JP2019526257A5 - - Google Patents
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- JP2019526257A5 JP2019526257A5 JP2019511456A JP2019511456A JP2019526257A5 JP 2019526257 A5 JP2019526257 A5 JP 2019526257A5 JP 2019511456 A JP2019511456 A JP 2019511456A JP 2019511456 A JP2019511456 A JP 2019511456A JP 2019526257 A5 JP2019526257 A5 JP 2019526257A5
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- 108020004414 DNA Proteins 0.000 claims description 229
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- 238000012360 testing method Methods 0.000 claims description 34
- 230000003321 amplification Effects 0.000 claims description 25
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 21
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- 238000012163 sequencing technique Methods 0.000 claims description 14
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- 238000012252 genetic analysis Methods 0.000 claims description 12
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
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- 208000037051 Chromosomal Instability Diseases 0.000 claims description 8
- 150000007523 nucleic acids Chemical group 0.000 claims description 8
- 238000001712 DNA sequencing Methods 0.000 claims description 6
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- 238000004458 analytical method Methods 0.000 claims description 6
- 239000013610 patient sample Substances 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 6
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 5
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- 238000012935 Averaging Methods 0.000 claims description 4
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- 102000012410 DNA Ligases Human genes 0.000 claims description 2
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- 239000003298 DNA probe Substances 0.000 claims description 2
- 102000009095 Fanconi Anemia Complementation Group A protein Human genes 0.000 claims description 2
- 108010087740 Fanconi Anemia Complementation Group A protein Proteins 0.000 claims description 2
- 108010067741 Fanconi Anemia Complementation Group N protein Proteins 0.000 claims description 2
- 102000016627 Fanconi Anemia Complementation Group N protein Human genes 0.000 claims description 2
- 102100034553 Fanconi anemia group J protein Human genes 0.000 claims description 2
- 208000031448 Genomic Instability Diseases 0.000 claims description 2
- 208000028782 Hereditary disease Diseases 0.000 claims description 2
- 102100039999 Histone deacetylase 2 Human genes 0.000 claims description 2
- 101000848171 Homo sapiens Fanconi anemia group J protein Proteins 0.000 claims description 2
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 claims description 2
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 claims description 2
- 208000024556 Mendelian disease Diseases 0.000 claims description 2
- 101100015391 Mus musculus Ralgds gene Proteins 0.000 claims description 2
- 239000012661 PARP inhibitor Substances 0.000 claims description 2
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims description 2
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 claims description 2
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 claims description 2
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
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- 239000000203 mixture Substances 0.000 claims 22
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021180899A JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2023044421A JP2023078336A (ja) | 2016-08-25 | 2023-03-20 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2024094503A JP2024107320A (ja) | 2016-08-25 | 2024-06-11 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662379593P | 2016-08-25 | 2016-08-25 | |
| US62/379,593 | 2016-08-25 | ||
| US201762481538P | 2017-04-04 | 2017-04-04 | |
| US62/481,538 | 2017-04-04 | ||
| PCT/US2017/048434 WO2018039463A1 (en) | 2016-08-25 | 2017-08-24 | Methods for the detection of genomic copy changes in dna samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180899A Division JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526257A JP2019526257A (ja) | 2019-09-19 |
| JP2019526257A5 true JP2019526257A5 (enExample) | 2020-08-20 |
| JP7217224B2 JP7217224B2 (ja) | 2023-02-02 |
Family
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511456A Active JP7217224B2 (ja) | 2016-08-25 | 2017-08-24 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2021180899A Active JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2023044421A Pending JP2023078336A (ja) | 2016-08-25 | 2023-03-20 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2024094503A Pending JP2024107320A (ja) | 2016-08-25 | 2024-06-11 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180899A Active JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2023044421A Pending JP2023078336A (ja) | 2016-08-25 | 2023-03-20 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2024094503A Pending JP2024107320A (ja) | 2016-08-25 | 2024-06-11 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11319594B2 (enExample) |
| EP (1) | EP3504347B1 (enExample) |
| JP (4) | JP7217224B2 (enExample) |
| KR (2) | KR102505122B1 (enExample) |
| CN (2) | CN109804080B (enExample) |
| AU (2) | AU2017315769B2 (enExample) |
| CA (1) | CA3034649A1 (enExample) |
| IL (2) | IL312894A (enExample) |
| MX (2) | MX2019002093A (enExample) |
| NZ (1) | NZ750902A (enExample) |
| RU (1) | RU2019108294A (enExample) |
| SG (1) | SG11201901371XA (enExample) |
| WO (1) | WO2018039463A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2929056A4 (en) | 2012-12-10 | 2016-11-09 | Resolution Bioscience Inc | METHODS FOR TARGETED GENOMIC ANALYSIS |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| RU2018121254A (ru) | 2015-11-11 | 2019-12-16 | Резолюшн Байосайенс, Инк. | Высокоэффективное построение библиотек днк |
| WO2018039463A1 (en) * | 2016-08-25 | 2018-03-01 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in dna samples |
| EP3762513A1 (en) * | 2018-03-08 | 2021-01-13 | St. Johns University | Circulating serum cell-free dna biomarkers and methods |
| CN119753091A (zh) | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| CN111118610A (zh) * | 2018-10-31 | 2020-05-08 | 深圳华大基因股份有限公司 | 用于基因突变高深度测序的基因芯片及其制备方法和应用 |
| AU2019372440B2 (en) * | 2018-11-02 | 2025-12-04 | The Regents Of The University Of California | Methods to diagnose and treat cancer using non-human nucleic acids |
| WO2020141464A1 (en) * | 2019-01-03 | 2020-07-09 | Boreal Genomics, Inc. | Linked target capture |
| EP4632078A2 (en) * | 2019-01-24 | 2025-10-15 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| KR20220021909A (ko) * | 2019-05-17 | 2022-02-22 | 더 존스 홉킨스 유니버시티 | 신속한 이수성 검출 |
| KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
| CA3147613A1 (en) * | 2019-08-19 | 2021-02-25 | Chang-Seok Ki | Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments |
| KR102184277B1 (ko) * | 2020-01-16 | 2020-11-30 | 성균관대학교산학협력단 | 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법 |
| EP4103749A4 (en) * | 2020-02-13 | 2024-03-13 | Garvan Institute of Medical Research | Reference ladders and adaptors |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| CN113496760B (zh) * | 2020-04-01 | 2024-01-12 | 深圳华大基因科技服务有限公司 | 基于第三代测序的多倍体基因组组装方法和装置 |
| CN113113085B (zh) * | 2021-03-15 | 2022-08-19 | 杭州杰毅生物技术有限公司 | 基于智能宏基因组测序数据肿瘤检测的分析系统及方法 |
| GB202108237D0 (en) * | 2021-06-09 | 2021-07-21 | Univ London | Cancer methods |
| CN114649094B (zh) * | 2022-03-30 | 2022-11-15 | 广东省人民医院 | 一种基于核磁共振的乳腺癌多参数临床决策辅助装置 |
| WO2024029814A1 (ko) | 2022-08-04 | 2024-02-08 | 주식회사 엘지에너지솔루션 | 배터리 팩 |
Family Cites Families (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
| US5888731A (en) | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| JP2002511767A (ja) | 1997-08-28 | 2002-04-16 | ピーイー コーポレイション（エヌワイ） | 化学切断による、核酸における変異の改良された検出 |
| US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| US6812341B1 (en) | 2001-05-11 | 2004-11-02 | Ambion, Inc. | High efficiency mRNA isolation methods and compositions |
| US7183052B2 (en) | 2001-07-17 | 2007-02-27 | Stratagene California | Methods for detection of a target nucleic acid using multi-subunit probes |
| WO2003020979A1 (en) | 2001-08-31 | 2003-03-13 | Rosetta Inpharmactis Llc. | Methods for preparing nucleic acid samples |
| US7361821B2 (en) | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
| JP4441623B2 (ja) | 2002-12-11 | 2010-03-31 | 学校法人慶應義塾 | 対応付け分子およびその構成要素のライブラリーの製造方法および利用方法 |
| TW200506052A (en) | 2003-05-07 | 2005-02-16 | Takara Bio Inc | Method of analyzing DNA region |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| WO2007006091A1 (en) | 2005-07-07 | 2007-01-18 | Athlomics Pty Ltd | Polynucleotide marker genes and their expression, for diagnosis of endotoxemia |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US7939645B2 (en) | 2006-01-06 | 2011-05-10 | Agilent Technologies, Inc | Reaction buffer composition for nucleic acid replication with packed DNA polymerases |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| US8383338B2 (en) | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| WO2008045158A1 (en) | 2006-10-10 | 2008-04-17 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| WO2009023676A1 (en) | 2007-08-12 | 2009-02-19 | Integrated Dna Technologies, Inc. | Microarray system with improved sequence specificity |
| US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
| JP5362738B2 (ja) | 2007-12-05 | 2013-12-11 | コンプリート・ジェノミックス・インコーポレイテッド | シーケンシング反応における効率のよい塩基決定 |
| WO2009091798A1 (en) | 2008-01-16 | 2009-07-23 | Helicos Biosciences Corporation | Quantitative genetic analysis |
| US8202691B2 (en) | 2008-01-25 | 2012-06-19 | Illumina, Inc. | Uniform fragmentation of DNA using binding proteins |
| US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
| US8728764B2 (en) | 2008-10-02 | 2014-05-20 | Illumina Cambridge Limited | Nucleic acid sample enrichment for sequencing applications |
| WO2010068856A1 (en) | 2008-12-11 | 2010-06-17 | Trustees Of Boston University | Isolation of rna |
| DK2414547T3 (da) | 2009-04-02 | 2014-06-16 | Fluidigm Corp | Multiprimer-amplifikationsmetode til stregkodning af målnukleinsyrer |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US20110003301A1 (en) | 2009-05-08 | 2011-01-06 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
| HUE030765T2 (en) | 2009-08-25 | 2017-05-29 | Illumina Inc | A method for selecting and amplifying polynucleotides |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US10378064B1 (en) | 2010-04-16 | 2019-08-13 | Chronix Biomedical | Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US8828688B2 (en) | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
| EP2580378A4 (en) | 2010-06-08 | 2014-01-01 | Nugen Technologies Inc | MULTIPLEX SEQUENCING METHODS AND COMPOSITION |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| US9309556B2 (en) | 2010-09-24 | 2016-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target DNA using immobilized primers |
| EA038374B1 (ru) | 2010-11-30 | 2021-08-17 | Те Чайниз Юниверсити Ов Гонконг | Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком |
| JP6054303B2 (ja) | 2010-12-30 | 2016-12-27 | ファウンデーション メディシン インコーポレイテッドＦｏｕｎｄａｔｉｏｎ Ｍｅｄｉｃｉｎｅ， Ｉｎｃ． | 腫瘍試料の多重遺伝子分析の最適化 |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| EP2697392B1 (en) | 2011-04-12 | 2016-03-02 | Verinata Health, Inc | Resolving genome fractions using polymorphism counts |
| EP3907297A1 (en) | 2011-04-15 | 2021-11-10 | The Johns Hopkins University | Safe sequencing system |
| US9809904B2 (en) * | 2011-04-21 | 2017-11-07 | University Of Washington Through Its Center For Commercialization | Methods for retrieval of sequence-verified DNA constructs |
| WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| CN103103624B (zh) | 2011-11-15 | 2014-12-31 | 深圳华大基因科技服务有限公司 | 高通量测序文库的构建方法及其应用 |
| US10227587B2 (en) | 2012-01-10 | 2019-03-12 | Berry Genomics Co., Ltd. | Method for constructing a plasma DNA sequencing library |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| HUE051845T2 (hu) | 2012-03-20 | 2021-03-29 | Univ Washington Through Its Center For Commercialization | Módszerek a tömegesen párhuzamos DNS-szekvenálás hibaarányának csökkentésére duplex konszenzus szekvenálással |
| US20130288915A1 (en) | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
| AU2013267609C1 (en) | 2012-05-31 | 2019-01-03 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of DNA |
| EP2872629B1 (en) | 2012-07-03 | 2019-09-04 | Integrated DNA Technologies Inc. | Tm-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection |
| HUE045880T2 (hu) | 2012-07-31 | 2020-01-28 | Novartis Ag | A humán double minute 2 (MDM2) inhibitorra való érzékenységgel összefüggõ markerek |
| AU2013296237B2 (en) | 2012-08-03 | 2019-05-16 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN110872617A (zh) | 2012-09-04 | 2020-03-10 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CA2886605A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
| CA2887094C (en) | 2012-10-04 | 2021-09-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20150291953A1 (en) | 2012-11-02 | 2015-10-15 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
| HK1214830A1 (zh) | 2012-11-05 | 2016-08-05 | Foundation Medicine, Inc. | 新型ntrk1融合分子及其应用 |
| EP2929056A4 (en) | 2012-12-10 | 2016-11-09 | Resolution Bioscience Inc | METHODS FOR TARGETED GENOMIC ANALYSIS |
| EP2931922B1 (en) | 2012-12-14 | 2018-10-17 | Chronix Biomedical | Personalized biomarkers for cancer |
| US11158425B2 (en) | 2013-01-05 | 2021-10-26 | Foundation Medicine, Inc. | System and method for managing genomic information |
| EP2958574A4 (en) * | 2013-01-23 | 2016-11-02 | Reproductive Genetics And Technology Solutions Llc | COMPOSITIONS AND METHODS FOR GENETIC ANALYSIS OF EMBRYOS |
| US10745686B2 (en) | 2013-02-08 | 2020-08-18 | Qiagen Gmbh | Method for separating DNA by size |
| CA3156663A1 (en) | 2013-03-15 | 2014-09-18 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| ES2831148T3 (es) | 2013-03-15 | 2021-06-07 | Univ Leland Stanford Junior | Identificación y uso de marcadores tumorales de ácido nucleico circulante |
| AU2014262481A1 (en) | 2013-05-10 | 2015-11-26 | Foundation Medicine, Inc. | Analysis of genetic variants |
| US20150072344A1 (en) * | 2013-09-10 | 2015-03-12 | Imdaptive Incorporated | Barcoded Universal Marker Indicator (BUMI) Tags |
| US10851414B2 (en) * | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| US9546399B2 (en) | 2013-11-13 | 2017-01-17 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| CN103668471B (zh) | 2013-12-19 | 2015-09-30 | 上海交通大学 | 一种构建dna高通量测序文库的方法及其配套试剂盒 |
| ES2784450T3 (es) * | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
| HUE058149T2 (hu) | 2014-01-31 | 2022-07-28 | Swift Biosciences Inc | Javított eljárások DNS-szubsztrátok feldolgozására |
| WO2015134552A1 (en) | 2014-03-03 | 2015-09-11 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| US10975371B2 (en) * | 2014-04-29 | 2021-04-13 | Illumina, Inc. | Nucleic acid sequence analysis from single cells |
| CA2953469A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| CA2957633A1 (en) | 2014-08-06 | 2016-02-11 | Nugen Technologies, Inc. | Digital measurements from targeted sequencing |
| DK3194612T3 (da) * | 2014-08-22 | 2024-10-14 | Resolution Bioscience Inc | Fremgangsmåder til kvantitativ genetisk analyse af cellefrit dna |
| US20160053301A1 (en) * | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| CN106661636A (zh) | 2014-09-05 | 2017-05-10 | 凯杰有限公司 | 衔接子连接的扩增子的制备 |
| EP3192869B1 (en) | 2014-09-12 | 2019-03-27 | MGI Tech Co., Ltd. | Isolated oligonucleotide and use thereof in nucleic acid sequencing |
| WO2016040901A1 (en) | 2014-09-12 | 2016-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| EP3227464B1 (en) | 2014-12-05 | 2022-04-20 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
| CN107750277B (zh) | 2014-12-12 | 2021-11-09 | 维里纳塔健康股份有限公司 | 使用无细胞dna片段大小来确定拷贝数变化 |
| EP4574996B1 (en) | 2014-12-31 | 2025-11-05 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| EP4279612B1 (en) | 2015-07-23 | 2025-07-02 | The Chinese University of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
| US11756655B2 (en) | 2015-10-09 | 2023-09-12 | Guardant Health, Inc. | Population based treatment recommender using cell free DNA |
| JP6824973B2 (ja) | 2015-10-10 | 2021-02-03 | ガーダント ヘルス， インコーポレイテッド | 無細胞ｄｎａ分析における遺伝子融合検出の方法および応用 |
| RU2018121254A (ru) * | 2015-11-11 | 2019-12-16 | Резолюшн Байосайенс, Инк. | Высокоэффективное построение библиотек днк |
| US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| EP3423828B1 (en) | 2016-02-29 | 2025-08-27 | Foundation Medicine, Inc. | Methods and systems for evaluating tumor mutational burden |
| WO2017214557A1 (en) | 2016-06-10 | 2017-12-14 | Counsyl, Inc. | Nucleic acid sequencing adapters and uses thereof |
| WO2018039463A1 (en) | 2016-08-25 | 2018-03-01 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in dna samples |
| ES2840003T3 (es) | 2016-09-30 | 2021-07-06 | Guardant Health Inc | Métodos para análisis multi-resolución de ácidos nucleicos libres de células |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| CA3043476A1 (en) | 2016-11-17 | 2018-05-24 | Seracare Life Sciences, Inc. | Methods for preparing dna reference materials and controls |
| JP7048609B2 (ja) | 2016-12-09 | 2022-04-05 | ボリアル ジェノミクス， インコーポレイテッド | 連結型ライゲーション |
| CA3057163A1 (en) | 2017-04-14 | 2018-10-18 | Guardant Health, Inc. | Methods of attaching adapters to sample nucleic acids |
| CN114901818B (zh) | 2018-11-21 | 2025-01-10 | 安捷伦科技有限公司 | 靶向核酸文库形成的方法 |
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