JP2015506355A5 - - Google Patents
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- Publication number
- JP2015506355A5 JP2015506355A5 JP2014549480A JP2014549480A JP2015506355A5 JP 2015506355 A5 JP2015506355 A5 JP 2015506355A5 JP 2014549480 A JP2014549480 A JP 2014549480A JP 2014549480 A JP2014549480 A JP 2014549480A JP 2015506355 A5 JP2015506355 A5 JP 2015506355A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- heterocyclyl
- substituted
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(N(*)I[Al]C(C1)CN1[Al])=O Chemical compound *C(N(*)I[Al]C(C1)CN1[Al])=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11196170.2 | 2011-12-30 | ||
| EP11196170 | 2011-12-30 | ||
| PCT/EP2012/077027 WO2013098375A1 (en) | 2011-12-30 | 2012-12-28 | New azetidine derivatives, pharmaceutical compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506355A JP2015506355A (ja) | 2015-03-02 |
| JP2015506355A5 true JP2015506355A5 (https=) | 2016-02-25 |
| JP6130399B2 JP6130399B2 (ja) | 2017-05-17 |
Family
ID=47553036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549480A Expired - Fee Related JP6130399B2 (ja) | 2011-12-30 | 2012-12-28 | 新規アゼチジン誘導体、医薬組成物およびそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8623860B2 (https=) |
| EP (1) | EP2797884B1 (https=) |
| JP (1) | JP6130399B2 (https=) |
| KR (1) | KR20140115307A (https=) |
| CN (1) | CN104093705A (https=) |
| AU (1) | AU2012360797A1 (https=) |
| BR (1) | BR112014015845A8 (https=) |
| CA (1) | CA2861013A1 (https=) |
| EA (1) | EA201400771A1 (https=) |
| IL (1) | IL232914A0 (https=) |
| MX (1) | MX2014007897A (https=) |
| PH (1) | PH12014501514A1 (https=) |
| WO (1) | WO2013098375A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2834164A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused benzoxazinones as ion channel modulators |
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (https=) | 2011-07-01 | 2018-04-28 | ||
| WO2014061693A1 (ja) * | 2012-10-17 | 2014-04-24 | 塩野義製薬株式会社 | 新規非芳香族炭素環又は非芳香族複素環誘導体 |
| CN103483273B (zh) * | 2013-09-12 | 2015-11-25 | 浙江工业大学 | 6-甲基-5-氟-2,4-嘧啶二胺类化合物及其制备与应用 |
| HK1217448A1 (zh) | 2013-09-12 | 2017-01-13 | 辉瑞大药厂 | 乙酰辅酶a羧化酶抑制剂用於治疗寻常痤疮的用途 |
| EP3670496A3 (en) | 2013-10-17 | 2020-09-30 | Shionogi&Co., Ltd. | Acc2 inhibitors |
| WO2015138909A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| US9745292B2 (en) | 2014-03-13 | 2017-08-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| EP3157917B1 (en) | 2014-06-19 | 2020-03-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| US10738011B2 (en) | 2014-12-23 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10344023B2 (en) | 2014-12-23 | 2019-07-09 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| BR112018007021B1 (pt) | 2015-10-06 | 2024-01-09 | Proteostasis Therapeutics, Inc | Composto, composição compreendendo os ditos compostos e uso dos mesmos para tratar fibrose cística |
| MA43775A (fr) | 2016-04-07 | 2021-05-05 | Proteostasis Therapeutics Inc | Analogues du ivacaftor conentant des atomes de silicium |
| MA45397A (fr) | 2016-06-21 | 2019-04-24 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| CN110776504B (zh) * | 2019-11-29 | 2021-07-30 | 扬州工业职业技术学院 | 一种苯异噁唑乙氧基环丁胺衍生物及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ534582A (en) | 2002-02-27 | 2006-03-31 | Pfizer Prod Inc | ACC inhibitors |
| DE102005055726A1 (de) | 2005-11-23 | 2007-08-30 | Sanofi-Aventis Deutschland Gmbh | Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| JP2009521448A (ja) | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | ヒスタミンｈ３アンタゴニストとして有用なフェノキシピペリジンおよびそのアナログ |
| EP2032566A4 (en) | 2006-06-12 | 2009-07-08 | Merck Frosst Canada Ltd | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
| AU2009304508A1 (en) | 2008-10-17 | 2010-04-22 | Merck Frosst Canada Ltd. | Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US20100280067A1 (en) | 2009-04-30 | 2010-11-04 | Pakala Kumara Savithru Sarma | Inhibitors of acetyl-coa carboxylase |
| AR080969A1 (es) | 2010-04-27 | 2012-05-23 | Takeda Pharmaceutical | Compuesto biciclico |
| MA34300B1 (fr) * | 2010-05-13 | 2013-06-01 | Amgen Inc | Composés azotés hétérocycliques convenant comme inhibiteurs de la pde10 |
-
2012
- 2012-12-14 US US13/714,525 patent/US8623860B2/en active Active
- 2012-12-28 CA CA2861013A patent/CA2861013A1/en not_active Abandoned
- 2012-12-28 AU AU2012360797A patent/AU2012360797A1/en not_active Abandoned
- 2012-12-28 EA EA201400771A patent/EA201400771A1/ru unknown
- 2012-12-28 EP EP12813379.0A patent/EP2797884B1/en active Active
- 2012-12-28 BR BR112014015845A patent/BR112014015845A8/pt not_active Application Discontinuation
- 2012-12-28 MX MX2014007897A patent/MX2014007897A/es unknown
- 2012-12-28 KR KR1020147018007A patent/KR20140115307A/ko not_active Withdrawn
- 2012-12-28 WO PCT/EP2012/077027 patent/WO2013098375A1/en not_active Ceased
- 2012-12-28 CN CN201280068972.3A patent/CN104093705A/zh active Pending
- 2012-12-28 JP JP2014549480A patent/JP6130399B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-02 IL IL232914A patent/IL232914A0/en unknown
- 2014-06-30 PH PH12014501514A patent/PH12014501514A1/en unknown
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