JP2015511122A5 - - Google Patents
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- JP2015511122A5 JP2015511122A5 JP2014554934A JP2014554934A JP2015511122A5 JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5 JP 2014554934 A JP2014554934 A JP 2014554934A JP 2014554934 A JP2014554934 A JP 2014554934A JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- tissue
- subject
- rna
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 35
- 210000001519 tissue Anatomy 0.000 claims 20
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- 108091092259 cell-free RNA Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 238000012163 sequencing technique Methods 0.000 claims 8
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 2
- 239000013614 RNA sample Substances 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- -1 sweat Substances 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001638 cerebellum Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003016 hypothalamus Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000005059 placental tissue Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591642P | 2012-01-27 | 2012-01-27 | |
| US61/591,642 | 2012-01-27 | ||
| PCT/US2013/023471 WO2013113012A2 (en) | 2012-01-27 | 2013-01-28 | Methods for profiling and quantitating cell-free rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Division JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞rnaをプロファイリングおよび定量するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511122A JP2015511122A (ja) | 2015-04-16 |
| JP2015511122A5 true JP2015511122A5 (enExample) | 2016-03-03 |
| JP6320302B2 JP6320302B2 (ja) | 2018-05-09 |
Family
ID=48874081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554934A Active JP6320302B2 (ja) | 2012-01-27 | 2013-01-28 | 無細胞rnaをプロファイリングおよび定量するための方法 |
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞rnaをプロファイリングおよび定量するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞rnaをプロファイリングおよび定量するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (14) | US20130252835A1 (enExample) |
| EP (2) | EP2807277A4 (enExample) |
| JP (2) | JP6320302B2 (enExample) |
| CN (2) | CN108359711A (enExample) |
| AU (1) | AU2013211850B8 (enExample) |
| CA (1) | CA2863035C (enExample) |
| HK (1) | HK1211624A1 (enExample) |
| SG (2) | SG11201505515XA (enExample) |
| WO (1) | WO2013113012A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| KR20130113447A (ko) | 2010-09-24 | 2013-10-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화 |
| US20160289762A1 (en) * | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| WO2015069900A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| HK1211624A1 (en) * | 2012-01-27 | 2016-05-27 | The Board Of Trustees Of The University Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US10689652B2 (en) | 2013-10-02 | 2020-06-23 | The Regents Of The University Of California | Methods for immortalization of epithelial cells |
| WO2015069933A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| KR20240038168A (ko) | 2013-11-07 | 2024-03-22 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
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| US10889861B2 (en) * | 2015-06-17 | 2021-01-12 | The Translational Genomics Research Institute | Systems and methods for obtaining biological molecules from a sample |
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| WO2017062517A1 (en) * | 2015-10-06 | 2017-04-13 | The Regents Of The University Of California | Non-coding rnas linked to immortality and associated methods and compositions |
| CN108369612A (zh) * | 2015-11-04 | 2018-08-03 | 梅塔博隆股份有限公司 | 自动化样品质量评估 |
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| CN111566228A (zh) * | 2017-10-23 | 2020-08-21 | 陈扎克伯格生物中心公司 | 用于在胎儿孕育中预测胎龄和早产的无创分子钟 |
| TWI833715B (zh) * | 2017-10-27 | 2024-03-01 | 美商奇諾診療公司 | 用於超低體積液體生物檢體之裝置、系統及方法 |
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| CA3082601A1 (en) | 2018-03-16 | 2019-09-19 | Karius, Inc. | Sample series to differentiate target nucleic acids from contaminant nucleic acids |
| CA3095030A1 (en) | 2018-03-30 | 2019-10-03 | Juno Diagnostics, Inc. | Deep learning-based methods, devices, and systems for prenatal testing |
| CN113874525A (zh) * | 2018-10-29 | 2021-12-31 | 分子听诊器公司 | 使用无细胞信使rna的骨髓表征 |
| CA3118990A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| WO2020132144A1 (en) * | 2018-12-18 | 2020-06-25 | Grail, Inc. | Methods for detecting disease using analysis of rna |
| EP4632078A2 (en) * | 2019-01-24 | 2025-10-15 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| GB2612911B (en) | 2019-02-14 | 2023-11-22 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| WO2020206184A1 (en) * | 2019-04-02 | 2020-10-08 | Mission Bio, Inc. | Methods, systems, and aparatus for nucleic acid detection |
| CA3138806A1 (en) | 2019-05-22 | 2020-11-26 | Dalia Dhingra | Method and apparatus for simultaneous targeted sequencing of dna, rna and protein |
| US11948684B2 (en) * | 2019-06-20 | 2024-04-02 | Latha Chakravarthy | Diagnostic process for disease detection using gene expression based multi layer PCA classifier |
| CN110964800B (zh) * | 2019-09-20 | 2021-10-22 | 北京航空航天大学 | 用于预测早产风险的cfRNA标志物 |
| EP4055180A4 (en) * | 2019-11-05 | 2023-12-06 | Cofactor Genomics, Inc. | METHODS AND SYSTEMS FOR PROCESSING COMPLEX DATA SETS USING ARTIFICIAL INTELLIGENCE AND DECONVOLUTION |
| AU2020378080A1 (en) * | 2019-11-08 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Accurate and robust information-deconvolution from bulk tissue transcriptomes |
| JP2023507798A (ja) * | 2019-12-20 | 2023-02-27 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 健康状態および疾患状態を監視および診断するための方法および組成物 |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| CA3172199A1 (en) * | 2020-03-18 | 2021-09-23 | Michael Nerenberg | Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay |
| AU2021324778A1 (en) * | 2020-08-13 | 2023-04-13 | Mirvie, Inc. | Methods and systems for determining a pregnancy-related state of a subject |
| WO2024182491A1 (en) * | 2023-02-28 | 2024-09-06 | Virginia Commonwealth University | Polygenic risk estimator for cervical length change during pregnancy |
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-
2013
- 2013-01-28 HK HK15104602.5A patent/HK1211624A1/xx unknown
- 2013-01-28 EP EP13740984.3A patent/EP2807277A4/en not_active Ceased
- 2013-01-28 CA CA2863035A patent/CA2863035C/en active Active
- 2013-01-28 CN CN201810084289.8A patent/CN108359711A/zh active Pending
- 2013-01-28 CN CN201380017554.6A patent/CN104334742A/zh active Pending
- 2013-01-28 SG SG11201505515XA patent/SG11201505515XA/en unknown
- 2013-01-28 US US13/752,131 patent/US20130252835A1/en not_active Abandoned
- 2013-01-28 JP JP2014554934A patent/JP6320302B2/ja active Active
- 2013-01-28 EP EP19173751.9A patent/EP3584327A1/en active Pending
- 2013-01-28 SG SG10201906331TA patent/SG10201906331TA/en unknown
- 2013-01-28 WO PCT/US2013/023471 patent/WO2013113012A2/en not_active Ceased
- 2013-01-28 AU AU2013211850A patent/AU2013211850B8/en active Active
-
2015
- 2015-09-22 US US14/861,650 patent/US10240200B2/en active Active
-
2016
- 2016-12-13 US US15/377,904 patent/US10240204B2/en active Active
- 2016-12-13 US US15/377,901 patent/US10155986B2/en active Active
- 2016-12-13 US US15/377,894 patent/US10287632B2/en active Active
-
2017
- 2017-01-20 JP JP2017008768A patent/JP2017063799A/ja active Pending
-
2018
- 2018-05-02 US US15/969,603 patent/US20180357379A1/en not_active Abandoned
-
2019
- 2019-04-03 US US16/373,996 patent/US20190226029A1/en not_active Abandoned
-
2020
- 2020-08-05 US US16/986,042 patent/US20200362416A1/en not_active Abandoned
- 2020-08-05 US US16/986,057 patent/US20200370121A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/187,298 patent/US20220042098A1/en active Pending
- 2021-08-06 US US17/396,457 patent/US20210363584A1/en not_active Abandoned
- 2021-08-06 US US17/396,490 patent/US20220010381A1/en not_active Abandoned
-
2022
- 2022-02-03 US US17/592,311 patent/US20220290236A1/en not_active Abandoned
- 2022-02-10 US US17/669,081 patent/US12365947B2/en active Active
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