AU2013211850B8 - Methods for profiling and quantitating cell-free RNA - Google Patents
Methods for profiling and quantitating cell-free RNA Download PDFInfo
- Publication number
- AU2013211850B8 AU2013211850B8 AU2013211850A AU2013211850A AU2013211850B8 AU 2013211850 B8 AU2013211850 B8 AU 2013211850B8 AU 2013211850 A AU2013211850 A AU 2013211850A AU 2013211850 A AU2013211850 A AU 2013211850A AU 2013211850 B8 AU2013211850 B8 AU 2013211850B8
- Authority
- AU
- Australia
- Prior art keywords
- tissue
- cell
- rna
- free
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F18/00—Pattern recognition
- G06F18/20—Analysing
- G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
- G06F18/213—Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods
- G06F18/2135—Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods based on approximation criteria, e.g. principal component analysis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Databases & Information Systems (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Public Health (AREA)
- Bioethics (AREA)
- Epidemiology (AREA)
- Data Mining & Analysis (AREA)
- Pathology (AREA)
- Primary Health Care (AREA)
- Software Systems (AREA)
- Evolutionary Computation (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591642P | 2012-01-27 | 2012-01-27 | |
| US61/591,642 | 2012-01-27 | ||
| PCT/US2013/023471 WO2013113012A2 (en) | 2012-01-27 | 2013-01-28 | Methods for profiling and quantitating cell-free rna |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| AU2013211850A1 AU2013211850A1 (en) | 2014-09-18 |
| AU2013211850B2 AU2013211850B2 (en) | 2017-03-02 |
| AU2013211850B8 true AU2013211850B8 (en) | 2017-06-29 |
| AU2013211850A8 AU2013211850A8 (en) | 2017-06-29 |
Family
ID=48874081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013211850A Active AU2013211850B8 (en) | 2012-01-27 | 2013-01-28 | Methods for profiling and quantitating cell-free RNA |
Country Status (9)
| Country | Link |
|---|---|
| US (14) | US20130252835A1 (enExample) |
| EP (2) | EP2807277A4 (enExample) |
| JP (2) | JP6320302B2 (enExample) |
| CN (2) | CN108359711A (enExample) |
| AU (1) | AU2013211850B8 (enExample) |
| CA (1) | CA2863035C (enExample) |
| HK (1) | HK1211624A1 (enExample) |
| SG (2) | SG11201505515XA (enExample) |
| WO (1) | WO2013113012A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| KR20130113447A (ko) | 2010-09-24 | 2013-10-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화 |
| US20160289762A1 (en) * | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| WO2015069900A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| HK1211624A1 (en) * | 2012-01-27 | 2016-05-27 | The Board Of Trustees Of The University Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US10689652B2 (en) | 2013-10-02 | 2020-06-23 | The Regents Of The University Of California | Methods for immortalization of epithelial cells |
| WO2015069933A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| KR20240038168A (ko) | 2013-11-07 | 2024-03-22 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| WO2016077709A1 (en) | 2014-11-14 | 2016-05-19 | Liquid Genomics, Inc. | Use of circulating cell-free rna for diagnosis and/or monitoring cancer |
| EP4450636A3 (en) | 2015-05-18 | 2025-01-01 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
| US10889861B2 (en) * | 2015-06-17 | 2021-01-12 | The Translational Genomics Research Institute | Systems and methods for obtaining biological molecules from a sample |
| US10692797B2 (en) * | 2015-06-30 | 2020-06-23 | Laird Technologies, Inc. | Thermal interface materials with low secant modulus of elasticity and high thermal conductivity |
| WO2017062517A1 (en) * | 2015-10-06 | 2017-04-13 | The Regents Of The University Of California | Non-coding rnas linked to immortality and associated methods and compositions |
| CN108369612A (zh) * | 2015-11-04 | 2018-08-03 | 梅塔博隆股份有限公司 | 自动化样品质量评估 |
| CN116987777A (zh) | 2016-03-25 | 2023-11-03 | 凯锐思公司 | 合成核酸掺入物 |
| EP3610034B1 (en) | 2017-04-12 | 2022-06-08 | Karius, Inc. | Sample preparation methods, systems and compositions |
| US20200165685A1 (en) * | 2017-05-10 | 2020-05-28 | Nantomics, Llc | Circulating rna for detection, prediction, and monitoring of cancer |
| IL296349A (en) * | 2017-05-16 | 2022-11-01 | Univ Hong Kong Chinese | Integrative single-cell and cell-free plasma rna analysis |
| CN111566228A (zh) * | 2017-10-23 | 2020-08-21 | 陈扎克伯格生物中心公司 | 用于在胎儿孕育中预测胎龄和早产的无创分子钟 |
| TWI833715B (zh) * | 2017-10-27 | 2024-03-01 | 美商奇諾診療公司 | 用於超低體積液體生物檢體之裝置、系統及方法 |
| WO2019094363A2 (en) | 2017-11-07 | 2019-05-16 | Nanthealth Labs, Inc. | Targeted cell free nucleic acid analysis |
| CA3082601A1 (en) | 2018-03-16 | 2019-09-19 | Karius, Inc. | Sample series to differentiate target nucleic acids from contaminant nucleic acids |
| CA3095030A1 (en) | 2018-03-30 | 2019-10-03 | Juno Diagnostics, Inc. | Deep learning-based methods, devices, and systems for prenatal testing |
| CN113874525A (zh) * | 2018-10-29 | 2021-12-31 | 分子听诊器公司 | 使用无细胞信使rna的骨髓表征 |
| CA3118990A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| WO2020132144A1 (en) * | 2018-12-18 | 2020-06-25 | Grail, Inc. | Methods for detecting disease using analysis of rna |
| EP4632078A2 (en) * | 2019-01-24 | 2025-10-15 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| GB2612911B (en) | 2019-02-14 | 2023-11-22 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| WO2020206184A1 (en) * | 2019-04-02 | 2020-10-08 | Mission Bio, Inc. | Methods, systems, and aparatus for nucleic acid detection |
| CA3138806A1 (en) | 2019-05-22 | 2020-11-26 | Dalia Dhingra | Method and apparatus for simultaneous targeted sequencing of dna, rna and protein |
| US11948684B2 (en) * | 2019-06-20 | 2024-04-02 | Latha Chakravarthy | Diagnostic process for disease detection using gene expression based multi layer PCA classifier |
| CN110964800B (zh) * | 2019-09-20 | 2021-10-22 | 北京航空航天大学 | 用于预测早产风险的cfRNA标志物 |
| EP4055180A4 (en) * | 2019-11-05 | 2023-12-06 | Cofactor Genomics, Inc. | METHODS AND SYSTEMS FOR PROCESSING COMPLEX DATA SETS USING ARTIFICIAL INTELLIGENCE AND DECONVOLUTION |
| AU2020378080A1 (en) * | 2019-11-08 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Accurate and robust information-deconvolution from bulk tissue transcriptomes |
| JP2023507798A (ja) * | 2019-12-20 | 2023-02-27 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 健康状態および疾患状態を監視および診断するための方法および組成物 |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| CA3172199A1 (en) * | 2020-03-18 | 2021-09-23 | Michael Nerenberg | Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay |
| AU2021324778A1 (en) * | 2020-08-13 | 2023-04-13 | Mirvie, Inc. | Methods and systems for determining a pregnancy-related state of a subject |
| WO2024182491A1 (en) * | 2023-02-28 | 2024-09-06 | Virginia Commonwealth University | Polygenic risk estimator for cervical length change during pregnancy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065629A1 (en) * | 2003-01-17 | 2004-08-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
| WO2009025852A2 (en) * | 2007-08-22 | 2009-02-26 | Xenomics, Inc. | Methods of using mirna for detection of in vivo cell death |
| WO2011156734A2 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Method of characterizing vascular diseases |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| US5432054A (en) | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
| WO2000040749A2 (en) * | 1999-01-06 | 2000-07-13 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| US20080009467A1 (en) | 2000-05-01 | 2008-01-10 | Accera, Inc. | Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism |
| US6727066B2 (en) | 2000-07-28 | 2004-04-27 | Incyte Corporation | Genes expressed in treated human C3A liver cell cultures |
| US6664056B2 (en) * | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
| US6977162B2 (en) * | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| WO2003095624A2 (en) | 2002-05-10 | 2003-11-20 | Phase-1 Molecular Toxicology, Inc. | Liver inflammation predictive genes |
| US20040086511A1 (en) | 2002-07-12 | 2004-05-06 | The Johns Hopkins University | Neuronal gene expression patterns |
| WO2004007674A2 (en) | 2002-07-12 | 2004-01-22 | The Johns Hopkins University | Neuronal and retinal gene expression patterns |
| US20060003342A1 (en) * | 2004-01-15 | 2006-01-05 | Bianchi Diana W | Fetal RNA in amniotic fluid to determine gene expression in the developing fetus |
| CA2574706A1 (en) * | 2004-07-21 | 2006-02-23 | The Regents Of The University Of California | Salivary transcriptome diagnostics |
| US7713693B1 (en) * | 2004-09-01 | 2010-05-11 | University Of Louisiana At Monroe | Human cancer cell specific gene transcript |
| CA2528531A1 (en) * | 2005-01-06 | 2006-07-06 | Mount Sinai Hospital | Markers of pre-term labor |
| KR100686816B1 (ko) * | 2005-07-22 | 2007-02-26 | 삼성에스디아이 주식회사 | 리튬 이차 전지 |
| TR201910868T4 (tr) * | 2006-02-02 | 2019-08-21 | Univ Leland Stanford Junior | Dijital analizle invazif olmayan fetal genetik tarama. |
| EP2302395B1 (en) | 2006-06-07 | 2015-04-15 | Health Diagnostic Laboratory, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| US20100145131A1 (en) * | 2007-05-01 | 2010-06-10 | Helena Grinberg-Rashi | Methods and kits for predicting cancer metastasis |
| WO2009009457A1 (en) | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
| US8298768B2 (en) * | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| JP2011510623A (ja) * | 2008-01-27 | 2011-04-07 | ロゼッタ ゲノミックス エルティーディー. | 妊娠の合併症を診断するための方法及び組成物 |
| US20110144076A1 (en) * | 2008-05-01 | 2011-06-16 | Michelle A Williams | Preterm delivery diagnostic assay |
| WO2009143576A1 (en) | 2008-05-27 | 2009-12-03 | Adelaide Research & Innovation Pty Ltd | Polymorphisms associated with pregnancy complications |
| US20110150775A1 (en) * | 2008-06-01 | 2011-06-23 | Tufts Medical Center, Inc. | Genomic approaches to fetal treatment and diagnosis |
| US7888030B2 (en) * | 2008-08-21 | 2011-02-15 | King's College London | Biomarkers |
| US20110263441A1 (en) | 2008-10-15 | 2011-10-27 | Golub Todd R | Compositions, kits, and methods for identification, assessment, prevention, and therapy of hepatic disorders |
| HUE027027T2 (en) | 2008-11-13 | 2016-08-29 | Modgene Llc | Reduction of amyloid beta load in non-brain tissue |
| US9051614B2 (en) | 2009-09-11 | 2015-06-09 | The Chinese University Of Hong Kong | Methods for assessing liver pathologies |
| WO2011032053A1 (en) * | 2009-09-11 | 2011-03-17 | Nugen Technologies, Inc. | Compositions and methods for whole transcriptome analysis |
| EP2510356B1 (en) * | 2009-12-08 | 2018-10-31 | Cedars-Sinai Medical Center | Diagnostic method to identify women at risk for preterm delivery |
| JP5755326B2 (ja) * | 2010-06-11 | 2015-07-29 | 日立化成株式会社 | 腎機能の特徴を決定する方法 |
| CA2802305A1 (en) * | 2010-07-08 | 2012-01-12 | Pronota N.V. | Biomarker for hypertensive disorders of pregnancy |
| KR20130041961A (ko) * | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액에서 질환 또는 상태의 특징을 검출하는 방법 |
| WO2013007708A1 (en) | 2011-07-08 | 2013-01-17 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for treatment of liver cancer |
| WO2013022953A2 (en) | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
| CA3067612A1 (en) | 2011-09-22 | 2013-03-28 | Lineage Biosciences, Inc. | Compositions and methods for analyzing heterogeneous samples |
| SG10201607331WA (en) | 2011-09-30 | 2016-11-29 | Somalogic Inc | Cardiovascular risk event prediction and uses thereof |
| US20140304845A1 (en) | 2011-10-31 | 2014-10-09 | Merck Sharp & Dohme Corp. | Alzheimer's disease signature markers and methods of use |
| HK1211624A1 (en) | 2012-01-27 | 2016-05-27 | The Board Of Trustees Of The University Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US20160289762A1 (en) * | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| EP2825665B1 (en) | 2012-03-14 | 2017-09-06 | Ruprecht-Karls-Universität Heidelberg | Epigenetic signatures as marker for cardiomyopathies and myocardial insufficiencies |
| US10054599B2 (en) * | 2013-03-12 | 2018-08-21 | Agency For Science, Technology And Research (A*Star) | Pre-eclampsia biomarkers |
| BR122019026188B1 (pt) | 2013-03-15 | 2024-01-02 | Somalogic Operating Co., Inc | Métodos para determinar se um indivíduo com esteatose não alcoólica tem esteato-hepatite não alcoólica e para monitorar um indivíduo com esteatose não alcoólica para o desenvolvimento de nash |
| JP2018518169A (ja) | 2015-06-05 | 2018-07-12 | レグルス セラピューティクス インコーポレイテッド | 非アルコール性脂肪肝疾患バイオマーカー |
| DK3350341T3 (da) | 2015-09-14 | 2021-09-27 | Genfit | Fremgangsmåder til diagnosticering og evaluering af non-alkoholisk steatohepatitis |
| EP3426826A4 (en) | 2016-03-09 | 2019-09-04 | Molecular Stethoscope, Inc. | METHOD AND SYSTEMS FOR DETECTING TISSUE STATES |
-
2013
- 2013-01-28 HK HK15104602.5A patent/HK1211624A1/xx unknown
- 2013-01-28 EP EP13740984.3A patent/EP2807277A4/en not_active Ceased
- 2013-01-28 CA CA2863035A patent/CA2863035C/en active Active
- 2013-01-28 CN CN201810084289.8A patent/CN108359711A/zh active Pending
- 2013-01-28 CN CN201380017554.6A patent/CN104334742A/zh active Pending
- 2013-01-28 SG SG11201505515XA patent/SG11201505515XA/en unknown
- 2013-01-28 US US13/752,131 patent/US20130252835A1/en not_active Abandoned
- 2013-01-28 JP JP2014554934A patent/JP6320302B2/ja active Active
- 2013-01-28 EP EP19173751.9A patent/EP3584327A1/en active Pending
- 2013-01-28 SG SG10201906331TA patent/SG10201906331TA/en unknown
- 2013-01-28 WO PCT/US2013/023471 patent/WO2013113012A2/en not_active Ceased
- 2013-01-28 AU AU2013211850A patent/AU2013211850B8/en active Active
-
2015
- 2015-09-22 US US14/861,650 patent/US10240200B2/en active Active
-
2016
- 2016-12-13 US US15/377,904 patent/US10240204B2/en active Active
- 2016-12-13 US US15/377,901 patent/US10155986B2/en active Active
- 2016-12-13 US US15/377,894 patent/US10287632B2/en active Active
-
2017
- 2017-01-20 JP JP2017008768A patent/JP2017063799A/ja active Pending
-
2018
- 2018-05-02 US US15/969,603 patent/US20180357379A1/en not_active Abandoned
-
2019
- 2019-04-03 US US16/373,996 patent/US20190226029A1/en not_active Abandoned
-
2020
- 2020-08-05 US US16/986,042 patent/US20200362416A1/en not_active Abandoned
- 2020-08-05 US US16/986,057 patent/US20200370121A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/187,298 patent/US20220042098A1/en active Pending
- 2021-08-06 US US17/396,457 patent/US20210363584A1/en not_active Abandoned
- 2021-08-06 US US17/396,490 patent/US20220010381A1/en not_active Abandoned
-
2022
- 2022-02-03 US US17/592,311 patent/US20220290236A1/en not_active Abandoned
- 2022-02-10 US US17/669,081 patent/US12365947B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065629A1 (en) * | 2003-01-17 | 2004-08-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
| WO2009025852A2 (en) * | 2007-08-22 | 2009-02-26 | Xenomics, Inc. | Methods of using mirna for detection of in vivo cell death |
| WO2011156734A2 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Method of characterizing vascular diseases |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12365947B2 (en) | Methods for profiling and quantitating cell-free RNA | |
| US20230250477A1 (en) | Methods and systems for determining a pregnancy-related state of a subject | |
| JP7334122B2 (ja) | 妊娠高血圧腎症に特異的な循環rnaシグネチャー | |
| CN104981548A (zh) | 用于阿尔茨海默氏病的诊断性miRNA标志物 | |
| US12359256B2 (en) | Circulating RNA signatures specific to preeclampsia | |
| WO2015069900A1 (en) | Methods for profiliing and quantitating cell-free rna | |
| HK40062225A (en) | Circulating rna signatures specific to preeclampsia | |
| HK1238299B (en) | Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna | |
| HK1238299A1 (en) | Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ KOH, LIAN CHYE WINSTON; QUAKE, STEPHEN R.; FAN, HEIMUN CHRISTINA AND PAN, WENYING |
|
| TH | Corrigenda |
Free format text: IN VOL 29 , NO 28 , PAGE(S) 4203 UNDER THE HEADING AMENDMENTS - AMENDMENTS MADE UNDER THE NAME BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, APPLICATION NO. 2013211850, UNDER INID (71) CORRECT THE APPLICANT NAME TO THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Free format text: IN VOL 28 , NO 37 , PAGE(S) 4978 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, APPLICATION NO. 2013211850, UNDER INID (71) CORRECT THE APPLICANT NAME TO THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Free format text: IN VOL 31 , NO 8 , PAGE(S) 1257 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, APPLICATION NO. 2013211850, UNDER INID (71) CORRECT THE APPLICANT NAME TO THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired | ||
| NA | Applications received for extensions of time, section 223 |
Free format text: AN APPLICATION TO EXTEND THE TIME FROM 28 JAN 2022 TO 28 JAN 2023 IN WHICH TO PAY A RENEWAL FEE HAS BEEN FILED |
|
| NB | Applications allowed - extensions of time section 223(2) |
Free format text: THE TIME IN WHICH TO PAY A RENEWAL FEE HAS BEEN EXTENDED TO 28 JAN 2023 |