR20100135847A (ko) 2008-03-27 2010-12-27 에보텍 뉴로사이언시즈 게엠베하 Nmda nr2b―서브타입 선택적 길항제를 사용한 질병 치료 방법
US8684624B2 (en) 2008-07-01 2014-04-01 Saint-Gobain Performance Plastics Rencol Limited Tolerance ring
EP2144462A1 (en) 2008-07-09 2010-01-13 Nokia Siemens Networks OY Reduced resource allocation parameter signalling
EP2297715A1 (de) 2008-07-09 2011-03-23 Siemens Aktiengesellschaft Verfahren, kommunikationsverbund und software zum auffinden von gesuchten objekten
US20110190348A1 (en) * 2008-08-21 2011-08-04 Pradeep Banerjee Methods for treating cns disorders
RU2011115815A (ru) 2008-09-29 2012-11-10 Гайлид Сайэнсиз, Инк. (Us) Комбинации средства, регулирующего частоту сердечных сокращений и агониста а-2-альфа рецепторов для применения в способах мультидетекторной компьютерной томографии
WO2010040003A2 (en) 2008-10-01 2010-04-08 The Scripps Research Institute Human a2a adenosine receptor crystals and uses thereof
US8282042B2 (en) 2009-06-22 2012-10-09 The Boeing Company Skin panel joint for improved airflow
US8301311B2 (en) 2009-07-06 2012-10-30 Siemens Aktiengesellschaft Frequency-responsive wind turbine output control
US20110007639A1 (en) 2009-07-10 2011-01-13 Qualcomm Incorporated Methods and apparatus for detecting identifiers
US20110105540A1 (en) 2009-10-29 2011-05-05 Jackson Paul F 2-AMINO-9-[4-(4-METHOXY-PHENOXY)-PIPERIDIN-1-YL]-4-PHENYL-INDENO[1,2-D]PYRIMIDIN-5-ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONIST
DE102010026274A1 (de) 2010-07-06 2012-01-12 Voith Patent Gmbh Bremsanlage und Verfahren zum Einstellen eines Bremsmomentes einer solchen
US9006177B2 (en) * 2010-09-24 2015-04-14 Advinus Therapeutics Limited Fused tricyclic compounds as adenosine receptor antagonist

Similar Documents

Publication Publication Date Title
JP2015514739A5 (enExample)
JP2012255026A5 (enExample)
CL2013001885A1 (es) Compuestos derivados de morfina, antagonistas del receptor ipiode periferico; composicion farmaceutica; formulacion oral; y uso para reducir los efectos colaterales de la terapia opioide (div. sol. 905-08).
JP2013014622A5 (enExample)
HRP20200600T1 (hr) Tapentadol za sprječavanje i liječenje depresije i tjeskobe
JP2016501828A5 (enExample)
JP2013509429A5 (enExample)
JP2017504611A5 (enExample)
JP2007145875A5 (enExample)
JP2012502037A5 (enExample)
JP2009525343A5 (enExample)
HRP20160135T1 (hr) Derivati 2-(2,4,5-supstituiranog-anilino) pirimidina kao modulatori egfr koji su korisni za lijeäśenje raka
JP2016106150A5 (enExample)
JP2014521735A5 (enExample)
JP2017519019A5 (enExample)
WO2012032209A3 (es) Uso de un agonista de trpm8 para la elaboración de un medicamento para el tratamiento de xeroftalmia, sequedad vaginal y síndrome de la boca seca y uso de un antagonista de trpm8 para la elaboración de un medicamento pra el tratamiento de la epífora.
JP2014507446A5 (enExample)
JP2011006431A5 (enExample)
JP2013505205A5 (enExample)
JP2013542246A5 (enExample)
EA201290394A1 (ru) Морфолинотиазолы в качестве позитивных аллостерических модуляторов альфа 7
BR112013032122A2 (pt) liberação modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)fenil] benzamida solubilizada usando ácidos orgânicos
JP2015523407A5 (enExample)
GEP20186839B (en) Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
JP2014218522A5 (enExample)