JP2020111602A5 - - Google Patents
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- Publication number
- JP2020111602A5 JP2020111602A5 JP2020068792A JP2020068792A JP2020111602A5 JP 2020111602 A5 JP2020111602 A5 JP 2020111602A5 JP 2020068792 A JP2020068792 A JP 2020068792A JP 2020068792 A JP2020068792 A JP 2020068792A JP 2020111602 A5 JP2020111602 A5 JP 2020111602A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyridin
- oxy
- carbamoyl
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C)(C)*C(C(N=C=O)=O)=* Chemical compound C*(C)(C)*C(C(N=C=O)=O)=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789971P | 2013-03-15 | 2013-03-15 | |
| US61/789,971 | 2013-03-15 | ||
| JP2018126337A JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018126337A Division JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020111602A JP2020111602A (ja) | 2020-07-27 |
| JP2020111602A5 true JP2020111602A5 (OSRAM) | 2021-04-22 |
| JP6985448B2 JP6985448B2 (ja) | 2021-12-22 |
Family
ID=51529946
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503187A Active JP6364472B2 (ja) | 2013-03-15 | 2014-03-14 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| JP2018126337A Pending JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| JP2020068792A Active JP6985448B2 (ja) | 2013-03-15 | 2020-04-07 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503187A Active JP6364472B2 (ja) | 2013-03-15 | 2014-03-14 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| JP2018126337A Pending JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9382228B2 (OSRAM) |
| EP (1) | EP2968287B1 (OSRAM) |
| JP (3) | JP6364472B2 (OSRAM) |
| KR (2) | KR102386952B1 (OSRAM) |
| CN (3) | CN105228620B (OSRAM) |
| AU (2) | AU2014233414B2 (OSRAM) |
| BR (1) | BR112015022263B1 (OSRAM) |
| CA (1) | CA2903288C (OSRAM) |
| ES (1) | ES2817902T3 (OSRAM) |
| IL (2) | IL241523B (OSRAM) |
| MX (2) | MX366429B (OSRAM) |
| PH (2) | PH12020550201A1 (OSRAM) |
| RU (1) | RU2769607C2 (OSRAM) |
| SG (1) | SG11201508532VA (OSRAM) |
| WO (1) | WO2014145028A2 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5335056B2 (ja) | 2011-11-16 | 2013-11-06 | 住友電気工業株式会社 | ボルト用アルミニウム合金線及びボルト並びにそれらの製造方法 |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| PH12020550201A1 (en) * | 2013-03-15 | 2024-01-15 | Deciphera Pharmaceuticals Llc | N-acyl-n-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
| TWI854164B (zh) | 2016-02-01 | 2024-09-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| KR101691954B1 (ko) | 2016-04-26 | 2017-01-02 | 고려대학교 산학협력단 | 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물 |
| CN110573500B (zh) * | 2017-05-24 | 2020-12-08 | 上海和誉生物医药科技有限公司 | N-(氮杂芳基)环内酰胺-1-甲酰胺衍生物及其制备方法和应用 |
| WO2018233526A1 (zh) * | 2017-06-19 | 2018-12-27 | 上海和誉生物医药科技有限公司 | 一种csf1r抑制剂及其制备方法和应用 |
| JP7189203B2 (ja) * | 2017-08-24 | 2022-12-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | ボロン酸誘導体 |
| CN109776401A (zh) * | 2017-11-14 | 2019-05-21 | 成都博腾药业有限公司 | 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法 |
| CN111818915B (zh) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| AU2019216351B2 (en) | 2018-01-31 | 2024-07-25 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of mastocytosis |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| SMT202500389T1 (it) | 2018-12-28 | 2025-11-10 | Deciphera Pharmaceuticals Llc | Inibitori di csf1r per l'uso nel trattamento di tumori tenosinoviali a cellule giganti |
| SMT202400003T1 (it) * | 2019-02-06 | 2024-03-13 | Lilly Co Eli | Derivati di 1-((2-(2,2,2-trifluoroetossi)piridin-4-il)metil)urea come potenziatori di kcnq |
| EP4295846A3 (en) | 2019-05-10 | 2024-02-28 | Deciphera Pharmaceuticals, LLC | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| PE20220597A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos |
| CA3143489A1 (en) | 2019-06-17 | 2020-12-24 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| NZ784949A (en) | 2019-08-12 | 2025-09-26 | Deciphera Pharmaceuticals Llc | Ripretinib for treating gastrointestinal stromal tumors |
| KR20250057151A (ko) | 2019-12-30 | 2025-04-28 | 데시페라 파마슈티칼스, 엘엘씨 | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의조성물 |
| AU2020419197B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| AU2021381949A1 (en) | 2020-11-18 | 2023-06-15 | Deciphera Pharmaceuticals, Llc | Gcn2 and perk kinase inhibitors and methods of use thereof |
| TW202300142A (zh) * | 2021-05-24 | 2023-01-01 | 大陸商上海和譽生物醫藥科技有限公司 | 一種結晶型csf-1r抑制劑酸式鹽及其製備方法和應用 |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| EP4444429A1 (en) | 2021-12-09 | 2024-10-16 | Deciphera Pharmaceuticals, LLC | Raf kinase inhibitors and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| WO2025122952A1 (en) | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU601145B2 (en) * | 1985-03-01 | 1990-09-06 | Duphar International Research B.V. | Benzoyl urea derivatives having anti-tumor activity |
| DE60233736D1 (de) * | 2001-06-22 | 2009-10-29 | Kirin Pharma K K | Chinolinderivat und chinazolinderivat, die die selbstphosphorylierung des hepatocytus-proliferator-rezeptors hemmen, und diese enthaltende medizinische zusammensetzung |
| DK1971601T3 (da) * | 2005-11-15 | 2010-02-08 | Array Biopharma Inc | N4-phenyl-quinazolin-4-aminderivater og beslægtede forbindelser som ERBB Type 1-receptortyrosinkinase-inhibitorer til behandling af hyperproliferative sygdomme |
| US20080255155A1 (en) * | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
| EP2125781A2 (en) * | 2006-12-20 | 2009-12-02 | Amgen Inc. | Substituted heterocycles and methods of use |
| CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
| EP2365752B1 (en) * | 2008-10-29 | 2014-09-24 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| PH12020550201A1 (en) * | 2013-03-15 | 2024-01-15 | Deciphera Pharmaceuticals Llc | N-acyl-n-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
-
2014
- 2014-03-14 PH PH1/2020/550201A patent/PH12020550201A1/en unknown
- 2014-03-14 EP EP14764601.2A patent/EP2968287B1/en active Active
- 2014-03-14 CN CN201480026796.6A patent/CN105228620B/zh active Active
- 2014-03-14 AU AU2014233414A patent/AU2014233414B2/en active Active
- 2014-03-14 PH PH1/2015/502336A patent/PH12015502336B1/en unknown
- 2014-03-14 SG SG11201508532VA patent/SG11201508532VA/en unknown
- 2014-03-14 MX MX2015013404A patent/MX366429B/es active IP Right Grant
- 2014-03-14 BR BR112015022263-3A patent/BR112015022263B1/pt active IP Right Grant
- 2014-03-14 US US14/214,185 patent/US9382228B2/en active Active
- 2014-03-14 KR KR1020217038874A patent/KR102386952B1/ko active Active
- 2014-03-14 ES ES14764601T patent/ES2817902T3/es active Active
- 2014-03-14 CA CA2903288A patent/CA2903288C/en active Active
- 2014-03-14 KR KR1020157029126A patent/KR102333718B1/ko active Active
- 2014-03-14 CN CN201910586017.2A patent/CN110563700A/zh active Pending
- 2014-03-14 RU RU2015143718A patent/RU2769607C2/ru not_active Application Discontinuation
- 2014-03-14 WO PCT/US2014/029664 patent/WO2014145028A2/en not_active Ceased
- 2014-03-14 JP JP2016503187A patent/JP6364472B2/ja active Active
- 2014-03-14 CN CN202010826889.4A patent/CN112047927A/zh active Pending
-
2015
- 2015-09-10 IL IL24152315A patent/IL241523B/en active IP Right Grant
- 2015-09-17 MX MX2019008003A patent/MX2019008003A/es unknown
-
2018
- 2018-07-02 JP JP2018126337A patent/JP2018184416A/ja active Pending
- 2018-09-24 AU AU2018236691A patent/AU2018236691B2/en active Active
-
2019
- 2019-09-19 IL IL269451A patent/IL269451B/en unknown
-
2020
- 2020-04-07 JP JP2020068792A patent/JP6985448B2/ja active Active
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