EA202192684A1 - Агонисты glp-1r и их применения - Google Patents

Агонисты glp-1r и их применения

Info

Publication number
EA202192684A1
EA202192684A1 EA202192684A EA202192684A EA202192684A1 EA 202192684 A1 EA202192684 A1 EA 202192684A1 EA 202192684 A EA202192684 A EA 202192684A EA 202192684 A EA202192684 A EA 202192684A EA 202192684 A1 EA202192684 A1 EA 202192684A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glp
agonists
prediabetes
obesity
formula
Prior art date
Application number
EA202192684A
Other languages
English (en)
Inventor
Вэнэ Чжун
Вэй ГО
Original Assignee
Цилу Регор Терапьютикс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Цилу Регор Терапьютикс Инк. filed Critical Цилу Регор Терапьютикс Инк.
Publication of EA202192684A1 publication Critical patent/EA202192684A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем изобретении представлены соединения формулы (I)и их фармацевтические композиции для применения, например, в лечении сахарного диабета 2 типа, преддиабета, ожирения, неалкогольной жировой болезни печени, неалкогольного стеатогепатита и сердечно-сосудистого заболевания.
EA202192684A 2019-04-12 2020-04-10 Агонисты glp-1r и их применения EA202192684A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019082381 2019-04-12
PCT/CN2020/084203 WO2020207474A1 (en) 2019-04-12 2020-04-10 Glp-1r agonists and uses thereof

Publications (1)

Publication Number Publication Date
EA202192684A1 true EA202192684A1 (ru) 2021-12-28

Family

ID=72750961

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192684A EA202192684A1 (ru) 2019-04-12 2020-04-10 Агонисты glp-1r и их применения

Country Status (20)

Country Link
US (1) US20230278991A1 (ru)
EP (1) EP3953344A4 (ru)
JP (1) JP2022527607A (ru)
KR (1) KR20210152513A (ru)
CN (1) CN113853371B (ru)
AU (1) AU2020256647A1 (ru)
BR (1) BR112021020335A2 (ru)
CA (1) CA3136375A1 (ru)
CL (1) CL2021002649A1 (ru)
CO (1) CO2021015060A2 (ru)
CR (1) CR20210562A (ru)
CU (1) CU20210083A7 (ru)
DO (1) DOP2021000208A (ru)
EA (1) EA202192684A1 (ru)
IL (1) IL287128A (ru)
MA (1) MA55627A (ru)
MX (1) MX2021012492A (ru)
PE (1) PE20220143A1 (ru)
SG (1) SG11202110825WA (ru)
WO (1) WO2020207474A1 (ru)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
TWI751585B (zh) * 2019-06-28 2022-01-01 美商美國禮來大藥廠 類升糖素肽1受體促效劑
KR20220092909A (ko) 2019-10-25 2022-07-04 길리애드 사이언시즈, 인코포레이티드 Glp-1r 조절 화합물
CN114761395A (zh) * 2019-12-02 2022-07-15 现代药品株式会社 Glp-1受体激动剂
KR20220133271A (ko) * 2020-01-29 2022-10-04 길리애드 사이언시즈, 인코포레이티드 Glp-1r 조절 화합물
CR20220371A (es) 2020-02-07 2022-10-27 Gasherbrum Bio Inc Agonistas heterocíclicos de glp-1
CN115697999A (zh) * 2020-02-13 2023-02-03 加舒布鲁姆生物公司 杂环glp-1激动剂
PE20230175A1 (es) * 2020-03-18 2023-02-01 Lg Chemical Ltd Agonista del receptor de glp-1, composicion farmaceutica que comprende el mismo, y metodo para preparar el mismo
CN115279750B (zh) * 2020-03-18 2024-06-21 株式会社Lg化学 Glp-1受体激动剂、包含该激动剂的药物组合物及其制备方法
TW202144340A (zh) * 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
WO2021259309A1 (zh) * 2020-06-24 2021-12-30 广州市恒诺康医药科技有限公司 Glp-1受体激动剂及其药物组合物和用途
IL300155A (en) 2020-08-06 2023-03-01 Gasherbrum Bio Inc Heterocyclic GLP-1 agonists
JP2023538949A (ja) 2020-08-28 2023-09-12 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
WO2022068772A1 (zh) * 2020-09-29 2022-04-07 深圳信立泰药业股份有限公司 一种苯并咪唑类衍生物及其制备方法和医药用途
CN116348464A (zh) 2020-10-12 2023-06-27 杭州中美华东制药有限公司 苯并咪唑酮类glp-1受体激动剂及其用途
CN116547279A (zh) * 2020-10-13 2023-08-04 加舒布鲁姆生物公司 杂环glp-1激动剂
AU2021359493A1 (en) * 2020-10-14 2023-06-15 Qilu Regor Therapeutics Inc. Crystal forms of glp-1r agonists and uses thereof
CN114478497B (zh) * 2020-11-12 2023-10-20 杭州中美华东制药有限公司 芳基烷基酸类glp-1受体激动剂及其用途
EP4247804A1 (en) * 2020-11-20 2023-09-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
MX2023006186A (es) * 2020-11-27 2023-08-07 Shenzhen Salubris Pharm Co Ltd Derivado de benzimidazol y método de preparación del mismo y uso médico del mismo.
MX2023007569A (es) * 2020-12-25 2023-09-21 Xizang Haisco Pharmaceutical Co Ltd Derivado de anillo de cinco miembros y uso medico de este.
WO2022184849A1 (en) 2021-03-04 2022-09-09 Les Laboratoires Servier Glp-1r agonists, uses and pharmaceutical compositions thereof
WO2022192428A1 (en) * 2021-03-11 2022-09-15 Gilead Sciences, Inc. Glp-1r modulating compounds
US20240208952A1 (en) 2021-03-22 2024-06-27 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. Thiophene glp-1 receptor agonist and use thereof
WO2022202864A1 (ja) 2021-03-24 2022-09-29 塩野義製薬株式会社 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物
CN117222631A (zh) * 2021-03-24 2023-12-12 诚益生物(美国)公司 苯基-[1,3]二氧杂环戊烯并[4,5-c]吡啶基-苯基-、苯基-[1,3]二氧杂环戊烯并[4,5-c]吡啶基-杂芳基-或苯基-[1,3]二氧杂环戊烯并[4,5-c]吡啶基-哌啶基-甲基-氧杂环丁烷基甲基-1h-苯并[d]咪唑-甲酸衍生物及其使用方法
WO2022216094A1 (ko) * 2021-04-08 2022-10-13 주식회사 엘지화학 Glp-1 수용체 효능제, 이를 포함하는 약학적 조성물 및 이의 제조방법
US11858918B2 (en) * 2021-04-21 2024-01-02 Gilead Sciences, Inc. GLP-1R modulating compounds
EP4271674A1 (en) * 2021-04-21 2023-11-08 Gilead Sciences, Inc. Carboxy-benzimidazole glp-1r modulating compounds
AU2022271223A1 (en) * 2021-05-03 2023-11-02 Carmot Therapeutics, Inc. Benzimidazoyl glp-1 receptor agonists, pharmaceutical compositions comprising the same, and methods for their use
TWI843104B (zh) * 2021-05-20 2024-05-21 美商美國禮來大藥廠 類升糖素肽1受體促效劑
IL309235A (en) 2021-06-24 2024-02-01 Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd GLP-1 receptor agonist and its preparation and use
CN117715906A (zh) * 2021-07-21 2024-03-15 和博医药有限公司 胰高血糖素样肽-1受体调节剂及其用途
CN113480534B (zh) * 2021-07-23 2022-05-13 广州必贝特医药股份有限公司 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用
MX2024001331A (es) * 2021-08-04 2024-04-19 Shanghai Hansoh Biomedical Co Ltd Regulador derivado del cicloalqueno, método de preparación de este y su aplicación.
CA3224598A1 (en) * 2021-08-30 2023-03-09 Long Zhang Novel aryl ether substituted heterocyclic compound as glp1r agonist
AU2022344074A1 (en) 2021-09-08 2024-02-29 Shionogi & Co., Ltd. Medicine for prevention and treatment of diseases linked to anti-obesity activity
WO2023057429A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
WO2023057414A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
WO2023057427A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes as glp-1 receptor modulators
AU2022375634A1 (en) 2021-10-25 2024-06-06 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
CA3239813A1 (en) * 2021-12-03 2023-06-08 Lu Gan Crystal forms of thienoimidazole compound and preparation method thereof
JPWO2023106310A1 (ru) * 2021-12-07 2023-06-15
WO2023111145A1 (en) 2021-12-16 2023-06-22 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
WO2023111144A1 (en) 2021-12-16 2023-06-22 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
CN116354945B (zh) * 2021-12-27 2024-08-30 长春金赛药业有限责任公司 一种稠合咪唑羧酸类化合物及其制备方法和应用
WO2023130878A1 (zh) * 2022-01-10 2023-07-13 海思科医药集团股份有限公司 一种glp-1激动剂盐及其晶型及在医药上的应用
AU2023225875A1 (en) * 2022-02-28 2024-09-26 Ascletis Bioscience Co., Ltd. Glp-1r modulating compounds
WO2023169436A1 (zh) * 2022-03-08 2023-09-14 广州市联瑞制药有限公司 苯并双环类化合物及其制备方法和应用
KR20240135652A (ko) * 2022-05-20 2024-09-11 쳉두 띠아오 지우홍 파마수티칼 팩토리 벤즈이미다졸 또는 아자벤즈이미다졸 화합물, 이의 제조 방법 및 그의 용도
TW202408504A (zh) * 2022-06-23 2024-03-01 大陸商西藏海思科製藥有限公司 噻吩[2,3-d]咪唑類化合物的鹽及其晶型和在醫藥上的用途
CN117362282A (zh) * 2022-07-07 2024-01-09 杭州德睿智药科技有限公司 Glp-1r激动剂的盐及其制备方法和应用
WO2024041609A1 (zh) * 2022-08-24 2024-02-29 广州市联瑞制药有限公司 苯并双环类化合物及其制备方法和应用
WO2024051749A1 (zh) * 2022-09-06 2024-03-14 德睿智药(苏州)新药研发有限公司 一种glp-1r激动剂化合物的多晶型物及其制备方法与用途
WO2024102625A1 (en) 2022-11-11 2024-05-16 Eli Lilly And Company Glucagon-like peptide 1 receptor agonists
WO2024107781A1 (en) 2022-11-16 2024-05-23 Eli Lilly And Company Glucagon-like peptide 1 receptor agonists
WO2024125442A1 (zh) * 2022-12-13 2024-06-20 杭州中美华东制药有限公司 Glp-1受体激动剂的新晶型和制备方法及其药物组合物和用途
CN118496200A (zh) * 2023-02-14 2024-08-16 成都康弘药业集团股份有限公司 吲唑啉酮类化合物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG185515A1 (en) * 2010-05-13 2012-12-28 Amgen Inc Nitrogen heterocyclic compounds useful as pde10 inhibitors
AU2012352349B2 (en) * 2011-12-12 2017-08-17 Receptos Llc Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes
JP6637641B1 (ja) * 2016-12-16 2020-01-29 ファイザー・インク Ｇｌｐ−１受容体アゴニストおよびその使用
EP3806855B1 (en) * 2018-06-15 2023-03-01 Pfizer Inc. Glp-1 receptor agonists and uses thereof
BR112021009877A2 (pt) * 2018-11-22 2021-08-17 Qilu Regor Therapeutics Inc. agonistas glp-1r e usos dos mesmos
KR20220092909A (ko) * 2019-10-25 2022-07-04 길리애드 사이언시즈, 인코포레이티드 Glp-1r 조절 화합물
CN114761395A (zh) * 2019-12-02 2022-07-15 现代药品株式会社 Glp-1受体激动剂
CN115697999A (zh) * 2020-02-13 2023-02-03 加舒布鲁姆生物公司 杂环glp-1激动剂
TW202144340A (zh) * 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用

Also Published As

Publication number Publication date
CN113853371B (zh) 2024-05-03
EP3953344A1 (en) 2022-02-16
KR20210152513A (ko) 2021-12-15
DOP2021000208A (es) 2021-11-21
EP3953344A4 (en) 2023-08-09
MX2021012492A (es) 2021-11-12
CO2021015060A2 (es) 2021-11-19
CU20210083A7 (es) 2022-05-11
CL2021002649A1 (es) 2022-05-06
CA3136375A1 (en) 2020-10-15
SG11202110825WA (en) 2021-10-28
IL287128A (en) 2021-12-01
AU2020256647A1 (en) 2021-11-18
CR20210562A (es) 2022-02-18
WO2020207474A1 (en) 2020-10-15
BR112021020335A2 (pt) 2021-12-14
US20230278991A1 (en) 2023-09-07
JP2022527607A (ja) 2022-06-02
CN113853371A (zh) 2021-12-28
MA55627A (fr) 2022-02-16
PE20220143A1 (es) 2022-01-27

Similar Documents

Publication Publication Date Title
EA202192684A1 (ru) Агонисты glp-1r и их применения
EA202191432A1 (ru) Агонисты glp-1r и их применения
AR123156A1 (es) Agonistas de glp-1r y sus usos
EA202092003A1 (ru) Соединения для лечения болезни гентингтона
EA202092896A1 (ru) Гетероциклические и гетероарильные соединения для лечения болезни гентингтона
EA201792562A1 (ru) Глюкагон и коагонисты гпп-1
EA200970337A1 (ru) Ингибиторы котранспортера натрий-глюкозы 2 и способы их применения
BR112017019300A2 (pt) conjugado de fórmula genérica ama - l - x - s - ab, método para sintetizar um conjugado de fórmula genérica ama - l - x - s - ab, kit, método para sintetizar o composto ama - l - x', composição farmacêutica e método para tratar uma doença associada a células que apresentam um alvo
UA96308C2 (ru) Антагонисты рецептора глюкагона, композиция, которая содержит такие соединения, и их применение
ECSP088120A (es) Derivados de piridazinona como agonistas del receptorde la hormona tiroidea
DE602007007211D1 (de) Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1
ATE526318T1 (de) Farnesoid-x-rezeptor-agonisten
CL2009001065A1 (es) Compuestos derivados de 4-pirimidinil-1,3-tiazol (o 1,3-oxazol) sulfonamidas sustituidas, inhibidores de quinasas raf; composicion farmaceutica; procedimiento de preparacion; y uso para tratar un neoplasma susceptible, seleccionado de adenocarcinoma de barret, carcinomas del tracto biliar y cancer de seno, entre otros.
MA30476B1 (fr) Derives de type cyclohexylpyrazole-lactame comme inhibiteurs de la 11-beta-hydroxysteroïde deshydrogenase de type 1
DE602006009095D1 (en) Diacylglycerol-acyltransferase-hemmer
MA33428B1 (fr) Agonistes du gpr119
EA200601279A1 (ru) Пиперидинилкарбонилпирролидины и их применение в качестве агонистов меланокортина
EA201170795A1 (ru) Антагонисты ccr2 группы 4-азетидинил-1-гетероарил-циклогексанола
BRPI0414868A (pt) composições e métodos compreendendo compostos relacionados com prostaglandina e peptìdios da famìlia do fator trifoliado para o tratamento de glaucoma com hiperemia reduzida
MX2019001667A (es) Sulfonamidas como agonistas de gpr40 y gpr120.
MX2020004981A (es) Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3.
CL2007000789A1 (es) Compuestos derivados de malonamida, inhibidores de la gamma-secretasa; proceso de preparacion; composicion farmaceutica; y su uso en el tratamiento de la enfermedad de alzheimer.
EA200901164A1 (ru) КОНДЕНСИРОВАННЫЕ ПИРИМИДИНОНЫ В КАЧЕСТВЕ ЛИГАНДОВ mGLUR
NO20064675L (no) Polymorfe og amorfe former av 2,5-dimetyl-2H-pyrazol-3-karboksylsyre {2-fluoro-5-[3-((E)-2-pyridin-2-yl-vinyl)-1 H-indasol-6-ylamino]-fenyl]-amid
WO2008156331A3 (en) Novel use of lignan compounds