JP2020188767A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020188767A5 JP2020188767A5 JP2020090411A JP2020090411A JP2020188767A5 JP 2020188767 A5 JP2020188767 A5 JP 2020188767A5 JP 2020090411 A JP2020090411 A JP 2020090411A JP 2020090411 A JP2020090411 A JP 2020090411A JP 2020188767 A5 JP2020188767 A5 JP 2020188767A5
- Authority
- JP
- Japan
- Prior art keywords
- capture probe
- cfdna
- gene
- tagged
- genetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 51
- 239000000523 sample Substances 0.000 claims 45
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 11
- 238000004458 analytical method Methods 0.000 claims 11
- 208000016361 genetic disease Diseases 0.000 claims 11
- 230000002068 genetic effect Effects 0.000 claims 11
- 230000003902 lesion Effects 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 108091026890 Coding region Proteins 0.000 claims 6
- 230000008707 rearrangement Effects 0.000 claims 6
- 101150023956 ALK gene Proteins 0.000 claims 4
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 4
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 4
- 102100027100 Echinoderm microtubule-associated protein-like 4 Human genes 0.000 claims 4
- 101710203446 Echinoderm microtubule-associated protein-like 4 Proteins 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 239000000090 biomarker Substances 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000004381 amniotic fluid Anatomy 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 210000003608 fece Anatomy 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 210000002751 lymph Anatomy 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 210000002381 plasma Anatomy 0.000 claims 3
- 210000003296 saliva Anatomy 0.000 claims 3
- 210000000582 semen Anatomy 0.000 claims 3
- 238000012163 sequencing technique Methods 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 210000004243 sweat Anatomy 0.000 claims 3
- 230000007704 transition Effects 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 238000001712 DNA sequencing Methods 0.000 claims 2
- 108060002716 Exonuclease Proteins 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 102000013165 exonuclease Human genes 0.000 claims 2
- 102000054767 gene variant Human genes 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000012410 DNA Ligases Human genes 0.000 claims 1
- 108010061982 DNA Ligases Proteins 0.000 claims 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108090000652 Flap endonucleases Proteins 0.000 claims 1
- 102000004150 Flap endonucleases Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000003766 bioinformatics method Methods 0.000 claims 1
- 108091092240 circulating cell-free DNA Proteins 0.000 claims 1
- 230000002153 concerted effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 101150068690 eml4 gene Proteins 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 238000012252 genetic analysis Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020090411A JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| JP2021139325A JP2021182940A (ja) | 2020-05-25 | 2021-08-27 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| JP2023142908A JP2023159462A (ja) | 2020-05-25 | 2023-09-04 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017510397A JP6709778B2 (ja) | 2014-08-22 | 2014-08-22 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| JP2020090411A JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510397A Division JP6709778B2 (ja) | 2014-08-22 | 2014-08-22 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139325A Division JP2021182940A (ja) | 2020-05-25 | 2021-08-27 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020188767A JP2020188767A (ja) | 2020-11-26 |
| JP2020188767A5 true JP2020188767A5 (enExample) | 2021-04-08 |
| JP7441584B2 JP7441584B2 (ja) | 2024-03-01 |
| JP7441584B6 JP7441584B6 (ja) | 2024-03-15 |
Family
ID=73453009
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020090411A Active JP7441584B6 (ja) | 2014-08-22 | 2020-05-25 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| JP2021139325A Withdrawn JP2021182940A (ja) | 2020-05-25 | 2021-08-27 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| JP2023142908A Pending JP2023159462A (ja) | 2020-05-25 | 2023-09-04 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139325A Withdrawn JP2021182940A (ja) | 2020-05-25 | 2021-08-27 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| JP2023142908A Pending JP2023159462A (ja) | 2020-05-25 | 2023-09-04 | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (3) | JP7441584B6 (enExample) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| LT3567124T (lt) * | 2011-04-12 | 2022-04-11 | Verinata Health, Inc. | Genominių frakcijų paskirstymas, naudojant polimorfizmo skaičiavimo rezultatus |
| EP3561072A1 (en) * | 2012-12-10 | 2019-10-30 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
| ES2703764T3 (es) * | 2012-12-14 | 2019-03-12 | Chronix Biomedical | Biomarcadores personalizados para el cáncer |
| DK3194612T3 (da) * | 2014-08-22 | 2024-10-14 | Resolution Bioscience Inc | Fremgangsmåder til kvantitativ genetisk analyse af cellefrit dna |
-
2020
- 2020-05-25 JP JP2020090411A patent/JP7441584B6/ja active Active
-
2021
- 2021-08-27 JP JP2021139325A patent/JP2021182940A/ja not_active Withdrawn
-
2023
- 2023-09-04 JP JP2023142908A patent/JP2023159462A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102210852B1 (ko) | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 | |
| US12264357B2 (en) | Universal Sanger sequencing from next-gen sequencing amplicons | |
| CN103748236B (zh) | 安全测序系统 | |
| JP2017525371A5 (enExample) | ||
| JP2019504618A5 (enExample) | ||
| US20010018180A1 (en) | Methods for detecting mutations using primer extension for detecting disease | |
| CN114574581A (zh) | 检测稀有突变和拷贝数变异的系统和方法 | |
| JP2017506908A (ja) | 対象シークエンスを有する核酸の量の減少または増加の検出方法 | |
| CN112210601B (zh) | 基于粪便样本的结直肠癌筛查试剂盒 | |
| CN109576350B (zh) | 一种dna与rna同时定量的试剂盒、方法及质控方法 | |
| JPWO2016159111A1 (ja) | 胎児の遺伝子状態を判定する方法 | |
| CN112210602B (zh) | 基于粪便样本的结直肠癌筛查方法 | |
| CN112970068B (zh) | 用于检测样品之间的污染的方法和系统 | |
| US20210292750A1 (en) | Methods and composition for targeted genomic analysis | |
| JP2020188767A5 (enExample) | ||
| EP4372103A1 (en) | Substance and method for tumor assessment | |
| CN104152568B (zh) | 高通量str序列核心重复数检测方法 | |
| CN111304331A (zh) | 基于多重pcr的靶向高通量测序的mds检测试剂盒及制备方法 | |
| EP2130927A1 (en) | Method for amplification of dna fragment | |
| JP2009518051A (ja) | 異なる個体の核酸を含む生体試料から遺伝子型を決定する方法 | |
| US20250051850A1 (en) | Method for analyzing structural variation, primer pair set, and method for designing primer pair set | |
| CN118139987A (zh) | 用于cfrna和cftna靶向ngs测序的组合物和方法 | |
| WO2024039272A1 (en) | Nucleic acid amplification | |
| EP4573217A1 (en) | A method for determining the tissue or cell of origin of dna | |
| CN118696131A (zh) | 用于靶向核酸捕获和条形码编码的系统和方法 |