JP2015505842A5 - - Google Patents
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- Publication number
- JP2015505842A5 JP2015505842A5 JP2014546193A JP2014546193A JP2015505842A5 JP 2015505842 A5 JP2015505842 A5 JP 2015505842A5 JP 2014546193 A JP2014546193 A JP 2014546193A JP 2014546193 A JP2014546193 A JP 2014546193A JP 2015505842 A5 JP2015505842 A5 JP 2015505842A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- pharmaceutically acceptable
- racemate
- enantiomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(CC*CC(*)C*CC1)CC1C(NI)=O Chemical compound CC(C)(CC*CC(*)C*CC1)CC1C(NI)=O 0.000 description 5
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569754P | 2011-12-12 | 2011-12-12 | |
| US61/569,754 | 2011-12-12 | ||
| US201161570789P | 2011-12-14 | 2011-12-14 | |
| US61/570,789 | 2011-12-14 | ||
| US201261734300P | 2012-12-06 | 2012-12-06 | |
| US61/734,300 | 2012-12-06 | ||
| PCT/US2012/069289 WO2013090454A2 (en) | 2011-12-12 | 2012-12-12 | Novel glp-1 receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505842A JP2015505842A (ja) | 2015-02-26 |
| JP2015505842A5 true JP2015505842A5 (https=) | 2016-02-04 |
| JP6061949B2 JP6061949B2 (ja) | 2017-01-18 |
Family
ID=47436261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546193A Expired - Fee Related JP6061949B2 (ja) | 2011-12-12 | 2012-12-12 | 糖尿病などの疾患の治療のためのｇｌｐ−１受容体モジュレーターとして作用する４つの環を含むカルボン酸誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8778923B2 (https=) |
| EP (1) | EP2791112B1 (https=) |
| JP (1) | JP6061949B2 (https=) |
| KR (1) | KR20140107340A (https=) |
| CN (1) | CN104080767A (https=) |
| AU (1) | AU2012352349B2 (https=) |
| BR (1) | BR112014013925B1 (https=) |
| CA (1) | CA2857197C (https=) |
| ES (1) | ES2836973T3 (https=) |
| HK (1) | HK1202119A1 (https=) |
| MX (1) | MX365923B (https=) |
| RU (1) | RU2634896C2 (https=) |
| WO (1) | WO2013090454A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013530963A (ja) | 2010-06-09 | 2013-08-01 | レセプトス インコーポレイテッド | 新規のｇｌｐ−１受容体安定化薬および調節薬 |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| BR112014013925B1 (pt) | 2011-12-12 | 2022-02-22 | Receptos Llc | Compostos moduladores do receptor de glp-1 e composição e combinação farmacêutica compreendendo os ditos compostos |
| CN109867630A (zh) * | 2013-06-11 | 2019-06-11 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
| CA2955836C (en) * | 2014-07-25 | 2023-02-14 | Celgene International Ii Sarl | Glp-1 receptor modulators |
| ES2844573T3 (es) | 2014-12-10 | 2021-07-22 | Receptos Llc | Moduladores del receptor de GLP-1 |
| CA3017797A1 (en) | 2016-03-17 | 2017-09-21 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
| WO2017192820A1 (en) | 2016-05-06 | 2017-11-09 | Ionis Pharmaceuticals, Inc. | Glp-1 receptor ligand moiety conjugated oligonucleotides and uses thereof |
| MX388576B (es) | 2016-06-07 | 2025-03-20 | Jacobio Pharmaceuticals Co Ltd | Derivados heterociclicos novedosos utiles como inhibidores de shp2. |
| EA202190196A1 (ru) | 2017-03-23 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| WO2018200833A1 (en) * | 2017-04-28 | 2018-11-01 | Celgene International Ii Sarl | Novel glp-1 receptor modulators |
| CA3076392A1 (en) | 2017-09-20 | 2019-03-28 | Thiogenesis Therapeutics, Inc. | Methods for the treatment of cysteamine sensitive disorders |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| MA54555A (fr) * | 2018-11-22 | 2021-09-29 | Qilu Regor Therapeutics Inc | Agonistes de glp-1r et leurs utilisations |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2020210582A1 (en) * | 2019-04-11 | 2020-10-15 | University Of The Sciences | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor |
| EP3953344A4 (en) * | 2019-04-12 | 2023-08-09 | Qilu Regor Therapeutics Inc. | GLP-IR AGONISTS AND THEIR USES |
| CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁（杭州）生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用 |
| EP4048664A1 (en) | 2019-10-25 | 2022-08-31 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| WO2021096284A1 (ko) * | 2019-11-15 | 2021-05-20 | 일동제약(주) | Glp-1 수용체 작용제 및 이의 용도 |
| IL296336A (en) * | 2020-03-18 | 2022-11-01 | Lg Chemical Ltd | Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same |
| CN117645601A (zh) * | 2020-06-10 | 2024-03-05 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
| EP4247804A1 (en) | 2020-11-20 | 2023-09-27 | Gilead Sciences, Inc. | Polyheterocyclic glp-1 r modulating compounds |
| MX2023006186A (es) | 2020-11-27 | 2023-08-07 | Shenzhen Salubris Pharm Co Ltd | Derivado de benzimidazol y método de preparación del mismo y uso médico del mismo. |
| CN117222644A (zh) * | 2021-04-12 | 2023-12-12 | 诺华股份有限公司 | 2-((4-((S)-2-(4-氯-2-氟苯基)-2-甲基苯并[d][1,3]二氧戊环-4-基)哌啶-1-基)甲基)-1-(((S)-氧杂环丁烷-2-基)甲基)-1H-咪唑衍生物作为GLP1受体激活剂治疗肥胖症 |
| IL306110A (en) | 2021-04-21 | 2023-11-01 | Gilead Sciences Inc | Carboxy-benzimidazole glp-1r modulating compounds |
| CN120981457A (zh) | 2023-09-14 | 2025-11-18 | 歌礼制药(中国)有限公司 | Glp-1r激动剂及其治疗方法 |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1062206B (it) | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | Derivati della tirosina attivi sulla muscolatura liscia |
| DE2423536A1 (de) | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| DE122007000044I2 (de) | 1997-01-07 | 2011-05-05 | Amylin Pharmaceuticals Inc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| PL338457A1 (en) * | 1997-07-31 | 2000-11-06 | Elan Pharm Inc | Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4 |
| EP1005445B1 (en) * | 1997-08-22 | 2004-05-26 | F. Hoffmann-La Roche Ag | N-alkanoylphenylalanine derivatives |
| US6191171B1 (en) | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
| EP1992641A3 (en) | 1998-12-07 | 2009-07-29 | Ipsen Pharma | GLP-1 analogues |
| US6902744B1 (en) | 1999-01-14 | 2005-06-07 | Amylin Pharmaceuticals, Inc. | Exendin agonist formulations and methods of administration thereof |
| EP1150565A1 (en) * | 1999-02-08 | 2001-11-07 | LION bioscience AG | Thiazole derivatives and combinatorial libraries thereof |
| TR200401217T4 (tr) | 2000-03-07 | 2004-06-21 | Aventis Pharma Deutschland Gmbh | İkameli 3-Fenil-5-Alkoksi-1,3,4-Oksdiazol-2-one (ve) hormona duyarlı lipazın önlenmesinde kullanılması |
| WO2002028830A1 (en) * | 2000-09-29 | 2002-04-11 | Ajinomoto Co.,Inc. | Novel phenylalanine derivatives |
| WO2003048081A2 (en) | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
| EP1477482B1 (en) | 2002-02-20 | 2010-04-14 | Ajinomoto Co., Inc. | Novel phenylalanine derivative |
| JPWO2003089410A1 (ja) * | 2002-04-19 | 2005-08-25 | 協和醗酵工業株式会社 | フェニルアラニン誘導体 |
| US7345049B2 (en) * | 2003-12-22 | 2008-03-18 | Ajinomoto Co., Inc. | Phenylalanine derivatives |
| CA2555594A1 (en) * | 2004-02-10 | 2005-08-25 | Janssen Pharmaceutica N.V. | Pyridazinones as antagonists of a4 integrins |
| US7825139B2 (en) | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7816324B2 (en) | 2007-03-13 | 2010-10-19 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by a peptide receptor |
| CA2688136A1 (en) | 2007-06-08 | 2008-12-11 | Advinus Therapeutics Private Limited | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application |
| WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| JP2013530963A (ja) | 2010-06-09 | 2013-08-01 | レセプトス インコーポレイテッド | 新規のｇｌｐ−１受容体安定化薬および調節薬 |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| CN105763220B (zh) | 2011-06-01 | 2021-03-05 | 康普技术有限责任公司 | 具有非双工器隔离子系统的宽带分布式天线系统 |
| BR112014013925B1 (pt) | 2011-12-12 | 2022-02-22 | Receptos Llc | Compostos moduladores do receptor de glp-1 e composição e combinação farmacêutica compreendendo os ditos compostos |
| CN109867630A (zh) | 2013-06-11 | 2019-06-11 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
-
2012
- 2012-12-12 BR BR112014013925-3A patent/BR112014013925B1/pt not_active IP Right Cessation
- 2012-12-12 US US13/712,624 patent/US8778923B2/en active Active
- 2012-12-12 EP EP12806828.5A patent/EP2791112B1/en active Active
- 2012-12-12 KR KR1020147017945A patent/KR20140107340A/ko not_active Withdrawn
- 2012-12-12 RU RU2014128522A patent/RU2634896C2/ru active
- 2012-12-12 MX MX2014006622A patent/MX365923B/es active IP Right Grant
- 2012-12-12 CN CN201280060896.1A patent/CN104080767A/zh active Pending
- 2012-12-12 HK HK15102640.3A patent/HK1202119A1/xx unknown
- 2012-12-12 ES ES12806828T patent/ES2836973T3/es active Active
- 2012-12-12 JP JP2014546193A patent/JP6061949B2/ja not_active Expired - Fee Related
- 2012-12-12 AU AU2012352349A patent/AU2012352349B2/en not_active Ceased
- 2012-12-12 CA CA2857197A patent/CA2857197C/en active Active
- 2012-12-12 WO PCT/US2012/069289 patent/WO2013090454A2/en not_active Ceased
-
2014
- 2014-06-05 US US14/296,907 patent/US9187522B2/en not_active Expired - Fee Related
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