CN104321057B - 用于治疗帕金森病的方法 - Google Patents

用于治疗帕金森病的方法 Download PDF

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Publication number
CN104321057B
CN104321057B CN201380027549.3A CN201380027549A CN104321057B CN 104321057 B CN104321057 B CN 104321057B CN 201380027549 A CN201380027549 A CN 201380027549A CN 104321057 B CN104321057 B CN 104321057B
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levodopa
antagonist
rats
nr2b
receptor
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Chinese (zh)
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CN104321057A (zh
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A·米歇尔
P·唐尼
F·蒙特尔
D·施乐尔
B·克里斯托弗
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UCB SA
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UCB SA
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201380027549.3A 2012-04-20 2013-04-19 用于治疗帕金森病的方法 Expired - Fee Related CN104321057B (zh)

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US201261636054P 2012-04-20 2012-04-20
US61/636,054 2012-04-20
PCT/EP2013/058212 WO2013156614A1 (en) 2012-04-20 2013-04-19 Methods for treating parkinson's disease

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CN104321057A CN104321057A (zh) 2015-01-28
CN104321057B true CN104321057B (zh) 2016-09-14

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US (2) US9387212B2 (enExample)
EP (1) EP2838530B1 (enExample)
JP (1) JP6042968B2 (enExample)
KR (1) KR20140146217A (enExample)
CN (1) CN104321057B (enExample)
AU (1) AU2013251079B2 (enExample)
CA (1) CA2869216A1 (enExample)
ES (1) ES2627541T3 (enExample)
WO (1) WO2013156614A1 (enExample)

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