JP2015509091A - ヒト化抗体 - Google Patents

ヒト化抗体 Download PDF

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Publication number
JP2015509091A
JP2015509091A JP2014551426A JP2014551426A JP2015509091A JP 2015509091 A JP2015509091 A JP 2015509091A JP 2014551426 A JP2014551426 A JP 2014551426A JP 2014551426 A JP2014551426 A JP 2014551426A JP 2015509091 A JP2015509091 A JP 2015509091A
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JP
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Prior art keywords
sequence
seq
cdr3
antibody
library
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Pending
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JP2014551426A
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Japanese (ja)
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JP2015509091A5 (cg-RX-API-DMAC10.html
Inventor
ボーン スミーダー
ボーン スミーダー
オマル エイ． バジルガン
オマル エイ． バジルガン
ホンユアン ヘレン マオ
ホンユアン ヘレン マオ
Original Assignee
ザ スクリプス リサーチ インスティテュート
ザ スクリプス リサーチ インスティテュート
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Publication of JP2015509091A publication Critical patent/JP2015509091A/ja
Publication of JP2015509091A5 publication Critical patent/JP2015509091A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014551426A 2012-01-09 2013-01-09 ヒト化抗体 Pending JP2015509091A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261584680P 2012-01-09 2012-01-09
US61/584,680 2012-01-09
PCT/US2013/020910 WO2013106489A1 (en) 2012-01-09 2013-01-09 Humanized antibodies with ultralong cdr3s

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017241282A Division JP2018095645A (ja) 2012-01-09 2017-12-18 ヒト化抗体

Publications (2)

Publication Number Publication Date
JP2015509091A true JP2015509091A (ja) 2015-03-26
JP2015509091A5 JP2015509091A5 (cg-RX-API-DMAC10.html) 2016-03-03

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014551426A Pending JP2015509091A (ja) 2012-01-09 2013-01-09 ヒト化抗体
JP2017241282A Pending JP2018095645A (ja) 2012-01-09 2017-12-18 ヒト化抗体
JP2019206681A Pending JP2020036611A (ja) 2012-01-09 2019-11-15 ヒト化抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017241282A Pending JP2018095645A (ja) 2012-01-09 2017-12-18 ヒト化抗体
JP2019206681A Pending JP2020036611A (ja) 2012-01-09 2019-11-15 ヒト化抗体

Country Status (7)

Country Link
US (3) US20150011431A1 (cg-RX-API-DMAC10.html)
EP (2) EP2802601B1 (cg-RX-API-DMAC10.html)
JP (3) JP2015509091A (cg-RX-API-DMAC10.html)
CN (1) CN104411717A (cg-RX-API-DMAC10.html)
AU (2) AU2013208007A1 (cg-RX-API-DMAC10.html)
CA (1) CA2862979A1 (cg-RX-API-DMAC10.html)
WO (1) WO2013106489A1 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018034225A1 (ja) * 2016-08-15 2018-02-22 国立大学法人北海道大学 抗ｐｄ－ｌ１抗体
WO2018034226A1 (ja) * 2016-08-15 2018-02-22 国立大学法人北海道大学 抗ｐｄ－１抗体
JP2018514573A (ja) * 2015-05-01 2018-06-07 メディミューン リミテッド 新規のファージディスプレイライブラリ、そのメンバーおよびその使用

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EP2802601B1 (en) 2012-01-09 2019-11-13 The Scripps Research Institute Humanized antibodies with ultralong cdr3s
US20140050720A1 (en) 2012-01-09 2014-02-20 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
DK2928921T3 (da) 2012-12-05 2021-04-19 Novartis Ag Sammensætninger og fremgangsmåder til antistoffer målrettet epo
EP2943512A4 (en) 2013-01-11 2016-06-01 California Inst Biomedical Res BOVINE FUSION ANTIBODY
DK3019533T3 (da) 2013-07-11 2020-03-23 Scripps Research Inst Dobbeltspiraliserede immunoglobulinfusionproteiner og sammensætninger deraf
JP6687520B2 (ja) 2013-07-18 2020-04-22 トーラス バイオサイエンシズ リミテッド ライアビリティ カンパニー 極めて長い相補性決定領域を有するヒト化抗体
CA2981077A1 (en) * 2015-04-03 2016-10-06 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
ES2913530T3 (es) 2015-08-12 2022-06-02 Novartis Ag Métodos para tratar trastornos oftálmicos
US10144768B2 (en) 2015-12-04 2018-12-04 Novartis Ag Antibody cytokine engrafted compositions and methods of use for immunoregulation
US11161891B2 (en) 2015-12-09 2021-11-02 The Scripps Research Institute Relaxin immunoglobulin fusion proteins and methods of use
KR102920712B1 (ko) 2017-05-24 2026-01-30 노파르티스 아게 항체-사이토카인 생착된 단백질 및 암 치료에 있어서의 사용 방법
JOP20190271A1 (ar) 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
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WO2019140150A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
ES3076179T3 (en) * 2018-03-21 2026-08-12 Crystal Bioscience Inc Transgenic chicken that produces human antibodies
CN115551594A (zh) * 2019-10-24 2022-12-30 米诺陶治疗公司 经细胞因子修饰的嵌合抗体及其使用方法
JP2023519576A (ja) * 2020-03-27 2023-05-11 ユーシービー バイオファルマ エスアールエル 自律ノブドメインペプチド
KR20240007256A (ko) * 2021-05-12 2024-01-16 어플라이드 바이오메디컬 사이언스 인스티튜트 이황화 결합된 결합 폴리펩타이드의 스크리닝 및 발현 방법
WO2023192478A1 (en) 2022-04-01 2023-10-05 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
TWI897189B (zh) 2023-01-18 2025-09-11 美商基利科學股份有限公司 具有經改變重鏈基因座之嵌合基因轉殖免疫球蛋白小鼠及其製造及使用方法

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