HK1202119A1 - Novel glp-1 receptor modulators glp-1 - Google Patents
Novel glp-1 receptor modulators glp-1Info
- Publication number
- HK1202119A1 HK1202119A1 HK15102640.3A HK15102640A HK1202119A1 HK 1202119 A1 HK1202119 A1 HK 1202119A1 HK 15102640 A HK15102640 A HK 15102640A HK 1202119 A1 HK1202119 A1 HK 1202119A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- glp
- novel
- receptor modulators
- modulators
- receptor
- Prior art date
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- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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US201161569754P | 2011-12-12 | 2011-12-12 | |
US201161570789P | 2011-12-14 | 2011-12-14 | |
US201261734300P | 2012-12-06 | 2012-12-06 | |
PCT/US2012/069289 WO2013090454A2 (en) | 2011-12-12 | 2012-12-12 | Novel glp-1 receptor modulators |
Publications (1)
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HK1202119A1 true HK1202119A1 (en) | 2015-09-18 |
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HK15102640.3A HK1202119A1 (en) | 2011-12-12 | 2015-03-16 | Novel glp-1 receptor modulators glp-1 |
HK15103363.6A HK1202864A1 (en) | 2011-12-12 | 2015-04-02 | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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HK15103363.6A HK1202864A1 (en) | 2011-12-12 | 2015-04-02 | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1 |
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US (2) | US8778923B2 (xx) |
EP (1) | EP2791112B1 (xx) |
JP (1) | JP6061949B2 (xx) |
KR (1) | KR20140107340A (xx) |
CN (1) | CN104080767A (xx) |
AU (1) | AU2012352349B2 (xx) |
BR (1) | BR112014013925B1 (xx) |
CA (1) | CA2857197C (xx) |
ES (1) | ES2836973T3 (xx) |
HK (2) | HK1202119A1 (xx) |
MX (1) | MX365923B (xx) |
RU (1) | RU2634896C2 (xx) |
WO (1) | WO2013090454A2 (xx) |
Families Citing this family (21)
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US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
US9278910B2 (en) | 2011-05-31 | 2016-03-08 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
RU2634896C2 (ru) | 2011-12-12 | 2017-11-08 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
WO2014201172A1 (en) | 2013-06-11 | 2014-12-18 | Receptos, Inc. | Novel glp-1 receptor modulators |
KR102564946B1 (ko) * | 2014-07-25 | 2023-08-08 | 리셉토스 엘엘씨 | 신규 glp-1 수용체 조절제 |
WO2016094729A1 (en) * | 2014-12-10 | 2016-06-16 | Celgene International Ii Sarl | Glp-1 receptor modulators |
MX2018011278A (es) | 2016-03-17 | 2019-07-08 | Thiogenesis Therapeutics Inc | Composiciones para la liberacion controlada de cisteamina y el tratamiento sistemico de trastornos sensibles a la cisteamina. |
KR20230109185A (ko) | 2016-06-07 | 2023-07-19 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
JP6878615B2 (ja) | 2017-03-23 | 2021-05-26 | ジャコバイオ ファーマスーティカルズ カンパニー リミテッドJacobio Pharmaceuticals Co., Ltd. | Shp2阻害剤として有用な新規な複素環式誘導体 |
US11530205B2 (en) | 2017-04-28 | 2022-12-20 | Receptos Llc | GLP-1 receptor modulators |
JP7208982B2 (ja) | 2017-09-20 | 2023-01-19 | チオジェネシス セラピューティクス, インコーポレイテッド | システアミン感受性障害の治療方法 |
PE20211871A1 (es) | 2018-11-22 | 2021-09-21 | Qilu Regor Therapeutics Inc | Agonistas de glp-1r y usos de los mismos |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US20220193080A1 (en) * | 2019-04-11 | 2022-06-23 | University Of The Sciences | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor |
EA202192684A1 (ru) * | 2019-04-12 | 2021-12-28 | Цилу Регор Терапьютикс Инк. | Агонисты glp-1r и их применения |
US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
KR102344561B1 (ko) * | 2019-11-15 | 2021-12-29 | 일동제약(주) | Glp-1 수용체 작용제 및 이의 용도 |
MX2022011349A (es) * | 2020-03-18 | 2022-11-10 | Lg Chemical Ltd | Agonista del receptor de glp-1, composición farmacéutica que comprende el mismo, y método para preparar el mismo. |
CN113773310B (zh) * | 2020-06-10 | 2023-12-22 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
MX2023006186A (es) | 2020-11-27 | 2023-08-07 | Shenzhen Salubris Pharm Co Ltd | Derivado de benzimidazol y método de preparación del mismo y uso médico del mismo. |
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CN101679365A (zh) | 2007-06-08 | 2010-03-24 | 艾德维纳斯医疗私人有限公司 | 作为葡萄糖激酶激活剂的新型吡咯-2-甲酰胺衍生物、它们的制造方法和药学应用 |
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EP3961933A1 (en) | 2011-06-01 | 2022-03-02 | CommScope Technologies LLC | Interference mitigation in a broadband distributed antenna system with non-duplexer isolator sub-system |
RU2634896C2 (ru) | 2011-12-12 | 2017-11-08 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
WO2014201172A1 (en) | 2013-06-11 | 2014-12-18 | Receptos, Inc. | Novel glp-1 receptor modulators |
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2012
- 2012-12-12 RU RU2014128522A patent/RU2634896C2/ru active
- 2012-12-12 CA CA2857197A patent/CA2857197C/en active Active
- 2012-12-12 CN CN201280060896.1A patent/CN104080767A/zh active Pending
- 2012-12-12 ES ES12806828T patent/ES2836973T3/es active Active
- 2012-12-12 WO PCT/US2012/069289 patent/WO2013090454A2/en active Application Filing
- 2012-12-12 JP JP2014546193A patent/JP6061949B2/ja active Active
- 2012-12-12 EP EP12806828.5A patent/EP2791112B1/en active Active
- 2012-12-12 AU AU2012352349A patent/AU2012352349B2/en active Active
- 2012-12-12 US US13/712,624 patent/US8778923B2/en active Active
- 2012-12-12 KR KR1020147017945A patent/KR20140107340A/ko not_active Application Discontinuation
- 2012-12-12 BR BR112014013925-3A patent/BR112014013925B1/pt active IP Right Grant
- 2012-12-12 MX MX2014006622A patent/MX365923B/es active IP Right Grant
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2014
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2015
- 2015-03-16 HK HK15102640.3A patent/HK1202119A1/xx unknown
- 2015-04-02 HK HK15103363.6A patent/HK1202864A1/xx unknown
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WO2013090454A2 (en) | 2013-06-20 |
AU2012352349B2 (en) | 2017-08-17 |
RU2634896C2 (ru) | 2017-11-08 |
KR20140107340A (ko) | 2014-09-04 |
EP2791112A2 (en) | 2014-10-22 |
MX365923B (es) | 2019-06-20 |
ES2836973T3 (es) | 2021-06-28 |
HK1202864A1 (en) | 2015-10-09 |
CN104080767A (zh) | 2014-10-01 |
BR112014013925B1 (pt) | 2022-02-22 |
RU2014128522A (ru) | 2016-02-10 |
US8778923B2 (en) | 2014-07-15 |
CA2857197C (en) | 2019-11-26 |
NZ626122A (en) | 2016-10-28 |
JP2015505842A (ja) | 2015-02-26 |
US20130178420A1 (en) | 2013-07-11 |
CA2857197A1 (en) | 2013-06-20 |
EP2791112B1 (en) | 2020-09-23 |
US20150038416A1 (en) | 2015-02-05 |
WO2013090454A3 (en) | 2013-10-10 |
US9187522B2 (en) | 2015-11-17 |
MX2014006622A (es) | 2014-09-22 |
AU2012352349A1 (en) | 2014-07-03 |
BR112014013925A2 (pt) | 2018-05-15 |
JP6061949B2 (ja) | 2017-01-18 |
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