EA200901164A1 - КОНДЕНСИРОВАННЫЕ ПИРИМИДИНОНЫ В КАЧЕСТВЕ ЛИГАНДОВ mGLUR - Google Patents

КОНДЕНСИРОВАННЫЕ ПИРИМИДИНОНЫ В КАЧЕСТВЕ ЛИГАНДОВ mGLUR

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Publication number
EA200901164A1
EA200901164A1 EA200901164A EA200901164A EA200901164A1 EA 200901164 A1 EA200901164 A1 EA 200901164A1 EA 200901164 A EA200901164 A EA 200901164A EA 200901164 A EA200901164 A EA 200901164A EA 200901164 A1 EA200901164 A1 EA 200901164A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidinons
condensed
mglur
ligands
mglur ligands
Prior art date
Application number
EA200901164A
Other languages
English (en)
Inventor
Рольф Глаттхар
Замуэль Хинтерманн
Иван-Тома Вранесиц
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200901164A1 publication Critical patent/EA200901164A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В заявке описаны соединения формулы (I)где заместители имеют значения, указанные в п. 1, композиции, включающие указанные соединения, и их применение в качестве фармацевтических агентов.
EA200901164A 2007-03-05 2008-03-03 КОНДЕНСИРОВАННЫЕ ПИРИМИДИНОНЫ В КАЧЕСТВЕ ЛИГАНДОВ mGLUR EA200901164A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0704230.2A GB0704230D0 (en) 2007-03-05 2007-03-05 Organic compounds
PCT/EP2008/052564 WO2008107418A1 (en) 2007-03-05 2008-03-03 Fused pyrimidinone compounds as mglur ligands

Publications (1)

Publication Number Publication Date
EA200901164A1 true EA200901164A1 (ru) 2010-10-29

Family

ID=37965945

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901164A EA200901164A1 (ru) 2007-03-05 2008-03-03 КОНДЕНСИРОВАННЫЕ ПИРИМИДИНОНЫ В КАЧЕСТВЕ ЛИГАНДОВ mGLUR

Country Status (12)

Country Link
US (1) US20100137340A1 (ru)
EP (1) EP2132210A1 (ru)
JP (1) JP2010520255A (ru)
KR (1) KR20090127272A (ru)
CN (1) CN101627040A (ru)
AU (1) AU2008223903A1 (ru)
BR (1) BRPI0808566A2 (ru)
CA (1) CA2678463A1 (ru)
EA (1) EA200901164A1 (ru)
GB (1) GB0704230D0 (ru)
MX (1) MX2009009345A (ru)
WO (1) WO2008107418A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011338339A1 (en) 2010-12-08 2013-06-27 Vanderbilt University Bicyclic pyrazole compounds as allosteric modulators of mGluR5 receptors
CA2830220A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imidazopyrimidin-5(6h)-ones as allosteric modulators of mglur5 receptors
US9688681B2 (en) * 2013-05-28 2017-06-27 Bayer Cropscience Aktiengesellschaft Heterocyclic compounds as pest control agents
EP3116868B1 (de) 2014-03-10 2018-06-06 Bayer CropScience Aktiengesellschaft Heterocylische verbindungen als schädlingsbekämpfungsmittel
RU2638530C2 (ru) * 2016-02-29 2017-12-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) ПРОИЗВОДНЫЕ 5-АМИНОИЗОКСАЗОЛА - КОНФОРМАЦИОННО-ЖЕСТКИЕ АНАЛОГИ γ-АМИНОМАСЛЯНОЙ КИСЛОТЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
EP3459939A1 (en) * 2017-09-26 2019-03-27 Pragma Therapeutics Novel heterocyclic compounds as modulators of mglur7

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156277A1 (en) * 2001-04-20 2002-10-24 Fick David B. Synthesis and methods of use of purine analogues and derivatives
WO2006081072A1 (en) * 2005-01-24 2006-08-03 Abbott Laboratories Antagonists of the mglu receptor and uses thereof
WO2007072094A1 (en) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. New compounds

Also Published As

Publication number Publication date
EP2132210A1 (en) 2009-12-16
KR20090127272A (ko) 2009-12-10
WO2008107418A1 (en) 2008-09-12
MX2009009345A (es) 2009-09-11
JP2010520255A (ja) 2010-06-10
CA2678463A1 (en) 2008-09-12
GB0704230D0 (en) 2007-04-11
BRPI0808566A2 (pt) 2014-09-02
CN101627040A (zh) 2010-01-13
US20100137340A1 (en) 2010-06-03
AU2008223903A1 (en) 2008-09-12

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