JP2019504618A5 - - Google Patents
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- JP2019504618A5 JP2019504618A5 JP2018524250A JP2018524250A JP2019504618A5 JP 2019504618 A5 JP2019504618 A5 JP 2019504618A5 JP 2018524250 A JP2018524250 A JP 2018524250A JP 2018524250 A JP2018524250 A JP 2018524250A JP 2019504618 A5 JP2019504618 A5 JP 2019504618A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- sample
- repair
- oligonucleotide
- ligation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004414 DNA Proteins 0.000 claims description 170
- 230000008439 repair process Effects 0.000 claims description 102
- 108091034117 Oligonucleotide Proteins 0.000 claims description 98
- 238000000034 method Methods 0.000 claims description 96
- 239000000523 sample Substances 0.000 claims description 47
- 102000053602 DNA Human genes 0.000 claims description 36
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 20
- 208000016361 genetic disease Diseases 0.000 claims description 20
- 239000012634 fragment Substances 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 16
- 102000004190 Enzymes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 239000012472 biological sample Substances 0.000 claims description 13
- 230000002068 genetic effect Effects 0.000 claims description 11
- 230000003902 lesion Effects 0.000 claims description 11
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 238000012252 genetic analysis Methods 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 8
- 210000003097 mucus Anatomy 0.000 claims description 8
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 8
- 108020004635 Complementary DNA Proteins 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 7
- 239000000090 biomarker Substances 0.000 claims description 7
- 238000010804 cDNA synthesis Methods 0.000 claims description 7
- 230000000295 complement effect Effects 0.000 claims description 7
- 239000002299 complementary DNA Substances 0.000 claims description 7
- 230000004927 fusion Effects 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 7
- 238000001712 DNA sequencing Methods 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 238000003766 bioinformatics method Methods 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 5
- 238000012217 deletion Methods 0.000 claims description 5
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- 238000003780 insertion Methods 0.000 claims description 5
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- 210000003296 saliva Anatomy 0.000 claims description 5
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- 230000007704 transition Effects 0.000 claims description 5
- 210000002700 urine Anatomy 0.000 claims description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 4
- 210000004381 amniotic fluid Anatomy 0.000 claims description 4
- 238000001574 biopsy Methods 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 4
- 239000000539 dimer Substances 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 102000054767 gene variant Human genes 0.000 claims description 3
- 208000035657 Abasia Diseases 0.000 claims description 2
- 206010003445 Ascites Diseases 0.000 claims description 2
- 108091093078 Pyrimidine dimer Proteins 0.000 claims description 2
- ASJWEHCPLGMOJE-LJMGSBPFSA-N ac1l3rvh Chemical compound N1C(=O)NC(=O)[C@@]2(C)[C@@]3(C)C(=O)NC(=O)N[C@H]3[C@H]21 ASJWEHCPLGMOJE-LJMGSBPFSA-N 0.000 claims description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 2
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 210000003780 hair follicle Anatomy 0.000 claims description 2
- 230000011987 methylation Effects 0.000 claims description 2
- 238000007069 methylation reaction Methods 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 210000004909 pre-ejaculatory fluid Anatomy 0.000 claims description 2
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- 238000011002 quantification Methods 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims description 2
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- 210000001519 tissue Anatomy 0.000 claims description 2
- 229940035893 uracil Drugs 0.000 claims description 2
- 210000004880 lymph fluid Anatomy 0.000 claims 2
- 231100000640 hair analysis Toxicity 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 description 4
- 238000011529 RT qPCR Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 108091023043 Alu Element Proteins 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254110P | 2015-11-11 | 2015-11-11 | |
| US62/254,110 | 2015-11-11 | ||
| PCT/US2016/061395 WO2017083562A1 (en) | 2015-11-11 | 2016-11-10 | High efficiency construction of dna libraries |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021010196A Division JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504618A JP2019504618A (ja) | 2019-02-21 |
| JP2019504618A5 true JP2019504618A5 (enExample) | 2019-12-19 |
| JP6913089B2 JP6913089B2 (ja) | 2021-08-04 |
Family
ID=58695623
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524250A Active JP6913089B2 (ja) | 2015-11-11 | 2016-11-10 | Ｄｎａライブラリーの高効率構築 |
| JP2021010196A Active JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
| JP2022070030A Active JP7318054B2 (ja) | 2015-11-11 | 2022-04-21 | Ｄｎａライブラリーの高効率構築 |
| JP2023099273A Pending JP2023113960A (ja) | 2015-11-11 | 2023-06-16 | Ｄｎａライブラリーの高効率構築 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021010196A Active JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
| JP2022070030A Active JP7318054B2 (ja) | 2015-11-11 | 2022-04-21 | Ｄｎａライブラリーの高効率構築 |
| JP2023099273A Pending JP2023113960A (ja) | 2015-11-11 | 2023-06-16 | Ｄｎａライブラリーの高効率構築 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11339391B2 (enExample) |
| EP (2) | EP3889257A1 (enExample) |
| JP (4) | JP6913089B2 (enExample) |
| KR (1) | KR102788327B1 (enExample) |
| CN (2) | CN115044645A (enExample) |
| AU (1) | AU2016353133B2 (enExample) |
| CA (1) | CA3004435A1 (enExample) |
| DK (1) | DK3374525T3 (enExample) |
| ES (1) | ES2856598T3 (enExample) |
| IL (2) | IL285202B2 (enExample) |
| MX (2) | MX2018005858A (enExample) |
| RU (1) | RU2018121254A (enExample) |
| WO (1) | WO2017083562A1 (enExample) |
Families Citing this family (21)
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| CA3004435A1 (en) | 2015-11-11 | 2017-05-18 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| EP4667584A2 (en) | 2016-08-25 | 2025-12-24 | Resolution Bioscience, Inc. | Methods for quantitative genetic analysis of dna fragments using adaptors with unique molecular identifiers and sample tags |
| WO2019006269A1 (en) * | 2017-06-30 | 2019-01-03 | The Regents Of The University Of California | METHODS AND SYSTEMS FOR ASSESSING METHYLATION OF DNA IN ACELLULAR DNA |
| CA3075280A1 (en) | 2017-09-11 | 2019-03-14 | Ludwig Institute For Cancer Research Ltd | Selective labeling of 5-methylcytosine in circulating cell-free dna |
| CA3080117A1 (en) | 2017-10-27 | 2019-05-02 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
| JP2021514663A (ja) | 2018-03-08 | 2021-06-17 | セント・ジョーンズ・ユニバーシティＳｔ． Ｊｏｈｎｓ Ｕｎｉｖｅｒｓｉｔｙ | 循環性血清無細胞ｄｎａバイオマーカー及び方法 |
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| PT3827011T (pt) * | 2018-07-24 | 2024-08-07 | Salish Bioscience Inc | Métodos e composição para análise genómica dirigida |
| CN113286881A (zh) | 2018-09-27 | 2021-08-20 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
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| CN111074353B (zh) * | 2018-10-18 | 2023-10-13 | 深圳华大智造科技股份有限公司 | 全基因组甲基化文库单链建库方法和得到的全基因组甲基化文库 |
| US11926821B2 (en) * | 2018-10-22 | 2024-03-12 | The Chinese University Of Hong Kong | Cell-free DNA quality |
| CN109576799B (zh) * | 2018-11-30 | 2022-04-26 | 深圳安吉康尔医学检验实验室 | Fh测序文库的构建方法和引物组及试剂盒 |
| CN113906146A (zh) * | 2019-03-27 | 2022-01-07 | 朱诺诊断学公司 | 优化的超低体积液体活检方法、系统和设备 |
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| EP4211246B1 (en) * | 2020-09-08 | 2025-07-23 | Resolution Bioscience, Inc. | Adaptors and methods for high efficiency construction of genetic libraries and genetic analysis |
| CN114317528A (zh) * | 2020-09-30 | 2022-04-12 | 北京吉因加科技有限公司 | 特异分子标签umi组、混合特异分子标签接头及应用 |
| CN114438184B (zh) * | 2022-04-08 | 2022-07-12 | 昌平国家实验室 | 游离dna甲基化测序文库构建方法及应用 |
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2016
- 2016-11-10 CA CA3004435A patent/CA3004435A1/en active Pending
- 2016-11-10 CN CN202210236083.9A patent/CN115044645A/zh active Pending
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