JP2017525371A5 - - Google Patents
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- JP2017525371A5 JP2017525371A5 JP2017510397A JP2017510397A JP2017525371A5 JP 2017525371 A5 JP2017525371 A5 JP 2017525371A5 JP 2017510397 A JP2017510397 A JP 2017510397A JP 2017510397 A JP2017510397 A JP 2017510397A JP 2017525371 A5 JP2017525371 A5 JP 2017525371A5
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- JP
- Japan
- Prior art keywords
- cfdna
- capture probe
- item
- genetic
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 57
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 239000000523 sample Substances 0.000 claims description 17
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 15
- 208000016361 genetic disease Diseases 0.000 claims description 15
- 230000002068 genetic effect Effects 0.000 claims description 15
- 230000003902 lesion Effects 0.000 claims description 13
- 238000012252 genetic analysis Methods 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 7
- 230000008707 rearrangement Effects 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 238000012163 sequencing technique Methods 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 210000004381 amniotic fluid Anatomy 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 210000002751 lymph Anatomy 0.000 claims description 4
- 210000003097 mucus Anatomy 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 210000004243 sweat Anatomy 0.000 claims description 4
- 230000007704 transition Effects 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 238000001712 DNA sequencing Methods 0.000 claims description 3
- 230000003321 amplification Effects 0.000 claims description 3
- 238000007622 bioinformatic analysis Methods 0.000 claims description 3
- 210000001508 eye Anatomy 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 101150023956 ALK gene Proteins 0.000 description 6
- 108091026890 Coding region Proteins 0.000 description 6
- 230000004927 fusion Effects 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 238000011529 RT qPCR Methods 0.000 description 3
- 239000000090 biomarker Substances 0.000 description 3
- 101150068690 eml4 gene Proteins 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 108091023043 Alu Element Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020090411A JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/052317 WO2016028316A1 (en) | 2014-08-22 | 2014-08-22 | Methods for quantitative genetic analysis of cell free dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020090411A Division JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525371A JP2017525371A (ja) | 2017-09-07 |
| JP2017525371A5 true JP2017525371A5 (enExample) | 2017-12-21 |
| JP6709778B2 JP6709778B2 (ja) | 2020-06-17 |
Family
ID=51494529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510397A Active JP6709778B2 (ja) | 2014-08-22 | 2014-08-22 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP4410978A3 (enExample) |
| JP (1) | JP6709778B2 (enExample) |
| CN (2) | CN107002118B (enExample) |
| CA (1) | CA2957657A1 (enExample) |
| DK (1) | DK3194612T3 (enExample) |
| ES (1) | ES2984266T3 (enExample) |
| HU (1) | HUE068191T2 (enExample) |
| PL (1) | PL3194612T3 (enExample) |
| PT (1) | PT3194612T (enExample) |
| SG (1) | SG11201701113WA (enExample) |
| WO (1) | WO2016028316A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10179937B2 (en) | 2014-04-21 | 2019-01-15 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| HK1214831A1 (zh) | 2012-11-05 | 2016-08-05 | Foundation Medicine, Inc. | 新型融合分子及其应用 |
| CN111254500B (zh) | 2012-12-10 | 2024-01-23 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| PT3543356T (pt) | 2014-07-18 | 2021-10-04 | Univ Hong Kong Chinese | Análise dos padrões de metilação de tecidos em mistura de adn |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| JP7441584B6 (ja) * | 2014-08-22 | 2024-03-15 | レゾリューション バイオサイエンス， インコーポレイテッド | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| ES2856598T3 (es) | 2015-11-11 | 2021-09-27 | Resolution Bioscience Inc | Construcción de alta eficiencia de bibliotecas de ADN |
| US11479878B2 (en) | 2016-03-16 | 2022-10-25 | Dana-Farber Cancer Institute, Inc. | Methods for genome characterization |
| ES2913468T3 (es) | 2016-04-15 | 2022-06-02 | Natera Inc | Métodos para la detección del cáncer de pulmón. |
| WO2017190067A1 (en) | 2016-04-28 | 2017-11-02 | Impact Genomics, Inc. | Methods of assessing and monitoring tumor load |
| US20200181681A1 (en) * | 2016-04-29 | 2020-06-11 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| CN106047998B (zh) * | 2016-05-27 | 2019-11-12 | 深圳市海普洛斯生物科技有限公司 | 一种肺癌基因的检测方法及应用 |
| WO2018013579A1 (en) * | 2016-07-11 | 2018-01-18 | cARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | Sweat as a biofluid for analysis and disease identification |
| SG11201901371XA (en) * | 2016-08-25 | 2019-03-28 | Resolution Bioscience Inc | Methods for the detection of genomic copy changes in dna samples |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| AU2017363180B2 (en) * | 2016-11-17 | 2023-11-02 | LGC Clinical Diagnostics, Inc. | Methods for preparing DNA reference material and controls |
| CA3039685A1 (en) | 2016-11-30 | 2018-06-07 | The Chinese University Of Hong Kong | Analysis of cell-free dna in urine and other samples |
| JP2020524519A (ja) | 2017-06-20 | 2020-08-20 | ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッドＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 全セルフリーｄｎａによる移植合併症リスクの評価 |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| CN111684078B (zh) * | 2018-02-12 | 2024-04-19 | 豪夫迈·罗氏有限公司 | 通过评价肿瘤遗传异质性来预测对治疗的应答的方法 |
| WO2019173552A1 (en) | 2018-03-08 | 2019-09-12 | St. John's University | Circulating serum cell-free dna biomarkers and methods |
| JP7573443B2 (ja) | 2018-04-14 | 2024-10-25 | ナテラ， インコーポレイテッド | 循環腫瘍ｄｎａの個別化された検出を用いる癌検出およびモニタリングの方法 |
| CN108517567B (zh) * | 2018-04-20 | 2020-08-11 | 江苏康为世纪生物科技有限公司 | 用于cfDNA建库的接头、引物组、试剂盒和建库方法 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN108676891B (zh) * | 2018-07-12 | 2022-02-01 | 吉林大学 | 一种直肠腺癌易感性预测试剂盒及系统 |
| US11926821B2 (en) * | 2018-10-22 | 2024-03-12 | The Chinese University Of Hong Kong | Cell-free DNA quality |
| US20220064708A1 (en) * | 2019-01-15 | 2022-03-03 | General Incorporated Association, Bio Education Laboratory | Method for preparing liquid biopsy using pva sponge |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| CN112301103B (zh) * | 2019-08-02 | 2023-04-11 | 北京贝瑞和康生物技术有限公司 | 一种非特异性扩增天然短片段核酸的方法和试剂盒 |
| CN110819622A (zh) * | 2019-10-09 | 2020-02-21 | 广州达正生物科技有限公司 | 一种快速提取石蜡组织rna的方法 |
| CN111254194B (zh) * | 2020-01-13 | 2021-09-07 | 东南大学 | 基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用 |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| WO2022020662A2 (en) * | 2020-07-24 | 2022-01-27 | Cornell University | Methods for assessing the severity and progression of sars-cov2 infections using cell-free dna |
| US20220073906A1 (en) * | 2020-09-08 | 2022-03-10 | Resolution Bioscience, Inc. | Adaptors and methods for high efficiency construction of genetic libraries and genetic analysis |
| US20250129429A1 (en) * | 2021-09-10 | 2025-04-24 | Foundation Medicine, Inc. | Gene fusions in sarcoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023769B2 (en) * | 2009-11-30 | 2015-05-05 | Complete Genomics, Inc. | cDNA library for nucleic acid sequencing |
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| US20130288915A1 (en) * | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
| WO2014052487A1 (en) * | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
| US20150291953A1 (en) * | 2012-11-02 | 2015-10-15 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
| CN111254500B (zh) * | 2012-12-10 | 2024-01-23 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| EP2954054B1 (en) * | 2013-02-08 | 2018-12-05 | Qiagen GmbH | Method for separating dna by size |
-
2014
- 2014-08-22 WO PCT/US2014/052317 patent/WO2016028316A1/en not_active Ceased
- 2014-08-22 CN CN201480081729.4A patent/CN107002118B/zh active Active
- 2014-08-22 CN CN202210630244.2A patent/CN115029342B/zh active Active
- 2014-08-22 JP JP2017510397A patent/JP6709778B2/ja active Active
- 2014-08-22 SG SG11201701113WA patent/SG11201701113WA/en unknown
- 2014-08-22 ES ES14761762T patent/ES2984266T3/es active Active
- 2014-08-22 CA CA2957657A patent/CA2957657A1/en active Pending
- 2014-08-22 PT PT147617625T patent/PT3194612T/pt unknown
- 2014-08-22 EP EP24182096.8A patent/EP4410978A3/en active Pending
- 2014-08-22 EP EP14761762.5A patent/EP3194612B1/en active Active
- 2014-08-22 DK DK14761762.5T patent/DK3194612T3/da active
- 2014-08-22 HU HUE14761762A patent/HUE068191T2/hu unknown
- 2014-08-22 PL PL14761762.5T patent/PL3194612T3/pl unknown
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