JP2015514679A5

JP2015514679A5 -

Download PDF

Info

Publication number: JP2015514679A5
Authority: JP; Japan
Prior art keywords: pyridin; pyrrolo; dihydro; oxo; ethyl
Prior art date: 2013-04-25
Legal status : Granted

Application number

JP2014551356A

Other languages

English (en)

Japanese (ja)

Other versions

JP6175672B2 (ja

JP2015514679A (ja

Filing date

2013-04-25

Publication date

2017-06-22

2013-04-25 Application filed filed Critical

2013-04-25 Priority to JP2014551356A priority Critical patent/JP6175672B2/ja

2013-04-25 Priority claimed from JP2014551356A external-priority patent/JP6175672B2/ja

2015-05-21 Publication of JP2015514679A publication Critical patent/JP2015514679A/ja

2017-06-22 Publication of JP2015514679A5 publication Critical patent/JP2015514679A5/ja

2017-08-09 Application granted granted Critical

2017-08-09 Publication of JP6175672B2 publication Critical patent/JP6175672B2/ja

Status Active legal-status Critical Current

2033-04-25 Anticipated expiration legal-status Critical

Links

125000000217 alkyl group Chemical group 0.000 claims description 263
125000001424 substituent group Chemical group 0.000 claims description 180
125000000623 heterocyclic group Chemical group 0.000 claims description 71
229910052736 halogen Inorganic materials 0.000 claims description 70
229910052739 hydrogen Inorganic materials 0.000 claims description 69
239000001257 hydrogen Substances 0.000 claims description 69
150000002367 halogens Chemical class 0.000 claims description 58
125000000753 cycloalkyl group Chemical group 0.000 claims description 57
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 51
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 51
125000003118 aryl group Chemical group 0.000 claims description 50
-1 aryl-C 1-6 alkyl Chemical group 0.000 claims description 36
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 32
239000000126 substance Substances 0.000 claims description 28
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 24
125000003342 alkenyl group Chemical group 0.000 claims description 24
150000001875 compounds Chemical class 0.000 claims description 22
125000003545 alkoxy group Chemical group 0.000 claims description 18
150000002431 hydrogen Chemical class 0.000 claims description 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
150000003839 salts Chemical class 0.000 claims description 17
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 12
125000005843 halogen group Chemical group 0.000 claims description 12
125000001624 naphthyl group Chemical group 0.000 claims description 12
229910052757 nitrogen Inorganic materials 0.000 claims description 12
125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
125000004430 oxygen atom Chemical group O* 0.000 claims description 12
229910052717 sulfur Inorganic materials 0.000 claims description 12
125000004434 sulfur atom Chemical group 0.000 claims description 12
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 6
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
125000005010 perfluoroalkyl group Chemical group 0.000 claims description 6
ORKUYZDMEWAUEZ-UHFFFAOYSA-N pyrrolo[3,2-b]pyridin-2-one Chemical group N1=CC=CC2=NC(=O)C=C21 ORKUYZDMEWAUEZ-UHFFFAOYSA-N 0.000 claims description 6
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 6
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
230000011987 methylation Effects 0.000 claims description 2
238000007069 methylation reaction Methods 0.000 claims description 2
208000002193 Pain Diseases 0.000 claims 13
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
208000035475 disorder Diseases 0.000 claims 10
208000004296 neuralgia Diseases 0.000 claims 8
206010015037 epilepsy Diseases 0.000 claims 6
125000001246 bromo group Chemical group Br* 0.000 claims 5
GTCAXTIRRLKXRU-UHFFFAOYSA-N carbamic acid methyl ester Natural products COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims 5
125000001309 chloro group Chemical group Cl* 0.000 claims 5
125000001153 fluoro group Chemical group F* 0.000 claims 5
208000020925 Bipolar disease Diseases 0.000 claims 4
208000008765 Sciatica Diseases 0.000 claims 4
150000001408 amides Chemical class 0.000 claims 4
208000021722 neuropathic pain Diseases 0.000 claims 4
208000009935 visceral pain Diseases 0.000 claims 4
KSOWXTHJYOUQGM-UHFFFAOYSA-N 2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(N)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 KSOWXTHJYOUQGM-UHFFFAOYSA-N 0.000 claims 3
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 3
201000010099 disease Diseases 0.000 claims 3
238000004519 manufacturing process Methods 0.000 claims 3
GVBLESHXBQPZGO-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 GVBLESHXBQPZGO-UHFFFAOYSA-N 0.000 claims 3
JFPNMBSRLAYEDT-ZGTCLIOFSA-N (2r)-n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 JFPNMBSRLAYEDT-ZGTCLIOFSA-N 0.000 claims 2
DOWAOHRHIPSMNF-QVDQXJPCSA-N (2r)-n-[2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 DOWAOHRHIPSMNF-QVDQXJPCSA-N 0.000 claims 2
SMTAYNFUWMLCMT-RRKGBCIJSA-N (2r)-n-[2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 SMTAYNFUWMLCMT-RRKGBCIJSA-N 0.000 claims 2
LFCGYUPHHXKFFH-RRKGBCIJSA-N (2r)-n-[2-[1-[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(Cl)=C1 LFCGYUPHHXKFFH-RRKGBCIJSA-N 0.000 claims 2
WVWCWPHYCHGSLA-ZGTCLIOFSA-N (2r)-n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 WVWCWPHYCHGSLA-ZGTCLIOFSA-N 0.000 claims 2
SOYGRUDRHUDDCV-SECBINFHSA-N (2r)-n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 SOYGRUDRHUDDCV-SECBINFHSA-N 0.000 claims 2
RSESXQUZZDQYRS-UHFFFAOYSA-N 2,2-dimethyl-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)C)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 RSESXQUZZDQYRS-UHFFFAOYSA-N 0.000 claims 2
OPQDCQZVDDWRLY-UHFFFAOYSA-N 2,2-dimethyl-n-[3-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound O=C1C2=CC=NC(NC(=O)C(C)(C)C)=C2C(C)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 OPQDCQZVDDWRLY-UHFFFAOYSA-N 0.000 claims 2
RPORMULAPVYECI-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(Cl)=C1 RPORMULAPVYECI-UHFFFAOYSA-N 0.000 claims 2
VJWCNSDXRQLDFO-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(Cl)=C1 VJWCNSDXRQLDFO-UHFFFAOYSA-N 0.000 claims 2
FGUGKUVERYOFSL-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(Cl)=C1 FGUGKUVERYOFSL-UHFFFAOYSA-N 0.000 claims 2
SWAXNXQXAMGZCR-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(Cl)=C1 SWAXNXQXAMGZCR-UHFFFAOYSA-N 0.000 claims 2
JCCSDNRYJKXBHX-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(Cl)=C1 JCCSDNRYJKXBHX-UHFFFAOYSA-N 0.000 claims 2
SIFLLABUCDWJCB-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(Cl)=C1 SIFLLABUCDWJCB-UHFFFAOYSA-N 0.000 claims 2
IRDJMFOKARPZPJ-UHFFFAOYSA-N 2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 IRDJMFOKARPZPJ-UHFFFAOYSA-N 0.000 claims 2
ZXGLEOVCTMFDSD-UHFFFAOYSA-N 2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(C)=C1 ZXGLEOVCTMFDSD-UHFFFAOYSA-N 0.000 claims 2
ZXILGTCFUHDALW-UHFFFAOYSA-N 2-[1-[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)F)C=N1 ZXILGTCFUHDALW-UHFFFAOYSA-N 0.000 claims 2
UVJGGIPLODCZCN-UHFFFAOYSA-N 2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)C=N1 UVJGGIPLODCZCN-UHFFFAOYSA-N 0.000 claims 2
SAGRIFZIWWFKKH-UHFFFAOYSA-N 2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)C=N1 SAGRIFZIWWFKKH-UHFFFAOYSA-N 0.000 claims 2
GNESQNZVISCRDQ-UHFFFAOYSA-N 2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)C=N1 GNESQNZVISCRDQ-UHFFFAOYSA-N 0.000 claims 2
ORLKMCYFRDXEHG-UHFFFAOYSA-N 2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1CC1 ORLKMCYFRDXEHG-UHFFFAOYSA-N 0.000 claims 2
IUSVFZOLIXAEHN-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 IUSVFZOLIXAEHN-UHFFFAOYSA-N 0.000 claims 2
JGDAJYWTYMFPNV-NFJWQWPMSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-[(2r)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 JGDAJYWTYMFPNV-NFJWQWPMSA-N 0.000 claims 2
DVWXIYRMJBVNGD-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 DVWXIYRMJBVNGD-UHFFFAOYSA-N 0.000 claims 2
GLTWQUPQEPLSIK-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 GLTWQUPQEPLSIK-UHFFFAOYSA-N 0.000 claims 2
LQBCQDLXMYJTLN-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 LQBCQDLXMYJTLN-UHFFFAOYSA-N 0.000 claims 2
AUQGAHIVBRSMSD-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 AUQGAHIVBRSMSD-UHFFFAOYSA-N 0.000 claims 2
YJPZNZHORKUMIE-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 YJPZNZHORKUMIE-UHFFFAOYSA-N 0.000 claims 2
ISCHXWGQQOFFJG-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 ISCHXWGQQOFFJG-UHFFFAOYSA-N 0.000 claims 2
UPBYVKPKLNYBOS-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 UPBYVKPKLNYBOS-UHFFFAOYSA-N 0.000 claims 2
IXWORXLDFQJLCS-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 IXWORXLDFQJLCS-UHFFFAOYSA-N 0.000 claims 2
OHHGAPDYUFXUEC-UHFFFAOYSA-N 2-[1-[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(Cl)=C1 OHHGAPDYUFXUEC-UHFFFAOYSA-N 0.000 claims 2
RAOFQWLUQHSQAQ-UHFFFAOYSA-N 2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(C=C1Cl)=CN=C1OCC1CC1 RAOFQWLUQHSQAQ-UHFFFAOYSA-N 0.000 claims 2
ANHLBIZHIZRVFJ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 ANHLBIZHIZRVFJ-UHFFFAOYSA-N 0.000 claims 2
QTTLKEHQXOPHAR-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 QTTLKEHQXOPHAR-UHFFFAOYSA-N 0.000 claims 2
YJZGPJPGTZDVNX-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-[2-(2-hydroxyethoxy)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCOCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 YJZGPJPGTZDVNX-UHFFFAOYSA-N 0.000 claims 2
SOQVVJALWFFQCV-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 SOQVVJALWFFQCV-UHFFFAOYSA-N 0.000 claims 2
NGNSXRXGYFMDHC-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 NGNSXRXGYFMDHC-UHFFFAOYSA-N 0.000 claims 2
APFUWCZKADWHIZ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 APFUWCZKADWHIZ-UHFFFAOYSA-N 0.000 claims 2
YBIANKYDIOKOOR-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 YBIANKYDIOKOOR-UHFFFAOYSA-N 0.000 claims 2
VOZKHQNDVHQOHC-KWCCSABGSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-[(2r)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 VOZKHQNDVHQOHC-KWCCSABGSA-N 0.000 claims 2
HEQLSYHRHUSCSK-UHFFFAOYSA-N 2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 HEQLSYHRHUSCSK-UHFFFAOYSA-N 0.000 claims 2
KCERCTAFCNXKFE-UHFFFAOYSA-N 2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC(O)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 KCERCTAFCNXKFE-UHFFFAOYSA-N 0.000 claims 2
QDVGYWVKBVNZPV-UHFFFAOYSA-N 2-[1-[6-(cyclopropylmethoxy)-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1OCC1CC1 QDVGYWVKBVNZPV-UHFFFAOYSA-N 0.000 claims 2
MNNZTNTXSPMBCW-UHFFFAOYSA-N 2-[1-[6-(cyclopropylmethoxy)-5-methylpyridin-3-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OCC1CC1 MNNZTNTXSPMBCW-UHFFFAOYSA-N 0.000 claims 2
JDWQGPCKBQWEHE-UHFFFAOYSA-N 2-[[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCO)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)C(Cl)=C1 JDWQGPCKBQWEHE-UHFFFAOYSA-N 0.000 claims 2
KKIFJECDGMFLQX-UHFFFAOYSA-N 2-[[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCCO)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)C(Cl)=C1 KKIFJECDGMFLQX-UHFFFAOYSA-N 0.000 claims 2
CEJCGKDMAROOOW-UHFFFAOYSA-N 2-[[3-chloro-4-(2,2-difluoroethoxy)phenyl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCCO)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)F)C(Cl)=C1 CEJCGKDMAROOOW-UHFFFAOYSA-N 0.000 claims 2
LSKRFTDVALVRNK-UHFFFAOYSA-N 2-[[4-(2,2-difluoroethoxy)-3-methylphenyl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=C1 LSKRFTDVALVRNK-UHFFFAOYSA-N 0.000 claims 2
HULDJPIKXHMHDV-UHFFFAOYSA-N 2-[[4-(2,2-difluoroethoxy)-3-methylphenyl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=C1 HULDJPIKXHMHDV-UHFFFAOYSA-N 0.000 claims 2
CTZNTVDQZAZIIO-UHFFFAOYSA-N 2-[[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)F)C=N1 CTZNTVDQZAZIIO-UHFFFAOYSA-N 0.000 claims 2
DMTUSNBUBDEZFN-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCO)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 DMTUSNBUBDEZFN-UHFFFAOYSA-N 0.000 claims 2
JFDOBYAPXRXIKK-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCCO)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 JFDOBYAPXRXIKK-UHFFFAOYSA-N 0.000 claims 2
RSLTVJAJZHTKNV-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 RSLTVJAJZHTKNV-UHFFFAOYSA-N 0.000 claims 2
NCFBVDFRYTVOCV-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCO)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 NCFBVDFRYTVOCV-UHFFFAOYSA-N 0.000 claims 2
KIOIEAMACFZXHP-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCCO)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 KIOIEAMACFZXHP-UHFFFAOYSA-N 0.000 claims 2
AWNKCJSPJFXRPO-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 AWNKCJSPJFXRPO-UHFFFAOYSA-N 0.000 claims 2
FOXIMSIFWVIFEO-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)C)=NC=C1CN1C(=O)C(C=CN=C2C(=O)NCCCO)=C2C1 FOXIMSIFWVIFEO-UHFFFAOYSA-N 0.000 claims 2
RZWKHSKJZDJSSY-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(Cl)=C1 RZWKHSKJZDJSSY-UHFFFAOYSA-N 0.000 claims 2
WROFOOBDNUPACU-UHFFFAOYSA-N 2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=C1 WROFOOBDNUPACU-UHFFFAOYSA-N 0.000 claims 2
XJPALSGIASSFFZ-UHFFFAOYSA-N 2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(C)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=C1 XJPALSGIASSFFZ-UHFFFAOYSA-N 0.000 claims 2
HMRVOYZRAZMELO-UHFFFAOYSA-N 2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(C)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=C1 HMRVOYZRAZMELO-UHFFFAOYSA-N 0.000 claims 2
JGUPOJCQUPVSBF-UHFFFAOYSA-N 2-amino-n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 JGUPOJCQUPVSBF-UHFFFAOYSA-N 0.000 claims 2
QNOUYKDMHLVBIW-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)C(F)F)N=C1 QNOUYKDMHLVBIW-UHFFFAOYSA-N 0.000 claims 2
YRZPFOHHMQSRFC-UHFFFAOYSA-N 2-methyl-n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(C)=C1 YRZPFOHHMQSRFC-UHFFFAOYSA-N 0.000 claims 2
LDXGMMDURLHNSF-UHFFFAOYSA-N 2-methyl-n-[2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 LDXGMMDURLHNSF-UHFFFAOYSA-N 0.000 claims 2
KVBGWLKLNUIRAC-UHFFFAOYSA-N 2-methyl-n-[2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)C=N1 KVBGWLKLNUIRAC-UHFFFAOYSA-N 0.000 claims 2
QKCREIPPDYWVRH-UHFFFAOYSA-N 2-methyl-n-[2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCCC(F)(F)F)C=N1 QKCREIPPDYWVRH-UHFFFAOYSA-N 0.000 claims 2
XATAJRZNYKEGSB-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)N=N1 XATAJRZNYKEGSB-UHFFFAOYSA-N 0.000 claims 2
NWSVZJDQADHMPB-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 NWSVZJDQADHMPB-UHFFFAOYSA-N 0.000 claims 2
RLLIOWSJQYESGZ-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)N=N1 RLLIOWSJQYESGZ-UHFFFAOYSA-N 0.000 claims 2
KOHMYDQYJIYTBB-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 KOHMYDQYJIYTBB-UHFFFAOYSA-N 0.000 claims 2
DFWXUMRJPPWVMF-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(C)=C1 DFWXUMRJPPWVMF-UHFFFAOYSA-N 0.000 claims 2
INLSKSMTNNNWOH-UHFFFAOYSA-N 2-methyl-n-[2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)C(C)=C1 INLSKSMTNNNWOH-UHFFFAOYSA-N 0.000 claims 2
YFSUQAIIONBXGP-UHFFFAOYSA-N 2-methyl-n-[2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)C=N1 YFSUQAIIONBXGP-UHFFFAOYSA-N 0.000 claims 2
OSWQBWYHHPUUCX-UHFFFAOYSA-N 2-methyl-n-[2-[[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCCC(F)(F)F)C=N1 OSWQBWYHHPUUCX-UHFFFAOYSA-N 0.000 claims 2
XQZRBHGSFCIQMF-UHFFFAOYSA-N 2-methyl-n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)N=N1 XQZRBHGSFCIQMF-UHFFFAOYSA-N 0.000 claims 2
RVVWTANHJFNFRF-UHFFFAOYSA-N 2-methyl-n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 RVVWTANHJFNFRF-UHFFFAOYSA-N 0.000 claims 2
FMUKLCUHVOJUKC-UHFFFAOYSA-N 2-methyl-n-[3-methyl-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound CC1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 FMUKLCUHVOJUKC-UHFFFAOYSA-N 0.000 claims 2
XCXHFRBQNYIHHF-UHFFFAOYSA-N 2-methyl-n-[3-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound CC1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 XCXHFRBQNYIHHF-UHFFFAOYSA-N 0.000 claims 2
KMPYLWOSOHRWFS-UHFFFAOYSA-N 2-methyl-n-[6-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC(C)=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 KMPYLWOSOHRWFS-UHFFFAOYSA-N 0.000 claims 2
AJIUNXZVXWUXHD-UHFFFAOYSA-N 3-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazolidin-2-one Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1CCOC1=O AJIUNXZVXWUXHD-UHFFFAOYSA-N 0.000 claims 2
MOPANPBQMJAFAI-PYMCNQPYSA-N 4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1C[C@@H](O)CC1=O MOPANPBQMJAFAI-PYMCNQPYSA-N 0.000 claims 2
KPIIVEZVTUVRPZ-AWEZNQCLSA-N 4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)N3C(C[C@H](O)C3)=O)C2)=O)=C1 KPIIVEZVTUVRPZ-AWEZNQCLSA-N 0.000 claims 2
208000019901 Anxiety disease Diseases 0.000 claims 2
206010003591 Ataxia Diseases 0.000 claims 2
208000008035 Back Pain Diseases 0.000 claims 2
208000000003 Breakthrough pain Diseases 0.000 claims 2
206010058019 Cancer Pain Diseases 0.000 claims 2
208000000094 Chronic Pain Diseases 0.000 claims 2
208000006561 Cluster Headache Diseases 0.000 claims 2
208000011231 Crohn disease Diseases 0.000 claims 2
208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
208000005171 Dysmenorrhea Diseases 0.000 claims 2
206010013935 Dysmenorrhoea Diseases 0.000 claims 2
208000001640 Fibromyalgia Diseases 0.000 claims 2
206010019233 Headaches Diseases 0.000 claims 2
208000007514 Herpes zoster Diseases 0.000 claims 2
206010021639 Incontinence Diseases 0.000 claims 2
208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
206010065390 Inflammatory pain Diseases 0.000 claims 2
208000004404 Intractable Pain Diseases 0.000 claims 2
208000019695 Migraine disease Diseases 0.000 claims 2
208000019022 Mood disease Diseases 0.000 claims 2
208000016285 Movement disease Diseases 0.000 claims 2
206010028836 Neck pain Diseases 0.000 claims 2
208000001294 Nociceptive Pain Diseases 0.000 claims 2
206010033645 Pancreatitis Diseases 0.000 claims 2
208000000450 Pelvic Pain Diseases 0.000 claims 2
206010036376 Postherpetic Neuralgia Diseases 0.000 claims 2
208000004550 Postoperative Pain Diseases 0.000 claims 2
208000006011 Stroke Diseases 0.000 claims 2
206010049447 Tachyarrhythmia Diseases 0.000 claims 2
208000001871 Tachycardia Diseases 0.000 claims 2
206010043269 Tension headache Diseases 0.000 claims 2
208000008548 Tension-Type Headache Diseases 0.000 claims 2
208000005298 acute pain Diseases 0.000 claims 2
230000036506 anxiety Effects 0.000 claims 2
206010003119 arrhythmia Diseases 0.000 claims 2
230000006793 arrhythmia Effects 0.000 claims 2
208000028683 bipolar I disease Diseases 0.000 claims 2
208000025307 bipolar depression Diseases 0.000 claims 2
208000018912 cluster headache syndrome Diseases 0.000 claims 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
201000003146 cystitis Diseases 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
231100000869 headache Toxicity 0.000 claims 2
208000002551 irritable bowel syndrome Diseases 0.000 claims 2
206010027599 migraine Diseases 0.000 claims 2
239000000203 mixture Substances 0.000 claims 2
201000006417 multiple sclerosis Diseases 0.000 claims 2
210000003205 muscle Anatomy 0.000 claims 2
RQIZXLVEKUARPG-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 RQIZXLVEKUARPG-UHFFFAOYSA-N 0.000 claims 2
GIYKDAXPUQADAC-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 GIYKDAXPUQADAC-UHFFFAOYSA-N 0.000 claims 2
WPGLFHOAMUCXHT-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCNC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 WPGLFHOAMUCXHT-UHFFFAOYSA-N 0.000 claims 2
SNOPDKIQGKENLB-UHFFFAOYSA-N n-(2-cyanoethyl)-2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC#N)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 SNOPDKIQGKENLB-UHFFFAOYSA-N 0.000 claims 2
KXBUKQFIPPGKDN-UHFFFAOYSA-N n-(2-cyanoethyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 KXBUKQFIPPGKDN-UHFFFAOYSA-N 0.000 claims 2
YTRPAWDZGDCJCZ-UHFFFAOYSA-N n-(2-cyanoethyl)-2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 YTRPAWDZGDCJCZ-UHFFFAOYSA-N 0.000 claims 2
MAAHXGUDLCGCME-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(C)=C1 MAAHXGUDLCGCME-UHFFFAOYSA-N 0.000 claims 2
BDOLLMDTEWUNMD-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 BDOLLMDTEWUNMD-UHFFFAOYSA-N 0.000 claims 2
VKDXEOATRRAXHG-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 VKDXEOATRRAXHG-UHFFFAOYSA-N 0.000 claims 2
RILGYFBWGLPXEY-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 RILGYFBWGLPXEY-UHFFFAOYSA-N 0.000 claims 2
UOVXQUNXUGGYOQ-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=C1 UOVXQUNXUGGYOQ-UHFFFAOYSA-N 0.000 claims 2
DHMOODQBOCOBTP-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=C1 DHMOODQBOCOBTP-UHFFFAOYSA-N 0.000 claims 2
QTJWVQNNYNNPMO-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)(F)C(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=C1 QTJWVQNNYNNPMO-UHFFFAOYSA-N 0.000 claims 2
LKTMUKSJWWBHEA-UHFFFAOYSA-N n-(2-methoxyethyl)-2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCOC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 LKTMUKSJWWBHEA-UHFFFAOYSA-N 0.000 claims 2
XGULPRHCGATTTF-UHFFFAOYSA-N n-(3-acetamidopropyl)-2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 XGULPRHCGATTTF-UHFFFAOYSA-N 0.000 claims 2
IHOJJZPJRQTHOT-UHFFFAOYSA-N n-(3-acetamidopropyl)-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 IHOJJZPJRQTHOT-UHFFFAOYSA-N 0.000 claims 2
CSGYPLHXFXATIY-UHFFFAOYSA-N n-(3-acetamidopropyl)-2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 CSGYPLHXFXATIY-UHFFFAOYSA-N 0.000 claims 2
MVMBCTXVMQSXCE-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 MVMBCTXVMQSXCE-UHFFFAOYSA-N 0.000 claims 2
RGNSJNRHWSJMQZ-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)C=N1 RGNSJNRHWSJMQZ-UHFFFAOYSA-N 0.000 claims 2
ZBBGGAPEJFAYEN-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCCC(F)(F)F)C=N1 ZBBGGAPEJFAYEN-UHFFFAOYSA-N 0.000 claims 2
QIMBWCMLDSTHMA-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)N=N1 QIMBWCMLDSTHMA-UHFFFAOYSA-N 0.000 claims 2
FCZRMWSWJWERJH-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 FCZRMWSWJWERJH-UHFFFAOYSA-N 0.000 claims 2
BRBIPFFZTASVOU-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)N=N1 BRBIPFFZTASVOU-UHFFFAOYSA-N 0.000 claims 2
YYTCUQCBKQGRRM-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 YYTCUQCBKQGRRM-UHFFFAOYSA-N 0.000 claims 2
YCLNNHHUGYAXQT-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(CCC(F)(F)F)C(C)=C1 YCLNNHHUGYAXQT-UHFFFAOYSA-N 0.000 claims 2
ZXTVWYRMTLGLQY-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(C(F)(F)F)C=N1 ZXTVWYRMTLGLQY-UHFFFAOYSA-N 0.000 claims 2
CXNXSXRMJWBEHG-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)(F)C(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=C1 CXNXSXRMJWBEHG-UHFFFAOYSA-N 0.000 claims 2
CLYRBYOYOBCFJV-UHFFFAOYSA-N n-(3-methylsulfonylpropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCS(C)(=O)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 CLYRBYOYOBCFJV-UHFFFAOYSA-N 0.000 claims 2
ZZPMXROSOUTGQD-PZORYLMUSA-N n-[(2r)-2-hydroxypropyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 ZZPMXROSOUTGQD-PZORYLMUSA-N 0.000 claims 2
MPBSJYMICFXTFU-PZORYLMUSA-N n-[(2r)-2-hydroxypropyl]-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 MPBSJYMICFXTFU-PZORYLMUSA-N 0.000 claims 2
GHZAZXYNMUMHBK-GFCCVEGCSA-N n-[(2r)-2-hydroxypropyl]-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 GHZAZXYNMUMHBK-GFCCVEGCSA-N 0.000 claims 2
OOKSNVKIOFYGBL-GFCCVEGCSA-N n-[(2r)-2-hydroxypropyl]-2-[[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 OOKSNVKIOFYGBL-GFCCVEGCSA-N 0.000 claims 2
DZDJVJNDZXHULQ-UEWDXFNNSA-N n-[(2s)-1-hydroxypropan-2-yl]-2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)N[C@H](CO)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 DZDJVJNDZXHULQ-UEWDXFNNSA-N 0.000 claims 2
OMLJUZPEXQLJQO-UEWDXFNNSA-N n-[(2s)-1-hydroxypropan-2-yl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)N[C@H](CO)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 OMLJUZPEXQLJQO-UEWDXFNNSA-N 0.000 claims 2
GCXJSKSXRXDBQU-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(Cl)=C1 GCXJSKSXRXDBQU-UHFFFAOYSA-N 0.000 claims 2
DYNOSJFQIUSJKK-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 DYNOSJFQIUSJKK-UHFFFAOYSA-N 0.000 claims 2
WBOFKKYLMVZEAF-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(Cl)=C1 WBOFKKYLMVZEAF-UHFFFAOYSA-N 0.000 claims 2
KVQOSBUKQWXIMG-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 KVQOSBUKQWXIMG-UHFFFAOYSA-N 0.000 claims 2
ZJKVUFBVHAQFKM-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(Cl)=C1 ZJKVUFBVHAQFKM-UHFFFAOYSA-N 0.000 claims 2
JOUBULFGTWTCHO-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(C)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 JOUBULFGTWTCHO-UHFFFAOYSA-N 0.000 claims 2
NXPBLPGQJMDISS-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 NXPBLPGQJMDISS-UHFFFAOYSA-N 0.000 claims 2
QSOAALQBZYKSSB-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 QSOAALQBZYKSSB-UHFFFAOYSA-N 0.000 claims 2
KXDHHQPNEKIJTP-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 KXDHHQPNEKIJTP-UHFFFAOYSA-N 0.000 claims 2
CTINMVYEKMYIGK-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 CTINMVYEKMYIGK-UHFFFAOYSA-N 0.000 claims 2
QTSDJGLBZMPJLH-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(C)=C1 QTSDJGLBZMPJLH-UHFFFAOYSA-N 0.000 claims 2
LQAUENWWAIKKIF-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 LQAUENWWAIKKIF-UHFFFAOYSA-N 0.000 claims 2
XGQPZTAPYACASW-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 XGQPZTAPYACASW-UHFFFAOYSA-N 0.000 claims 2
XXMNLFCXJJXXCY-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 XXMNLFCXJJXXCY-UHFFFAOYSA-N 0.000 claims 2
UHSFTWZDGYUTOI-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 UHSFTWZDGYUTOI-UHFFFAOYSA-N 0.000 claims 2
CVRPLURIYCEXMM-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 CVRPLURIYCEXMM-UHFFFAOYSA-N 0.000 claims 2
JSZWEJRTDTWRKG-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(C)=C1 JSZWEJRTDTWRKG-UHFFFAOYSA-N 0.000 claims 2
NJFMXPSQEMVXLV-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 NJFMXPSQEMVXLV-UHFFFAOYSA-N 0.000 claims 2
VXHCCERZBYMYPI-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C(C)=C(OCC(F)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 VXHCCERZBYMYPI-UHFFFAOYSA-N 0.000 claims 2
RXLLVONELUYMBF-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(F)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 RXLLVONELUYMBF-UHFFFAOYSA-N 0.000 claims 2
KZTNLPGLDJKHKO-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC(F)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 KZTNLPGLDJKHKO-UHFFFAOYSA-N 0.000 claims 2
VOEIZMUBEYALFG-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 VOEIZMUBEYALFG-UHFFFAOYSA-N 0.000 claims 2
XDUFVWRKIDKDPY-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(F)(F)C(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 XDUFVWRKIDKDPY-UHFFFAOYSA-N 0.000 claims 2
HNTGSZFMHAUHPM-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC(F)(F)C(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 HNTGSZFMHAUHPM-UHFFFAOYSA-N 0.000 claims 2
ILTFIYSVIBNGCU-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C(C)=C(OCCC(F)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 ILTFIYSVIBNGCU-UHFFFAOYSA-N 0.000 claims 2
MKUXQRMHOYJBNE-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC(C)=C(OCCC(F)(F)F)C=N1 MKUXQRMHOYJBNE-UHFFFAOYSA-N 0.000 claims 2
WOKOHSLUMCMBCJ-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)F)C=N1 WOKOHSLUMCMBCJ-UHFFFAOYSA-N 0.000 claims 2
LVYWVXGXQRPZBH-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 LVYWVXGXQRPZBH-UHFFFAOYSA-N 0.000 claims 2
FUXDWEZIWORDLZ-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(C)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FUXDWEZIWORDLZ-UHFFFAOYSA-N 0.000 claims 2
APFNMOQPTBLEEA-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC(C)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 APFNMOQPTBLEEA-UHFFFAOYSA-N 0.000 claims 2
KPOHMYMCGNHOCK-UHFFFAOYSA-N n-[2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1CC1 KPOHMYMCGNHOCK-UHFFFAOYSA-N 0.000 claims 2
VHEQAWGMEXBYGQ-UHFFFAOYSA-N n-[2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC2CC2)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 VHEQAWGMEXBYGQ-UHFFFAOYSA-N 0.000 claims 2
CFFYAPJKQVHMKY-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 CFFYAPJKQVHMKY-UHFFFAOYSA-N 0.000 claims 2
GRFWZSVGBFGKSC-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 GRFWZSVGBFGKSC-UHFFFAOYSA-N 0.000 claims 2
DBALXLFWBMKYHS-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)C(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 DBALXLFWBMKYHS-UHFFFAOYSA-N 0.000 claims 2
OCSHJUOLEUHKCA-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 OCSHJUOLEUHKCA-UHFFFAOYSA-N 0.000 claims 2
UXYDLLHHMKIIIV-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 UXYDLLHHMKIIIV-UHFFFAOYSA-N 0.000 claims 2
OIJCWYWOPZKXOH-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-3-methylbutanamide Chemical compound C1C=2C(NC(=O)CC(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 OIJCWYWOPZKXOH-UHFFFAOYSA-N 0.000 claims 2
ZPQHJLYEAPTREE-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCC1 ZPQHJLYEAPTREE-UHFFFAOYSA-N 0.000 claims 2
SCLXZDQKYGFDRR-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 SCLXZDQKYGFDRR-UHFFFAOYSA-N 0.000 claims 2
FOYKMUGKVBGZRD-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 FOYKMUGKVBGZRD-UHFFFAOYSA-N 0.000 claims 2
DSIGWXLJQSSFEA-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 DSIGWXLJQSSFEA-UHFFFAOYSA-N 0.000 claims 2
NYGQRLQVAHSXAT-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 NYGQRLQVAHSXAT-UHFFFAOYSA-N 0.000 claims 2
RCEGWXVHSTVIFH-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC2CC2)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 RCEGWXVHSTVIFH-UHFFFAOYSA-N 0.000 claims 2
QYWPMDZWESTJCT-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1Cl)=CN=C1OCC1CC1 QYWPMDZWESTJCT-UHFFFAOYSA-N 0.000 claims 2
GMQYVTNNIPYBOK-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC2CC2)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 GMQYVTNNIPYBOK-UHFFFAOYSA-N 0.000 claims 2
LORZBMGJFWWBSK-UHFFFAOYSA-N n-[2-[1-[5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound N1=C(OCC(F)(F)F)C(OC)=CC(C(C)N2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 LORZBMGJFWWBSK-UHFFFAOYSA-N 0.000 claims 2
INTVPEYRQMCZAW-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C(C)=C(OCC(F)(F)F)N=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 INTVPEYRQMCZAW-UHFFFAOYSA-N 0.000 claims 2
PTNZYRBEFLYISU-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC(F)(F)F)N=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 PTNZYRBEFLYISU-UHFFFAOYSA-N 0.000 claims 2
LEYVPWSJIXCDAZ-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 LEYVPWSJIXCDAZ-UHFFFAOYSA-N 0.000 claims 2
HVXJBJQMSDFSRC-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 HVXJBJQMSDFSRC-UHFFFAOYSA-N 0.000 claims 2
JJPKDOVLLCIOCV-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCC1 JJPKDOVLLCIOCV-UHFFFAOYSA-N 0.000 claims 2
CPDAMQJJHJIHKD-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopentanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCCC1 CPDAMQJJHJIHKD-UHFFFAOYSA-N 0.000 claims 2
HULXVUCDHRGPJY-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]furan-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CO1 HULXVUCDHRGPJY-UHFFFAOYSA-N 0.000 claims 2
KFEDCDGTEDVSQD-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 KFEDCDGTEDVSQD-UHFFFAOYSA-N 0.000 claims 2
RPRLPDGTPODJGK-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 RPRLPDGTPODJGK-UHFFFAOYSA-N 0.000 claims 2
WDZXBZVDBFMEIG-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyridine-3-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CN=C1 WDZXBZVDBFMEIG-UHFFFAOYSA-N 0.000 claims 2
WWJHQLGHWIAWRD-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(F)(F)C(F)F)N=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 WWJHQLGHWIAWRD-UHFFFAOYSA-N 0.000 claims 2
IIXBIRWBCZHFFW-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)N=N1 IIXBIRWBCZHFFW-UHFFFAOYSA-N 0.000 claims 2
FXJUQYUAIMSWSU-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)C(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FXJUQYUAIMSWSU-UHFFFAOYSA-N 0.000 claims 2
MYOGREFUQZDWJV-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 MYOGREFUQZDWJV-UHFFFAOYSA-N 0.000 claims 2
LRPCEJGDFPPVMC-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(C)=C1 LRPCEJGDFPPVMC-UHFFFAOYSA-N 0.000 claims 2
YPFVSXBHACLPFE-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 YPFVSXBHACLPFE-UHFFFAOYSA-N 0.000 claims 2
YTVIIDVBTIFFDK-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 YTVIIDVBTIFFDK-UHFFFAOYSA-N 0.000 claims 2
WPHNOVNUAOGHHZ-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(C)=C1 WPHNOVNUAOGHHZ-UHFFFAOYSA-N 0.000 claims 2
XXUUTTODLQVQCX-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 XXUUTTODLQVQCX-UHFFFAOYSA-N 0.000 claims 2
VBTBTINJLWCPME-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(C)=C1 VBTBTINJLWCPME-UHFFFAOYSA-N 0.000 claims 2
RGJPVEBTCQAQDD-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(CCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 RGJPVEBTCQAQDD-UHFFFAOYSA-N 0.000 claims 2
FJJQAGBKQRBTNI-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(CCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FJJQAGBKQRBTNI-UHFFFAOYSA-N 0.000 claims 2
YDYMQUKJHRTELC-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(N2N=CC(=C2)C(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 YDYMQUKJHRTELC-UHFFFAOYSA-N 0.000 claims 2
QSSBLQGGNDACJV-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 QSSBLQGGNDACJV-UHFFFAOYSA-N 0.000 claims 2
AKCJPEGSPLRUFW-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 AKCJPEGSPLRUFW-UHFFFAOYSA-N 0.000 claims 2
NBGKEPQGVWGQNI-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-3-methylbutanamide Chemical compound C1C=2C(NC(=O)CC(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 NBGKEPQGVWGQNI-UHFFFAOYSA-N 0.000 claims 2
ALOLXMNEXBJIPX-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCC1 ALOLXMNEXBJIPX-UHFFFAOYSA-N 0.000 claims 2
KIULWCHSHHVGQN-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 KIULWCHSHHVGQN-UHFFFAOYSA-N 0.000 claims 2
GGLQBZVWNBRBDA-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 GGLQBZVWNBRBDA-UHFFFAOYSA-N 0.000 claims 2
KXQVOWNLOPEQMO-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 KXQVOWNLOPEQMO-UHFFFAOYSA-N 0.000 claims 2
TXIWUCSYFMPPIO-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 TXIWUCSYFMPPIO-UHFFFAOYSA-N 0.000 claims 2
SLOGSTNTJSNHMK-UHFFFAOYSA-N n-[2-[1-[6-(3-fluorophenoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1=CC=CC(F)=C1 SLOGSTNTJSNHMK-UHFFFAOYSA-N 0.000 claims 2
JAIUZSXMISMXRZ-UHFFFAOYSA-N n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(N2N=CC(Cl)=C2)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 JAIUZSXMISMXRZ-UHFFFAOYSA-N 0.000 claims 2
OOKHGSVKIDPZET-UHFFFAOYSA-N n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 OOKHGSVKIDPZET-UHFFFAOYSA-N 0.000 claims 2
SHQPSQVGHLDBFG-UHFFFAOYSA-N n-[2-[1-[6-(4-fluorophenoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1=CC=C(F)C=C1 SHQPSQVGHLDBFG-UHFFFAOYSA-N 0.000 claims 2
UEBBKISXTMVQTP-UHFFFAOYSA-N n-[2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3N=COC=3)C2)=O)=N1 UEBBKISXTMVQTP-UHFFFAOYSA-N 0.000 claims 2
HRONGUBRHDKXBU-UHFFFAOYSA-N n-[2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3OC=NC=3)C2)=O)=N1 HRONGUBRHDKXBU-UHFFFAOYSA-N 0.000 claims 2
BGNPQDRCUHAIAY-UHFFFAOYSA-N n-[2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=N1 BGNPQDRCUHAIAY-UHFFFAOYSA-N 0.000 claims 2
UCLURESYBYBCMH-UHFFFAOYSA-N n-[2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)C=N1 UCLURESYBYBCMH-UHFFFAOYSA-N 0.000 claims 2
LZMBJFHLRQPCFK-UHFFFAOYSA-N n-[2-[[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C1=C(OCCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3N=COC=3)C2)=O)=N1 LZMBJFHLRQPCFK-UHFFFAOYSA-N 0.000 claims 2
GLCHBHOVVHHZBD-UHFFFAOYSA-N n-[2-[[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OCCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3OC=NC=3)C2)=O)=N1 GLCHBHOVVHHZBD-UHFFFAOYSA-N 0.000 claims 2
WCVOUSNLOVJKTF-UHFFFAOYSA-N n-[2-[[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3N=COC=3)C2)=O)=N1 WCVOUSNLOVJKTF-UHFFFAOYSA-N 0.000 claims 2
GJLGFIMBSJTWSX-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3N=COC=3)=C2C1 GJLGFIMBSJTWSX-UHFFFAOYSA-N 0.000 claims 2
MOXKTCAHILWMJP-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 MOXKTCAHILWMJP-UHFFFAOYSA-N 0.000 claims 2
YXPYXAQGHOQGQB-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CC3)=C2C1 YXPYXAQGHOQGQB-UHFFFAOYSA-N 0.000 claims 2
LIYGREXOZARVDN-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)C(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3OC=NC=3)=C2C1 LIYGREXOZARVDN-UHFFFAOYSA-N 0.000 claims 2
HEDQVNFJSSJONI-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 HEDQVNFJSSJONI-UHFFFAOYSA-N 0.000 claims 2
VCBAXJZEGPCSGC-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 VCBAXJZEGPCSGC-UHFFFAOYSA-N 0.000 claims 2
XPKJRJUIYVFOJB-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)C(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CC3)=C2C1 XPKJRJUIYVFOJB-UHFFFAOYSA-N 0.000 claims 2
MGNIFXXYNSJWOZ-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)C)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3OC=NC=3)=C2C1 MGNIFXXYNSJWOZ-UHFFFAOYSA-N 0.000 claims 2
GDGVPQCRYJYIIF-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(Cl)=C1 GDGVPQCRYJYIIF-UHFFFAOYSA-N 0.000 claims 2
VIKUIOCULKKEDZ-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(Cl)=C1 VIKUIOCULKKEDZ-UHFFFAOYSA-N 0.000 claims 2
HEERIXLKIJVHQM-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=N1 HEERIXLKIJVHQM-UHFFFAOYSA-N 0.000 claims 2
ZXXOKAVIERROBW-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3OC=NC=3)C2)=O)=C1 ZXXOKAVIERROBW-UHFFFAOYSA-N 0.000 claims 2
XUCYQKDKFLLICX-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 XUCYQKDKFLLICX-UHFFFAOYSA-N 0.000 claims 2
DXKQKVXUJRKGKB-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(OCC(F)(F)C(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3OC=NC=3)C2)=O)=C1 DXKQKVXUJRKGKB-UHFFFAOYSA-N 0.000 claims 2
VOYPGIANRDENGP-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(OCC(C)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3OC=NC=3)C2)=O)=C1 VOYPGIANRDENGP-UHFFFAOYSA-N 0.000 claims 2
QSULKUOGXYPCCT-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(C)=C1 QSULKUOGXYPCCT-UHFFFAOYSA-N 0.000 claims 2
FVLTXRUZWBEETC-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(C)=C1 FVLTXRUZWBEETC-UHFFFAOYSA-N 0.000 claims 2
MQNUJJRYFGRXNI-UHFFFAOYSA-N n-[3-methyl-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound CC1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 MQNUJJRYFGRXNI-UHFFFAOYSA-N 0.000 claims 2
SXLYREPDKZXNAJ-UHFFFAOYSA-N n-[3-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound O=C1C2=CC=NC(NC(C)=O)=C2C(C)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 SXLYREPDKZXNAJ-UHFFFAOYSA-N 0.000 claims 2
IFKSRUXPBJSZTH-UHFFFAOYSA-N n-[3-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound O=C1C2=CC=NC(NC(=O)C3CC3)=C2C(C)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 IFKSRUXPBJSZTH-UHFFFAOYSA-N 0.000 claims 2
LZKMVAYWYRXLNF-UHFFFAOYSA-N n-[3-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound CC1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 LZKMVAYWYRXLNF-UHFFFAOYSA-N 0.000 claims 2
IUXCRJNFJJQHQD-UHFFFAOYSA-N n-cyclopropyl-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NC1CC1 IUXCRJNFJJQHQD-UHFFFAOYSA-N 0.000 claims 2
SUGXQYTZBSCVKP-UHFFFAOYSA-N n-ethyl-2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 SUGXQYTZBSCVKP-UHFFFAOYSA-N 0.000 claims 2
YCFZEQHSJXIUEP-UHFFFAOYSA-N n-ethyl-2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)C=N1 YCFZEQHSJXIUEP-UHFFFAOYSA-N 0.000 claims 2
FYAGLHFQYNFCLH-UHFFFAOYSA-N n-ethyl-2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCCC(F)(F)F)C=N1 FYAGLHFQYNFCLH-UHFFFAOYSA-N 0.000 claims 2
ICIXUUMYRJOGAZ-UHFFFAOYSA-N n-ethyl-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 ICIXUUMYRJOGAZ-UHFFFAOYSA-N 0.000 claims 2
FUVRLCVQZIYNCK-UHFFFAOYSA-N n-ethyl-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)N=N1 FUVRLCVQZIYNCK-UHFFFAOYSA-N 0.000 claims 2
PZJWPCLKMJICFP-UHFFFAOYSA-N n-ethyl-2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(CCC(F)(F)F)C(C)=C1 PZJWPCLKMJICFP-UHFFFAOYSA-N 0.000 claims 2
JPQGXVKFEYCSRY-UHFFFAOYSA-N n-ethyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)N=N1 JPQGXVKFEYCSRY-UHFFFAOYSA-N 0.000 claims 2
RFXOPYGPZXMPLD-UHFFFAOYSA-N n-methyl-2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)C=N1 RFXOPYGPZXMPLD-UHFFFAOYSA-N 0.000 claims 2
SOBNLVWUDKVUHB-UHFFFAOYSA-N n-methyl-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 SOBNLVWUDKVUHB-UHFFFAOYSA-N 0.000 claims 2
KGCBTCJXRPTIPG-UHFFFAOYSA-N n-methyl-2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)N=N1 KGCBTCJXRPTIPG-UHFFFAOYSA-N 0.000 claims 2
NLMWKMSCXFQVIV-UHFFFAOYSA-N n-methyl-2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CN=C(CCC(F)(F)F)C(C)=C1 NLMWKMSCXFQVIV-UHFFFAOYSA-N 0.000 claims 2
210000005036 nerve Anatomy 0.000 claims 2
208000015122 neurodegenerative disease Diseases 0.000 claims 2
208000015706 neuroendocrine disease Diseases 0.000 claims 2
230000002981 neuropathic effect Effects 0.000 claims 2
201000008482 osteoarthritis Diseases 0.000 claims 2
230000002093 peripheral effect Effects 0.000 claims 2
239000008194 pharmaceutical composition Substances 0.000 claims 2
208000020016 psychiatric disease Diseases 0.000 claims 2
206010039073 rheumatoid arthritis Diseases 0.000 claims 2
230000009885 systemic effect Effects 0.000 claims 2
206010044652 trigeminal neuralgia Diseases 0.000 claims 2
PCOQIQYMTMGXCT-QVDQXJPCSA-N (2r)-n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 PCOQIQYMTMGXCT-QVDQXJPCSA-N 0.000 claims 1
RDMCRZZDWVCXMN-WVQRXBFSSA-N (2r)-n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxolane-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)[C@H]1CCCO1 RDMCRZZDWVCXMN-WVQRXBFSSA-N 0.000 claims 1
CZCAXTGKDVNSGW-PIJUOVFKSA-N (2r)-n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 CZCAXTGKDVNSGW-PIJUOVFKSA-N 0.000 claims 1
JHKORHBYHQWUSR-ZGTCLIOFSA-N (2r)-n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 JHKORHBYHQWUSR-ZGTCLIOFSA-N 0.000 claims 1
WPPLVWYBKLOQBM-SNVBAGLBSA-N (2r)-n-[2-[[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)C(Cl)=C1 WPPLVWYBKLOQBM-SNVBAGLBSA-N 0.000 claims 1
UKRMIMGBVBVYCG-LLVKDONJSA-N (2r)-n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@H](O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(C)=C1 UKRMIMGBVBVYCG-LLVKDONJSA-N 0.000 claims 1
PCOQIQYMTMGXCT-AXDSSHIGSA-N (2s)-n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxypropanamide Chemical compound C1C=2C(NC(=O)[C@@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 PCOQIQYMTMGXCT-AXDSSHIGSA-N 0.000 claims 1
LTZXMJYPHKQDGT-NBFOKTCDSA-N (2s)-n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxolane-2-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)[C@@H]1CCCO1 LTZXMJYPHKQDGT-NBFOKTCDSA-N 0.000 claims 1
FUHAYEUDSPESKY-RUINGEJQSA-N (2s)-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyrrolidine-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)[C@@H]1CCCN1 FUHAYEUDSPESKY-RUINGEJQSA-N 0.000 claims 1
FAMXJDSZZKQZDL-WVQRXBFSSA-N (3r)-n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]morpholine-3-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)[C@H]1COCCN1 FAMXJDSZZKQZDL-WVQRXBFSSA-N 0.000 claims 1
FAMXJDSZZKQZDL-NBFOKTCDSA-N (3s)-n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]morpholine-3-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)[C@@H]1COCCN1 FAMXJDSZZKQZDL-NBFOKTCDSA-N 0.000 claims 1
HZINNBATIYKFKA-XPKAQORNSA-N (5s)-3-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-5-propan-2-yl-1,3-oxazolidin-2-one Chemical compound O=C1O[C@@H](C(C)C)CN1C1=NC=CC2=C1CN(C(C)C=1C=C(C)C(OCC(F)F)=NC=1)C2=O HZINNBATIYKFKA-XPKAQORNSA-N 0.000 claims 1
HQPRDQKOADIUJZ-UHFFFAOYSA-N 1-methyl-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]imidazole-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=NC=CN1C HQPRDQKOADIUJZ-UHFFFAOYSA-N 0.000 claims 1
QJQVESPMOMFIEB-UHFFFAOYSA-N 1-oxo-2,3-dihydropyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound O=C1NCC=2C(=NC=CC=21)C(=O)N QJQVESPMOMFIEB-UHFFFAOYSA-N 0.000 claims 1
XAZIEDXEDRUFAK-UHFFFAOYSA-N 2,2-dimethyl-n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)C)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(C)=C1 XAZIEDXEDRUFAK-UHFFFAOYSA-N 0.000 claims 1
GRNDVJGSSMZTLH-UHFFFAOYSA-N 2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1OC1CCC1 GRNDVJGSSMZTLH-UHFFFAOYSA-N 0.000 claims 1
WVVYNVKZEIHTGO-UHFFFAOYSA-N 2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1OC1CCC1 WVVYNVKZEIHTGO-UHFFFAOYSA-N 0.000 claims 1
UTGPIULPNHLYGP-UHFFFAOYSA-N 2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1CCC1 UTGPIULPNHLYGP-UHFFFAOYSA-N 0.000 claims 1
ZMQVJNAPIIYZFM-UHFFFAOYSA-N 2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1CCC1 ZMQVJNAPIIYZFM-UHFFFAOYSA-N 0.000 claims 1
VAOZGQYFCZAESB-YUZLPWPTSA-N 2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1C=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1C[C@@H](O)CC1=O VAOZGQYFCZAESB-YUZLPWPTSA-N 0.000 claims 1
IFUIERWZNLVKMD-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(Cl)=C1 IFUIERWZNLVKMD-UHFFFAOYSA-N 0.000 claims 1
ZBSQEWSGBUBJLO-UHFFFAOYSA-N 2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(Cl)=C1 ZBSQEWSGBUBJLO-UHFFFAOYSA-N 0.000 claims 1
APZLHUNXOQHELA-UHFFFAOYSA-N 2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 APZLHUNXOQHELA-UHFFFAOYSA-N 0.000 claims 1
KUHGBTPANBTLJH-UHFFFAOYSA-N 2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 KUHGBTPANBTLJH-UHFFFAOYSA-N 0.000 claims 1
FBTWJWISZHDITJ-UHFFFAOYSA-N 2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 FBTWJWISZHDITJ-UHFFFAOYSA-N 0.000 claims 1
PVHDFTOKYGMGAT-UHFFFAOYSA-N 2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 PVHDFTOKYGMGAT-UHFFFAOYSA-N 0.000 claims 1
AHVHDXVJHTYGRV-WUJWULDRSA-N 2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1C=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1C[C@@H](O)CC1=O AHVHDXVJHTYGRV-WUJWULDRSA-N 0.000 claims 1
LKJZZPYFPMXQOC-UHFFFAOYSA-N 2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 LKJZZPYFPMXQOC-UHFFFAOYSA-N 0.000 claims 1
HPJXEMLQAYBXKT-UHFFFAOYSA-N 2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(C)=C1 HPJXEMLQAYBXKT-UHFFFAOYSA-N 0.000 claims 1
MYUBKNKXTPOTLI-UHFFFAOYSA-N 2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(C)=C1 MYUBKNKXTPOTLI-UHFFFAOYSA-N 0.000 claims 1
AIWROIQBBJOVPN-UHFFFAOYSA-N 2-[1-[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)F)C=N1 AIWROIQBBJOVPN-UHFFFAOYSA-N 0.000 claims 1
DYPXEDOVXJFQAA-UHFFFAOYSA-N 2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)C=N1 DYPXEDOVXJFQAA-UHFFFAOYSA-N 0.000 claims 1
LGBRKNFBFBJTKM-UHFFFAOYSA-N 2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1CC1 LGBRKNFBFBJTKM-UHFFFAOYSA-N 0.000 claims 1
CZSLKUOIUXVVDP-UHFFFAOYSA-N 2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1CC1 CZSLKUOIUXVVDP-UHFFFAOYSA-N 0.000 claims 1
BRBOPPFIGYRQEF-UHFFFAOYSA-N 2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1CC1 BRBOPPFIGYRQEF-UHFFFAOYSA-N 0.000 claims 1
NSCZPOUXMICUED-UHFFFAOYSA-N 2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1=CC=C(F)C=C1 NSCZPOUXMICUED-UHFFFAOYSA-N 0.000 claims 1
MRMAZFSDYLNECT-UHFFFAOYSA-N 2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1=CC=C(F)C=C1 MRMAZFSDYLNECT-UHFFFAOYSA-N 0.000 claims 1
AKZVHLQZVDNGHI-UHFFFAOYSA-N 2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1=CC=C(F)C=C1 AKZVHLQZVDNGHI-UHFFFAOYSA-N 0.000 claims 1
KBEZKTXOZBDPDS-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-(2-cyanoethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 KBEZKTXOZBDPDS-UHFFFAOYSA-N 0.000 claims 1
KDBQTVRCWYTZHK-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-(2-methoxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCOC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 KDBQTVRCWYTZHK-UHFFFAOYSA-N 0.000 claims 1
OJPTXIQSVPJMNS-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-(oxetan-3-yl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NC1COC1 OJPTXIQSVPJMNS-UHFFFAOYSA-N 0.000 claims 1
HOYNVNGBYPDHOF-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-[2-(2-hydroxyethoxy)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCOCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 HOYNVNGBYPDHOF-UHFFFAOYSA-N 0.000 claims 1
IBCHLLYEINQHCX-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 IBCHLLYEINQHCX-UHFFFAOYSA-N 0.000 claims 1
KCGZGTXUQJJJPN-NFJWQWPMSA-N 2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-n-[(2r)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 KCGZGTXUQJJJPN-NFJWQWPMSA-N 0.000 claims 1
DLIREDRNPCANEO-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-(2-cyanoethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 DLIREDRNPCANEO-UHFFFAOYSA-N 0.000 claims 1
FFYGBVOCNABWFL-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 FFYGBVOCNABWFL-UHFFFAOYSA-N 0.000 claims 1
KFZUVZHLXWOUMT-UHFFFAOYSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-(3-methyloxetan-3-yl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NC1(C)COC1 KFZUVZHLXWOUMT-UHFFFAOYSA-N 0.000 claims 1
PQIHOVDARLMOFE-NFJWQWPMSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-[(2r)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 PQIHOVDARLMOFE-NFJWQWPMSA-N 0.000 claims 1
PQIHOVDARLMOFE-VUWPPUDQSA-N 2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-n-[(2s)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 PQIHOVDARLMOFE-VUWPPUDQSA-N 0.000 claims 1
HAPRCDMGICJOPY-JHJMLUEUSA-N 2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-n-[(2r)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 HAPRCDMGICJOPY-JHJMLUEUSA-N 0.000 claims 1
CVCKAAPJVLLZBS-UHFFFAOYSA-N 2-[1-[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(Cl)=C1 CVCKAAPJVLLZBS-UHFFFAOYSA-N 0.000 claims 1
WGCNLZDPDAYNMY-UHFFFAOYSA-N 2-[1-[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCCC(F)(F)F)C(Cl)=C1 WGCNLZDPDAYNMY-UHFFFAOYSA-N 0.000 claims 1
QLNFYOOOZHGAFI-UHFFFAOYSA-N 2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C(C=C1Cl)=CN=C1OCC1CC1 QLNFYOOOZHGAFI-UHFFFAOYSA-N 0.000 claims 1
HPLKNVIDRQJYBM-UHFFFAOYSA-N 2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C(C=C1Cl)=CN=C1OCC1CC1 HPLKNVIDRQJYBM-UHFFFAOYSA-N 0.000 claims 1
NOSNZAZJCPNPGJ-UHFFFAOYSA-N 2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C(C=C1Cl)=CN=C1OCC1CC1 NOSNZAZJCPNPGJ-UHFFFAOYSA-N 0.000 claims 1
NIITWGAIVJGNHG-UHFFFAOYSA-N 2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-n-propan-2-yl-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 NIITWGAIVJGNHG-UHFFFAOYSA-N 0.000 claims 1
QBNPAHCEHGYMKT-UHFFFAOYSA-N 2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-4-(2-oxo-3-propan-2-ylimidazolidin-1-yl)-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound O=C1N(C(C)C)CCN1C1=NC=CC2=C1CN(C(C)C=1C=C(C)C(OCC(F)(F)F)=NC=1)C2=O QBNPAHCEHGYMKT-UHFFFAOYSA-N 0.000 claims 1
LSHODJXRWAMRRM-UHFFFAOYSA-N 2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-4-(2-oxopyrrolidin-1-yl)-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1CCCC1=O LSHODJXRWAMRRM-UHFFFAOYSA-N 0.000 claims 1
ZHHLEWOZTXQDNW-UHFFFAOYSA-N 2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-(2-morpholin-4-ylethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCCN1CCOCC1 ZHHLEWOZTXQDNW-UHFFFAOYSA-N 0.000 claims 1
ZBCXENPXPXIFOY-UHFFFAOYSA-N 2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-n-(oxetan-3-yl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NC1COC1 ZBCXENPXPXIFOY-UHFFFAOYSA-N 0.000 claims 1
JKZWCSBEOPRXFP-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-n-propan-2-yl-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 JKZWCSBEOPRXFP-UHFFFAOYSA-N 0.000 claims 1
QPXSDIHXPWJGLF-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxy-2-methylpropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCC(C)(C)O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 QPXSDIHXPWJGLF-UHFFFAOYSA-N 0.000 claims 1
NNXQYUBZFVXNQZ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-(2-methoxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCOC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 NNXQYUBZFVXNQZ-UHFFFAOYSA-N 0.000 claims 1
ARWPHGGSPYEJTP-UEWDXFNNSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-[(2s)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 ARWPHGGSPYEJTP-UEWDXFNNSA-N 0.000 claims 1
DGQUWYIXVOSJPD-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-[2-(dimethylamino)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCN(C)C)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 DGQUWYIXVOSJPD-UHFFFAOYSA-N 0.000 claims 1
MMZCCCOVKVCKDC-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 MMZCCCOVKVCKDC-UHFFFAOYSA-N 0.000 claims 1
KOJJLVAXROMUGZ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 KOJJLVAXROMUGZ-UHFFFAOYSA-N 0.000 claims 1
ABHRWHOOXUYMDL-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 ABHRWHOOXUYMDL-UHFFFAOYSA-N 0.000 claims 1
GTOAWMPLEQPXBJ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 GTOAWMPLEQPXBJ-UHFFFAOYSA-N 0.000 claims 1
IPDNNOKFHUUOOB-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-n-[3-(2-oxopyrrolidin-1-yl)propyl]-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCCCN1CCCC1=O IPDNNOKFHUUOOB-UHFFFAOYSA-N 0.000 claims 1
KIEGKYJRMXYMNG-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-(1h-imidazol-2-ylmethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCC1=NC=CN1 KIEGKYJRMXYMNG-UHFFFAOYSA-N 0.000 claims 1
OCLPXMBQPMWWCA-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-[(1-methylimidazol-2-yl)methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCC1=NC=CN1C OCLPXMBQPMWWCA-UHFFFAOYSA-N 0.000 claims 1
WFNVIAMFPZPIGO-LSLKUGRBSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-[(2s)-1-(methylamino)-1-oxopropan-2-yl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)N[C@@H](C)C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 WFNVIAMFPZPIGO-LSLKUGRBSA-N 0.000 claims 1
PXGUCWKQTBUPGJ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-[(5-methyl-1h-1,2,4-triazol-3-yl)methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCC1=NNC(C)=N1 PXGUCWKQTBUPGJ-UHFFFAOYSA-N 0.000 claims 1
XAKOUPRNJMKPBJ-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-[2-(2-methylimidazol-1-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCCN1C=CN=C1C XAKOUPRNJMKPBJ-UHFFFAOYSA-N 0.000 claims 1
FCVIVGGSRGHQKW-UHFFFAOYSA-N 2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-n-[2-(5-methyl-1h-imidazol-2-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NCCC1=NC=C(C)N1 FCVIVGGSRGHQKW-UHFFFAOYSA-N 0.000 claims 1
JHOZGXOUYDMPLC-VYIIXAMBSA-N 2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1N=C(N2N=CC(Cl)=C2)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1C[C@@H](O)CC1=O JHOZGXOUYDMPLC-VYIIXAMBSA-N 0.000 claims 1
GQFGUWKMOWGRDM-UHFFFAOYSA-N 2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 GQFGUWKMOWGRDM-UHFFFAOYSA-N 0.000 claims 1
NHMYUKJCDSFKFN-UHFFFAOYSA-N 2-[1-[6-(cyclopropylmethoxy)-5-methylpyridin-3-yl]ethyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OCC1CC1 NHMYUKJCDSFKFN-UHFFFAOYSA-N 0.000 claims 1
GRPGURUWDDNLLM-UHFFFAOYSA-N 2-[1-[6-[(4-fluorophenyl)methoxy]-5-methylpyridin-3-yl]ethyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1OCC1=CC=C(F)C=C1 GRPGURUWDDNLLM-UHFFFAOYSA-N 0.000 claims 1
KWKJZKFFWKPIQJ-LBPRGKRZSA-N 2-[[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound O=C1C[C@H](O)CN1C1=NC=CC2=C1CN(CC=1C=C(Cl)C(OCC(F)(F)F)=CC=1)C2=O KWKJZKFFWKPIQJ-LBPRGKRZSA-N 0.000 claims 1
VCHNMNCBOVKXIP-UHFFFAOYSA-N 2-[[3-chloro-4-(2,2-difluoroethoxy)phenyl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCO)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)F)C(Cl)=C1 VCHNMNCBOVKXIP-UHFFFAOYSA-N 0.000 claims 1
FGDYZKYEICDBBF-UHFFFAOYSA-N 2-[[4-(cyclopropylmethylcarbamoyl)-3-methylphenyl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC(C=C1C)=CC=C1C(=O)NCC1CC1 FGDYZKYEICDBBF-UHFFFAOYSA-N 0.000 claims 1
IMARISYQTDXYFT-UHFFFAOYSA-N 2-[[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=N1 IMARISYQTDXYFT-UHFFFAOYSA-N 0.000 claims 1
RDMXDKJDLOFFTC-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-n-(3-methylsulfonylpropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCCS(=O)(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 RDMXDKJDLOFFTC-UHFFFAOYSA-N 0.000 claims 1
MKAVIWUNUYLHSW-SNVBAGLBSA-N 2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-n-[(2r)-2-hydroxypropyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@H](O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 MKAVIWUNUYLHSW-SNVBAGLBSA-N 0.000 claims 1
CZWOWWSOVFFKAS-JTQLQIEISA-N 2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-n-[(2s)-1-hydroxypropan-2-yl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)N[C@H](CO)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 CZWOWWSOVFFKAS-JTQLQIEISA-N 0.000 claims 1
XIOWYFCFBLFHKC-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 XIOWYFCFBLFHKC-UHFFFAOYSA-N 0.000 claims 1
CLVQZUXREBTUOX-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCCO)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(Cl)=C1 CLVQZUXREBTUOX-UHFFFAOYSA-N 0.000 claims 1
IZSOXKDWWHXYOH-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)C)=NC=C1CN1C(=O)C(C=CN=C2C(=O)NCCO)=C2C1 IZSOXKDWWHXYOH-UHFFFAOYSA-N 0.000 claims 1
DRISXOOKWCSBNF-UHFFFAOYSA-N 2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(Cl)=C1 DRISXOOKWCSBNF-UHFFFAOYSA-N 0.000 claims 1
CTEOCCCWMNHEBD-UHFFFAOYSA-N 2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=C1 CTEOCCCWMNHEBD-UHFFFAOYSA-N 0.000 claims 1
MVLHOSIJIACYGY-UHFFFAOYSA-N 2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(C)=C1 MVLHOSIJIACYGY-UHFFFAOYSA-N 0.000 claims 1
LNJPKRDJVMXOBM-UHFFFAOYSA-N 2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-n-(2-hydroxyethyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound CC1=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=CN=C1N1CCC(F)(F)CC1 LNJPKRDJVMXOBM-UHFFFAOYSA-N 0.000 claims 1
FVCMJPUCFXMXFO-UHFFFAOYSA-N 2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-n-(3-hydroxypropyl)-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound CC1=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=CN=C1N1CCC(F)(F)CC1 FVCMJPUCFXMXFO-UHFFFAOYSA-N 0.000 claims 1
RXFOAUCRLVMASA-UHFFFAOYSA-N 2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-n-ethyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC(C=C1C)=CN=C1N1CCC(F)(F)CC1 RXFOAUCRLVMASA-UHFFFAOYSA-N 0.000 claims 1
KCTKETOPCZZHON-UHFFFAOYSA-N 2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-n-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1CC(C=C1C)=CN=C1N1CCC(F)(F)CC1 KCTKETOPCZZHON-UHFFFAOYSA-N 0.000 claims 1
BOJVMICKMSEZOT-UHFFFAOYSA-N 2-amino-n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 BOJVMICKMSEZOT-UHFFFAOYSA-N 0.000 claims 1
WUIGIUVYSWUWKC-UHFFFAOYSA-N 2-amino-n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 WUIGIUVYSWUWKC-UHFFFAOYSA-N 0.000 claims 1
HEHQFINUWZACSD-UHFFFAOYSA-N 2-amino-n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)(N)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 HEHQFINUWZACSD-UHFFFAOYSA-N 0.000 claims 1
WKCQQUWFNUPRDJ-UHFFFAOYSA-N 2-amino-n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C(C)(C)N)C2)=O)=C1 WKCQQUWFNUPRDJ-UHFFFAOYSA-N 0.000 claims 1
BFDXCYYFVIDXLP-UHFFFAOYSA-N 2-cyano-n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)C#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 BFDXCYYFVIDXLP-UHFFFAOYSA-N 0.000 claims 1
ODYZGWURPQALDI-UHFFFAOYSA-N 2-hydroxy-2-methyl-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 ODYZGWURPQALDI-UHFFFAOYSA-N 0.000 claims 1
LMVOPACOCBLWAK-UHFFFAOYSA-N 2-methoxy-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)COC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 LMVOPACOCBLWAK-UHFFFAOYSA-N 0.000 claims 1
QTGNRVDJRQYFNO-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)C(F)F)C=C1 QTGNRVDJRQYFNO-UHFFFAOYSA-N 0.000 claims 1
NPIAAUCKIILVEA-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C=C1 NPIAAUCKIILVEA-UHFFFAOYSA-N 0.000 claims 1
YAJFHWGDNKMHEK-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)N=C1 YAJFHWGDNKMHEK-UHFFFAOYSA-N 0.000 claims 1
SRYKLSFSWIUYKF-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]propyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)C)=C2C(=O)N1C(CC)C1=CC=C(OCC(F)(F)F)N=C1 SRYKLSFSWIUYKF-UHFFFAOYSA-N 0.000 claims 1
JWVNMHBABXUDCT-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[6-(2,2,3,3,3-pentafluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)C(F)(F)F)N=C1 JWVNMHBABXUDCT-UHFFFAOYSA-N 0.000 claims 1
CFIXLWPWAAGQAR-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[1-[6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCCC(F)(F)F)N=C1 CFIXLWPWAAGQAR-UHFFFAOYSA-N 0.000 claims 1
LVOLIDYDGXLHMK-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[2-[6-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CCC1=CC=CC(OCC(F)(F)F)=N1 LVOLIDYDGXLHMK-UHFFFAOYSA-N 0.000 claims 1
REBXQCBTBUAYHF-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[[6-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC=CC(OCC(F)(F)F)=N1 REBXQCBTBUAYHF-UHFFFAOYSA-N 0.000 claims 1
DRFSWCOPXQHNIQ-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)N=C1 DRFSWCOPXQHNIQ-UHFFFAOYSA-N 0.000 claims 1
GNNXTCYBOIGQJG-UHFFFAOYSA-N 2-methyl-n-[1-oxo-2-[[6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)C(F)F)N=C1 GNNXTCYBOIGQJG-UHFFFAOYSA-N 0.000 claims 1
JUTCGZNPVDECDF-UHFFFAOYSA-N 2-methyl-n-[2-[(5-methyl-6-pyrazol-1-ylpyridin-3-yl)methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC(C=C1C)=CN=C1N1C=CC=N1 JUTCGZNPVDECDF-UHFFFAOYSA-N 0.000 claims 1
HPHVCUXKEBMKMJ-UHFFFAOYSA-N 2-methyl-n-[2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 HPHVCUXKEBMKMJ-UHFFFAOYSA-N 0.000 claims 1
CEVFUFUOQMBDMZ-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethylamino)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(NCC(F)(F)F)C(C)=C1 CEVFUFUOQMBDMZ-UHFFFAOYSA-N 0.000 claims 1
KFKHPURFDMIHPR-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(CCC(F)(F)F)C(C)=C1 KFKHPURFDMIHPR-UHFFFAOYSA-N 0.000 claims 1
WRXPQDQYBOXKAO-UHFFFAOYSA-N 2-methyl-n-[2-[1-[5-methyl-6-[6-(trifluoromethyl)pyridin-3-yl]oxypyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1=CC=C(C(F)(F)F)N=C1 WRXPQDQYBOXKAO-UHFFFAOYSA-N 0.000 claims 1
WMIYAGDIGWKQGQ-UHFFFAOYSA-N 2-methyl-n-[2-[1-[6-methyl-5-(2,2,2-trifluoroethoxy)pyrazin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=N1 WMIYAGDIGWKQGQ-UHFFFAOYSA-N 0.000 claims 1
NTUUCJOILKISSO-UHFFFAOYSA-N 3-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazinan-2-one Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1CCCOC1=O NTUUCJOILKISSO-UHFFFAOYSA-N 0.000 claims 1
VEOJSYJCMZXRMM-UHFFFAOYSA-N 3-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazolidin-2-one Chemical compound C=1N=C(OCCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1CCOC1=O VEOJSYJCMZXRMM-UHFFFAOYSA-N 0.000 claims 1
KJBSWYDDSKEZDH-UHFFFAOYSA-N 3-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazolidin-2-one Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)N3C(OCC3)=O)C2)=O)=C1 KJBSWYDDSKEZDH-UHFFFAOYSA-N 0.000 claims 1
BFJMHTOBRRZELQ-UHFFFAOYSA-N 3-iodo-2h-pyrazolo[3,4-c]pyridine Chemical compound N1=CC=C2C(I)=NNC2=C1 BFJMHTOBRRZELQ-UHFFFAOYSA-N 0.000 claims 1
JWLBQPZPRJWTQT-INSVYWFGSA-N 4-[(3s)-3-hydroxy-2-oxopyrrolidin-1-yl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1CC[C@H](O)C1=O JWLBQPZPRJWTQT-INSVYWFGSA-N 0.000 claims 1
OWWHSCRLGOQXLB-WUJWULDRSA-N 4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound C=1C=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2N1C[C@@H](O)CC1=O OWWHSCRLGOQXLB-WUJWULDRSA-N 0.000 claims 1
HLFCPAMKCMDADO-ZDUSSCGKSA-N 4-[(4s)-4-hydroxy-2-oxopyrrolidin-1-yl]-2-[[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-3h-pyrrolo[3,4-c]pyridin-1-one Chemical compound N1=C(OCC(F)(F)C(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)N3C(C[C@H](O)C3)=O)C2)=O)=C1 HLFCPAMKCMDADO-ZDUSSCGKSA-N 0.000 claims 1
LRNYZZNRTGFPBN-UHFFFAOYSA-N CC(C(C=N1)=CC(C)=C1OCC(F)F)N(CC1=C2C=CN=C1C(C=C1)=NC(C)=C1C(N)=O)C2=O Chemical compound CC(C(C=N1)=CC(C)=C1OCC(F)F)N(CC1=C2C=CN=C1C(C=C1)=NC(C)=C1C(N)=O)C2=O LRNYZZNRTGFPBN-UHFFFAOYSA-N 0.000 claims 1
UNEONQVKPTZCJC-UHFFFAOYSA-N CC(C=C(CN(C(C1=C2C=CN=C1)N(CC(C1)O)C1=O)C2=O)C=N1)=C1OCC(F)(F)F Chemical compound CC(C=C(CN(C(C1=C2C=CN=C1)N(CC(C1)O)C1=O)C2=O)C=N1)=C1OCC(F)(F)F UNEONQVKPTZCJC-UHFFFAOYSA-N 0.000 claims 1
FQNOLWDWSBWNFO-UHFFFAOYSA-N CC=1C=C(C=NC=1OCC(F)(F)F)C(C)N1CC=2C(=NC=CC=2C1=O)N1C=NC=C1C(=O)N Chemical compound CC=1C=C(C=NC=1OCC(F)(F)F)C(C)N1CC=2C(=NC=CC=2C1=O)N1C=NC=C1C(=O)N FQNOLWDWSBWNFO-UHFFFAOYSA-N 0.000 claims 1
208000001387 Causalgia Diseases 0.000 claims 1
208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 1
241001465754 Metazoa Species 0.000 claims 1
KWUVMPPURILWPD-UHFFFAOYSA-N O1N=C(C=C1)C(=O)NC1=NC=CC2=C1CN(C2=O)C(C)C=1C=NC(=C(C=1)C)OCC(F)(F)F Chemical compound O1N=C(C=C1)C(=O)NC1=NC=CC2=C1CN(C2=O)C(C)C=1C=NC(=C(C=1)C)OCC(F)(F)F KWUVMPPURILWPD-UHFFFAOYSA-N 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
208000014439 complex regional pain syndrome type 2 Diseases 0.000 claims 1
229940125904 compound 1 Drugs 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
239000000178 monomer Substances 0.000 claims 1
JKPXSWZPEZUCGZ-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C(C=C1C)=CN=C1OC1CCC1 JKPXSWZPEZUCGZ-UHFFFAOYSA-N 0.000 claims 1
GDBGMTLQHQZOPX-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(Cl)=C1 GDBGMTLQHQZOPX-UHFFFAOYSA-N 0.000 claims 1
ZEDGORVIVXCWAM-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 ZEDGORVIVXCWAM-UHFFFAOYSA-N 0.000 claims 1
RASLCFARYJLRLD-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[4-(2,2-difluoropropoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OCC(C)(F)F)C(C)=C1 RASLCFARYJLRLD-UHFFFAOYSA-N 0.000 claims 1
RQQPVZRWNOVROG-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1CC1 RQQPVZRWNOVROG-UHFFFAOYSA-N 0.000 claims 1
WTPODLONHOLFDW-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1=CC=C(F)C=C1 WTPODLONHOLFDW-UHFFFAOYSA-N 0.000 claims 1
HGYXCCWPXICDDI-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 HGYXCCWPXICDDI-UHFFFAOYSA-N 0.000 claims 1
YGHUBYICQOUDGP-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 YGHUBYICQOUDGP-UHFFFAOYSA-N 0.000 claims 1
RQBYYQSTYUROCP-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C(C=C1Cl)=CN=C1OCC1CC1 RQBYYQSTYUROCP-UHFFFAOYSA-N 0.000 claims 1
KRUUNUYXYPJIJT-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 KRUUNUYXYPJIJT-UHFFFAOYSA-N 0.000 claims 1
USJDUBRKDLVZQO-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[1-[6-(cyclopropylmethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNC(C)=O)=C2C(=O)N1C(C)C(C=C1C)=CN=C1OCC1CC1 USJDUBRKDLVZQO-UHFFFAOYSA-N 0.000 claims 1
TVHJTPXIUKKXGP-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCNC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(Cl)=C1 TVHJTPXIUKKXGP-UHFFFAOYSA-N 0.000 claims 1
OMSIDSONSXDXEL-UHFFFAOYSA-N n-(2-acetamidoethyl)-2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCNC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(C)=C1 OMSIDSONSXDXEL-UHFFFAOYSA-N 0.000 claims 1
GDNCMKLSBLTRQG-UHFFFAOYSA-N n-(2-amino-2-oxoethyl)-2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCC(N)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 GDNCMKLSBLTRQG-UHFFFAOYSA-N 0.000 claims 1
OXSGYANASZPKFB-UHFFFAOYSA-N n-(2-amino-2-oxoethyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCC(N)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 OXSGYANASZPKFB-UHFFFAOYSA-N 0.000 claims 1
JYCOHQJDHBZTCJ-UHFFFAOYSA-N n-(2-hydroxy-2-methylpropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCC(C)(C)O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 JYCOHQJDHBZTCJ-UHFFFAOYSA-N 0.000 claims 1
XQYRIWAPBAJSLC-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 XQYRIWAPBAJSLC-UHFFFAOYSA-N 0.000 claims 1
OLKKEGKRPGQEEW-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)C=N1 OLKKEGKRPGQEEW-UHFFFAOYSA-N 0.000 claims 1
UAWGFAOLBSILLN-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCCC(F)(F)F)C=N1 UAWGFAOLBSILLN-UHFFFAOYSA-N 0.000 claims 1
LNODGNIIPAPUJH-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)N=N1 LNODGNIIPAPUJH-UHFFFAOYSA-N 0.000 claims 1
DZLQPAWROLXWJX-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(CCC(F)(F)F)C(C)=C1 DZLQPAWROLXWJX-UHFFFAOYSA-N 0.000 claims 1
DODAWJOVGGCVKO-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(C(F)(F)F)C=N1 DODAWJOVGGCVKO-UHFFFAOYSA-N 0.000 claims 1
SMGSPJWXNDLDEO-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[1-[6-methyl-5-(2,2,2-trifluoroethoxy)pyrazin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=N1 SMGSPJWXNDLDEO-UHFFFAOYSA-N 0.000 claims 1
CUIYADYPBCCNLZ-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=N1 CUIYADYPBCCNLZ-UHFFFAOYSA-N 0.000 claims 1
RKIOYYXRCQIULV-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=N1 RKIOYYXRCQIULV-UHFFFAOYSA-N 0.000 claims 1
PVWMOGSICGJWBV-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-[[5-methyl-6-[[4-(trifluoromethyl)phenyl]methylcarbamoyl]pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound CC1=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCO)C2)=O)=CN=C1C(=O)NCC1=CC=C(C(F)(F)F)C=C1 PVWMOGSICGJWBV-UHFFFAOYSA-N 0.000 claims 1
KMVPLPYHHHPEQO-UHFFFAOYSA-N n-(2-methoxyethyl)-2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCCOC)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)C=N1 KMVPLPYHHHPEQO-UHFFFAOYSA-N 0.000 claims 1
LOFKSDSDMGNGKI-UHFFFAOYSA-N n-(2-methylsulfonylethyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCS(C)(=O)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 LOFKSDSDMGNGKI-UHFFFAOYSA-N 0.000 claims 1
RGZPQYYTOIZVMH-UHFFFAOYSA-N n-(3-acetamidopropyl)-2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(Cl)=C1 RGZPQYYTOIZVMH-UHFFFAOYSA-N 0.000 claims 1
NXBXOAFZRPCIOU-UHFFFAOYSA-N n-(3-acetamidopropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCNC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 NXBXOAFZRPCIOU-UHFFFAOYSA-N 0.000 claims 1
WUWLMKKRSATDPV-UHFFFAOYSA-N n-(3-amino-3-oxopropyl)-2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC(N)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 WUWLMKKRSATDPV-UHFFFAOYSA-N 0.000 claims 1
MKNLJLYIKRGGPF-UHFFFAOYSA-N n-(3-amino-3-oxopropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCC(N)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 MKNLJLYIKRGGPF-UHFFFAOYSA-N 0.000 claims 1
AODRUIHKCJIMJR-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 AODRUIHKCJIMJR-UHFFFAOYSA-N 0.000 claims 1
BMCADLTXTYJLSP-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethylamino)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(NCC(F)(F)F)C(C)=C1 BMCADLTXTYJLSP-UHFFFAOYSA-N 0.000 claims 1
IXNWOLBRFZSNCB-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[1-[6-methyl-5-(2,2,2-trifluoroethoxy)pyrazin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=N1 IXNWOLBRFZSNCB-UHFFFAOYSA-N 0.000 claims 1
LZWCGDQSFYRRIG-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=N1 LZWCGDQSFYRRIG-UHFFFAOYSA-N 0.000 claims 1
ABHQIBYQRLDMRH-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1=C(OCCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=N1 ABHQIBYQRLDMRH-UHFFFAOYSA-N 0.000 claims 1
BEARHIIXPSFWQJ-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=C1 BEARHIIXPSFWQJ-UHFFFAOYSA-N 0.000 claims 1
LKKVJZHYUZPXTE-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-[[6-methyl-5-(2,2,2-trifluoroethoxy)pyrazin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=NC(CN2C(C3=C(C(=NC=C3)C(=O)NCCCO)C2)=O)=C1 LKKVJZHYUZPXTE-UHFFFAOYSA-N 0.000 claims 1
ZQSPYMJKKYGJSK-UHFFFAOYSA-N n-(3-methyloxetan-3-yl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NC1(C)COC1 ZQSPYMJKKYGJSK-UHFFFAOYSA-N 0.000 claims 1
IXAWADSSMXOXRR-UHFFFAOYSA-N n-(cyanomethyl)-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCC#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 IXAWADSSMXOXRR-UHFFFAOYSA-N 0.000 claims 1
YIHHBVGVTPDRDO-UHFFFAOYSA-N n-(cyanomethyl)-2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCC#N)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 YIHHBVGVTPDRDO-UHFFFAOYSA-N 0.000 claims 1
OMLJUZPEXQLJQO-PZORYLMUSA-N n-[(2r)-1-hydroxypropan-2-yl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)N[C@@H](CO)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 OMLJUZPEXQLJQO-PZORYLMUSA-N 0.000 claims 1
ABWGGPZLLBJXLQ-TYZXPVIJSA-N n-[(2r)-2,3-dihydroxypropyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NC[C@@H](O)CO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 ABWGGPZLLBJXLQ-TYZXPVIJSA-N 0.000 claims 1
ILMCGDVOELPDAV-LBPRGKRZSA-N n-[(2s)-1-hydroxypropan-2-yl]-2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)N[C@H](CO)C)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)C=N1 ILMCGDVOELPDAV-LBPRGKRZSA-N 0.000 claims 1
ABWGGPZLLBJXLQ-PYMCNQPYSA-N n-[(2s)-2,3-dihydroxypropyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NC[C@H](O)CO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 ABWGGPZLLBJXLQ-PYMCNQPYSA-N 0.000 claims 1
ZZPMXROSOUTGQD-UEWDXFNNSA-N n-[(2s)-2-hydroxypropyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC[C@@H](O)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 ZZPMXROSOUTGQD-UEWDXFNNSA-N 0.000 claims 1
QQNFXZVYGNZQEP-UHFFFAOYSA-N n-[1-oxo-2-[1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OC(F)(F)C(F)F)C=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 QQNFXZVYGNZQEP-UHFFFAOYSA-N 0.000 claims 1
QZZOVBJEKOXADK-UHFFFAOYSA-N n-[1-oxo-2-[1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)C(F)F)C=C1 QZZOVBJEKOXADK-UHFFFAOYSA-N 0.000 claims 1
YAHYROWRNWSVKE-UHFFFAOYSA-N n-[1-oxo-2-[1-[4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)(F)F)C=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 YAHYROWRNWSVKE-UHFFFAOYSA-N 0.000 claims 1
PILKRWFGRDUTDU-UHFFFAOYSA-N n-[1-oxo-2-[1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]propyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)(F)F)N=CC=1C(CC)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 PILKRWFGRDUTDU-UHFFFAOYSA-N 0.000 claims 1
FUMWUSYWUQJQOX-UHFFFAOYSA-N n-[1-oxo-2-[1-[6-(2,2,3,3,3-pentafluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)(F)C(F)(F)F)N=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 FUMWUSYWUQJQOX-UHFFFAOYSA-N 0.000 claims 1
KJBWVZPPYOHBIK-UHFFFAOYSA-N n-[1-oxo-2-[1-[6-(2,2,3,3,3-pentafluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)C(F)(F)F)N=C1 KJBWVZPPYOHBIK-UHFFFAOYSA-N 0.000 claims 1
MTQAYBUXMCBYSX-UHFFFAOYSA-N n-[1-oxo-2-[1-[6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)(F)C(F)F)N=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 MTQAYBUXMCBYSX-UHFFFAOYSA-N 0.000 claims 1
IBXGBMYWJLKEJF-UHFFFAOYSA-N n-[1-oxo-2-[1-[6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)(F)C(F)F)N=C1 IBXGBMYWJLKEJF-UHFFFAOYSA-N 0.000 claims 1
ZCURSOXPTQHRJX-UHFFFAOYSA-N n-[1-oxo-2-[1-[6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCCC(F)(F)F)N=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 ZCURSOXPTQHRJX-UHFFFAOYSA-N 0.000 claims 1
QKCKFLAYLCULRX-UHFFFAOYSA-N n-[1-oxo-2-[2-[6-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound FC(F)(F)COC1=CC=CC(CCN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=N1 QKCKFLAYLCULRX-UHFFFAOYSA-N 0.000 claims 1
FCACJDJSMIPKMW-UHFFFAOYSA-N n-[1-oxo-2-[2-[6-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CCC1=CC=CC(OCC(F)(F)F)=N1 FCACJDJSMIPKMW-UHFFFAOYSA-N 0.000 claims 1
ROHMLHHRVWUOQQ-UHFFFAOYSA-N n-[1-oxo-2-[[6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=NC(OCC(F)(F)C(F)F)=CC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CC3)=C2C1 ROHMLHHRVWUOQQ-UHFFFAOYSA-N 0.000 claims 1
TWAGUHLIJLSGPM-UHFFFAOYSA-N n-[1-oxo-2-[[6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)C(F)F)N=C1 TWAGUHLIJLSGPM-UHFFFAOYSA-N 0.000 claims 1
PXEFOTAPERDSNX-UHFFFAOYSA-N n-[2-(2-hydroxyethoxy)ethyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCOCCO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 PXEFOTAPERDSNX-UHFFFAOYSA-N 0.000 claims 1
NEKFDPUUDWTTCP-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCN(C)C)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 NEKFDPUUDWTTCP-UHFFFAOYSA-N 0.000 claims 1
HTLTYJQVYGYSAB-UHFFFAOYSA-N n-[2-(methanesulfonamido)ethyl]-2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C(C(=NC=C2)C(=O)NCCNS(C)(=O)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=C1 HTLTYJQVYGYSAB-UHFFFAOYSA-N 0.000 claims 1
FMFVGPZQDOMHJQ-UHFFFAOYSA-N n-[2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OC2CCC2)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FMFVGPZQDOMHJQ-UHFFFAOYSA-N 0.000 claims 1
LJXFTFZBICWACR-UHFFFAOYSA-N n-[2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1CCC1 LJXFTFZBICWACR-UHFFFAOYSA-N 0.000 claims 1
HGEQUFHIPTZQTB-UHFFFAOYSA-N n-[2-[1-(6-cyclobutyloxy-5-methylpyridin-3-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OC2CCC2)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 HGEQUFHIPTZQTB-UHFFFAOYSA-N 0.000 claims 1
QQGVWHYETLVHEU-UHFFFAOYSA-N n-[2-[1-[3-(2,2-difluoroethoxy)-5-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=CC(OCC(F)F)=C1 QQGVWHYETLVHEU-UHFFFAOYSA-N 0.000 claims 1
DLNKBKQIXIZMON-UHFFFAOYSA-N n-[2-[1-[3-(2,2-difluoroethoxy)-5-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=CC(OCC(F)F)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 DLNKBKQIXIZMON-UHFFFAOYSA-N 0.000 claims 1
DTMCVXVPTGESOX-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 DTMCVXVPTGESOX-UHFFFAOYSA-N 0.000 claims 1
IWDUSQCNPQVABZ-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(Cl)=C1 IWDUSQCNPQVABZ-UHFFFAOYSA-N 0.000 claims 1
UWPAOYLNBINZIL-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(Cl)=C1 UWPAOYLNBINZIL-UHFFFAOYSA-N 0.000 claims 1
FDOODRMWLWZPSL-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FDOODRMWLWZPSL-UHFFFAOYSA-N 0.000 claims 1
QSGHGNZJQZUNII-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(Cl)=C1 QSGHGNZJQZUNII-UHFFFAOYSA-N 0.000 claims 1
ORIANHYAXLPPCQ-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(Cl)=C1 ORIANHYAXLPPCQ-UHFFFAOYSA-N 0.000 claims 1
ZOJUOEBBGVNUNP-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 ZOJUOEBBGVNUNP-UHFFFAOYSA-N 0.000 claims 1
IXGLGRFIOMYQGB-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1C=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 IXGLGRFIOMYQGB-UHFFFAOYSA-N 0.000 claims 1
GMJISCRIDSWZQS-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(Cl)=C1 GMJISCRIDSWZQS-UHFFFAOYSA-N 0.000 claims 1
FFHREQJJRHDYLI-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(2,2-difluoropropoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OCC(C)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FFHREQJJRHDYLI-UHFFFAOYSA-N 0.000 claims 1
SXABJDLIJCTYEW-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 SXABJDLIJCTYEW-UHFFFAOYSA-N 0.000 claims 1
UFWXWBBFNRGBQO-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 UFWXWBBFNRGBQO-UHFFFAOYSA-N 0.000 claims 1
TZRRUOBKZFFGEX-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 TZRRUOBKZFFGEX-UHFFFAOYSA-N 0.000 claims 1
BVXXVCZSXJFFTC-UHFFFAOYSA-N n-[2-[1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(Cl)=C1 BVXXVCZSXJFFTC-UHFFFAOYSA-N 0.000 claims 1
JHCZQORYBDEXKJ-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OCC(F)(F)F)C(C)=C1 JHCZQORYBDEXKJ-UHFFFAOYSA-N 0.000 claims 1
YDBUFMXUNCWREW-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCC1 YDBUFMXUNCWREW-UHFFFAOYSA-N 0.000 claims 1
MQEPFKQXIRVSDR-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1C=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 MQEPFKQXIRVSDR-UHFFFAOYSA-N 0.000 claims 1
YHIGXMRQOKJDEC-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 YHIGXMRQOKJDEC-UHFFFAOYSA-N 0.000 claims 1
MUPNFLLWQUFIQX-UHFFFAOYSA-N n-[2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 MUPNFLLWQUFIQX-UHFFFAOYSA-N 0.000 claims 1
NVPDAMAPARZKHY-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methoxyphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1=C(OCC(F)F)C(OC)=CC(C(C)N2C(C3=C(C(=NC=C3)NC(=O)C(C)C)C2)=O)=C1 NVPDAMAPARZKHY-UHFFFAOYSA-N 0.000 claims 1
KZYKNZLRRUULNX-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methoxyphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(OCC(F)F)C(OC)=CC(C(C)N2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 KZYKNZLRRUULNX-UHFFFAOYSA-N 0.000 claims 1
JCWSTRNLGKBPNO-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methoxyphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(OC)=C1 JCWSTRNLGKBPNO-UHFFFAOYSA-N 0.000 claims 1
DOGZOMOJAQNYOI-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 DOGZOMOJAQNYOI-UHFFFAOYSA-N 0.000 claims 1
TUNIRYFPBVTLFB-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 TUNIRYFPBVTLFB-UHFFFAOYSA-N 0.000 claims 1
LXTSBQXGYAZGTD-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC=C(OCC(F)F)C(C)=C1 LXTSBQXGYAZGTD-UHFFFAOYSA-N 0.000 claims 1
XMSUJVKUXSRCFL-UHFFFAOYSA-N n-[2-[1-[4-(2,2-difluoroethoxy)-3-methylphenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1C=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 XMSUJVKUXSRCFL-UHFFFAOYSA-N 0.000 claims 1
UEZSRXKSLUNKPC-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)C=N1 UEZSRXKSLUNKPC-UHFFFAOYSA-N 0.000 claims 1
FSQJFKCAZPREPH-UHFFFAOYSA-N n-[2-[1-[4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCCC(F)(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 FSQJFKCAZPREPH-UHFFFAOYSA-N 0.000 claims 1
HIFCILVYTXKQDO-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1C(C)=C(OCC(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 HIFCILVYTXKQDO-UHFFFAOYSA-N 0.000 claims 1
YWEHANNTXAZSOV-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(F)F)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 YWEHANNTXAZSOV-UHFFFAOYSA-N 0.000 claims 1
XCHPULXGXZRNGD-UHFFFAOYSA-N n-[2-[1-[5-(2,2-difluoropropoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)C=N1 XCHPULXGXZRNGD-UHFFFAOYSA-N 0.000 claims 1
UOEWUKVFRZYPMV-UHFFFAOYSA-N n-[2-[1-[5-(cyclopropylmethoxy)-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC2CC2)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 UOEWUKVFRZYPMV-UHFFFAOYSA-N 0.000 claims 1
YCICYHNIRKAPCS-UHFFFAOYSA-N n-[2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC=2C=CC(F)=CC=2)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 YCICYHNIRKAPCS-UHFFFAOYSA-N 0.000 claims 1
ZDOSEFYYLLYUAT-UHFFFAOYSA-N n-[2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1=CC=C(F)C=C1 ZDOSEFYYLLYUAT-UHFFFAOYSA-N 0.000 claims 1
YVDUHPWAPSYONG-UHFFFAOYSA-N n-[2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1C(C)=C(OCC=2C=CC(F)=CC=2)C=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 YVDUHPWAPSYONG-UHFFFAOYSA-N 0.000 claims 1
LEEHCISQNGNOJV-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1h-pyrazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=NN1 LEEHCISQNGNOJV-UHFFFAOYSA-N 0.000 claims 1
QLWPQKCBIBYJTK-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2,2-dimethylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)C)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 QLWPQKCBIBYJTK-UHFFFAOYSA-N 0.000 claims 1
DKNOCSUIIDQHGH-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 DKNOCSUIIDQHGH-UHFFFAOYSA-N 0.000 claims 1
ZDSMFBXYFLJZNI-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxyacetamide Chemical compound C1C(C(=NC=C2)NC(=O)CO)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 ZDSMFBXYFLJZNI-UHFFFAOYSA-N 0.000 claims 1
JZRPADFSLYDHEK-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methyl-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=C(C)O1 JZRPADFSLYDHEK-UHFFFAOYSA-N 0.000 claims 1
GMWWNAYHMLVVRK-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 GMWWNAYHMLVVRK-UHFFFAOYSA-N 0.000 claims 1
UWLOFEKQJTYVTJ-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpyridine-3-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CN=C1C UWLOFEKQJTYVTJ-UHFFFAOYSA-N 0.000 claims 1
IRVGBPFWMKGQPD-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-3-methylimidazole-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CN1C IRVGBPFWMKGQPD-UHFFFAOYSA-N 0.000 claims 1
WTIGJETUZAKSBV-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-5-methylpyridine-3-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CC(C)=C1 WTIGJETUZAKSBV-UHFFFAOYSA-N 0.000 claims 1
FBKIPXJPOZTVNC-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 FBKIPXJPOZTVNC-UHFFFAOYSA-N 0.000 claims 1
GFHRZASLHZUBPC-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]butanamide Chemical compound C1C=2C(NC(=O)CCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(Cl)=C1 GFHRZASLHZUBPC-UHFFFAOYSA-N 0.000 claims 1
ZTLVHTKDWLWJOP-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclohexanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCCCC1 ZTLVHTKDWLWJOP-UHFFFAOYSA-N 0.000 claims 1
DXSQFXUPEKGOQH-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 DXSQFXUPEKGOQH-UHFFFAOYSA-N 0.000 claims 1
YZGASFAAVSRFFA-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,2-trifluoroethoxymethyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(COCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 YZGASFAAVSRFFA-UHFFFAOYSA-N 0.000 claims 1
MLCLKHPEXCTAAR-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)C(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 MLCLKHPEXCTAAR-UHFFFAOYSA-N 0.000 claims 1
LDLAWKJWGNETBU-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-thiazole-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CSC=N1 LDLAWKJWGNETBU-UHFFFAOYSA-N 0.000 claims 1
AUJCDYSYYLQXBD-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2,2-dimethylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)C)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 AUJCDYSYYLQXBD-UHFFFAOYSA-N 0.000 claims 1
GPDYFCNVTKIAME-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methyl-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=C(C)O1 GPDYFCNVTKIAME-UHFFFAOYSA-N 0.000 claims 1
JBSNPXINTZHHNW-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 JBSNPXINTZHHNW-UHFFFAOYSA-N 0.000 claims 1
MQMQWZYICRSKJS-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-3-methylimidazole-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CN1C MQMQWZYICRSKJS-UHFFFAOYSA-N 0.000 claims 1
MUYVHBQYKIXHFW-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]butanamide Chemical compound C1C=2C(NC(=O)CCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 MUYVHBQYKIXHFW-UHFFFAOYSA-N 0.000 claims 1
QANTVFZJTGEEFA-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 QANTVFZJTGEEFA-UHFFFAOYSA-N 0.000 claims 1
JRZNMIJONIVOGE-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 JRZNMIJONIVOGE-UHFFFAOYSA-N 0.000 claims 1
GCSUHFGBOHLMTH-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyridine-3-carboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CN=C1 GCSUHFGBOHLMTH-UHFFFAOYSA-N 0.000 claims 1
GRLXXXRKTRVWKO-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound CC1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(Cl)=C1 GRLXXXRKTRVWKO-UHFFFAOYSA-N 0.000 claims 1
BLYUQSRREIJLSH-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]ethyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(Cl)=CC=1C(C)N(C1=O)C(C)C2=C1C=CN=C2NC(=O)C1CC1 BLYUQSRREIJLSH-UHFFFAOYSA-N 0.000 claims 1
XAOUFDBQVYCUNJ-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCC(C)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 XAOUFDBQVYCUNJ-UHFFFAOYSA-N 0.000 claims 1
QEJZVTMPJYTEMT-UHFFFAOYSA-N n-[2-[1-[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(Cl)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 QEJZVTMPJYTEMT-UHFFFAOYSA-N 0.000 claims 1
JBOBBLXMMQRVKG-UHFFFAOYSA-N n-[2-[1-[5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(F)=C1 JBOBBLXMMQRVKG-UHFFFAOYSA-N 0.000 claims 1
MNOFGMRCRQVDTR-UHFFFAOYSA-N n-[2-[1-[5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(F)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 MNOFGMRCRQVDTR-UHFFFAOYSA-N 0.000 claims 1
AGRJYPSHKOJSAR-UHFFFAOYSA-N n-[2-[1-[5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(OC)=CC(C(C)N2C(C3=C(C(=NC=C3)NC(=O)C=3N=COC=3)C2)=O)=C1 AGRJYPSHKOJSAR-UHFFFAOYSA-N 0.000 claims 1
WQVAWTWCSZZPRK-UHFFFAOYSA-N n-[2-[1-[5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound N1=C(OCC(F)(F)F)C(OC)=CC(C(C)N2C(C3=C(C(=NC=C3)NC(=O)C(C)C)C2)=O)=C1 WQVAWTWCSZZPRK-UHFFFAOYSA-N 0.000 claims 1
OSKPZXULSYWKFH-UHFFFAOYSA-N n-[2-[1-[5-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(OC)=C1 OSKPZXULSYWKFH-UHFFFAOYSA-N 0.000 claims 1
GACVCRNHCSOVBF-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(F)(F)F)N=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 GACVCRNHCSOVBF-UHFFFAOYSA-N 0.000 claims 1
NEHLKKYMCYJIJR-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)N=N1 NEHLKKYMCYJIJR-UHFFFAOYSA-N 0.000 claims 1
UZZABLOAQHZKOK-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)F)N=N1 UZZABLOAQHZKOK-UHFFFAOYSA-N 0.000 claims 1
VZPHUEVWNPRXNN-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,2-oxazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=NO1 VZPHUEVWNPRXNN-UHFFFAOYSA-N 0.000 claims 1
MILDFSGYBBZAKY-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=NC=CO1 MILDFSGYBBZAKY-UHFFFAOYSA-N 0.000 claims 1
YXPLMXLSTPWIHW-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-thiazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CS1 YXPLMXLSTPWIHW-UHFFFAOYSA-N 0.000 claims 1
NEWPEVJNBLAQGE-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1h-pyrazole-5-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=NN1 NEWPEVJNBLAQGE-UHFFFAOYSA-N 0.000 claims 1
BDZSFRILLRYSRB-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-phenylacetamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)CC1=CC=CC=C1 BDZSFRILLRYSRB-UHFFFAOYSA-N 0.000 claims 1
ZUDZGUQWBJZVQP-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]benzamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CC=C1 ZUDZGUQWBJZVQP-UHFFFAOYSA-N 0.000 claims 1
AQWXBZVUAMNIQF-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclohexanecarboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCCCC1 AQWXBZVUAMNIQF-UHFFFAOYSA-N 0.000 claims 1
UNLVDEPGURGZGA-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyrazine-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CC=N1 UNLVDEPGURGZGA-UHFFFAOYSA-N 0.000 claims 1
RQGWIKKXGYUUJG-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyridazine-3-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CN=N1 RQGWIKKXGYUUJG-UHFFFAOYSA-N 0.000 claims 1
LICSAEIYIBIKAJ-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyridine-2-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CC=N1 LICSAEIYIBIKAJ-UHFFFAOYSA-N 0.000 claims 1
MNKKZZARPAAKMA-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=NC=C1 MNKKZZARPAAKMA-UHFFFAOYSA-N 0.000 claims 1
QYKKGUSEDSXYLG-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(F)(F)C(F)F)N=N1 QYKKGUSEDSXYLG-UHFFFAOYSA-N 0.000 claims 1
WNVCEJJAGIUNIF-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C=1N=C(OCC(F)(F)C(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=COC=N1 WNVCEJJAGIUNIF-UHFFFAOYSA-N 0.000 claims 1
SZPGIRIQZRUYIS-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)(F)C(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 SZPGIRIQZRUYIS-UHFFFAOYSA-N 0.000 claims 1
CTZFLXHDXXYASH-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCC1 CTZFLXHDXXYASH-UHFFFAOYSA-N 0.000 claims 1
HWOOFLPOEJZSPS-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1N=C(OCCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 HWOOFLPOEJZSPS-UHFFFAOYSA-N 0.000 claims 1
DOWGSIWLLQNSEZ-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-(3,3,3-trifluoropropyl)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(CCC(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 DOWGSIWLLQNSEZ-UHFFFAOYSA-N 0.000 claims 1
MVPWVFFKYULCFZ-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(N2N=CC(=C2)C(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 MVPWVFFKYULCFZ-UHFFFAOYSA-N 0.000 claims 1
OWGLRIOFPXAFPP-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(C(F)(F)F)C=N1 OWGLRIOFPXAFPP-UHFFFAOYSA-N 0.000 claims 1
FUMWUVILPZCROF-UHFFFAOYSA-N n-[2-[1-[5-methyl-6-[4-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1N=C(N2N=CC(=C2)C(F)(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 FUMWUVILPZCROF-UHFFFAOYSA-N 0.000 claims 1
PUHPVXTTZMCPHE-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-2-methoxypyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound COC1=NC(OCC(F)F)=CC=C1C(C)N1C(=O)C(C=CN=C2NC(=O)C(C)C)=C2C1 PUHPVXTTZMCPHE-UHFFFAOYSA-N 0.000 claims 1
HDZPGGWBYWPTDJ-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-2-methoxypyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound COC1=NC(OCC(F)F)=CC=C1C(C)N1C(=O)C(C=CN=C2NC(=O)C3CC3)=C2C1 HDZPGGWBYWPTDJ-UHFFFAOYSA-N 0.000 claims 1
JQCZRXMJRAQFEU-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-2-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=NC=CO1 JQCZRXMJRAQFEU-UHFFFAOYSA-N 0.000 claims 1
IITNSXXEQHMIJC-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2,2-dimethylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)C)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 IITNSXXEQHMIJC-UHFFFAOYSA-N 0.000 claims 1
GJCMLDQTIFPMCC-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-3-methylimidazole-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CN1C GJCMLDQTIFPMCC-UHFFFAOYSA-N 0.000 claims 1
CWWQEQDKWCTCQG-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-5-methylpyridine-3-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CC(C)=C1 CWWQEQDKWCTCQG-UHFFFAOYSA-N 0.000 claims 1
QEFAISIQTJGFMV-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 QEFAISIQTJGFMV-UHFFFAOYSA-N 0.000 claims 1
ABWNQTQPKDACTI-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]butanamide Chemical compound C1C=2C(NC(=O)CCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 ABWNQTQPKDACTI-UHFFFAOYSA-N 0.000 claims 1
YDXNMFPKFAMYHZ-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopentanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCCC1 YDXNMFPKFAMYHZ-UHFFFAOYSA-N 0.000 claims 1
WUJWGQUXYNJJBO-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 WUJWGQUXYNJJBO-UHFFFAOYSA-N 0.000 claims 1
SJTFGDJMHQOQNQ-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]furan-2-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CO1 SJTFGDJMHQOQNQ-UHFFFAOYSA-N 0.000 claims 1
YECAEKRZJGKAIP-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1CCOCC1 YECAEKRZJGKAIP-UHFFFAOYSA-N 0.000 claims 1
MHWNHWWXRUJIJR-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 MHWNHWWXRUJIJR-UHFFFAOYSA-N 0.000 claims 1
DSHZDMFEIUTCMB-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]pyridine-3-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CC=CN=C1 DSHZDMFEIUTCMB-UHFFFAOYSA-N 0.000 claims 1
YIICDMHOXQXOKX-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound CC1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 YIICDMHOXQXOKX-UHFFFAOYSA-N 0.000 claims 1
FJFQRENWYPIHDK-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)C(C)C2=C1C=CN=C2NC(=O)C1CCC1 FJFQRENWYPIHDK-UHFFFAOYSA-N 0.000 claims 1
AOVQGEIVQVVZLC-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)C(C)C2=C1C=CN=C2NC(=O)C1CC1 AOVQGEIVQVVZLC-UHFFFAOYSA-N 0.000 claims 1
BNPXBRIYUPSWDP-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound CC1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)F)C(C)=C1 BNPXBRIYUPSWDP-UHFFFAOYSA-N 0.000 claims 1
DQTROHZXHMJLMO-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1C(C)=C(OCC(C)(F)F)N=NC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 DQTROHZXHMJLMO-UHFFFAOYSA-N 0.000 claims 1
WEEFGVPPLASXIR-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 WEEFGVPPLASXIR-UHFFFAOYSA-N 0.000 claims 1
PSZGGYQFEBUOQW-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 PSZGGYQFEBUOQW-UHFFFAOYSA-N 0.000 claims 1
RYDODUCNKBBNAS-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 RYDODUCNKBBNAS-UHFFFAOYSA-N 0.000 claims 1
GFOMIJSMQIZWPG-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C1=CC(C)=C(OCC(C)(F)F)N=N1 GFOMIJSMQIZWPG-UHFFFAOYSA-N 0.000 claims 1
APSPTPBHPZWPOB-UHFFFAOYSA-N n-[2-[1-[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C1=CN=C(OCC(C)(F)F)C(C)=C1 APSPTPBHPZWPOB-UHFFFAOYSA-N 0.000 claims 1
INALKKHLYJNPPO-UHFFFAOYSA-N n-[2-[1-[6-(3,4-difluorophenoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1=CC=C(F)C(F)=C1 INALKKHLYJNPPO-UHFFFAOYSA-N 0.000 claims 1
WYXHWQQNQHTBKU-UHFFFAOYSA-N n-[2-[1-[6-(4-chlorophenoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1=CC=C(Cl)C=C1 WYXHWQQNQHTBKU-UHFFFAOYSA-N 0.000 claims 1
AMPACCNAUCOWPE-UHFFFAOYSA-N n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(N2N=CC(Cl)=C2)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 AMPACCNAUCOWPE-UHFFFAOYSA-N 0.000 claims 1
JKTFBNLXNXYGRY-UHFFFAOYSA-N n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C(C(=NC=C2)NC(=O)C(C)(C)O)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 JKTFBNLXNXYGRY-UHFFFAOYSA-N 0.000 claims 1
MXNROIQKHHBFMH-UHFFFAOYSA-N n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 MXNROIQKHHBFMH-UHFFFAOYSA-N 0.000 claims 1
XKAYOKCWSJQMIB-UHFFFAOYSA-N n-[2-[1-[6-(4-chloropyrazol-1-yl)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C(C(=NC=C2)NC(C)=O)=C2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=C(Cl)C=N1 XKAYOKCWSJQMIB-UHFFFAOYSA-N 0.000 claims 1
BMFDRCBBPXAMBA-UHFFFAOYSA-N n-[2-[1-[6-(4-fluorophenoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(OC=2C=CC(F)=CC=2)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 BMFDRCBBPXAMBA-UHFFFAOYSA-N 0.000 claims 1
ZRUBVBXHTFRLEC-UHFFFAOYSA-N n-[2-[1-[6-(4-fluorophenoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1OC1=CC=C(F)C=C1 ZRUBVBXHTFRLEC-UHFFFAOYSA-N 0.000 claims 1
QIYNCIPJXMWUGQ-UHFFFAOYSA-N n-[2-[1-[6-(4-fluorophenyl)sulfanyl-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1SC1=CC=C(F)C=C1 QIYNCIPJXMWUGQ-UHFFFAOYSA-N 0.000 claims 1
UVXORLCBWPXUKU-UHFFFAOYSA-N n-[2-[[2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound COC1=NC(OCC(F)(F)F)=CC=C1CN1C(=O)C(C=CN=C2NC(=O)C(C)C)=C2C1 UVXORLCBWPXUKU-UHFFFAOYSA-N 0.000 claims 1
SWYLXGIKCPIKQN-UHFFFAOYSA-N n-[2-[[2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound COC1=NC(OCC(F)(F)F)=CC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CC3)=C2C1 SWYLXGIKCPIKQN-UHFFFAOYSA-N 0.000 claims 1
GBQURDFDVSCWGE-UHFFFAOYSA-N n-[2-[[3-chloro-4-(2,2-difluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C1=C(Cl)C(OCC(F)F)=CC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3N=COC=3)=C2C1 GBQURDFDVSCWGE-UHFFFAOYSA-N 0.000 claims 1
NNLJSJVUJOOUOB-UHFFFAOYSA-N n-[2-[[3-chloro-4-(2,2-difluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(Cl)C(OCC(F)F)=CC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3OC=NC=3)=C2C1 NNLJSJVUJOOUOB-UHFFFAOYSA-N 0.000 claims 1
UGDKHRGOQCUKLP-UHFFFAOYSA-N n-[2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)C(C)=C1 UGDKHRGOQCUKLP-UHFFFAOYSA-N 0.000 claims 1
WNVPVPKJUPUTNF-UHFFFAOYSA-N n-[2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CCC3)C2)=O)=C1 WNVPVPKJUPUTNF-UHFFFAOYSA-N 0.000 claims 1
VFCRJSKZKMBMMG-UHFFFAOYSA-N n-[2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 VFCRJSKZKMBMMG-UHFFFAOYSA-N 0.000 claims 1
PLNXRZDTKGTQRE-UHFFFAOYSA-N n-[2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CCOCC3)C2)=O)=C1 PLNXRZDTKGTQRE-UHFFFAOYSA-N 0.000 claims 1
GUBSFVFBIQUCDJ-UHFFFAOYSA-N n-[2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CC=C(OCC(F)(F)F)C(C)=C1 GUBSFVFBIQUCDJ-UHFFFAOYSA-N 0.000 claims 1
VGUVPEDVCAPARH-UHFFFAOYSA-N n-[2-[[4-(2,2-difluoroethoxy)-3-methoxyphenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(OCC(F)F)C(OC)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 VGUVPEDVCAPARH-UHFFFAOYSA-N 0.000 claims 1
STQHCMDBYMEUDO-UHFFFAOYSA-N n-[2-[[4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)(F)F)C=N1 STQHCMDBYMEUDO-UHFFFAOYSA-N 0.000 claims 1
LVAKUIWIWIXVCI-UHFFFAOYSA-N n-[2-[[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)F)C=N1 LVAKUIWIWIXVCI-UHFFFAOYSA-N 0.000 claims 1
HKOYWDGEXMLQBP-UHFFFAOYSA-N n-[2-[[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=N1 HKOYWDGEXMLQBP-UHFFFAOYSA-N 0.000 claims 1
PMXVECXVYZAVLE-UHFFFAOYSA-N n-[2-[[5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CC(C)=C(OCC(F)F)C=N1 PMXVECXVYZAVLE-UHFFFAOYSA-N 0.000 claims 1
XNNOOYUUQXVFRJ-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3OC=NC=3)=C2C1 XNNOOYUUQXVFRJ-UHFFFAOYSA-N 0.000 claims 1
VRGBSGUULRIPMY-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 VRGBSGUULRIPMY-UHFFFAOYSA-N 0.000 claims 1
UIRIUVVAMCKFMT-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]oxane-4-carboxamide Chemical compound C1=C(Cl)C(OCC(F)(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CCOCC3)=C2C1 UIRIUVVAMCKFMT-UHFFFAOYSA-N 0.000 claims 1
GSQSSAXNMJBUCK-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(Cl)=C1 GSQSSAXNMJBUCK-UHFFFAOYSA-N 0.000 claims 1
GUONLVFBIRSIKH-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)(O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)C(F)F)C(Cl)=C1 GUONLVFBIRSIKH-UHFFFAOYSA-N 0.000 claims 1
KHSIQFAHMXFIGB-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound C1=C(Cl)C(OCC(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C=3N=COC=3)=C2C1 KHSIQFAHMXFIGB-UHFFFAOYSA-N 0.000 claims 1
GYXZJWKEVZRWHQ-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(Cl)=C1 GYXZJWKEVZRWHQ-UHFFFAOYSA-N 0.000 claims 1
DUSYRLBICAEUGF-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound C1=C(Cl)C(OCC(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CCC3)=C2C1 DUSYRLBICAEUGF-UHFFFAOYSA-N 0.000 claims 1
MTWLVGIZXDSSBQ-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopentanecarboxamide Chemical compound C1=C(Cl)C(OCC(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CCCC3)=C2C1 MTWLVGIZXDSSBQ-UHFFFAOYSA-N 0.000 claims 1
UCHUPFPGZJWAEC-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C1=C(Cl)C(OCC(F)F)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C3CC3)=C2C1 UCHUPFPGZJWAEC-UHFFFAOYSA-N 0.000 claims 1
JPLAYXVXYZNGIQ-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(Cl)=C1 JPLAYXVXYZNGIQ-UHFFFAOYSA-N 0.000 claims 1
XELCOXTYUGNXMY-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoroethoxy)pyridin-3-yl]methyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound CC1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(Cl)=C1 XELCOXTYUGNXMY-UHFFFAOYSA-N 0.000 claims 1
HBKKEVXMNYWZAB-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound C1=C(Cl)C(OCC(F)(F)C)=NC=C1CN1C(=O)C(C=CN=C2NC(=O)C(C)(C)O)=C2C1 HBKKEVXMNYWZAB-UHFFFAOYSA-N 0.000 claims 1
PSWFJTNJUXZQAR-UHFFFAOYSA-N n-[2-[[5-chloro-6-(2,2-difluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(Cl)=C1 PSWFJTNJUXZQAR-UHFFFAOYSA-N 0.000 claims 1
KIQGVKSPPODTGT-UHFFFAOYSA-N n-[2-[[5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(F)=C1 KIQGVKSPPODTGT-UHFFFAOYSA-N 0.000 claims 1
QRCVWWGBVGOAKN-UHFFFAOYSA-N n-[2-[[5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound N1=C(OCC(F)(F)F)C(F)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 QRCVWWGBVGOAKN-UHFFFAOYSA-N 0.000 claims 1
ZHAZVMFNQFSGNK-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3N=COC=3)C2)=O)=N1 ZHAZVMFNQFSGNK-UHFFFAOYSA-N 0.000 claims 1
BILFBKWUACKETB-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 BILFBKWUACKETB-UHFFFAOYSA-N 0.000 claims 1
UDHOVRYVMCUVAR-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound N1=C(OCC(F)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 UDHOVRYVMCUVAR-UHFFFAOYSA-N 0.000 claims 1
BVGFHNCAPOQFEU-UHFFFAOYSA-N n-[2-[[5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-4-carboxamide Chemical compound N1=C(OCC(F)(F)C(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3N=COC=3)C2)=O)=C1 BVGFHNCAPOQFEU-UHFFFAOYSA-N 0.000 claims 1
ONLMLHSDTBBWCJ-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3ON=CC=3)C2)=O)=C1 ONLMLHSDTBBWCJ-UHFFFAOYSA-N 0.000 claims 1
ALPNXIYUOKLYMH-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C=3OC=NC=3)C2)=O)=C1 ALPNXIYUOKLYMH-UHFFFAOYSA-N 0.000 claims 1
KZGGXGQAHXWRJO-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(C)=C1 KZGGXGQAHXWRJO-UHFFFAOYSA-N 0.000 claims 1
VZAWNPOWYOONAX-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclobutanecarboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CCC3)C2)=O)=C1 VZAWNPOWYOONAX-UHFFFAOYSA-N 0.000 claims 1
SFCFJRIWOJHLIZ-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopentanecarboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CCCC3)C2)=O)=C1 SFCFJRIWOJHLIZ-UHFFFAOYSA-N 0.000 claims 1
JLBJIANVXZMMOG-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound N1=C(OCC(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C3CC3)C2)=O)=C1 JLBJIANVXZMMOG-UHFFFAOYSA-N 0.000 claims 1
HPFBSWZXWNFNCL-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(C)=C1 HPFBSWZXWNFNCL-UHFFFAOYSA-N 0.000 claims 1
WAJGMDYDPPFPIJ-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]methyl]-3-methyl-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound CC1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC1=CN=C(OCC(F)F)C(C)=C1 WAJGMDYDPPFPIJ-UHFFFAOYSA-N 0.000 claims 1
FFXPVISKYHJQBM-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-hydroxy-2-methylpropanamide Chemical compound N1=C(OCC(C)(F)F)C(C)=CC(CN2C(C3=C(C(=NC=C3)NC(=O)C(C)(C)O)C2)=O)=C1 FFXPVISKYHJQBM-UHFFFAOYSA-N 0.000 claims 1
NBLGISCZPCZRTI-UHFFFAOYSA-N n-[2-[[6-(2,2-difluoropropoxy)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]propanamide Chemical compound C1C=2C(NC(=O)CC)=NC=CC=2C(=O)N1CC1=CN=C(OCC(C)(F)F)C(C)=C1 NBLGISCZPCZRTI-UHFFFAOYSA-N 0.000 claims 1
VFURAQPJJYLESK-UHFFFAOYSA-N n-[2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-1,3-oxazole-5-carboxamide Chemical compound C=1N=C(N2CCC(F)(F)CC2)C(C)=CC=1CN(C1=O)CC2=C1C=CN=C2NC(=O)C1=CN=CO1 VFURAQPJJYLESK-UHFFFAOYSA-N 0.000 claims 1
HDSSHPYKJYLELB-UHFFFAOYSA-N n-[2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]-2-methylpropanamide Chemical compound C1C=2C(NC(=O)C(C)C)=NC=CC=2C(=O)N1CC(C=C1C)=CN=C1N1CCC(F)(F)CC1 HDSSHPYKJYLELB-UHFFFAOYSA-N 0.000 claims 1
HMHSCXNECRFNEV-UHFFFAOYSA-N n-[2-[[6-(4,4-difluoropiperidin-1-yl)-5-methylpyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]cyclopropanecarboxamide Chemical compound C=1N=C(N2CCC(F)(F)CC2)C(C)=CC=1CN(C1=O)CC2=C1C=CN=C2NC(=O)C1CC1 HMHSCXNECRFNEV-UHFFFAOYSA-N 0.000 claims 1
DLWXONIIRMTTNO-UHFFFAOYSA-N n-[3-methyl-2-[[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound O=C1C2=CC=NC(NC(C)=O)=C2C(C)N1CC1=CC=C(OCC(F)(F)F)C(C)=C1 DLWXONIIRMTTNO-UHFFFAOYSA-N 0.000 claims 1
LIUMNMWFHIWLMV-UHFFFAOYSA-N n-[6-methyl-2-[[5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridin-4-yl]acetamide Chemical compound C1C=2C(NC(=O)C)=NC(C)=CC=2C(=O)N1CC1=CN=C(OCC(F)(F)F)C(C)=C1 LIUMNMWFHIWLMV-UHFFFAOYSA-N 0.000 claims 1
FTTPYETWRXBTLI-UHFFFAOYSA-N n-cyclopropyl-2-[1-[6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C=1N=C(OCC(F)F)C(C)=CC=1C(C)N(C1=O)CC2=C1C=CN=C2C(=O)NC1CC1 FTTPYETWRXBTLI-UHFFFAOYSA-N 0.000 claims 1
PLRPORLWGHVVGQ-UHFFFAOYSA-N n-ethyl-2-[(5-methyl-6-pyrazol-1-ylpyridin-3-yl)methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC(C=C1C)=CN=C1N1C=CC=N1 PLRPORLWGHVVGQ-UHFFFAOYSA-N 0.000 claims 1
OLTYMPAQRCMMDB-UHFFFAOYSA-N n-ethyl-2-[1-(5-methyl-6-pyrazol-1-ylpyridin-3-yl)ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C(C=C1C)=CN=C1N1C=CC=N1 OLTYMPAQRCMMDB-UHFFFAOYSA-N 0.000 claims 1
VJKGBWINTBWYQJ-UHFFFAOYSA-N n-ethyl-2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 VJKGBWINTBWYQJ-UHFFFAOYSA-N 0.000 claims 1
YGSQIGGDMDATJJ-UHFFFAOYSA-N n-ethyl-2-[1-[5-[(4-fluorophenyl)methoxy]-4-methylpyridin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C(N=C1)=CC(C)=C1OCC1=CC=C(F)C=C1 YGSQIGGDMDATJJ-UHFFFAOYSA-N 0.000 claims 1
NASDDINEXCCIQO-UHFFFAOYSA-N n-ethyl-2-[1-[5-methyl-6-(2,2,2-trifluoroethylamino)pyridin-3-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(NCC(F)(F)F)C(C)=C1 NASDDINEXCCIQO-UHFFFAOYSA-N 0.000 claims 1
LTQWPWTXLFFCHZ-UHFFFAOYSA-N n-ethyl-2-[1-[6-methyl-5-(2,2,2-trifluoroethoxy)pyrazin-2-yl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1C(C)C1=CN=C(OCC(F)(F)F)C(C)=N1 LTQWPWTXLFFCHZ-UHFFFAOYSA-N 0.000 claims 1
WIBXMPRMURECDW-UHFFFAOYSA-N n-ethyl-2-[[3-methyl-4-(phenylcarbamoyl)phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC(C=C1C)=CC=C1C(=O)NC1=CC=CC=C1 WIBXMPRMURECDW-UHFFFAOYSA-N 0.000 claims 1
ZDZHZQJKKHEPMS-UHFFFAOYSA-N n-ethyl-2-[[3-methyl-4-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl]methyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NCC)=NC=CC=2C(=O)N1CC(C=C1C)=CC=C1C(=O)NC1=CC=C(C(F)(F)F)C=C1 ZDZHZQJKKHEPMS-UHFFFAOYSA-N 0.000 claims 1
UHAGXWYCNQSDAU-UHFFFAOYSA-N n-methyl-2-[1-[3-methyl-4-(trifluoromethoxy)phenyl]ethyl]-1-oxo-3h-pyrrolo[3,4-c]pyridine-4-carboxamide Chemical compound C1C=2C(C(=O)NC)=NC=CC=2C(=O)N1C(C)C1=CC=C(OC(F)(F)F)C(C)=C1 UHAGXWYCNQSDAU-UHFFFAOYSA-N 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
XIPFMBOWZXULIA-UHFFFAOYSA-N pivalamide Chemical compound CC(C)(C)C(N)=O XIPFMBOWZXULIA-UHFFFAOYSA-N 0.000 claims 1
239000012453 solvate Substances 0.000 claims 1
229940124597 therapeutic agent Drugs 0.000 claims 1
229940002612 prodrug Drugs 0.000 description 4
239000000651 prodrug Substances 0.000 description 4

JP2014551356A 2012-04-25 2013-04-25 Ｔｔｘ−ｓ遮断薬としてのピロロピリジノン誘導体 Active JP6175672B2 (ja)