JP2015505842A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015505842A5 JP2015505842A5 JP2014546193A JP2014546193A JP2015505842A5 JP 2015505842 A5 JP2015505842 A5 JP 2015505842A5 JP 2014546193 A JP2014546193 A JP 2014546193A JP 2014546193 A JP2014546193 A JP 2014546193A JP 2015505842 A5 JP2015505842 A5 JP 2015505842A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- pharmaceutically acceptable
- racemate
- enantiomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(CC*CC(*)C*CC1)CC1C(NI)=O Chemical compound CC(C)(CC*CC(*)C*CC1)CC1C(NI)=O 0.000 description 5
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569754P | 2011-12-12 | 2011-12-12 | |
| US61/569,754 | 2011-12-12 | ||
| US201161570789P | 2011-12-14 | 2011-12-14 | |
| US61/570,789 | 2011-12-14 | ||
| US201261734300P | 2012-12-06 | 2012-12-06 | |
| US61/734,300 | 2012-12-06 | ||
| PCT/US2012/069289 WO2013090454A2 (en) | 2011-12-12 | 2012-12-12 | Novel glp-1 receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505842A JP2015505842A (ja) | 2015-02-26 |
| JP2015505842A5 true JP2015505842A5 (https=) | 2016-02-04 |
| JP6061949B2 JP6061949B2 (ja) | 2017-01-18 |
Family
ID=47436261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546193A Expired - Fee Related JP6061949B2 (ja) | 2011-12-12 | 2012-12-12 | 糖尿病などの疾患の治療のためのｇｌｐ−１受容体モジュレーターとして作用する４つの環を含むカルボン酸誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8778923B2 (https=) |
| EP (1) | EP2791112B1 (https=) |
| JP (1) | JP6061949B2 (https=) |
| KR (1) | KR20140107340A (https=) |
| CN (1) | CN104080767A (https=) |
| AU (1) | AU2012352349B2 (https=) |
| BR (1) | BR112014013925B1 (https=) |
| CA (1) | CA2857197C (https=) |
| ES (1) | ES2836973T3 (https=) |
| HK (1) | HK1202119A1 (https=) |
| MX (1) | MX365923B (https=) |
| RU (1) | RU2634896C2 (https=) |
| WO (1) | WO2013090454A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| AU2012352349B2 (en) | 2011-12-12 | 2017-08-17 | Receptos Llc | Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes |
| CN109867630A (zh) * | 2013-06-11 | 2019-06-11 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
| EP3172199B1 (en) | 2014-07-25 | 2020-07-01 | Celgene International II Sarl | Pyrimidine derivatives as glp-1 receptor modulators |
| AU2015360364B2 (en) | 2014-12-10 | 2020-04-30 | Receptos Llc | GLP-1 receptor modulators |
| JP7418958B2 (ja) | 2016-03-17 | 2024-01-22 | チオジェネシス セラピューティクス， インコーポレイテッド | システアミンの制御放出のための組成物及びシステアミン感受性障害の全身治療 |
| JP7091255B2 (ja) | 2016-05-06 | 2022-06-27 | アイオニス・ファーマシューティカルズ・インコーポレイテッド | Ｇｌｐ－１受容体リガンド部分コンジュゲート化オリゴヌクレオチドおよびその使用 |
| EA202092441A1 (ru) | 2016-06-07 | 2021-05-21 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| KR20240026521A (ko) | 2017-03-23 | 2024-02-28 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| ES2937835T3 (es) * | 2017-04-28 | 2023-03-31 | Receptos Llc | Nuevos moduladores del receptor de GLP-1 |
| JP7208982B2 (ja) | 2017-09-20 | 2023-01-19 | チオジェネシス セラピューティクス， インコーポレイテッド | システアミン感受性障害の治療方法 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| CR20210341A (es) * | 2018-11-22 | 2021-11-25 | Qilu Regor Therapeutics Inc | Agonistas de glp-ir y usos de los mismos |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US20220193080A1 (en) * | 2019-04-11 | 2022-06-23 | University Of The Sciences | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor |
| US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
| AU2020256647B2 (en) | 2019-04-12 | 2025-07-31 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
| CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁（杭州）生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用 |
| CA3157525A1 (en) | 2019-10-25 | 2021-04-29 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| JP7386997B2 (ja) * | 2019-11-15 | 2023-11-27 | イルドン ファーマシューティカル カンパニー リミテッド | Ｇｌｐ－１受容体アゴニストおよびその使用 |
| MY207021A (en) * | 2020-03-18 | 2025-01-24 | Lg Chemical Ltd | Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same |
| CN117645601A (zh) * | 2020-06-10 | 2024-03-05 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
| EP4247804A1 (en) | 2020-11-20 | 2023-09-27 | Gilead Sciences, Inc. | Polyheterocyclic glp-1 r modulating compounds |
| US20240246959A1 (en) | 2020-11-27 | 2024-07-25 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Benzimidazole derivative and preparation method therefor and medical use thereof |
| CN117222644A (zh) * | 2021-04-12 | 2023-12-12 | 诺华股份有限公司 | 2-((4-((S)-2-(4-氯-2-氟苯基)-2-甲基苯并[d][1,3]二氧戊环-4-基)哌啶-1-基)甲基)-1-(((S)-氧杂环丁烷-2-基)甲基)-1H-咪唑衍生物作为GLP1受体激活剂治疗肥胖症 |
| PH12023552860A1 (en) | 2021-04-21 | 2024-05-20 | Gilead Sciences Inc | Carboxy-benzimidazole glp-1r modulating compounds |
| TW202521533A (zh) | 2023-09-14 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| US12291530B1 (en) | 2023-11-24 | 2025-05-06 | Ascletis Pharma (China) Co., Limited | GLP-1R agonist and therapeutic method thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1062206B (it) | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | Derivati della tirosina attivi sulla muscolatura liscia |
| DE2423536A1 (de) | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| EP0996459B1 (en) | 1997-01-07 | 2005-09-21 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
| US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| HUP0003921A3 (en) * | 1997-07-31 | 2001-03-28 | Wyeth Corp | Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use |
| BR9811730B1 (pt) * | 1997-08-22 | 2014-04-08 | Hoffmann La Roche | Derivados de n-aroilfenilalanina, uso dos mesmos, medicamentos contendo os mesmos. |
| US6191171B1 (en) | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
| JP2002538081A (ja) | 1998-12-07 | 2002-11-12 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | Ｇｌｐ−１の類似体 |
| NZ512663A (en) | 1999-01-14 | 2004-05-28 | Amylin Pharmaceuticals Inc | Novel exendin agonist formulations and methods of administration thereof |
| AU3487500A (en) * | 1999-02-08 | 2000-08-25 | Lion Bioscience Ag | Thiazole derivatives and combinatorial libraries thereof |
| RU2281283C2 (ru) | 2000-03-07 | 2006-08-10 | Санофи-Авентис Дойчланд Гмбх | Замещенные 3-фенил-5-алкокси-1,3,4-оксадиазол-2-оны и их применение для ингибирования гормоночувствительной липазы |
| JP4895067B2 (ja) * | 2000-09-29 | 2012-03-14 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
| AU2002350217A1 (en) | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
| AU2003211560A1 (en) * | 2002-02-20 | 2003-09-09 | Ajinomoto Co., Inc. | Novel phenylalanine derivative |
| WO2003089410A1 (en) * | 2002-04-19 | 2003-10-30 | Kyowa Hakko Kogyo Co., Ltd. | Phenylalanine derivative |
| KR101194176B1 (ko) * | 2003-12-22 | 2012-10-24 | 아지노모토 가부시키가이샤 | 신규한 페닐알라닌 유도체 |
| KR20070004676A (ko) * | 2004-02-10 | 2007-01-09 | 얀센 파마슈티카 엔.브이. | 알파４ 인테그린의 길항제로서의 피리다지논 |
| US7825139B2 (en) | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| WO2008112939A2 (en) | 2007-03-13 | 2008-09-18 | Board Of Regents, The University Of Texas System | Composition and method for making oligo-benzamide compounds |
| EP2155720B1 (en) | 2007-06-08 | 2013-07-17 | Advinus Therapeutics Private Limited | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application |
| WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| CA2837334C (en) | 2011-06-01 | 2022-05-10 | Andrew Llc | Broadband distributed antenna system with non-duplexer isolator sub-system |
| AU2012352349B2 (en) | 2011-12-12 | 2017-08-17 | Receptos Llc | Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes |
| CN109867630A (zh) | 2013-06-11 | 2019-06-11 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
-
2012
- 2012-12-12 AU AU2012352349A patent/AU2012352349B2/en not_active Ceased
- 2012-12-12 BR BR112014013925-3A patent/BR112014013925B1/pt not_active IP Right Cessation
- 2012-12-12 MX MX2014006622A patent/MX365923B/es active IP Right Grant
- 2012-12-12 CA CA2857197A patent/CA2857197C/en active Active
- 2012-12-12 WO PCT/US2012/069289 patent/WO2013090454A2/en not_active Ceased
- 2012-12-12 HK HK15102640.3A patent/HK1202119A1/xx unknown
- 2012-12-12 CN CN201280060896.1A patent/CN104080767A/zh active Pending
- 2012-12-12 US US13/712,624 patent/US8778923B2/en active Active
- 2012-12-12 ES ES12806828T patent/ES2836973T3/es active Active
- 2012-12-12 KR KR1020147017945A patent/KR20140107340A/ko not_active Withdrawn
- 2012-12-12 RU RU2014128522A patent/RU2634896C2/ru active
- 2012-12-12 JP JP2014546193A patent/JP6061949B2/ja not_active Expired - Fee Related
- 2012-12-12 EP EP12806828.5A patent/EP2791112B1/en active Active
-
2014
- 2014-06-05 US US14/296,907 patent/US9187522B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015505842A5 (https=) | ||
| RU2014128522A (ru) | Новые модуляторы рецептора glp-1 | |
| JP2016528180A5 (https=) | ||
| JP2014527027A5 (https=) | ||
| ES2524916T3 (es) | Compuestos heterocíclicos de ácido borónico | |
| TWI385163B (zh) | 吡咯啉啶化合物 | |
| KR101025400B1 (ko) | 치환된 테트라시클린 화합물 | |
| JP2017526734A5 (https=) | ||
| KR101245062B1 (ko) | 칼슘이온-방출-활성화-칼슘이온 채널을 조절하는 방법 | |
| JP2013510883A5 (https=) | ||
| JP2017524005A5 (https=) | ||
| CN1471509A (zh) | 9-取代的二甲胺四环素化合物 | |
| JP2018505898A5 (https=) | ||
| JP2017531019A5 (https=) | ||
| JP2008513508A (ja) | 炎症及び免疫に関連する用途に用いる化合物 | |
| RU2011137419A (ru) | Обратные агонисты и антагонисты гистамина н3 и способы их применения | |
| WO2007049532A1 (ja) | アミノジヒドロチアジン誘導体 | |
| OA12047A (en) | Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents. | |
| RU2016105436A (ru) | Нейроактивные стероиды, композиции и их использование | |
| RU2018111106A (ru) | Производные карбоксизамещенных (гетеро)ароматических колец, способ их получения и применение | |
| JP2017538689A5 (https=) | ||
| JP2017538711A5 (https=) | ||
| KR20190020170A (ko) | 통풍 또는 고뇨산혈증과 관련된 증상의 치료 또는 예방을 위한 화합물, 조성물 및 방법 | |
| RU2014119711A (ru) | Трициклические соединения, композиции, содержащие указанные соединения, и их применения | |
| JP2023027160A (ja) | ＮｏｔｃｈシグナリングのエンハンサーならびにＮｏｔｃｈのアップレギュレーションにより治療可能ながんおよび悪性腫瘍の治療におけるその使用 |