JP2015511122A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015511122A5 JP2015511122A5 JP2014554934A JP2014554934A JP2015511122A5 JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5 JP 2014554934 A JP2014554934 A JP 2014554934A JP 2014554934 A JP2014554934 A JP 2014554934A JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- tissue
- subject
- rna
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 35
- 210000001519 tissue Anatomy 0.000 claims 20
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- 108091092259 cell-free RNA Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 238000012163 sequencing technique Methods 0.000 claims 8
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 2
- 239000013614 RNA sample Substances 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- -1 sweat Substances 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001638 cerebellum Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003016 hypothalamus Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000005059 placental tissue Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591642P | 2012-01-27 | 2012-01-27 | |
| US61/591,642 | 2012-01-27 | ||
| PCT/US2013/023471 WO2013113012A2 (en) | 2012-01-27 | 2013-01-28 | Methods for profiling and quantitating cell-free rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Division JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511122A JP2015511122A (ja) | 2015-04-16 |
| JP2015511122A5 true JP2015511122A5 (enExample) | 2016-03-03 |
| JP6320302B2 JP6320302B2 (ja) | 2018-05-09 |
Family
ID=48874081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554934A Active JP6320302B2 (ja) | 2012-01-27 | 2013-01-28 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (15) | US20130252835A1 (enExample) |
| EP (2) | EP3584327A1 (enExample) |
| JP (2) | JP6320302B2 (enExample) |
| CN (2) | CN108359711A (enExample) |
| AU (1) | AU2013211850B8 (enExample) |
| CA (1) | CA2863035C (enExample) |
| HK (1) | HK1211624A1 (enExample) |
| SG (2) | SG11201505515XA (enExample) |
| WO (1) | WO2013113012A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| CA2779750C (en) | 2009-11-06 | 2019-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive diagnosis of graft rejection in organ transplant patients |
| CN103228798B (zh) | 2010-09-24 | 2015-12-09 | 斯坦福大学托管董事会 | 使用固定的引物直接捕获、扩增及测序靶标dna |
| WO2015069900A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| US20160289762A1 (en) | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| EP3584327A1 (en) | 2012-01-27 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US10689652B2 (en) | 2013-10-02 | 2020-06-23 | The Regents Of The University Of California | Methods for immortalization of epithelial cells |
| WO2015069933A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| ES2790823T3 (es) | 2014-11-14 | 2020-10-29 | Liquid Genomics Inc | Uso de ARN sin células circulante para el diagnóstico y/o la monitorización de cáncer |
| AU2016264102A1 (en) | 2015-05-18 | 2017-12-21 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
| US10889861B2 (en) * | 2015-06-17 | 2021-01-12 | The Translational Genomics Research Institute | Systems and methods for obtaining biological molecules from a sample |
| US10692797B2 (en) * | 2015-06-30 | 2020-06-23 | Laird Technologies, Inc. | Thermal interface materials with low secant modulus of elasticity and high thermal conductivity |
| WO2017062517A1 (en) * | 2015-10-06 | 2017-04-13 | The Regents Of The University Of California | Non-coding rnas linked to immortality and associated methods and compositions |
| EP3371730A4 (en) * | 2015-11-04 | 2019-06-19 | Metabolon, Inc. | AUTOMATED SAMPLE QUALITY ASSESSMENT |
| EP3433382B1 (en) | 2016-03-25 | 2021-09-01 | Karius, Inc. | Synthetic nucleic acid spike-ins |
| WO2018191563A1 (en) | 2017-04-12 | 2018-10-18 | Karius, Inc. | Sample preparation methods, systems and compositions |
| US20200165685A1 (en) * | 2017-05-10 | 2020-05-28 | Nantomics, Llc | Circulating rna for detection, prediction, and monitoring of cancer |
| TWI782020B (zh) * | 2017-05-16 | 2022-11-01 | 香港中文大學 | 整合單細胞及血漿游離rna分析 |
| US12444478B2 (en) | 2017-10-23 | 2025-10-14 | Cz Biohub Sf, Llc | Noninvasive molecular clock for fetal development predicts gestational age and preterm delivery |
| KR20200085783A (ko) | 2017-10-27 | 2020-07-15 | 주노 다이어그노스틱스, 인크. | 초저용량 액체 생검을 위한 장치, 시스템 및 방법 |
| WO2019094363A2 (en) | 2017-11-07 | 2019-05-16 | Nanthealth Labs, Inc. | Targeted cell free nucleic acid analysis |
| CA3082601A1 (en) | 2018-03-16 | 2019-09-19 | Karius, Inc. | Sample series to differentiate target nucleic acids from contaminant nucleic acids |
| US12462935B2 (en) | 2018-03-30 | 2025-11-04 | Nucleix Ltd. | Deep learning-based methods, devices, and systems for prenatal testing |
| SG11202102954QA (en) | 2018-10-04 | 2021-04-29 | Bluestar Genomics Inc | Simultaneous, sequencing-based analysis of proteins, nucleosomes, and cell-free nucleic acids from a single biological sample |
| EP3874042A4 (en) * | 2018-10-29 | 2023-06-28 | Molecular Stethoscope, Inc. | Characterization of bone marrow using cell-free messenger-rna |
| DK4428234T3 (da) | 2018-11-21 | 2026-01-26 | Karius Inc | Direkte-til-bibliotek-fremgangsmåder, systemer og sammensætninger |
| US11512349B2 (en) | 2018-12-18 | 2022-11-29 | Grail, Llc | Methods for detecting disease using analysis of RNA |
| EP3914731A1 (en) * | 2019-01-24 | 2021-12-01 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| GB2612911B (en) * | 2019-02-14 | 2023-11-22 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| AU2020253585A1 (en) * | 2019-04-02 | 2021-11-18 | Mission Bio, Inc. | Methods, systems, and apparatus for nucleic acid detection |
| US11365441B2 (en) | 2019-05-22 | 2022-06-21 | Mission Bio, Inc. | Method and apparatus for simultaneous targeted sequencing of DNA, RNA and protein |
| US11948684B2 (en) * | 2019-06-20 | 2024-04-02 | Latha Chakravarthy | Diagnostic process for disease detection using gene expression based multi layer PCA classifier |
| CN110964800B (zh) * | 2019-09-20 | 2021-10-22 | 北京航空航天大学 | 用于预测早产风险的cfRNA标志物 |
| EP4055180A4 (en) * | 2019-11-05 | 2023-12-06 | Cofactor Genomics, Inc. | METHODS AND SYSTEMS FOR PROCESSING COMPLEX DATA SETS USING ARTIFICIAL INTELLIGENCE AND DECONVOLUTION |
| AU2020378080B2 (en) * | 2019-11-08 | 2026-02-19 | Regeneron Pharmaceuticals, Inc. | Accurate and robust information-deconvolution from bulk tissue transcriptomes |
| US20230008870A1 (en) * | 2019-12-20 | 2023-01-12 | University Of Utah Research Foundation | Methods and compositions for monitoring and diagnosing healthy and disease states |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| WO2021188825A1 (en) * | 2020-03-18 | 2021-09-23 | Michael Nerenberg | Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay |
| MX2023001781A (es) * | 2020-08-13 | 2023-04-26 | Mirvie Inc | Metodos y sistemas para determinar un estado relacionado con el embarazo de un sujeto. |
| WO2024182491A1 (en) * | 2023-02-28 | 2024-09-06 | Virginia Commonwealth University | Polygenic risk estimator for cervical length change during pregnancy |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| US5432054A (en) | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| WO2000040749A2 (en) * | 1999-01-06 | 2000-07-13 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| US20080009467A1 (en) | 2000-05-01 | 2008-01-10 | Accera, Inc. | Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism |
| US6727066B2 (en) | 2000-07-28 | 2004-04-27 | Incyte Corporation | Genes expressed in treated human C3A liver cell cultures |
| US6664056B2 (en) * | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
| US6977162B2 (en) * | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| EP1506395A2 (en) | 2002-05-10 | 2005-02-16 | Phase-1 Molecular Toxicology Inc. | Liver inflammation predictive genes |
| AU2003272204A1 (en) | 2002-07-12 | 2004-02-02 | The Johns Hopkins University | Neuronal and retinal gene expression patterns |
| WO2004007673A2 (en) | 2002-07-12 | 2004-01-22 | The Johns Hopkins University | Neuronal gene expression patterns |
| CA2513292C (en) | 2003-01-17 | 2016-04-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
| US20060003342A1 (en) * | 2004-01-15 | 2006-01-05 | Bianchi Diana W | Fetal RNA in amniotic fluid to determine gene expression in the developing fetus |
| EP1877574A4 (en) * | 2004-07-21 | 2009-05-06 | Univ California | SPEICHELTRANSKRIPTOMDIAGNOSE |
| US7713693B1 (en) * | 2004-09-01 | 2010-05-11 | University Of Louisiana At Monroe | Human cancer cell specific gene transcript |
| CA2528531A1 (en) * | 2005-01-06 | 2006-07-06 | Mount Sinai Hospital | Markers of pre-term labor |
| KR100686816B1 (ko) * | 2005-07-22 | 2007-02-26 | 삼성에스디아이 주식회사 | 리튬 이차 전지 |
| SI3002338T1 (sl) * | 2006-02-02 | 2019-11-29 | Univ Leland Stanford Junior | Neinvaziven genetski pregled zarodka z digitalno analizo |
| WO2007146229A2 (en) | 2006-06-07 | 2007-12-21 | Tethys Bioscience, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| WO2008132752A2 (en) * | 2007-05-01 | 2008-11-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for predicting cancer metastasis |
| WO2009009457A1 (en) | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
| AU2008289447B2 (en) * | 2007-08-22 | 2014-09-04 | Trovagene, Inc. | Methods of using miRNA for detection of in vivo cell death |
| US8298768B2 (en) * | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| AU2009207291B2 (en) * | 2008-01-27 | 2014-11-06 | Mor Research Applications | Methods and compositions for diagnosing complications of pregnancy |
| EP2283155A4 (en) * | 2008-05-01 | 2011-05-11 | Swedish Health Services | DIAGNOSTIC TEST FOR BREAKFAST |
| WO2009143576A1 (en) | 2008-05-27 | 2009-12-03 | Adelaide Research & Innovation Pty Ltd | Polymorphisms associated with pregnancy complications |
| WO2009149026A2 (en) * | 2008-06-01 | 2009-12-10 | Tufts Medical Center, Inc. | Genomic approaches to fetal treatment and diagnosis |
| US7888030B2 (en) * | 2008-08-21 | 2011-02-15 | King's College London | Biomarkers |
| WO2010045470A2 (en) | 2008-10-15 | 2010-04-22 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of hepatic disorders |
| EP2365804B1 (en) | 2008-11-13 | 2015-05-06 | Modgene, Llc | Reduction of amyloid-beta load in non-brain tissue |
| US20110189679A1 (en) * | 2009-09-11 | 2011-08-04 | Nugen Technologies, Inc. | Compositions and methods for whole transcriptome analysis |
| CN102741426B (zh) | 2009-09-11 | 2015-03-25 | 香港中文大学 | 用于评估肝病变的方法 |
| WO2011071893A1 (en) * | 2009-12-08 | 2011-06-16 | Cedars-Sinai Medical Center | Diagnostic biomarker to identify women at risk for preterm delivery |
| WO2011156734A2 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Method of characterizing vascular diseases |
| JP5755326B2 (ja) | 2010-06-11 | 2015-07-29 | 日立化成株式会社 | 腎機能の特徴を決定する方法 |
| JP2013531799A (ja) * | 2010-07-08 | 2013-08-08 | プロノタ エヌ．ヴェ． | 妊娠の高血圧障害についてのバイオマーカー |
| MX382244B (es) * | 2010-07-23 | 2025-03-13 | Harvard College | Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales |
| ES2627120T3 (es) | 2011-07-08 | 2017-07-26 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicamento para el tratamiento del cáncer de hígado |
| EP2742155B1 (en) | 2011-08-08 | 2018-01-24 | Advanced Genomic Technology LLC | Biomarker for alzheimer's disease and/or mild cognitively impairment |
| CA3069089A1 (en) | 2011-09-22 | 2013-03-28 | Lineage Biosciences, Inc. | Compositions and methods for analyzing heterogeneous samples |
| JP6652781B2 (ja) | 2011-09-30 | 2020-02-26 | ソマロジック・インコーポレーテッド | 心血管系リスクイベントの予測およびその使用 |
| WO2013066764A2 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Alzheimer's disease signature markers and methods of use |
| EP3584327A1 (en) * | 2012-01-27 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US20160289762A1 (en) * | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| US9938580B2 (en) | 2012-03-14 | 2018-04-10 | Ruprecht-Karls-Universität Heidelberg | Epigenetic signatures as marker for cardiomyopathies and myocardial insufficiencies |
| US10054599B2 (en) * | 2013-03-12 | 2018-08-21 | Agency For Science, Technology And Research (A*Star) | Pre-eclampsia biomarkers |
| US9612248B2 (en) | 2013-03-15 | 2017-04-04 | Somalogic, Inc. | Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) biomarkers and uses thereof |
| JP2018518169A (ja) | 2015-06-05 | 2018-07-12 | レグルス セラピューティクス インコーポレイテッド | 非アルコール性脂肪肝疾患バイオマーカー |
| ES2980812T3 (es) | 2015-09-14 | 2024-10-03 | Genfit | Métodos para diagnosticar y evaluar la esteatohepatitis no alcohólica |
| US20190071795A1 (en) | 2016-03-09 | 2019-03-07 | Molecular Stethoscope, Inc. | Methods and systems for detecting tissue conditions |
-
2013
- 2013-01-28 EP EP19173751.9A patent/EP3584327A1/en active Pending
- 2013-01-28 US US13/752,131 patent/US20130252835A1/en not_active Abandoned
- 2013-01-28 HK HK15104602.5A patent/HK1211624A1/xx unknown
- 2013-01-28 WO PCT/US2013/023471 patent/WO2013113012A2/en not_active Ceased
- 2013-01-28 EP EP13740984.3A patent/EP2807277A4/en not_active Ceased
- 2013-01-28 CA CA2863035A patent/CA2863035C/en active Active
- 2013-01-28 JP JP2014554934A patent/JP6320302B2/ja active Active
- 2013-01-28 AU AU2013211850A patent/AU2013211850B8/en active Active
- 2013-01-28 SG SG11201505515XA patent/SG11201505515XA/en unknown
- 2013-01-28 CN CN201810084289.8A patent/CN108359711A/zh active Pending
- 2013-01-28 SG SG10201906331TA patent/SG10201906331TA/en unknown
- 2013-01-28 CN CN201380017554.6A patent/CN104334742A/zh active Pending
-
2015
- 2015-09-22 US US14/861,650 patent/US10240200B2/en active Active
-
2016
- 2016-12-13 US US15/377,894 patent/US10287632B2/en active Active
- 2016-12-13 US US15/377,901 patent/US10155986B2/en active Active
- 2016-12-13 US US15/377,904 patent/US10240204B2/en active Active
-
2017
- 2017-01-20 JP JP2017008768A patent/JP2017063799A/ja active Pending
-
2018
- 2018-05-02 US US15/969,603 patent/US20180357379A1/en not_active Abandoned
-
2019
- 2019-04-03 US US16/373,996 patent/US20190226029A1/en not_active Abandoned
-
2020
- 2020-08-05 US US16/986,042 patent/US20200362416A1/en not_active Abandoned
- 2020-08-05 US US16/986,057 patent/US20200370121A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/187,298 patent/US20220042098A1/en active Pending
- 2021-08-06 US US17/396,457 patent/US20210363584A1/en not_active Abandoned
- 2021-08-06 US US17/396,490 patent/US20220010381A1/en not_active Abandoned
-
2022
- 2022-02-03 US US17/592,311 patent/US20220290236A1/en not_active Abandoned
- 2022-02-10 US US17/669,081 patent/US12365947B2/en active Active
-
2025
- 2025-06-10 US US19/234,022 patent/US20260055464A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015511122A5 (enExample) | ||
| Shabaninejad et al. | Electrochemical-based biosensors for microRNA detection: Nanotechnology comes into view | |
| JP7679306B2 (ja) | 腫瘍モデルの同定のための方法および組成物 | |
| JP7678837B2 (ja) | 妊娠高血圧腎症に特異的な循環ｒｎａシグネチャー | |
| TWI580788B (zh) | 用於檢測川崎病的方法及套組 | |
| EP2733219A1 (en) | Diagnostic miRNA markers for Alzheimer | |
| CN109295218B (zh) | 环状RNA标志物hsa_circ_0001788及其应用 | |
| JP2013505020A5 (enExample) | ||
| JP2010500867A5 (enExample) | ||
| CN104651513B (zh) | 一种痛风血清miRNAs生物标志物及其表达量的检测方法 | |
| US20210189491A1 (en) | DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF LONG NONCODING RNAs FOR PATHOLOGIES AND TOXICITIES INDUCING HEART DISORDERS | |
| CN102628082B (zh) | 基于高通量测序技术进行核酸定性定量检测的方法 | |
| US20140272993A1 (en) | Method of sequencing a full microrna profile from cerebrospinal fluid | |
| WO2013125691A1 (ja) | テスト体液サンプルの分類方法 | |
| CN109504784B (zh) | 用于预测人辅助生殖技术中早期胚胎质量的miRNA分子标志及其应用 | |
| CA2859081A1 (en) | Method for the diagnosis and/or prognosis of acute renal damage | |
| CN108977533B (zh) | 一种用于预测慢性乙肝炎症损伤的miRNA组合物 | |
| CN113234817B (zh) | 利用CpG位点甲基化水平检测早期肝癌的标志物 | |
| CN108728532A (zh) | 一种微小rna标志物及其应用 | |
| CN105624308B (zh) | 一种检测染色体16p11.2微缺失的产品 | |
| JP2013526869A5 (enExample) | ||
| CN110724743A (zh) | 人血液中结直肠癌诊断相关的甲基化生物标记物及其应用 | |
| CN108424963A (zh) | 血清中circ_0079591作为URSA诊断及妊娠结局评估标志物的应用 | |
| CN109136382A (zh) | 一种对四种人体体液来源进行鉴定的方法和系统 | |
| CN108753949B (zh) | 血清中circ_0082660作为URSA诊断及妊娠结局评估标志物的应用 |