HK1202864A1 - Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1 - Google Patents
Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1Info
- Publication number
- HK1202864A1 HK1202864A1 HK15103363.6A HK15103363A HK1202864A1 HK 1202864 A1 HK1202864 A1 HK 1202864A1 HK 15103363 A HK15103363 A HK 15103363A HK 1202864 A1 HK1202864 A1 HK 1202864A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- glp
- therapy
- diseases
- carboxylic acid
- acid derivatives
- Prior art date
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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US201161570789P | 2011-12-14 | 2011-12-14 | |
US201261734300P | 2012-12-06 | 2012-12-06 | |
PCT/US2012/069289 WO2013090454A2 (en) | 2011-12-12 | 2012-12-12 | Novel glp-1 receptor modulators |
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HK1202864A1 true HK1202864A1 (en) | 2015-10-09 |
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HK15103363.6A HK1202864A1 (en) | 2011-12-12 | 2015-04-02 | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1 |
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EP (1) | EP2791112B1 (xx) |
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KR (1) | KR20140107340A (xx) |
CN (1) | CN104080767A (xx) |
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MX (1) | MX365923B (xx) |
RU (1) | RU2634896C2 (xx) |
WO (1) | WO2013090454A2 (xx) |
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US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
DK2713722T3 (en) | 2011-05-31 | 2017-07-03 | Celgene Int Ii Sarl | Newly known GLP-1 receptor stabilizers and modulators |
RU2634896C2 (ru) | 2011-12-12 | 2017-11-08 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
ES2864349T3 (es) * | 2013-06-11 | 2021-10-13 | Receptos Llc | Nuevos moduladores del receptor GLP-1 |
KR102564946B1 (ko) * | 2014-07-25 | 2023-08-08 | 리셉토스 엘엘씨 | 신규 glp-1 수용체 조절제 |
CA2969944A1 (en) * | 2014-12-10 | 2016-06-16 | Celgene International Ii Sarl | Glp-1 receptor modulators |
US11173135B2 (en) | 2016-03-17 | 2021-11-16 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
CN109475568A (zh) | 2016-05-06 | 2019-03-15 | Ionis制药公司 | Glp-1受体配体部分缀合的寡核苷酸及其用途 |
EA201990001A1 (ru) | 2016-06-07 | 2019-05-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
JP7116745B2 (ja) * | 2017-04-28 | 2022-08-10 | レセプトス・リミテッド・ライアビリティ・カンパニー | 新規なglp-1受容体モジュレーター |
EP3684418A4 (en) | 2017-09-20 | 2021-06-16 | Thiogenesis Therapeutics, Inc. | TREATMENT METHODS FOR CYSTEAMINE SENSITIVE CONDITIONS |
JP2022508203A (ja) * | 2018-11-22 | 2022-01-19 | キル・レガー・セラピューティクス・インコーポレーテッド | Glp-1rアゴニスト及びその使用 |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
WO2020210582A1 (en) * | 2019-04-11 | 2020-10-15 | University Of The Sciences | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor |
SG11202110825WA (en) * | 2019-04-12 | 2021-10-28 | Qilu Regor Therapeutics Inc | Glp-1r agonists and uses thereof |
US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
US20230002348A1 (en) * | 2019-11-15 | 2023-01-05 | Ildong Pharmaceutical Co., Ltd. | GLP-1 Receptor Agonist and Use Thereof |
US20230203021A1 (en) * | 2020-03-18 | 2023-06-29 | Lg Chem, Ltd. | Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same |
CN113773310B (zh) * | 2020-06-10 | 2023-12-22 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
CA3200245A1 (en) | 2020-11-27 | 2022-06-02 | Junjun Wu | Benzimidazole derivative and preparation method therefor and medical use thereof |
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IT1062206B (it) | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | Derivati della tirosina attivi sulla muscolatura liscia |
DE2423536A1 (de) | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
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CN1265672A (zh) * | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 能抑制由vla-4介导的白细胞粘连的磺酰化二肽化合物 |
US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
DK1005445T3 (da) | 1997-08-22 | 2004-10-04 | Hoffmann La Roche | N-alkanoylphenylaninderivater |
US6191171B1 (en) | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
BR9916027A (pt) | 1998-12-07 | 2001-08-28 | Sod Conseils Rech Applic | Análogos de glp-1 |
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AU3487500A (en) * | 1999-02-08 | 2000-08-25 | Lion Bioscience Ag | Thiazole derivatives and combinatorial libraries thereof |
EE04877B1 (et) | 2000-03-07 | 2007-08-15 | Aventis Pharma Deutschland Gmbh | Asendatud 3-fenl-5-alkoks-1,3,4-oksadiasol-2-oon, selle valmistamine ja kasutamine hormoontundlikku lipaasi prssivas ravimis ning seda sisaldav suhkurt?ve ravim |
DE60124573T2 (de) * | 2000-09-29 | 2007-06-21 | Ajinomoto Co., Inc. | Neue phenylalanin-derivate |
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JPWO2003089410A1 (ja) * | 2002-04-19 | 2005-08-25 | 協和醗酵工業株式会社 | フェニルアラニン誘導体 |
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US7816324B2 (en) | 2007-03-13 | 2010-10-19 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by a peptide receptor |
WO2008149382A1 (en) | 2007-06-08 | 2008-12-11 | Advinus Therapeutics Private Limited | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application |
WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
DK2713722T3 (en) | 2011-05-31 | 2017-07-03 | Celgene Int Ii Sarl | Newly known GLP-1 receptor stabilizers and modulators |
CA2837334C (en) | 2011-06-01 | 2022-05-10 | Andrew Llc | Broadband distributed antenna system with non-duplexer isolator sub-system |
RU2634896C2 (ru) | 2011-12-12 | 2017-11-08 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
ES2864349T3 (es) | 2013-06-11 | 2021-10-13 | Receptos Llc | Nuevos moduladores del receptor GLP-1 |
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2012
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- 2012-12-12 AU AU2012352349A patent/AU2012352349B2/en not_active Ceased
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- 2012-12-12 US US13/712,624 patent/US8778923B2/en active Active
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2014
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2015
- 2015-03-16 HK HK15102640.3A patent/HK1202119A1/xx unknown
- 2015-04-02 HK HK15103363.6A patent/HK1202864A1/xx unknown
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CA2857197A1 (en) | 2013-06-20 |
NZ626122A (en) | 2016-10-28 |
EP2791112B1 (en) | 2020-09-23 |
BR112014013925B1 (pt) | 2022-02-22 |
WO2013090454A2 (en) | 2013-06-20 |
AU2012352349A1 (en) | 2014-07-03 |
BR112014013925A2 (pt) | 2018-05-15 |
CN104080767A (zh) | 2014-10-01 |
AU2012352349B2 (en) | 2017-08-17 |
JP2015505842A (ja) | 2015-02-26 |
RU2634896C2 (ru) | 2017-11-08 |
RU2014128522A (ru) | 2016-02-10 |
EP2791112A2 (en) | 2014-10-22 |
WO2013090454A3 (en) | 2013-10-10 |
MX2014006622A (es) | 2014-09-22 |
US20130178420A1 (en) | 2013-07-11 |
CA2857197C (en) | 2019-11-26 |
KR20140107340A (ko) | 2014-09-04 |
US20150038416A1 (en) | 2015-02-05 |
HK1202119A1 (en) | 2015-09-18 |
US9187522B2 (en) | 2015-11-17 |
ES2836973T3 (es) | 2021-06-28 |
MX365923B (es) | 2019-06-20 |
JP6061949B2 (ja) | 2017-01-18 |
US8778923B2 (en) | 2014-07-15 |
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