JP2019526257A5 - - Google Patents

Download PDF

Info

Publication number
JP2019526257A5
JP2019526257A5 JP2019511456A JP2019511456A JP2019526257A5 JP 2019526257 A5 JP2019526257 A5 JP 2019526257A5 JP 2019511456 A JP2019511456 A JP 2019511456A JP 2019511456 A JP2019511456 A JP 2019511456A JP 2019526257 A5 JP2019526257 A5 JP 2019526257A5
Authority
JP
Japan
Prior art keywords
region
sample
genomic dna
adapters
adapter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019511456A
Other languages
English (en)
Japanese (ja)
Other versions
JP7217224B2 (ja
JP2019526257A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/048434 external-priority patent/WO2018039463A1/en
Publication of JP2019526257A publication Critical patent/JP2019526257A/ja
Publication of JP2019526257A5 publication Critical patent/JP2019526257A5/ja
Priority to JP2021180899A priority Critical patent/JP7304393B2/ja
Application granted granted Critical
Publication of JP7217224B2 publication Critical patent/JP7217224B2/ja
Priority to JP2023044421A priority patent/JP2023078336A/ja
Priority to JP2024094503A priority patent/JP2024107320A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019511456A 2016-08-25 2017-08-24 Ｄｎａ試料中のゲノムコピー変化の検出方法 Active JP7217224B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021180899A JP7304393B2 (ja) 2016-08-25 2021-11-05 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2023044421A JP2023078336A (ja) 2016-08-25 2023-03-20 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2024094503A JP2024107320A (ja) 2016-08-25 2024-06-11 Ｄｎａ試料中のゲノムコピー変化の検出方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662379593P 2016-08-25 2016-08-25
US62/379,593 2016-08-25
US201762481538P 2017-04-04 2017-04-04
US62/481,538 2017-04-04
PCT/US2017/048434 WO2018039463A1 (en) 2016-08-25 2017-08-24 Methods for the detection of genomic copy changes in dna samples

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021180899A Division JP7304393B2 (ja) 2016-08-25 2021-11-05 Ｄｎａ試料中のゲノムコピー変化の検出方法

Publications (3)

Publication Number Publication Date
JP2019526257A JP2019526257A (ja) 2019-09-19
JP2019526257A5 true JP2019526257A5 (enExample) 2020-08-20
JP7217224B2 JP7217224B2 (ja) 2023-02-02

Family

ID=61245331

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019511456A Active JP7217224B2 (ja) 2016-08-25 2017-08-24 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2021180899A Active JP7304393B2 (ja) 2016-08-25 2021-11-05 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2023044421A Pending JP2023078336A (ja) 2016-08-25 2023-03-20 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2024094503A Pending JP2024107320A (ja) 2016-08-25 2024-06-11 Ｄｎａ試料中のゲノムコピー変化の検出方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021180899A Active JP7304393B2 (ja) 2016-08-25 2021-11-05 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2023044421A Pending JP2023078336A (ja) 2016-08-25 2023-03-20 Ｄｎａ試料中のゲノムコピー変化の検出方法
JP2024094503A Pending JP2024107320A (ja) 2016-08-25 2024-06-11 Ｄｎａ試料中のゲノムコピー変化の検出方法

Country Status (13)

Country Link
US (2) US11319594B2 (enExample)
EP (2) EP4667584A3 (enExample)
JP (4) JP7217224B2 (enExample)
KR (2) KR102505122B1 (enExample)
CN (2) CN117286217A (enExample)
AU (2) AU2017315769B2 (enExample)
CA (1) CA3034649A1 (enExample)
ES (1) ES3053343T3 (enExample)
IL (2) IL312894A (enExample)
MX (2) MX2019002093A (enExample)
RU (1) RU2019108294A (enExample)
SG (1) SG11201901371XA (enExample)
WO (1) WO2018039463A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105531375B (zh) 2012-12-10 2020-03-03 分析生物科学有限公司 靶向基因组分析的方法
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
EP3889257A1 (en) 2015-11-11 2021-10-06 Resolution Bioscience, Inc. High efficiency construction of dna libraries
KR102505122B1 (ko) 2016-08-25 2023-03-08 레졸루션 바이오사이언스, 인크. Dna 샘플 중 게놈 카피 변화의 검출을 위한 방법
US11767562B2 (en) 2018-03-08 2023-09-26 St. John's University Circulating serum cell-free DNA biomarkers and methods
CA3302676A1 (en) 2018-04-02 2026-05-13 Grail, Inc. Methylation markers and targeted methylation probe panels
US11519033B2 (en) * 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
CN111118610A (zh) * 2018-10-31 2020-05-08 深圳华大基因股份有限公司 用于基因突变高深度测序的基因芯片及其制备方法和应用
US20210355546A1 (en) * 2018-11-02 2021-11-18 The Regents Of The University Of California Methods to Diagnose and Treat Cancer Using Non-Human Nucleic Acids
EP4538389A3 (en) * 2019-01-03 2025-07-30 Ncan Genomics, Inc. Linked target capture
KR20260023068A (ko) * 2019-01-24 2026-02-20 일루미나, 인코포레이티드 장기 건강 및 질환을 모니터링하기 위한 방법 및 시스템
KR20220021909A (ko) * 2019-05-17 2022-02-22 더 존스 홉킨스 유니버시티 신속한 이수성 검출
JP7859967B2 (ja) * 2019-08-19 2026-05-15 グリーン クロス ゲノム コーポレーション 核酸断片間距離情報を用いた染色体異常検出方法
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
KR102184277B1 (ko) * 2020-01-16 2020-11-30 성균관대학교산학협력단 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법
EP4534700A3 (en) * 2020-02-13 2025-07-09 Garvan Institute of Medical Research Reference ladders and adaptors
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
CN113496760B (zh) * 2020-04-01 2024-01-12 深圳华大基因科技服务有限公司 基于第三代测序的多倍体基因组组装方法和装置
CN113113085B (zh) * 2021-03-15 2022-08-19 杭州杰毅生物技术有限公司 基于智能宏基因组测序数据肿瘤检测的分析系统及方法
EP4314340B1 (en) 2021-03-30 2026-04-22 Resolution Bioscience, Inc. Compositions and methods for simultaneous genetic analysis of multiple libraries
GB202108237D0 (en) * 2021-06-09 2021-07-21 Univ London Cancer methods
CN114649094B (zh) * 2022-03-30 2022-11-15 广东省人民医院 一种基于核磁共振的乳腺癌多参数临床决策辅助装置
CA3230267A1 (en) 2022-08-04 2024-02-08 Nam Hoon Hur Battery pack

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591582A (en) 1985-07-23 1997-01-07 The Board Of Rijks Universiteit Leiden Methods for detecting activated RAS oncogenes
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
CA2185239C (en) 1994-03-16 2002-12-17 Nanibhushan Dattagupta Isothermal strand displacement nucleic acid amplification
US5514551A (en) 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
US5888731A (en) 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
US6025133A (en) 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
AU731069B2 (en) 1997-08-28 2001-03-22 Applied Biosystems, Llc Improved detection of mutations in nucleic acids by chemical cleavage
WO1999023258A1 (en) 1997-10-31 1999-05-14 Gen-Probe Incorporated Methods of nucleic acid detection
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
US7081527B2 (en) 2000-09-12 2006-07-25 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of Cryptosporidium parvum organisms in a test sample
US6812341B1 (en) 2001-05-11 2004-11-02 Ambion, Inc. High efficiency mRNA isolation methods and compositions
AU2002365028A1 (en) 2001-07-17 2003-06-30 Stratagene Methods for detection of a target nucleic acid using multi-subunit probes
WO2003020979A1 (en) 2001-08-31 2003-03-13 Rosetta Inpharmactis Llc. Methods for preparing nucleic acid samples
US7361821B2 (en) 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
JP4441623B2 (ja) 2002-12-11 2010-03-31 学校法人慶應義塾 対応付け分子およびその構成要素のライブラリーの製造方法および利用方法
TW200506052A (en) 2003-05-07 2005-02-16 Takara Bio Inc Method of analyzing DNA region
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
CN101501215A (zh) 2005-07-07 2009-08-05 阿什洛米克斯控股有限公司 用于诊断内毒素血症的多核苷酸标记基因及它们的表达
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7572643B2 (en) 2005-11-21 2009-08-11 E. I. Du Pont De Nemours And Company Nanoparticle composite-coated glass microspheres for use in bioassays
US20070117089A1 (en) 2005-11-21 2007-05-24 Croker Kevin M Sol-gel coated glass microspheres for use in bioassay
US7939645B2 (en) 2006-01-06 2011-05-10 Agilent Technologies, Inc Reaction buffer composition for nucleic acid replication with packed DNA polymerases
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
US20090075343A1 (en) 2006-11-09 2009-03-19 Complete Genomics, Inc. Selection of dna adaptor orientation by nicking
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
WO2009023676A1 (en) 2007-08-12 2009-02-19 Integrated Dna Technologies, Inc. Microarray system with improved sequence specificity
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
SG193776A1 (en) 2007-12-05 2013-10-30 Complete Genomics Inc Efficient base determination in sequencing reactions
WO2009091798A1 (en) 2008-01-16 2009-07-23 Helicos Biosciences Corporation Quantitative genetic analysis
US8202691B2 (en) 2008-01-25 2012-06-19 Illumina, Inc. Uniform fragmentation of DNA using binding proteins
WO2009099602A1 (en) 2008-02-04 2009-08-13 Massachusetts Institute Of Technology Selection of nucleic acids by solution hybridization to oligonucleotide baits
DE102008008313A1 (de) 2008-02-07 2009-08-13 Qiagen Gmbh Amplifikation von bisulfitierten Nukleinsäuren
US9624489B2 (en) 2008-03-10 2017-04-18 Illumina, Inc. Methods for selecting and amplifying polynucleotides
US8999642B2 (en) 2008-03-10 2015-04-07 Illumina, Inc. Methods for selecting and amplifying polynucleotides
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US8728764B2 (en) 2008-10-02 2014-05-20 Illumina Cambridge Limited Nucleic acid sample enrichment for sequencing applications
EP2664678B1 (en) 2008-10-24 2014-10-08 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
US8370079B2 (en) 2008-11-20 2013-02-05 Pacific Biosciences Of California, Inc. Algorithms for sequence determination
WO2010068856A1 (en) 2008-12-11 2010-06-17 Trustees Of Boston University Isolation of rna
CN103952482A (zh) 2009-04-02 2014-07-30 弗卢伊蒂格姆公司 用于对目标核酸进行条形码化的多引物扩增方法
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20110003301A1 (en) 2009-05-08 2011-01-06 Life Technologies Corporation Methods for detecting genetic variations in dna samples
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US10378064B1 (en) 2010-04-16 2019-08-13 Chronix Biomedical Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
WO2011156529A2 (en) 2010-06-08 2011-12-15 Nugen Technologies, Inc. Methods and composition for multiplex sequencing
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
EP2619327B1 (en) 2010-09-21 2014-10-22 Population Genetics Technologies LTD. Increasing confidence of allele calls with molecular counting
AU2011305445B2 (en) 2010-09-24 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
KR102040307B1 (ko) 2010-11-30 2019-11-27 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
WO2012138365A1 (en) 2011-04-05 2012-10-11 E. I. Du Pont De Nemours And Company Amine-accelerated process for the surface treatment of colloidal silica and products thereof
ES2572912T3 (es) 2011-04-12 2016-06-03 Verinata Health, Inc Resolución de fracciones de genoma mediante recuento de polimorfismos
EP3246416B1 (en) 2011-04-15 2024-06-05 The Johns Hopkins University Safe sequencing system
US9809904B2 (en) 2011-04-21 2017-11-07 University Of Washington Through Its Center For Commercialization Methods for retrieval of sequence-verified DNA constructs
WO2013018882A1 (ja) 2011-08-04 2013-02-07 独立行政法人国立がん研究センター Ｋｉｆ５ｂ遺伝子とｒｅｔ遺伝子との融合遺伝子、並びに該融合遺伝子を標的としたがん治療の有効性を判定する方法
WO2013028817A1 (en) 2011-08-23 2013-02-28 Foundation Medicine , Inc. Novel kif5b-ret fusion molecules and uses thereof
WO2013056178A2 (en) 2011-10-14 2013-04-18 Foundation Medicine, Inc. Novel estrogen receptor mutations and uses thereof
WO2013059740A1 (en) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Novel alk and ntrk1 fusion molecules and uses thereof
CN103103624B (zh) 2011-11-15 2014-12-31 深圳华大基因科技服务有限公司 高通量测序文库的构建方法及其应用
CN103298955B (zh) 2012-01-10 2016-06-08 北京贝瑞和康生物技术股份有限公司 用于构建血浆dna测序文库的方法和试剂盒
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US20130288915A1 (en) 2012-04-27 2013-10-31 Htg Molecular Diagnostics, Inc. Compositions and methods for alk molecular testing
AU2013267609C1 (en) 2012-05-31 2019-01-03 Board Of Regents, The University Of Texas System Method for accurate sequencing of DNA
JP6433893B2 (ja) 2012-07-03 2018-12-05 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド Ｔｍ増強ブロッキングオリゴヌクレオチド、ならびに標的濃縮の改善およびオフターゲット選択の低減のためのベイト
WO2014020502A2 (en) 2012-07-31 2014-02-06 Novartis Ag Markers associated with human double minute 2 inhibitors
HK1213044A1 (zh) 2012-08-03 2016-06-24 Foundation Medicine, Inc. 人乳头瘤病毒作为肿瘤预後的预测因子
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
PL2893040T3 (pl) 2012-09-04 2019-05-31 Guardant Health Inc Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
PL2902029T3 (pl) 2012-09-25 2019-01-31 Chugai Seiyaku Kabushiki Kaisha Inhibitor RET
EP2900836B1 (en) 2012-09-28 2023-05-10 Cepheid Two-primer pcr for microrna multiplex assay
US10482994B2 (en) * 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA3120521A1 (en) * 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150291953A1 (en) 2012-11-02 2015-10-15 Enzymatics Inc. Methods and kits for nucleic acid sample preparation for sequencing
EP2914621B1 (en) 2012-11-05 2023-06-07 Foundation Medicine, Inc. Novel ntrk1 fusion molecules and uses thereof
EP4223770A3 (en) 2012-11-05 2023-10-18 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
CN105531375B (zh) 2012-12-10 2020-03-03 分析生物科学有限公司 靶向基因组分析的方法
US9909186B2 (en) 2012-12-14 2018-03-06 Chronix Biomedical Personalized biomarkers for cancer
US11158425B2 (en) 2013-01-05 2021-10-26 Foundation Medicine, Inc. System and method for managing genomic information
EP2958574A4 (en) * 2013-01-23 2016-11-02 Reproductive Genetics And Technology Solutions Llc COMPOSITIONS AND METHODS FOR GENETIC ANALYSIS OF EMBRYOS
US10745686B2 (en) 2013-02-08 2020-08-18 Qiagen Gmbh Method for separating DNA by size
WO2014145078A1 (en) 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
WO2014151734A1 (en) 2013-03-15 2014-09-25 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
US20160032396A1 (en) 2013-03-15 2016-02-04 The Board Of Trustees Of The Leland Stanford Junior University Identification and Use of Circulating Nucleic Acid Tumor Markers
AU2014262481A1 (en) 2013-05-10 2015-11-26 Foundation Medicine, Inc. Analysis of genetic variants
EP3019628A4 (en) 2013-07-12 2017-05-10 The Regents Of The University Of Michigan Recurrent gene fusions in cancer
US10705087B2 (en) 2013-07-26 2020-07-07 Japanese Foundation For Cancer Research Detection method for NTRK3 fusion
EP3628749A1 (en) 2013-07-30 2020-04-01 Blueprint Medicines Corporation Ntrk2 fusions
US10208354B2 (en) 2013-08-07 2019-02-19 Universität Zu Köln NRG1 fusion genes in cancer
US20150072344A1 (en) * 2013-09-10 2015-03-12 Imdaptive Incorporated Barcoded Universal Marker Indicator (BUMI) Tags
US10851414B2 (en) * 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ， インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
CN103668471B (zh) 2013-12-19 2015-09-30 上海交通大学 一种构建dna高通量测序文库的方法及其配套试剂盒
CN111534580B (zh) 2013-12-28 2024-06-04 夸登特健康公司 用于检测遗传变异的方法和系统
HUE058149T2 (hu) 2014-01-31 2022-07-28 Swift Biosciences Inc Javított eljárások DNS-szubsztrátok feldolgozására
US10208338B2 (en) * 2014-03-03 2019-02-19 Swift Biosciences, Inc. Enhanced adaptor ligation
US10975371B2 (en) 2014-04-29 2021-04-13 Illumina, Inc. Nucleic acid sequence analysis from single cells
EP3155131B1 (en) 2014-06-10 2020-02-12 Blueprint Medicines Corporation Raf1 fusions
KR20170026383A (ko) 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. 핵산 서열의 분석
EP3177740B1 (en) * 2014-08-06 2021-01-13 Nugen Technologies, Inc. Digital measurements from targeted sequencing
HUE068191T2 (hu) 2014-08-22 2024-12-28 Resolution Bioscience Inc A sejtmentes dns kvantitatív genetikai elemzésére szolgáló eljárások
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
CN106661636A (zh) 2014-09-05 2017-05-10 凯杰有限公司 衔接子连接的扩增子的制备
WO2016037358A1 (zh) 2014-09-12 2016-03-17 深圳华大基因科技有限公司 分离的寡核苷酸及其在核酸测序中的用途
WO2016040901A1 (en) 2014-09-12 2016-03-17 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acids
TWI746426B (zh) 2014-11-16 2021-11-21 美商亞雷生物製藥股份有限公司 (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
ES2989276T3 (es) 2014-12-05 2024-11-25 Found Medicine Inc Análisis multigénico de muestras tumorales
DK3230469T3 (da) 2014-12-12 2019-07-15 Verinata Health Inc Anvendelse af cellefri DNA-fragmentstørrelse til bestemmelse af kopiantalsvariationer
WO2016109452A1 (en) 2014-12-31 2016-07-07 Guardant Health , Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
DK3256605T3 (da) 2015-02-10 2022-03-14 Univ Hong Kong Chinese Påvisning af mutationer til cancerscreening og føtal analyse
WO2016201454A1 (en) 2015-06-12 2016-12-15 The Translational Genomics Research Institute Targeted therapies for cancer
US10453556B2 (en) 2015-07-23 2019-10-22 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free DNA
US10954609B2 (en) 2015-07-29 2021-03-23 Dupont Safety & Construction, Inc. Yarn from polymers having different decomposition temperatures and process for forming same
US9522125B1 (en) 2015-08-10 2016-12-20 Macau University Of Science And Technology Method of treating cancer
JP6991134B2 (ja) 2015-10-09 2022-01-12 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａを使用する集団ベースの処置レコメンダ
US12603152B2 (en) 2015-10-10 2026-04-14 Guardant Health, Inc. Methods and applications of gene fusion detection in cell-free DNA analysis
EP3889257A1 (en) 2015-11-11 2021-10-06 Resolution Bioscience, Inc. High efficiency construction of dna libraries
WO2017122816A1 (ja) 2016-01-15 2017-07-20 公益財団法人がん研究会 新規融合体及びその検出法
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
WO2017151524A1 (en) 2016-02-29 2017-09-08 Foundation Medicine, Inc. Methods and systems for evaluating tumor mutational burden
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
WO2017214557A1 (en) 2016-06-10 2017-12-14 Counsyl, Inc. Nucleic acid sequencing adapters and uses thereof
KR102505122B1 (ko) * 2016-08-25 2023-03-08 레졸루션 바이오사이언스, 인크. Dna 샘플 중 게놈 카피 변화의 검출을 위한 방법
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3792922A1 (en) 2016-09-30 2021-03-17 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018094183A1 (en) 2016-11-17 2018-05-24 Seracare Life Sciences, Inc. Methods for preparing dna reference material and controls
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
JP7048609B2 (ja) 2016-12-09 2022-04-05 ボリアル ジェノミクス， インコーポレイテッド 連結型ライゲーション
CN117442719A (zh) 2017-02-21 2024-01-26 瑞泽恩制药公司 用于治疗肺癌的抗pd-1抗体
PL3885445T3 (pl) 2017-04-14 2024-01-29 Guardant Health, Inc. Sposoby przyłączania adapterów do próbek kwasów nukleinowych
KR102074559B1 (ko) 2017-10-31 2020-02-06 사회복지법인 삼성생명공익재단 위암의 항암제 내성 진단용 바이오마커 및 이의 용도
US10329627B1 (en) 2018-04-23 2019-06-25 Inivata Ltd. Method for predicting and monitoring response to an immune checkpoint inhibitor
AU2019384154B2 (en) 2018-11-21 2025-11-20 Agilent Technologies, Inc. Methods for targeted nucleic acid library formation
WO2021163546A1 (en) 2020-02-14 2021-08-19 The Johns Hopkins University Methods and materials for assessing nucleic acids
DK4211246T3 (da) 2020-09-08 2025-08-18 Resolution Bioscience Inc Adaptorer og fremgangsmåder til højeffektiv konstruktion af genetiske biblioteker og genetisk analyse
EP4314340B1 (en) 2021-03-30 2026-04-22 Resolution Bioscience, Inc. Compositions and methods for simultaneous genetic analysis of multiple libraries

Similar Documents

Publication Publication Date Title
RU2019108294A (ru) Способы обнаружения изменений количества геномных копий в образцах днк
US20240102101A1 (en) Systems and methods to detect rare mutations and copy number variation
JP7119014B2 (ja) まれな変異およびコピー数多型を検出するためのシステムおよび方法
US11111541B2 (en) Diagnostic MiRNA markers for Parkinson's disease
US20200299756A1 (en) Systems and methods to detect rare mutations and copy number variation
RU2018121254A (ru) Высокоэффективное построение библиотек днк
JP2019504618A5 (enExample)
RS59073B1 (sr) Analiza zasnovana na veličini frakcije fetusne dnk u majčinoj plazmi
TWI670495B (zh) 一種鑑定樣本中腫瘤負荷的方法和系統
JP2017525371A5 (enExample)
CN105793438B (zh) 未知序列的双股线性核酸的全长扩增方法
US10457988B2 (en) MiRNAs as diagnostic markers
JP5789720B2 (ja) 遺伝子変異分析装置、遺伝子変異分析システム及び遺伝子変異分析方法
JP6571526B2 (ja) 鎖を除外することによりマイクロアレイの性能を向上する方法
KR20150014937A (ko) Rna 완전성을 결정하는 방법
CN106591425A (zh) 基于连接反应的多重靶向检测核酸指标的方法
WO2018186687A1 (ko) 생물학적 시료의 핵산 품질을 결정하는 방법
HK40113932A (en) Short tandem repeat sequence sequencing and analysis methods
EP2733634A1 (en) Method for obtaining gene signature scores
HK1202135B (en) Size-based analysis of fetal dna fraction in maternal plasma