JP2014527027A5 - - Google Patents
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- JP2014527027A5 JP2014527027A5 JP2014513706A JP2014513706A JP2014527027A5 JP 2014527027 A5 JP2014527027 A5 JP 2014527027A5 JP 2014513706 A JP2014513706 A JP 2014513706A JP 2014513706 A JP2014513706 A JP 2014513706A JP 2014527027 A5 JP2014527027 A5 JP 2014527027A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- ring
- atom
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 124
- 150000001875 compounds Chemical class 0.000 claims description 102
- 125000003545 alkoxy group Chemical group 0.000 claims description 70
- 125000003118 aryl group Chemical group 0.000 claims description 65
- 125000006413 ring segment Chemical group 0.000 claims description 65
- 125000001072 heteroaryl group Chemical group 0.000 claims description 64
- 125000000623 heterocyclic group Chemical group 0.000 claims description 62
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 59
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 50
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 46
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 38
- -1 hydroxy, methyl Chemical group 0.000 claims description 25
- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
- 125000004043 oxo group Chemical group O=* 0.000 claims description 24
- OSDBJMYIUDLIRI-UHFFFAOYSA-N oxo-[[1-[[4-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]cyclohexyl]oxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COC1CCC(OCN2C=CC(=C[NH+]=O)C=C2)CC1 OSDBJMYIUDLIRI-UHFFFAOYSA-N 0.000 claims description 23
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical group 0.000 claims description 17
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- VHVGFEDTMPYCSX-UHFFFAOYSA-N [1-[[2,2-dimethyl-3-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]propoxy]methyl]pyridin-4-ylidene]methyl-oxoazanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COCC(C)(C)COCN1C=CC(=C[NH+]=O)C=C1 VHVGFEDTMPYCSX-UHFFFAOYSA-N 0.000 claims description 9
- 125000002619 bicyclic group Chemical group 0.000 claims description 9
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 230000004913 activation Effects 0.000 claims description 7
- 230000008484 agonism Effects 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims description 6
- 125000004980 cyclopropylene group Chemical group 0.000 claims description 6
- 102000005962 receptors Human genes 0.000 claims description 6
- 108020003175 receptors Proteins 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 5
- 230000002159 abnormal effect Effects 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- 206010064720 Lack of satiety Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000004104 gestational diabetes Diseases 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 16
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 claims 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 description 40
- 125000005843 halogen group Chemical group 0.000 description 34
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 32
- 229910052717 sulfur Inorganic materials 0.000 description 19
- 229910052760 oxygen Inorganic materials 0.000 description 14
- 125000001715 oxadiazolyl group Chemical group 0.000 description 10
- 125000002971 oxazolyl group Chemical group 0.000 description 10
- 125000003226 pyrazolyl group Chemical group 0.000 description 9
- 125000000714 pyrimidinyl group Chemical group 0.000 description 9
- 125000001425 triazolyl group Chemical group 0.000 description 9
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 8
- 229940002612 prodrug Drugs 0.000 description 8
- 239000000651 prodrug Substances 0.000 description 8
- 239000012453 solvate Substances 0.000 description 8
- 125000004429 atom Chemical group 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 0 Cc(ccc(*)c1)c1OC Chemical compound Cc(ccc(*)c1)c1OC 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 description 4
- 235000010290 biphenyl Nutrition 0.000 description 4
- 239000004305 biphenyl Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 description 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical group O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 description 1
- INSZEJWMNPZYCP-SNAWJCMRSA-N CC(C)(N)[IH]/C=C/C Chemical compound CC(C)(N)[IH]/C=C/C INSZEJWMNPZYCP-SNAWJCMRSA-N 0.000 description 1
- MAIFURVUXIRYSZ-UHFFFAOYSA-N Cc(cc1)c(C(F)(F)F)cc1OC Chemical compound Cc(cc1)c(C(F)(F)F)cc1OC MAIFURVUXIRYSZ-UHFFFAOYSA-N 0.000 description 1
- FPGUYDZXCTUCOX-UHFFFAOYSA-N Cc(cc1)ccc1-c(cc1)ccc1-c1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc(cc3)ccc3N(C)C)=O)=O)cc2)n[o]1 Chemical compound Cc(cc1)ccc1-c(cc1)ccc1-c1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc(cc3)ccc3N(C)C)=O)=O)cc2)n[o]1 FPGUYDZXCTUCOX-UHFFFAOYSA-N 0.000 description 1
- TXXAVEHDCDMGNW-UHFFFAOYSA-N Cc(cc1)ccc1-c(cc1)ccc1-c1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc3cccc(CN)c3)=O)=O)cc2)n[o]1 Chemical compound Cc(cc1)ccc1-c(cc1)ccc1-c1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc3cccc(CN)c3)=O)=O)cc2)n[o]1 TXXAVEHDCDMGNW-UHFFFAOYSA-N 0.000 description 1
- KWYVKFLUXLNHSP-UHFFFAOYSA-N Cc(cc1)ccc1C#Cc1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc(cc3)c(C(F)(F)F)cc3OC)=O)=O)cc2)n[o]1 Chemical compound Cc(cc1)ccc1C#Cc1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc(cc3)c(C(F)(F)F)cc3OC)=O)=O)cc2)n[o]1 KWYVKFLUXLNHSP-UHFFFAOYSA-N 0.000 description 1
- BFUWWCJOMJNPLE-UHFFFAOYSA-N Cc(cc1)ccc1NC(c1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc(cc3)c(C(F)(F)F)cc3OC)=O)=O)cc2)n[o]1)=O Chemical compound Cc(cc1)ccc1NC(c1nc(-c2ccc(CN(CC(O)=O)C(c(cc3)ccc3NC(Cc(cc3)c(C(F)(F)F)cc3OC)=O)=O)cc2)n[o]1)=O BFUWWCJOMJNPLE-UHFFFAOYSA-N 0.000 description 1
- CHLICZRVGGXEOD-UHFFFAOYSA-N Cc(cc1)ccc1OC Chemical compound Cc(cc1)ccc1OC CHLICZRVGGXEOD-UHFFFAOYSA-N 0.000 description 1
- ZVHGCLSSXMTEBV-UHFFFAOYSA-N Cc1ccc(CCCc2nc(-c3ccc(CN(CC(O)=O)C(c(cc4)ccc4NC(Cc(cc4)c(C(F)(F)F)cc4OC)=O)=O)cc3)n[o]2)cc1 Chemical compound Cc1ccc(CCCc2nc(-c3ccc(CN(CC(O)=O)C(c(cc4)ccc4NC(Cc(cc4)c(C(F)(F)F)cc4OC)=O)=O)cc3)n[o]2)cc1 ZVHGCLSSXMTEBV-UHFFFAOYSA-N 0.000 description 1
- 108010011459 Exenatide Proteins 0.000 description 1
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 1
- 108010063919 Glucagon Receptors Proteins 0.000 description 1
- 102100040890 Glucagon receptor Human genes 0.000 description 1
- 102000015626 Glucagon-Like Peptide-2 Receptor Human genes 0.000 description 1
- 108010024044 Glucagon-Like Peptide-2 Receptor Proteins 0.000 description 1
- 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 description 1
- 108010019598 Liraglutide Proteins 0.000 description 1
- YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 description 1
- XVVOERDUTLJJHN-UHFFFAOYSA-N Lixisenatide Chemical compound C=1NC2=CC=CC=C2C=1CC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NCC(=O)NCC(=O)N1C(CCC1)C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N1C(CCC1)C(=O)N1C(CCC1)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC=1C=CC=CC=1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(N)CC=1NC=NC=1)C(C)O)C(C)O)C(C)C)CC1=CC=CC=C1 XVVOERDUTLJJHN-UHFFFAOYSA-N 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 229940123464 Thiazolidinedione Drugs 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 229960001519 exenatide Drugs 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960002701 liraglutide Drugs 0.000 description 1
- 108010004367 lixisenatide Proteins 0.000 description 1
- 229960001093 lixisenatide Drugs 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 229960003105 metformin Drugs 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000005447 octyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 108010048573 taspoglutide Proteins 0.000 description 1
- WRGVLTAWMNZWGT-VQSPYGJZSA-N taspoglutide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 WRGVLTAWMNZWGT-VQSPYGJZSA-N 0.000 description 1
- 229950007151 taspoglutide Drugs 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161491446P | 2011-05-31 | 2011-05-31 | |
| US61/491,446 | 2011-05-31 | ||
| US201161535750P | 2011-09-16 | 2011-09-16 | |
| US61/535,750 | 2011-09-16 | ||
| US201161569759P | 2011-12-12 | 2011-12-12 | |
| US61/569,759 | 2011-12-12 | ||
| PCT/US2012/040250 WO2012166951A1 (en) | 2011-05-31 | 2012-05-31 | Novel glp-1 receptor stabilizers and modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016061862A Division JP2016128509A (ja) | 2011-05-31 | 2016-03-25 | 新規ｇｌｐ−１受容体安定剤および調節剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527027A JP2014527027A (ja) | 2014-10-09 |
| JP2014527027A5 true JP2014527027A5 (https=) | 2016-05-19 |
| JP6007417B2 JP6007417B2 (ja) | 2016-10-12 |
Family
ID=47259864
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513706A Expired - Fee Related JP6007417B2 (ja) | 2011-05-31 | 2012-05-31 | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| JP2016061862A Pending JP2016128509A (ja) | 2011-05-31 | 2016-03-25 | 新規ｇｌｐ−１受容体安定剤および調節剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016061862A Pending JP2016128509A (ja) | 2011-05-31 | 2016-03-25 | 新規ｇｌｐ−１受容体安定剤および調節剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9278910B2 (https=) |
| EP (1) | EP2713722B1 (https=) |
| JP (2) | JP6007417B2 (https=) |
| DK (1) | DK2713722T3 (https=) |
| ES (1) | ES2634716T3 (https=) |
| PT (1) | PT2713722T (https=) |
| WO (1) | WO2012166951A1 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| AU2012352349B2 (en) | 2011-12-12 | 2017-08-17 | Receptos Llc | Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes |
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2012
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- 2012-05-31 EP EP12793320.8A patent/EP2713722B1/en active Active
- 2012-05-31 PT PT127933208T patent/PT2713722T/pt unknown
- 2012-05-31 US US14/122,176 patent/US9278910B2/en not_active Expired - Fee Related
- 2012-05-31 WO PCT/US2012/040250 patent/WO2012166951A1/en not_active Ceased
- 2012-05-31 ES ES12793320.8T patent/ES2634716T3/es active Active
- 2012-05-31 DK DK12793320.8T patent/DK2713722T3/en active
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2016
- 2016-01-15 US US14/997,364 patent/US9700543B2/en active Active
- 2016-03-25 JP JP2016061862A patent/JP2016128509A/ja active Pending
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