JP2017525371A5 - - Google Patents
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- JP2017525371A5 JP2017525371A5 JP2017510397A JP2017510397A JP2017525371A5 JP 2017525371 A5 JP2017525371 A5 JP 2017525371A5 JP 2017510397 A JP2017510397 A JP 2017510397A JP 2017510397 A JP2017510397 A JP 2017510397A JP 2017525371 A5 JP2017525371 A5 JP 2017525371A5
- Authority
- JP
- Japan
- Prior art keywords
- cfdna
- capture probe
- item
- genetic
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 57
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 239000000523 sample Substances 0.000 claims description 17
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 15
- 208000016361 genetic disease Diseases 0.000 claims description 15
- 230000002068 genetic effect Effects 0.000 claims description 15
- 230000003902 lesion Effects 0.000 claims description 13
- 238000012252 genetic analysis Methods 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 7
- 230000008707 rearrangement Effects 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 238000012163 sequencing technique Methods 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 210000004381 amniotic fluid Anatomy 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 210000002751 lymph Anatomy 0.000 claims description 4
- 210000003097 mucus Anatomy 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 210000004243 sweat Anatomy 0.000 claims description 4
- 230000007704 transition Effects 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 238000001712 DNA sequencing Methods 0.000 claims description 3
- 230000003321 amplification Effects 0.000 claims description 3
- 238000007622 bioinformatic analysis Methods 0.000 claims description 3
- 210000001508 eye Anatomy 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 101150023956 ALK gene Proteins 0.000 description 6
- 108091026890 Coding region Proteins 0.000 description 6
- 230000004927 fusion Effects 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 238000011529 RT qPCR Methods 0.000 description 3
- 239000000090 biomarker Substances 0.000 description 3
- 101150068690 eml4 gene Proteins 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 108091023043 Alu Element Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020090411A JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/052317 WO2016028316A1 (en) | 2014-08-22 | 2014-08-22 | Methods for quantitative genetic analysis of cell free dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020090411A Division JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525371A JP2017525371A (ja) | 2017-09-07 |
| JP2017525371A5 true JP2017525371A5 (enExample) | 2017-12-21 |
| JP6709778B2 JP6709778B2 (ja) | 2020-06-17 |
Family
ID=51494529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510397A Active JP6709778B2 (ja) | 2014-08-22 | 2014-08-22 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP3194612B1 (enExample) |
| JP (1) | JP6709778B2 (enExample) |
| CN (2) | CN115029342B (enExample) |
| CA (1) | CA2957657A1 (enExample) |
| DK (1) | DK3194612T3 (enExample) |
| ES (1) | ES2984266T3 (enExample) |
| HU (1) | HUE068191T2 (enExample) |
| PL (1) | PL3194612T3 (enExample) |
| PT (1) | PT3194612T (enExample) |
| SG (1) | SG11201701113WA (enExample) |
| WO (1) | WO2016028316A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US11230589B2 (en) | 2012-11-05 | 2022-01-25 | Foundation Medicine, Inc. | Fusion molecules and uses thereof |
| CN111254500B (zh) | 2012-12-10 | 2024-01-23 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| TWI813141B (zh) | 2014-07-18 | 2023-08-21 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| JP7441584B6 (ja) * | 2014-08-22 | 2024-03-15 | レゾリューション バイオサイエンス， インコーポレイテッド | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| JP6913089B2 (ja) * | 2015-11-11 | 2021-08-04 | レゾリューション バイオサイエンス， インコーポレイテッド | Ｄｎａライブラリーの高効率構築 |
| EP3430170B1 (en) * | 2016-03-16 | 2023-08-16 | Dana-Farber Cancer Institute, Inc. | Methods for genome characterization |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| WO2017190067A1 (en) | 2016-04-28 | 2017-11-02 | Impact Genomics, Inc. | Methods of assessing and monitoring tumor load |
| WO2017190104A1 (en) * | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| CN106047998B (zh) * | 2016-05-27 | 2019-11-12 | 深圳市海普洛斯生物科技有限公司 | 一种肺癌基因的检测方法及应用 |
| EP3482202A4 (en) * | 2016-07-11 | 2020-03-18 | Arizona Board of Regents on behalf of Arizona State University | USE OF SWEAT AS A BIOFLUID FOR THE ANALYSIS AND IDENTIFICATION OF DISEASES |
| US11319594B2 (en) * | 2016-08-25 | 2022-05-03 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in DNA samples |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| IL307463B2 (en) * | 2016-11-17 | 2026-01-01 | Lgc Clinical Diagnostics Inc | Methods for preparing DNA reference material and controls |
| KR20260032575A (ko) | 2016-11-30 | 2026-03-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| JP2021513342A (ja) * | 2018-02-12 | 2021-05-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 腫瘍の遺伝的不均一性を評価することによって治療法に対する応答を予測する方法 |
| EP3762513A1 (en) * | 2018-03-08 | 2021-01-13 | St. Johns University | Circulating serum cell-free dna biomarkers and methods |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| CN108517567B (zh) * | 2018-04-20 | 2020-08-11 | 江苏康为世纪生物科技有限公司 | 用于cfDNA建库的接头、引物组、试剂盒和建库方法 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN108676891B (zh) * | 2018-07-12 | 2022-02-01 | 吉林大学 | 一种直肠腺癌易感性预测试剂盒及系统 |
| US11926821B2 (en) * | 2018-10-22 | 2024-03-12 | The Chinese University Of Hong Kong | Cell-free DNA quality |
| US20220064708A1 (en) * | 2019-01-15 | 2022-03-03 | General Incorporated Association, Bio Education Laboratory | Method for preparing liquid biopsy using pva sponge |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| CN112301103B (zh) * | 2019-08-02 | 2023-04-11 | 北京贝瑞和康生物技术有限公司 | 一种非特异性扩增天然短片段核酸的方法和试剂盒 |
| CN110819622A (zh) * | 2019-10-09 | 2020-02-21 | 广州达正生物科技有限公司 | 一种快速提取石蜡组织rna的方法 |
| CN111254194B (zh) * | 2020-01-13 | 2021-09-07 | 东南大学 | 基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用 |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| WO2022020662A2 (en) * | 2020-07-24 | 2022-01-27 | Cornell University | Methods for assessing the severity and progression of sars-cov2 infections using cell-free dna |
| WO2022055984A1 (en) * | 2020-09-08 | 2022-03-17 | Resolution Bioscience, Inc. | Adaptors and methods for high efficiency construction of genetic libraries and genetic analysis |
| WO2023039539A1 (en) * | 2021-09-10 | 2023-03-16 | Foundation Medicine, Inc. | Gene fusions in sarcoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023769B2 (en) * | 2009-11-30 | 2015-05-05 | Complete Genomics, Inc. | cDNA library for nucleic acid sequencing |
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| US20130288915A1 (en) * | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
| WO2014052487A1 (en) * | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
| WO2014071295A1 (en) * | 2012-11-02 | 2014-05-08 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
| CN111254500B (zh) * | 2012-12-10 | 2024-01-23 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| US10745686B2 (en) * | 2013-02-08 | 2020-08-18 | Qiagen Gmbh | Method for separating DNA by size |
-
2014
- 2014-08-22 CN CN202210630244.2A patent/CN115029342B/zh active Active
- 2014-08-22 WO PCT/US2014/052317 patent/WO2016028316A1/en not_active Ceased
- 2014-08-22 CA CA2957657A patent/CA2957657A1/en active Pending
- 2014-08-22 SG SG11201701113WA patent/SG11201701113WA/en unknown
- 2014-08-22 ES ES14761762T patent/ES2984266T3/es active Active
- 2014-08-22 EP EP14761762.5A patent/EP3194612B1/en active Active
- 2014-08-22 DK DK14761762.5T patent/DK3194612T3/da active
- 2014-08-22 JP JP2017510397A patent/JP6709778B2/ja active Active
- 2014-08-22 PL PL14761762.5T patent/PL3194612T3/pl unknown
- 2014-08-22 HU HUE14761762A patent/HUE068191T2/hu unknown
- 2014-08-22 CN CN201480081729.4A patent/CN107002118B/zh active Active
- 2014-08-22 PT PT147617625T patent/PT3194612T/pt unknown
- 2014-08-22 EP EP24182096.8A patent/EP4410978A3/en active Pending
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